To understand the molecular mechanisms involved in the interaction of bone with orthopedic implants comprised of novel biomaterials, researchers have made a mouse model in which they can assess early tissue responses to surfaces such as bioactive glass. The ease of genetically modifying this mouse model makes it especially valuable in designing novel biomaterials for use in regenerative medicine, as describe in an article published in Tissue Engineering, Part C Methods, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers .