A smartphone app that uses deep learning lets people with Parkinson’s disease test their symptoms at home in just 4 minutes. The app could help people monitor the disease’s progression more closely, and uncover how lifestyle factors may affect their symptoms.

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British doctors treated a grandmother’s dangerously high blood pressure by inserting an electric wire in her brain in a world first. Amely Hoffmann, 55, had blood pressure that was so high she was at risk of suffering a stroke at any time.

WHEN ten-year-old Finlay Rowan decided to help other people like his grandad who are suffering from Parkinson’s Disease, he enlisted the help of his mum. “He told me he wanted to have his head shaved to raise funds for Parkinson’s UK – and he said, ”Will you do it with me?’ I couldn’t really say no, could I?” laughed Wendy, of Eldwick , Bingley .

Accumulating evidence suggests that insulin-like growth factor 1 plays an important role in Parkinson’s disease pathogenesis. However, it is not clear if IGF1 polymorphism contributes to PD risk.

A small number of British Columbians suffering from Parkinson’s disease will soon be able to try the costly medication Duodopa, with fees covered by the province, as long as they have no other option of treatment. In a statement released Tuesday, Health Minister Terry Lake said he’s been in discussion with Parkinson Society British Columbia and the Pacific Parkinson’s Research Centre about the high cost of the drug and its effectiveness.

Alpha-synuclein is expressed during neuronal development and is mainly involved in the modulation of synaptic transmission. Missense mutations and amplifications of this gene have been associated with the pathogenesis of Parkinson’s disease.

This was a longitudinal single-center cohort study to comprehensively explore multimodal progression markers for Parkinson disease in patients with recently diagnosed PD and age-matched, neurologically healthy controls . Thirty tests at baseline and after 24 months covered nonmotor symptoms , cognitive function, and REM sleep behavior disorder by polysomnography , voxel-based morphometry of the brain by MRI, and CSF markers.

… ways to monitor the progression of Parkinson’s disease in patients. Jenn Jakobi and Gareth Jones at UBCO’s school of health and exercise sciences found that a hand-grip test could be a reliable way to monitor possible declines.

Variants in the RIC3 gene have recently been suggested as a novel cause of Parkinson’s disease . Herein, the entire RIC3 gene was sequenced in a French-Canadian and French sample series of 535 PD patients and 527 unaffected controls.

To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document. I -Synuclein is the major component of Lewy bodies, Lewy neurites, and glial cytoplasmic inclusions.

To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document. Molecular imaging has proven to be a powerful tool for investigation of parkinsonian disorders.

Our study was aimed to evaluate the risk of a selected non-motor symptom, namely rapid eye movement behavior disorder symptoms, among patients with newly diagnosed Parkinson disease compared with health controls. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for meta-analysis and Cochrane manual were followed.

… and appealing to different “listening” audiences. Stanford Medicine is leading the biomedical revolution in precision health, defining and developing the next generation of care that is proactive, predictive and precise.

Scientists have identified two distinct mechanisms in the human brain that control the balance between speed and accuracy when making decisions. One network increases the amount of information needed to make accurate choices, while the other tends to lower this threshold for quick decision making.

Neurodegenerative diseases such as Alzheimer’s disease , Parkinson’s disease , and Multiple Sclerosis are characterized by neuronal degeneration and neuronal death in specific regions of the central nervous system . In AD, neurons of the hippocampus and entorhinal cortex are the first to degenerate, whereas in PD, dopaminergic neurons in the substantia nigra degenerate.

Identifying endophenotypes of schizophrenia is of critical importance and has profound implications on clinical practice. Here we propose an innovative approach to clarify the mechanims through which temperament and character deviance relates to risk for schizophrenia and predict long-term treatment outcomes.

Expression of prion protein in the cerebrospinal fluid of patients with Parkinson’s disease complicated with rapid eye movement sleep behavior disorder. Parkinson’s disease is one of the most common neurodegenerative diseases and mainly manifests with decreasing numbers of dopaminergic neurons.

Passing Thoughts 13, created by Artist Susan Aldworth printed directly from slices of human brains which forms part of the Realisation exhibition aiming to raise awareness of the need for brain donation and research into Parkinson’s disease. Artwork printed directly from slices of human brains forms part of a Cambridge exhibition aiming to raise awareness of the need for brain donation and research into Parkinson’s disease.

On Song: Robyn Sharpe, Jeanette Pritchett, Lyn Lehane, Len Hoy, Daffydd Wiesner-Ellix and Andrew Suggett participating in Parkinsong. Picture: Amy Paton MEMBERS of Warrnambool’s Parkinson’s Disease support group were hoping to raise the roof of Macey’s Bistro on Wednesday.

Blood RNA biomarkers in prodromal PARK4 and REM sleep behavior disorder show role of complexin-1 loss for risk of Parkinson’s disease. Parkinson’s disease is a frequent neurodegenerative process at old age.

TAKING ACTION: Colin Woodcroft will be speaking at the Family History Centre, sharing his journey with Parkinson’s Disease. Picture: supplied.

LRRK2 mutations and risk variants increase susceptibility to inherited and idiopathic Parkinson’s disease, while recent studies have identified potential protective variants. This, and the fact that LRRK2 mutation carriers develop symptoms and brain pathology almost indistinguishable from idiopathic Parkinson’s disease, has led to enormous interest in this protein.

Mutations in parkin and Pink1 are responsible for autosomal recessive forms of early onset Parkinson’s disease . Attributed to the failure of neurons to clear dysfunctional mitochondria, loss of gene expression leads to loss of nigrostriatal neurons.

Voyager Therapeutics, Inc. , a clinical-stage gene therapy company developing life-changing treatments for severe diseases of the central nervous system , today announced updates regarding the Phase 1b trial of VY-AADC01 for patients with advanced Parkinson’s disease. “The clinical trial of VY-AADC01 is progressing well with all five patients in Cohort 3 successfully completing treatment,” said Bernard Ravina, M.D., M.S., vice president of clinical development at Voyager Therapeutics.

Former President George H.W. Bush has been diagnosed with pneumonia and suffers from a rare syndrome called vascular parkinsonism, which mimics the effects of Parkinson’s disease. Bush, 92, has been using a wheelchair ever since breaking a vertebra in 2015.

The presentation of Parkinson’s disease patients with mutations in the LRRK2 gene is highly variable, suggesting a strong influence of modifying factors. In this context, inflammation is a potential candidate inducing clinical subtypes.