Leading gainers Monday morning included Cytokinetics , whose shares rallied about 7% premarket after Needham upgraded the late-stage biopharma company to a Strong Buy with a $22 per share upside. Among other things, Needham analyst Chad Messer wrote that Cytokinetics’ “Phase III VITALITY-ALS study of tirasemtiv in amyotrophic lateral sclerosis is expected to read out by year end”.