Statistical inference for multi-scale models using high-performance computing Parallel implementation of the ABC SMC algorithm Study of tumor spheroid growth in droplets using growth curves and histological data Proof of principle for fitting of mechanistic model with 106 single cells Mechanistic understanding of multi-scale biological processes, such as cell proliferation in a changing biological tissue, is readily facilitated by computational models. While tools exist to construct and simulate multi-scale models, the statistical inference of the unknown model parameters remains an open problem.