New daily weight-loss pill shows success at clinical trial

Orforglipron also reduced blood sugar levels in participants with type 2 diabetes

A significant trial of a daily weight-loss pill has found that it helped people to shed the pounds and reduce their blood sugar levels, making it a contender to join the new wave of drugs that combat obesity and diabetes.

People who took a 36mg pill of orforglipron lost an average of 7.3kg (16lbs) over nine months, according to results from a phase 3 clinical trial reported by the drug’s manufacturer, Eli Lilly, on Thursday.

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Uyghur rights group calls on hotel chains not to ‘sanitise’ China abuses in Xinjiang

Growth in international hotels coincides with government effort to push region as a tourism destination

Almost 200 international hotels are operating or planning to open in Xinjiang, despite calls from human rights groups for global corporations not to help “sanitise” the Chinese government’s human rights abuses in the region, a report has said.

The report by the Uyghur Human Rights Project (UHRP) identified 115 operational hotels which the organisation said “benefit from a presence in the Uyghur region”. At least another 74 were in various stages of construction or planning, the report said. The UHRP said some of the hotels also had exposure or links of concern to forced labour and labour transfer programmes.

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Nvidia’s CEO makes surprise visit to Beijing after US restricts chip sales to China

Jensen Huang causes stir on social media and is reported to have met founder of AI company DeepSeek

The chief executive of the American chip maker Nvidia visited Beijing on Thursday, days after the US issued fresh restrictions on sales of the only AI chip it was still allowed to sell to China.

Jensen Huang’s surprise visit was on the invitation of a trade organisation, according to a social media account affiliated with state media.

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China accuses UK politicians of ‘arrogance’ in British Steel row

Embassy criticises ‘slandering’ of Chinese government and defends Jingye over furnaces dispute

China has accused UK politicians of “arrogance, ignorance and a twisted mindset” as it defended British Steel’s owner, Jingye, after a barrage of criticism over the narrowly averted shutdown of its blast furnaces.

Beijing’s embassy to the UK accused unspecified British public figures of slandering China’s government and businesses, in comments published on Wednesday on its website.

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China to snub UK energy summit amid row over infrastructure projects

Exclusive: Absence of world’s biggest clean energy producer will be welcomed by US pushing oil and gas exports

China is to snub a major UK summit on energy security next week, the Guardian has learned, amid a growing row over the country’s involvement in UK infrastructure projects.

The US will send a senior White House official to the 60-country summit, to be co-hosted with the International Energy Agency. Leading oil and gas companies are also invited, along with big technology businesses, and petrostates including Saudi Arabia, Qatar and the United Arab Emirates.

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Hong Kong halts postal service for US-bound goods over Trump’s ‘bullying’ tariffs

Post office says it ‘definitely’ won’t collect tariffs on Washington’s behalf and Hongkongers should prepare to pay exorbitant fees

Hong Kong Post said on Wednesday it had suspended goods mail services by sea to the US and will suspend its air mail postal service for items containing goods from 27 April due to “bullying” US tariffs.

When sending items to the US, people in Hong Kong “should be prepared to pay exorbitant and unreasonable fees due to the US’s unreasonable and bullying acts”, Hong Kong Post said in a statement.

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UK trade secretary to visit China with aim of reviving key joint trade commission

Jonathan Reynold’s trip suggests government will continue its rapprochement with Beijing despite security concerns

The trade secretary, Jonathan Reynolds, will travel to Beijing to revive a key trade dialogue with China despite saying it had been naive to allow Chinese investment in sensitive sectors, the Guardian has learned.

Reynolds is scheduled to travel to China later this year for high-level talks in an effort to boost bilateral trade and investment.

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Revealed: Chinese researchers can access half a million UK GP records

Medical information will be available from UK Biobank, despite western intelligence agencies’ security fears

Researchers from China are to be allowed access to half a million UK GP records despite western intelligence agencies’ fears about the authoritarian regime amassing health data, the Guardian can reveal.

Preparations are under way to transfer the records to UK Biobank, a research hub that holds detailed medical information donated by 500,000 volunteers. One of the world’s largest troves of health data, the facility makes its information available to universities, scientific institutes and private companies. A Guardian analysis shows one in five successful applications for access come from China.

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Australian PM voices concern after report Russia requested access to Indonesia air force base

Anthony Albanese says ‘obviously do not want to see Russian influence in our region’, and analysts say it is unlikely the unusual request would be granted

Australian prime minister Anthony Albanese has said officials are seeking further information after a report emerged that Russia is seeking to base military aircraft in Indonesia’s remote Papua region, on Australia’s northern doorstep.

Albanese said on Tuesday: “We obviously do not want to see Russian influence in our region, very clearly.

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UN calls on Trump to exempt poorest countries from ‘reciprocal’ tariffs

Unctad says many countries targeted with high tariff rates are unlikely to be a threat to US

The UN’s trade and development arm, Unctad, is calling on Donald Trump to exempt the world’s poorest and smallest countries from “reciprocal” tariffs, or risk “serious economic harm”.

In a report published on Monday, Unctad identifies 28 nations the US president singled out for a higher tariff rate than the 10% baseline – despite each accounting for less than 0.1% of the US trade deficit.

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Sky-high US-China tariffs are a mutual trade embargo that will hurt both sides

Effects could tip one into recession and undermine other’s fragile economy but prospects for rapprochement are not hopeless

Sky-high tariffs that now hang heavily over US-China trade mean, effectively, that they have declared a trade embargo on each other, normally an act of war. The economic consequences for both will hurt.

The US’s $150bn (£113bn) or so of exports to China will fall away quickly, while China’s $440bn worth of exports to the US may drop by up to 75% over the next 18 months, unless some sort of negotiation happens. No one will be spared the effects.

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‘No winners’ in a trade war, says China’s Xi as he heads to Vietnam on charm offensive

Xi Jinping expected to present China as reliable partner in contrast to US, which imposed – then suspended – tariffs over 40% on some countries

The Chinese president, Xi Jinping, warned there would be “no winners” in a trade war and that protectionism “leads nowhere”, as he began a three-nation trip to south-east Asia, starting in Vietnam on Monday.

Xi’s tour, which started in Hanoi, also includes rare visits to Malaysia and Cambodia and will seek to strengthen ties with China’s closest neighbours amid a trade war that has sent shock waves through global markets.

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‘The sky won’t fall’: China plays down Trump tariff risks as stock markets rally

Chinese customs official says trade has diversified away from US in recent years and plays up its ‘vast domestic market’

China has played down the risk of damage to its exports from Donald Trump’s tariffs, with an official saying the “the sky won’t fall”, as stock markets rose on Monday amid signs of a retreat on electronics restrictions.

The world’s second-largest economy has diversified its trade away from the US in recent years, according to Lyu Daliang, a customs administration spokesperson, in comments reported by state-owned agency Xinhua.

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UK MP refused entry to Hong Kong accuses China of ‘hidden blacklist’

Wera Hobhouse says her apparent presence on secret list of critics of country’s human rights record made her a target

A Liberal Democrat MP refused entry to Hong Kong to see her young grandson has said her experience should be “a wake-up call for any parliamentarian”, given that it seems to show China holds a secret list of banned politicians.

Wera Hobhouse, who was turned back by officials on Thursday, said she was given no explanation as to why this happened, and could only assume that it was because she had spoken out about rights abuses by China.

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UK could target parts of Chinese state under new foreign influence rules

Exclusive: Government is weighing up security concerns against economic benefits of closer ties with Beijing

The government could target parts of China’s security apparatus under new foreign influence rules, the Guardian has learned.

Ministers are considering including parts of the Chinese state accused of interference activities on the enhanced tier of the foreign influence registration scheme (Firs).

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Xi Jinping seeks to strengthen economic ties during tour of south-east Asia

President’s first stop is Vietnam as China urges US to end trade war and return to ‘right path of mutual respect’

The Chinese president, Xi Jinping, will visit Vietnam on Monday as he begins a tour of south-east Asia where he will seek to strengthen ties with neighbouring countries amid an escalating trade war.

Xi will visit Vietnam from Monday before travelling to Malaysia and Cambodia, a high-profile tour that Chinese officials have described as being of “major importance”.

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Japan’s World Expo: a positive vision of the future for our divided world?

Fifty-five years since Osaka last hosted, rocks from Mars, domestic androids and artificial hearts are part of showcase on ‘unloved’ island

As clunky as it sounds, “designing a future society for our lives” isn’t a bad ambition for the world in these troubled times. From this Sunday, organisers of the 2025 Exposition in Osaka will be hoping that appeal will put the event’s unsettled preparations in the shade for a six-month celebration of our common humanity.

The western Japan city is preparing to host its second World Expo, 55 years after the first was held in a country eager to capitalise on fading memories of the second world war as it embarked on its postwar journey to become an industrial and technological powerhouse.

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Chaos in China as cold vortex from Mongolia brings strongest April winds in decades

Flights cancelled, train services suspended and tourist attractions closed as weather service says wind speeds could surpass records set in 1951

Strong winds caused havoc in Beijing and parts of northern China on Saturday, forcing hundreds of flights to be cancelled, attractions to close and rail lines to be suspended, state media said.

The powerful winds stemmed mainly from a cold vortex system formed over Mongolia that was moving east and south, sweeping across northern China from Friday and through the weekend, the China Meteorological Administration (CMA) said.

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Did Trump’s tariffs kill economic populism?

Lasting damage has been done not only to Trump’s political credibility but to globalisation as a system

At the beginning of this helter-skelter week, Downing Street was declaring globalisation not only dead but a failure. Now, only five trading days later, the autopsy is still under way but the victim may instead be economic populism, strangled by Wall Street, the citadel of globalisation. Donald Trump’s so-called liberation day may in fact have been the anti-globalist’s entombment day.

In an effort to deny even a tactical retreat, Trump’s aides insist the White House goal all along was not to weaken globalism, or even to protect the US economy with tariffs, but instead to get into a negotiation to lower tariffs around the world and to punish China. As cover stories go, it is hardly credible, partly because the tariffs were repeatedly lauded by Trump as a macroeconomic revenue-raising measure, or a means to bolster US manufacturing.

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Tesla stops taking orders in China for two models imported from US

Carmaker removes ‘order now’ buttons for Model S saloon and Model X SUV on its Chinese website amid tariffs war

Tesla has stopped taking orders in China for two models it previously imported from the US, as companies scramble to adapt to prohibitive tariffs imposed in Donald Trump’s trade war.

The manufacturer, run by Trump’s close ally Elon Musk, removed “order now” buttons on its Chinese website for its Model S saloon and Model X sports utility vehicle.

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