Discoveries in basic research, new technology, next-generation treatments, early intervention and diagnostic tools, ranged from new experiments that reveal the brain circuitry behind the inability to experience pleasure, a milestone in the search for the cause of schizophrenia, and findings that explain how ketamine exerts its rapid antidepressant effects. “The top 10 discoveries were selected because of their significant contributions to our understanding of brain and behavior disorders as well as potential new treatments,” says , M.D., president and CEO of the Brain & Behavior Research Foundation, the top non-governmental mental health research funder cited in published articles.