Murine Study Finds Potential Boost for Ovarian Cancer Drug Olaparib

Researchers from the Chinese Academy of Sciences have discovered that the metabolic enzyme phosphoglycerate mutase 1 helps cancer cells repair their DNA and found that inhibiting PGAM1 sensitizes tumors to the cancer drug Olaparib . Their findings in the study ” Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells ,” which has been published in The Journal of Cell Biology , suggest that this FDA-approved ovarian cancer medicine has the potential to treat a wider range of cancer types than currently indicated.