President signed executive order directing FDA to expedite review of psychedelic drugs including ibogaine
Donald Trump on Saturday announced reforms intended to speed up access to medical research and treatment based on psychedelic drugs.
The president signed an executive order directing the federal Food and Drug Administration (FDA) to expedite review of drugs such as ibogaine, which US military veteran groups have said can help treat post-traumatic stress disorder.
Continue reading...Mo-Rez reduced or eliminated tumours in over 60% of patients and is expected to be a blockbuster drug
GSK has revealed positive results for a treatment for gynaecological cancers as its chief executive, Luke Miels, seeks to speed up drug development at the group.
The company said that in an early-stage trial Mocertatug Rezetecan, known as Mo-Rez, shrank or eliminated tumours in 62% of patients with ovarian cancer where chemotherapy had failed, and in 67% of those with endometrial cancer.
Continue reading...Study highlights the movements in people’s gait that give away most about their emotional state
A long face is not the only sign that someone is down in the dumps. How people walk is revealing too, particularly the swing of the arms and legs, researchers say.
Scientists asked volunteers to guess people’s emotions from video clips of them walking and found that bigger swings portrayed more aggression while smaller swings implied fear and sadness.
Continue reading...International researchers find ‘very little evidence’ medical form of the drug can treat anxiety, anorexia and other disorders
Cannabis is not an effective treatment for common mental health conditions despite the global surge in patients using it for that purpose, a review has found.
Researchers concluded there was “very little evidence for its efficacy” in treating anxiety, anorexia nervosa, psychotic disorders, post-traumatic stress disorder or opioid use disorder.
Continue reading...Latest research based on animal model trials shows GLP-1 drugs may prevent problem of ‘no-reflow’ in recovery
Weight-loss drugs could help people who have had a heart attack avoid suffering potentially fatal complications afterwards, research has found.
Drugs such as Ozempic and Wegovy reduce the risk of the tissue damage that affects up to half of the 100,000 people a year in the UK who suffer a heart attack, according to the study.
Continue reading...Zimbabwe refuses to sign agreement and Kenya faces a court case over data sharing as new aid deals come under scrutiny
A series of bilateral health agreements being negotiated between African countries and the administration of President Donald Trump have been labelled “clearly lop-sided” and “immoral” amid growing outrage at US demands, including countries being forced to share biological resources and data.
It emerged this week that Zimbabwe had halted negotiations with the US for $350m (£258m) of health funding, saying the proposals risked undermining its sovereignty and independence.
Continue reading...Sorfequiline shows stronger action than existing treatments against illness that killed 1.23 million last year
A new treatment for tuberculosis could boost cure rates and shorten the time needed to treat the disease by months, trial results suggest.
Globally, an estimated 10.7 million people fell ill with TB last year and 1.23 million died from it.
Continue reading...Draft template seen by the Guardian has no reference to countries receiving benefits for sharing information, such as guaranteed access to medicines developed as a result
The US wants countries to agree to hand over information on bugs that could cause large-scale disease outbreaks in return for restoring aid to tackle health problems such as HIV and malaria, according to government documents.
The Trump administration is seeking new bilateral aid agreements with dozens of countries, after an abrupt withdrawal from existing arrangements at the start of this year. The agreements form part of a new America First Global Health Strategy announced in September.
Continue reading...Three monkeys remain at large and are being searched for, officials said after initially reporting they were infectious
A group of monkeys being transported on a Mississippi highway that escaped captivity on Tuesday after the truck carrying them overturned did not carry a dangerous infectious disease, a university has said.
The truck was carrying rhesus monkeys, which typically weigh around 16lb (7.7kg) and are among the most medically studied animals on the planet.
Continue reading...Analysis of DNA from teeth of troops buried in mass grave suggests soldiers had paratyphoid fever and relapsing fever
When Napoleon ordered his army to retreat from Russia in October 1812, disaster ensued. Starving, cold, exhausted and struggling with sickness, an estimated 300,000 soldiers died.
Researchers now say they have identified two unexpected diseases among soldiers who died in the retreat – paratyphoid fever and relapsing fever – which provide fresh insights into their plight.
Continue reading...Patients who had more cells had better outcomes, particularly for aggressive types such as triple-negative breast cancer
In the 18th century, physicians noticed nuns had some of the highest rates of breast cancer. It was one of the earliest clues that led scientists to suspect that child-bearing and breastfeeding could protect against the disease.
Modern data has confirmed the centuries-old observation but the biological reasons behind it have remained unclear. Explanations have often focused on pregnancy-related hormonal changes, but research published Tuesday in Nature has found breastfeeding provides long-lasting immune protection.
Continue reading...Triple-action therapy drug amivantamab could be given as an injection to help treat recurrent or metastatic cancers
Doctors have hailed “incredibly encouraging” trial results that show a triple-action smart jab can shrink tumours in head and neck cancer patients within six weeks.
Head and neck cancer is the world’s sixth most common form of the disease. If it spreads or comes back after standard treatment, patients may be offered immunotherapy and platinum chemotherapy. But if this fails, there is often little else doctors can do.
Continue reading...Mary E Brunkow, Fred Ramsdell and Shimon Sakaguchi worked on how the immune system can be prevented from harming the body
The Nobel prize in physiology or medicine 2025 has been awarded to three scientists for their work on how the immune system is kept in check and prevented from attacking our own body.
Mary E Brunkow, Fred Ramsdell and Shimon Sakaguchi have been awarded the prize “for their discoveries concerning peripheral immune tolerance”.
Continue reading...Surgical procedure to treat devastating illness slowed progress of disease by 75% in patients after three years
Huntington’s disease, a devastating degenerative illness that runs in families, has been treated successfully for the first time in a breakthrough gene therapy trial.
The disease, caused by a single gene defect, steadily kills brain cells leading to dementia, paralysis and ultimately death. Those with a parent with Huntington’s have a 50% chance of developing the disease, which until now has been incurable.
Continue reading...More than 1,000 patients to take part in trial to see if the approach leads to faster and more reliable diagnoses
Doctors have launched a clinical trial of a £100 blood test for Alzheimer’s disease in the hope of transforming diagnosis of the devastating condition in the NHS.
More than 1,000 patients with suspected dementia are being recruited from memory clinics across the UK to see whether the test leads to faster and more reliable diagnoses and better care for those found to have the disease.
Continue reading...Stigma around mifepristone is stopping studies, experts in reproductive health claim in Lancet opinion piece
A drug used in medical abortions could help prevent women at high risk of breast cancer from developing the disease, according to an international group of doctors and scientists.
However, “stigma” around mifepristone is stopping pharmaceutical companies from investigating its potential as a new treatment doctors could offer to reduce the risk of breast cancer, they say.
Continue reading...Target easier to achieve than 10,000 steps and linked to 37% reduction in cancer deaths
Walking more could reduce your risk of dementia, depression and dying from cancer, as well as being good for your heart, according to research. And you may not need to walk as far as previously thought to reap those benefits.
The NHS recommends a brisk 10-minute walk every day. Many people aim to walk 10,000 steps, but struggle to achieve it. Now researchers have calculated that even 7,000 steps could be enough to protect health.
Continue reading...Previously, the only way to reduce levels of Pfas was by bloodletting or a drug with unpleasant side effects
Certain kinds of gut microbes absorb toxic Pfas “forever chemicals” and help expel them from the body via feces, new first-of-its-kind University of Cambridge research shows.
The findings are welcome news as the only options that exist for reducing the level of dangerous Pfas compounds from the body are bloodletting and a cholesterol drug that induces unpleasant side effects.
Continue reading...Study discovered abnormal process in womb lining, with potential for new treatments to prevent pregnancy loss
Scientists have developed a test to identify women with an increased risk of miscarriage, which could pave the way for new treatments to prevent pregnancy loss.
About one in six of all pregnancies are lost, most before 12 weeks, and each miscarriage increases the risk of another one happening.
Continue reading...Scores of National Institutes of Health researchers and staffers sign letter criticizing agency policies: ‘We dissent’
In his confirmation hearings to lead the National Institutes of Health, Jay Bhattacharya pledged his openness to views that might conflict with his own. “Dissent,” he said, “is the very essence of science.”
That commitment is being put to the test.
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