Newly discovered breast stem cells wake up when exposed to ovarian hormones

Walter and Eliza Hall Institute researchers have used advanced cellular, bioinformatics and imaging technology to reveal a long-lived type of stem cell in the breast that is responsible for the growth of the mammary glands during pregnancy. The newly discovered stem cells, which respond to the ‘ovarian hormones’ progesterone and oestrogen, may also be linked to a high-risk form of breast cancer.

Newly discovered breast stem cells wake up when exposed to ovarian hormones

Walter and Eliza Hall Institute researchers have used advanced cellular, bioinformatics and imaging technology to reveal a long-lived type of stem cell in the breast that is responsible for the growth of the mammary glands during pregnancy. The newly discovered stem cells, which respond to the ‘ovarian hormones’ progesterone and oestrogen, may also be linked to a high-risk form of breast cancer.

Hypoxia in primary tumors influences dormant DTCs that evade cancer therapy, study shows

In a first of its kind study, Mount Sinai researchers have discovered the conditions by which specific signals in primary tumors of head and neck and breast cancers, pre-program cancer cells to become dormant and evade chemotherapy after spreading. Their findings, published in the January 31, 2017 issue of Nature Cell Biology and featured on the cover, could lead to new drug development, treatment options and transform the way doctors care for cancer patients to treat metastatic disease.

Scientists create mature heart muscle cells from stem cells

The mature heart muscle cells were created by implanting stem cells from a healthy adult or one with a type of heart disease into newborn rat hearts. The host hearts then give biological signals and chemistry necessary for the implanted immature heart muscle cells to overcome a developmental blockage that usually stops growth.

Scientists create mature heart muscle cells from stem cells

The mature heart muscle cells were created by implanting stem cells from a healthy adult or one with a type of heart disease into newborn rat hearts. The host hearts then give biological signals and chemistry necessary for the implanted immature heart muscle cells to overcome a developmental blockage that usually stops growth.

Gene expression of pluripotency determinants is conserved between mammalian and planarian stem cells.

Freshwater planaria possess extreme regeneration capabilities mediated by abundant, pluripotent stem cells in adult animals. Although planaria emerged as an attractive in vivo model system for stem cell biology, gene expression in neoblasts has not been profiled comprehensively and it is unknown how molecular mechanisms for pluripotency in neoblasts relate to those in mammalian embryonic stem cells .

Postdoctoral Fellow Positions Available

Postdoctoral fellow positions in neuroscience are available at the Department of Neurosurgery in the State University of New York Upstate Medical University in the . We are looking for highly motivated postdocs with experience in both in vivo and in vitro to join our research team for performing US federal government funded research projects.