Category Archives: Embryos

Work on synthetic human embryos to get code of practice in UK

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Code will remove grey area around stem cell-based technology and ensure responsible research, say scientists

Biological models of human embryos that can develop heartbeats, spinal cords and other distinctive features will be governed by a code of practice in Britain to ensure that researchers work on them responsibly.

Made from stem cells, they mimic, to a greater or less extent, the biological processes at work in real embryos. By growing them in the laboratory, scientists hope to learn more about how human embryos develop and respond to their environment, questions that would be impossible to answer with real embryos donated for research.

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Call to help UK IVF patients donate unused embryos after shortage hinders research

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Scientists complain after ‘sheer waste’ of human embryos discarded despite patients’ wishes

Leading scientists are calling for a change in the law to help IVF patients donate unused embryos to biomedical research after a collapse in donations over the past 15 years.

The increasing commercialisation of IVF, overstretched NHS clinics and cumbersome paperwork are blamed for a 25-fold decrease in the number of donated embryos. Scientists described some patients going to “extraordinary lengths” to ensure their embryos could be used for research rather than discarded, with many private clinics failing to routinely offer donation as an option.

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Model embryo with heartbeat replicates cells in early pregnancy

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Exclusive: Scientists used stem cells to create the structures, which were unable to develop into a foetus

Scientists have created a model human embryo with a heartbeat and traces of blood in an advance that offers an extraordinary window into the first weeks of life.

The synthetic structure, created from human stem cells without the need for eggs, sperm or fertilisation, replicated some of the cells and structures that would typically appear in the third and fourth week of pregnancy. But it was specifically designed to lack the tissues that go on to form the placenta and yolk sac in a natural embryo, meaning that it did not have the theoretical potential of developing into a foetus.

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John Howard overrode George Pell’s objections to allow research using surplus IVF embryos

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Cabinet papers 2002: PM lifted ban despite opposition of conservatives and religious leaders, including then Archbishop Pell

John Howard’s decision to allow stem cell research using surplus IVF embryos might surprise people “who saw Howard as only a rightwing person”, the former senator and cabinet minister Amanda Vanstone has said.

Despite opposition from conservative and religious groups, and despite seeking advice from the then Catholic archbishop of Sydney, George Pell, the former Liberal prime minister lifted the national ban in 2002.

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Human cells grown in monkey embryos reignite ethics debate

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Scientists confirm they have produced ‘chimera’ embryos from long-tailed macaques and humans

Monkey embryos containing human cells have been produced in a laboratory, a study has confirmed, spurring fresh debate into the ethics of such experiments.

The embryos are known as chimeras, organisms whose cells come from two or more “individuals”, and in this case, different species: a long-tailed macaque and a human.

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Scientists form human cell clumps that act like early-stage embryos

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Cultured stem cells turn into blastoid ‘balls’, like natural blastocysts after egg fertilisation

Scientists have made clumps of human tissue that behave like early-stage embryos, a feat that promises to transform research into the first tentative steps of human development.

The clumps of cells, named blastoids, are less than a millimetre across and resemble structures called blastocysts, which form within a few days of an egg being fertilised. Typically blastocysts contain about 100 cells, which give rise to every tissue in the body.

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First human-monkey chimera raises concern among scientists

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Researchers reprogrammed human cells before injecting them in the monkey embryo

Efforts to create human-animal chimeras have rebooted an ethical debate after reports emerged that scientists have produced monkey embryos containing human cells.

A chimera is an organism whose cells come from two or more “individuals”, with recent work looking at combinations from different species. The word comes from a beast from Greek mythology which was said to be part lion, part goat and part snake.

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