Researchers at the University of Tubingen, working with colleagues in other parts of Germany and in the United States, have identified an enzyme as a kind of biological gauge regulating inflammation in the human body. Professor Alexander Weber of the Interfaculty Institute of Cell Biology says the enzyme – Bruton’s tyrosine kinase or BTK – is switched on when an inflammation occurs in the body, playing a key role in the inflammation’s subsequent development.
Category: Cell Biology
Cancer cells adapt nerve cell mechanisms to fuel aggressive tumor growth and spread
How we think and fall in love are controlled by lightning-fast electrochemical signals across synapses, the dynamic spaces between nerve cells. Until now, nobody knew that cancer cells can repurpose tools of neuronal communication to fuel aggressive tumor growth and spread.
Molecular aid to insulin secretion identified
Blood sugar triggers the secretion of insulin from cells in the pancreas, a process that is impaired in diabetes. A team of Yale researchers have identified a mechanism at the membranes of these pancreatic cells that controls this fundamental function.
Research findings could lead to effective repair therapies for peripheral nerve damage
Research published today, 30th January 2017 online in the Journal of Cell Biology , has for the first time identified how a bodily protein allows nerves of the peripheral nervous system to repair following injury. The findings, discovered by research neuroscientists at Plymouth University Peninsula Schools of Medicine and Dentistry and funded by the Medical Research Council, could lead to effective repair therapies for those who have suffered peripheral nerve damage in trauma cases or perhaps via battlefield injuries.
Murine Study Finds Potential Boost for Ovarian Cancer Drug Olaparib
Researchers from the Chinese Academy of Sciences have discovered that the metabolic enzyme phosphoglycerate mutase 1 helps cancer cells repair their DNA and found that inhibiting PGAM1 sensitizes tumors to the cancer drug Olaparib . Their findings in the study ” Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells ,” which has been published in The Journal of Cell Biology , suggest that this FDA-approved ovarian cancer medicine has the potential to treat a wider range of cancer types than currently indicated.
Study provides insights into CPEB4 gene and fatty liver disease
This condition generally leads to chronic inflammation , which can trigger fibrosis, cirrhosis and ultimately liver cancer. This study on the basic biology of the liver paves the way to examine therapeutic strategies to fight and prevent fatty liver disease .
Postdoctoral Fellow Positions Available
Postdoctoral fellow positions in neuroscience are available at the Department of Neurosurgery in the State University of New York Upstate Medical University in the . We are looking for highly motivated postdocs with experience in both in vivo and in vitro to join our research team for performing US federal government funded research projects.
RAGE regulates key signaling pathway that promotes acute and chronic inflammation
… Editor-in-Chief, of DNA and Cell Biology and Professor, Departments of Biology and Neural Science, and Global Public Health at New York University, NY. “By developing new drugs to block the interaction of RAGE with its receptor, in the future, there …