Antibiotic-resistant bacteria increasingly leaving children vulnerable to common infections, global study finds

Exclusive: Research spanning 82 countries finds antibiotic resistance increased in every region between 2004 and 2022

Harry Booth has had a rough run through Australia’s coldest months. The 13-year-old has been in and out of hospital with a range of common chest and urinary tract infections that his doctors find challenging to treat.

Harry was born with kidney failure and began dialysis at six months old, before receiving a kidney transplant from his father at age four. The surgery saved his life but comes with a trade-off: he now needs to take medications that suppress his immune system to prevent his body from rejecting the kidney.

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Mexican drug lord ‘El Mayo’ sentenced to life in prison in US federal court

Case against Ismael Zambada García, who helped co-found and lead the violent Sinaloa cartel, unfolded in New York

The Mexican drug kingpin, Ismael Zambada García, known as “El Mayo”, was sentenced in a US federal court on Monday to life in prison, after a plea deal last year in which he admitted ⁠to shipping vast amounts of cocaine and other substances as leader of the violent Sinaloa cartel.

Zambada is 76 and one of the most high-profile Mexican ⁠drug traffickers to be sentenced in a US court since his fellow Sinaloa leader Joaquín “El Chapo” Guzmán ​was sentenced to life in prison in ‌2019. The case unfolded in federal court in Brooklyn, New York.

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‘Truly international’ network of drug-facilitated rape uncovered by UK crime agency

NCA says offenders arrange to sexually assault and film victims via online networks with crimes often taking place in trusting relationships

Criminal investigators in the UK say they have uncovered a “truly international network” of organised drug-facilitated sexual assault in which victims are sedated before being raped and sexually assaulted.

The National Crime Agency [NCA] has said online networks, “many as yet unidentified by law enforcement”, were allowing offenders to arrange to rape and abuse victims or arrange for sexual assaults to be filmed.

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Almost three tonnes of cocaine found buried under Sydney property in Australia’s biggest ever seizure, police say

Australian federal police arrested and charged two men after allegedly finding $800m worth of cocaine in ‘bunkers’ under shipping containers

Police claim to have made Australia’s biggest ever cocaine bust after finding $800m worth of the drug buried under false flooring on a semi-rural property.

Two men, aged 21 and 25, allegedly tried to run from police and were arrested on Friday after an operation by Australian federal police, alongside investigators in multiple states.

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Cannabis commercialisation not decriminalisation drives up usage, study finds

Review reveals rise in users and rates of psychosis in countries where cannabis is sold commercially

Decriminalising the possession of cannabis or strictly regulating access to the drug do not appear to drive up usage, but when the drug is sold commercially the number of users increases and more mental health problems are seen, a review has found.

An international team analysed the dramatic shift in policies on cannabis between 2000 and 2025, including how the numbers of people taking the drug, its potency, and rates of psychosis changed after new rules came in.

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Guatemala requests US military cooperation against drug trafficking

Central American country says its president spoke with Pete Hegseth to confirm terms of cooperation

Guatemala has requested US military cooperation spanning access to equipment, training and experts to assist Guatemalan operations against drug trafficking, the country’s president, Bernardo Arévalo, said on Thursday.

The joint plans stopped short of US military operations on Guatemalan soil and fall within existing bilateral agreements, the government noted.

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Three dead and 18 first responders sickened by apparent fentanyl exposure in New Mexico

First responders hospitalized and decontaminated after four people were found apparently overdosing

Three people died and 18 first responders were sickened by exposure to fentanyl in a rural New Mexico home this week, New Mexico state police said.

Police initially found four people unconscious at the home in Mountainair, 90 miles (145km) east of Albuquerque. Two were declared dead at the scene and a third died at a hospital.

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13 men killed by US military boat strikes identified: ‘These were flesh-and-blood people’

All victims of US strikes in eastern Pacific and the Caribbean identified so far came from extremely poor communities

A five-month investigation has named 13 previously unidentified victims of US attacks on boats allegedly carrying narcotics in a campaign that has killed nearly 200 people in the Caribbean and the eastern Pacific.

It is unclear if the US has ever identified any of its 194 victims before attacking them, and the names of just three had previously emerged, after their families launched legal cases against the White House.

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How the Trump White House works against itself in its efforts to prevent overdoses

Contradictory policies that gut harm reduction programs while supporting naloxone access are confusing experts

Within just a few weeks, the Trump administration has proposed multiple contradictory policies related to overdose prevention – some that could help save lives and others that experts say could further strain health resources and put people at risk for overdose.

These policies include a new prohibition on funding for fentanyl test strips, which help people avoid overdoses; proposed budget cuts that would gut the country’s overdose prevention efforts; and an ambitious drug control strategy that will be impossible to implement if the aforementioned cuts go through.

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Australian director Phillip Noyce shoots feature film for Saudi Arabia celebrating ‘heroism of security men in combating drugs’

Exclusive: Regime, which executed 243 people last year for drug offences, accused of investing in entertainment to whitewash its human rights record

The acclaimed Australian film-maker Phillip Noyce is being paid by the Saudi regime to make a feature film portraying the repressive state’s narcotics officers as heroes.

The Watchful Eyes, based on a real Saudi ministry of interior narcotics case, is billed as a dramatic depiction of the “heroism of security men in combating drugs”.

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Federal authorities arrest 18 people in Los Angeles raid amid drug crackdown

Justice department targets MacArthur Park, which has long struggled with fentanyl use, overdoses and homelessness

Federal authorities arrested 18 people in Los Angeles in a crackdown on drugs in MacArthur Park, the Department of Justice announced on Wednesday.

The DoJ said it was targeting an “open-air drug market” in the park near downtown, which has long struggled with fentanyl use and overdoses and has at times had large encampments of unhoused people.

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Polanski says he is not ready to be PM, but might be in two years’ time – UK politics live

Green leader also apologised for misrepresenting his work with the Red Cross, and defended party policy on drugs

Labour has criticised Zack Polanski for saying he was concerned about how the suspect in the Golders Green stabbings was treated when he was arrested by the police.

Referring to what Polanski said about this in his Today interview this morning (see 9.33am), a Labour party spokesperson said:

Our brave police ran towards a suspected terrorist and tackled him while he was still carrying a knife and before they could handcuff him.

The fact that Zack Polanski is still sympathising with this individual is utterly astounding. For the Green party leader to be litigating the case for the defence against the police shows whose side he is truly on.

The latest unemployment figures for February showed a fall, interest rates were expected to come down, the markets were pricing in a couple of cuts during the course of the year.

The truth is, with the effect of the Iran war, we can’t count on any of that at the moment. There is likely to be an effect on prices, which feeds through from energy costs, and there may well be labour market implications.

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First malaria drug for babies is approved in ‘major public health milestone’

WHO prequalification of Coartem Baby means newborns can be safely treated rather than using medication for older children

The first malaria treatment for babies has been approved by the World Health Organization, opening the door to widespread use around the globe.

In parts of Africa, up to 18% of children under six months will be infected with malaria, but there has historically been no safe treatment for the smallest of them. There were 610,000 deaths from malaria in 2024, about three quarters of which were under-fives in Africa.

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Australia’s use of methamphetamine has doubled in a decade, wastewater monitoring reveals

Consumption is at a record high along with that of cocaine, Australian Criminal Intelligence Commission figures show

Methamphetamine use in Australia has almost doubled in the past decade and stimulants are being taken at record highs, new wastewater monitoring reveals.

On Wednesday evening the Australian Criminal Intelligence Commission (Acic) released its latest annual report after testing wastewater samples from 64 treatment plants across the country between August 2024 and 2025.

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Trump psychedelics order largely symbolic, analysts say

Executive order to speed access to psychedelic treatments likely to have limited legal impact despite high-profile push

The Trump administration issued an executive order earlier this month to accelerate access to psychedelic medication for people with “serious mental illnesses”, but experts say the order is more likely to make a difference symbolically than legally.

“Policymakers and the medical field have long struggled to address the burden of suicide and serious mental illness rates in America,” the order reads, noting that some people do not respond to available treatments.

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Trump announces reforms to accelerate access to psychedelic drug treatments

President signed executive order directing FDA to expedite review of psychedelic drugs including ibogaine

Donald Trump on Saturday announced reforms intended to speed up access to medical research and treatment based on psychedelic drugs.

The president signed an executive order directing the federal Food and Drug Administration (FDA) to expedite review of drugs such as ibogaine, which US military veteran groups have said can help treat post-traumatic stress disorder.

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GSK reports promising early results in ovarian and womb cancer drug trial

Mo-Rez reduced or eliminated tumours in over 60% of patients and is expected to be a blockbuster drug

GSK has revealed positive results for a treatment for gynaecological cancers as its chief executive, Luke Miels, seeks to speed up drug development at the group.

The company said that in an early-stage trial Mocertatug Rezetecan, known as Mo-Rez, shrank or eliminated tumours in 62% of patients with ovarian cancer where chemotherapy had failed, and in 67% of those with endometrial cancer.

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Medicines watchdog to investigate UK peptide clinics over health claims

Exclusive: Guardian investigation finds several clinics making potentially unlawful claims about benefits of unregulated therapies

The medicines regulator is investigating whether UK clinics are breaking the law by making claims about the benefits of unregulated, experimental peptide therapies, the Guardian can reveal.

Interest in experimental peptides has boomed in recent years. The substances are delivered by injection and are touted by sellers, influencers and even some medics as aiding everything from anti-ageing to recovery from injury.

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What are peptides, are they safe and is there evidence to back up the hype?

Influencers and athletes are among those claiming substances can help with injury repair, weight loss and angi-ageing

From influencers to athletes, high-profile figures are hailing peptides as the route to wellness, claiming they help with injury repair, weight loss, anti-ageing and mood. We take a look at what these substances are, and the murky industry surrounding them.

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Nine charged over alleged conspiracy to import tonnes of cocaine and meth via ‘mother ship’ in Australian waters

Police allege drugs were to be collected from a drop zone in Bass Strait and distributed across the nation using trucking connections

When a commercial trawler sank off Victoria with four crew members needing rescuing, police became suspicious about an alleged drug trafficking operation.

Nine men are accused over a conspiracy to import tonnes of cocaine and methamphetamine before distributing the drugs across Australia using trucking connections.

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