Myriad Genetics, Inc. , a global leader in personalized medicine, today announced new data demonstrating the utility of the ProlarisA test to more accurately classify mortality risk and guide the management of newly diagnosed men with prostate cancer. The data are being presented at the 2017 Genitourinary Cancers Symposium meeting in Orlando, Fla.
Category: Genetics
Type 1 diabetes (Juvenile Diabetes) Therapeutic and Drug Overview Pipeline Review H2
PUNE, INDIA, February 17, 2017 / EINPresswire.com / — Type 1 diabetes is an autoimmune disease in which a pancreas stops producing insulin, a hormone that enables people to get energy from food. It occurs when the body’s immune system attacks and destroys the insulin-producing cells in the pancreas, called beta cells.
Analyzing copies of genes may offer new therapeutic approaches for ovarian cancer
… the pathway that stood out was autophagy — a natural process of cell death that helps maintain normal cellular health. Ovarian cancer cells use autophagy all of the time, but also lose several copies of autophagy genes resulting in a compromised …
Genetic Testing Your Health
If one or more close family members has a disease with a genetic link, testing for the gene may make sense. In some diseases, genetic testing gives doctors the ability to detect problems early.
Lawmakers question pricing of drug for genetic disease
… “exorbitantly” pricing potentially life-saving medications hurts patient access and drives up prices for the entire health care sector. Lawmakers challenged Mylan NV last year for its EpiPen pricing, which has climbed more than 500 percent since …
Improving infant screening to save lives
Health care advocates across the state will head to the Arizona state legislature to support increased testing for Severe Combined Immunodeficiency in babies.
Epidemiology, environmental risk factors and genetics of Parkinson’s disease.
To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document. Parkinson’s disease is a frequent neurodegenerative disease with a premotor phase that lasts several years.
12 Heart-Smart Tips You Haven’t Heard
When I flip my calendar to February, two things usually come to my mind. One, I’m getting tired of the cold and snowy winter, and two, Valentine’s Day is coming.
Epilepsy drug discovered in fish model shows promise in small pediatric clinical trial
… supported by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health. “This is the first time that scientists have taken a potential therapy discovered in a fish model directly into people in a …
Will Seattle Genetics’ Deal With Immunomedics Get Scuttled?
The deal could be a big win for Seattle Genetics, but it doesn’t have the full support of all of Immunomedics investors. After the closing market bell on Friday, venBio Select Advisors, LLC — the beneficial owner of 9.9% of Immunomedics shares — said Immunomedics’ board of directors is “giving away its crown jewel.”
Health Notes: Go with the Flow to dodge air pollution
The world’s first air pollution tracker has been launched in an effort to help cyclists and other commuters steer clear of toxic ‘hotspots’ while travelling in cities. Air pollution reached a six-year high in London last month, forcing health chiefs to issue a warning to city-dwellers to stay indoors to protect their health – part of a global problem.
Fish oil asthma benefits may be blocked by medication
… “If an individual is unable to produce desirable levels of SPMs-due to lifestyle behaviour, dietary choices, or health status-in response to an immune challenge, the resolution of the immune response can be impacted. Omega-3 fish oils can be found …
My Double Mastectomy Scars Have Their Own Instagram Account
When I was 22, my mother urged me to get tested to see if I was genetically predisposed to get cancer. The disease runs in my family: My mom’s aunt died of breast cancer when I was a baby, and my paternal grandmother, Cookie, died of ovarian cancer when I was five.
Researchers call this year’s flu vaccine effectiveness ‘decent’
… when we tally the serious outcomes at the end of the season.” Young children, the elderly and people with underlying health conditions like heart disease are vulnerable to complications from flu; H3N2 flu is particularly hard on the elderly. An …
Scientists are growing healthy skin for diseased patients
… Medicine, announced last week. The center, a new joint initiative of Stanford Healthcare, Stanford Children’s Health, and the Stanford School of Medicine, is designed to accelerate cellular therapies at the university’s state-of-the-art …
Phanerochaete sordida as a cause of pulmonary nodule in an immunocompromised patient: a case report
Phanerochaete sordida is a species of wood rotting fungus, which can degrade lignin, cellulose and hemicellulose contained in wood and other hard-to-biodegrade organic substances. However, to date, there have been no other reports demonstrating that P. sordida can infect humans.
Gene Variant Identified for Kawasaki Disease Susceptibility
… iego and Rady Children’s Hospital-San Diego. Funding for this research came, in part, from the National Institutes of Health (U54HL108460)
Gene Variant Identified for Kawasaki Disease Susceptibility
… iego and Rady Children’s Hospital-San Diego. Funding for this research came, in part, from the National Institutes of Health (U54HL108460)
Ovid Therapeutics and NeuroPointDX Announce Collaboration to Identify …
Ovid Therapeutics, a privately held biopharmaceutical company committed to developing medicines that transform the lives of people with rare neurological disorders, and NeuroPointDX, a privately held biotech company based in Madison, Wisconsin and Cambridge, Massachusetts, today announced that they have entered into a collaboration to identify novel biomarkers of Angelman syndrome by analyzing metabolomic profile data as part of Ovid’s ongoing randomized, double-blind, placebo-controlled Phase 2 clinical trial .
Your heart will thank you if you do these things
If you’ve taken the steps to cease and desist some of your more unhealthy habits, it’s now time to add some healthy ones to your arsenal. Putting a priority on heart health will allow you to have a fulfilling and active lifestyle and will contribute to fewer visits to the doctor.
Many high-risk patients with breast cancer arena t getting genetic testing. Herea s why.
… tool for certain women,” said study author Reshma Jagsi, a radiation oncologist at the University of Michigan Health System. “It is worrisome to see so many of these women at highest risk for mutations failing even to have a visit focused on genetic …
Endurance training may have a protective effect on the heart
… a single bout of endurance exercise . This may contribute to the protective effects of exercise on cardiovascular health.’ More information: Andrew T. Ludlow et al, Acute exercise activates p38 MAPK and increases the expression of telomere …
Scientists evaluate rapid test that detects colistin resistance gene in bacterial isolates
… antibiotic resistance in gut bacteria. The research team combines expertise from scientific institutions and public health. Alongside scientists from the Justus Liebig University Giessen, further members of the association include scientists from …
Studies reveal link between rotator cuff disease and genetics
A new study presented this week at the Association of Academic Physiatrists Annual Meeting in Las Vegas shows rotator cuff disease might be a heritable trait. Rotator cuff disease is a common disorder that affects 30 to 50 percent of people over the age of 50. The disease often leads to shoulder pain and loss of function.
Genes point to who develops lung disease, study finds
Scientists unveiled a trove of newly-discovered gene variants on Monday to help predict who will most likely develop a killer lung disease, both among smokers and non-smokers. The world’s biggest probe of the genetics of lung health yielded 43 new gene variants linked to chronic obstructive pulmonary disease , a major cause of death.
Scientists catalogue ‘parts list’ of brain cell types in a major appetite center
Using Harvard-developed technology, scientists at Beth Israel Deaconess Medical Center have catalogued more than 20,000 brain cells in one region of the mouse hypothalamus. The study, published in Nature Neuroscience , revealed some 50 distinct cell types, including a previously undescribed neuron type that may underlie some of the genetic risk of human obesity.
Square advice on your new hip
When a friend of mine went to China a couple of years ago, he experienced difficulty navigating the Great Wall because of osteoarthritis of his hip. When he got back home and had to crawl up the steps to his bedroom, he realized it was time to have his hip replaced.
Genetic Research Shows Promise as Cancer Treatment
World Cancer Day is Feb. 4, and hundreds of activities are planned around the world. According to the World Health Organization, about 14 million people are diagnosed with cancer every year and more than 8 million people die.
Technavio Predicts the MRSA Testing Market to Grow at 11% CAGR Through 2021
In this report, Technavio covers the market outlook and growth prospects of the global MRSA testing market for 2017-2021. By product type, the market is divided into immunodiagnostics and molecular diagnostics segments.
Gene variants can add 2cm to your height
PIC: Chandra Bahadur Dangi, from Nepal, the shortest adult in the world, poses for pictures with the world’s tallest man Sultan Kosen from Turkey, during a photocall in London on November 13, 2014. Researchers have unveiled 83 rare gene variants which exert a strong influence on human height, with some capable of adding or subtracting more than two centimetres .
OPKO’S GeneDx Announces Research Collaboration with the Wellcome Trust Sanger Institute
OPKO Health, Inc. announced today that its subsidiary and business unit, GeneDx, is entering into a collaboration with the Deciphering Developmental Disorder study led by the Wellcome Trust Sanger Institute. The Wellcome Trust Sanger Institute is a non-profit research institute that played a central role in the human genome project.
Scientists shocked by discovery about brains
… USC Viterbi School of Engineering. The researchers analyzed data of 3,647 65- to 79-year-old women from the Women’s Health Initiative Memory Study (WHIMS). These women lived across 48 states and did not have dementia when they enrolled. The …
European researchers highlight potential of xenografts in cancer research and treatment
European research lays the foundation for the development of new and ambitious research projects with xenografts derived from patients, preclinical models with great potential to advance research and treatment in cancer. The review article, published in Nature Reviews Cancer , is the result of the joint work of the European consortium of researchers EurOPDX, which includes different researchers from the Bellvitge Biomedical Research Institute – Catalan Institute of Oncology , among which there are Eva Gonzalez-Suarez and Alberto Villanueva.
Defects in key gene spur breast and ovarian cancer growth, study shows
Defects in a key gene – long thought to drive cancer by turning off the protection afforded by the well-known BRCA genes – spur cancer growth on their own, according to a study led by researchers from NYU Langone Medical Center. The study gene, known as EMSY, has some of the same functions as BRCA1 and BRCA2, which are known to protect against breast and ovarian cancer when normal.
Aevi Genomic Medicine Announces Enrollment of First Patient in Phase…
“We are pleased to have the first patient enrolled into this important study,” said Garry Neil, Chief Scientific Officer of Aevi Genomic Medicine. “Patients with 22q Deletion Syndrome often suffer from a range of debilitating psychiatric conditions, including anxiety disorders, ASD, and ADHD, with many patients progressing to psychosis and schizophrenia.
Dimension Announces Interim Topline Results from Ongoing Phase 1/2…
Dimension Announces Interim Topline Results from Ongoing Phase 1/2 Clinical Program for DTX101, Dimension’s Lead AAV Product Candidate in Development for Adult Patients with Moderate/Severe to Severe Hemophilia B CAMBRIDGE, Mass., Jan. 31, 2017 — Dimension Therapeutics, Inc. , a biopharmaceutical company advancing novel, adeno-associated virus gene therapies targeting the liver, a key organ for human metabolism, today announced preliminary topline safety and early efficacy results of Dimension’s multi-center phase 1/2 study of DTX101 for the treatment of adult patients with moderate/severe to severe hemophilia B. DTX101, Dimension’s lead AAV candidate, is designed to deliver stable expression of blood clotting Factor IX in patients with hemophilia B, a rare genetic bleeding disorder resulting from a deficiency in FIX.
Jefferson researchers reveal new insight into two states of viral protein
To generate swarms of new viral particles, a virus hijacks a cell into producing masses of self-assembling cages that are then loaded with the genetic blueprint for the next infection. But the picture of how that DNA is loaded into those viral cages, or capsids, was blurry, especially for two of the most common types of DNA virus on earth, bacterial viruses and human herpesvirus.
LSU scientist helps find method of extracting DNA from rare, often extinct, museum specimens
LSU Museum of Natural Science Curator Chris Austin developed and tested a protocol to sequence the DNA of rare and even extinct animals from historic museum collections. LSU Museum of Natural Science Curator Chris Austin developed and tested a protocol to sequence the DNA of rare and even extinct animals from historic museum collections.
New Pharmacotherapies in Chronic Lymphocytic Leukemia
… 82.6% of CLL patients are expected to survive at least five years, based on data from the National Institutes of Health’s Surveillance, Epidemiology, and End Results or SEER program. 4 Advances in molecular and cytogenetic analyses have allowed more …
Busy minds may be better at fighting dementia
Mentally stimulating activities can protect your brain against aging, even if you’re genetically predisposed toward dementia or Alzheimer’s disease , a new study reports. Activities that keep the brain busy — using a computer, crafting, playing games and participating in social activities — appear to lower the risk of age-related mental decline in people 70 and older, the Mayo Clinic study found.