Journal of Human Hypertension 31, 178–188; doi:10.1038/jhh.2016.54; published online 11 August 2016 The DISTINCT study investigated the efficacy and safety of nifedipine GITS candesartan cilexetil combinations vs respective monotherapies and placebo in patients with hypertension. This descriptive sub-analysis examined blood pressure -lowering effects in high-risk participants, including those with renal impairment disease are at increased risk of future events and mortality.