‘Real hope’ for cystic fibrosis patients as NHS rolls out life-changing drug

Campaigners hail decision to give thousands of sufferers access to new set of drugs known as ‘modulators’

Alix Oxlade was 30 weeks into her pregnancy when scans showed fluid building up in the stomach and bowels of her unborn son, Rufus. The cause was unclear, though there was an early suspect: cystic fibrosis.

One of the most common inherited illnesses in the west, cystic fibrosis is caused by a defective protein that allows mucus to build up in the lungs, bowels and other organs and can lead to chronic infections that worsen through life. Tests subsequently showed Alix and her partner, Ben, who live in East Yorkshire, were both carriers of the disease.

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Mounjaro is second obesity drug to be approved for use in England

Those with BMI of 35 and a comorbidity can now be prescribed tirzepatide and Nice says it is more effective than Wegovy

The medical treatment regulator for England has approved a second drug to combat obesity, giving patients and doctors what it says is a more effective alternative to semaglutide.

The National Institute for Health and Care Excellence (Nice) issued draft guidance on Tuesday recommending that very obese people should be prescribed tirzepatide, which is marketed in the UK as Mounjaro.

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People with MND in England and Wales fear losing access to life-extending drug

Exclusive: NHS cost threshold has not been raised by National Institute for Health and Care Excellence since 2004

People with motor neurone disease have spoken of their devastation at a likely loss of access to a life-extending drug due to an NHS cost threshold that has not been raised since 2004.

Tofersen has slowed the progress of the illness in trials but the chances of the drug being recommended for use in England and Wales are said to be slim.

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People severely ill with suspected sepsis should be given antibiotics, Nice says

National Institute for Health and Care Excellence says national early warning score should be used to assess severity of illness

People who are severely ill with suspected sepsis should promptly be given life-saving access to antibiotics to prevent unnecessary deaths, according to updated guidance from a health watchdog.

The National Institute for Health and Care Excellence (Nice) has said that the national early warning score should be used to assess people with suspected sepsis aged 16 and over, who are not and have not recently been pregnant, and are in an acute hospital setting or ambulance.

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New menopause therapy guidance will harm women’s health, say campaigners

Nice guidelines for GPs ‘placing CBT on a par with HRT’ are criticised as ‘patronising’ and ‘scaremongering’

New official guidance on treating menopause will harm women’s health, experts, MPs and campaigners have warned.

Last month, new draft guidelines to GPs from the National Institute for Health and Care Excellence (Nice) said that women experiencing hot flushes, night sweats, depression and sleep problems could be offered cognitive behavioural therapy (CBT) “alongside or as an alternative to” hormone replacement therapy (HRT) to help reduce their menopause symptoms.

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Nice calls for routine use of at-home faeces tests for bowel cancer screening

Hopes guidance could help diagnose colorectal cancer faster and cut NHS waiting times for colonoscopies

At-home faeces tests could spare tens of thousands of people in England and Wales from having to undergo invasive procedures to rule out bowel cancer.

It is hoped the move could help diagnose colorectal cancer faster and cut NHS waiting times by reducing the need to refer people for a colonoscopy.

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New migraine drug on NHS could help thousands of patients in England

Nice approves rimegepant for preventing migraines in cases where at least three previous treatments have failed

Thousands of people in England who get migraines could benefit from a drug that has been approved on the NHS.

The National Institute for Health and Care Excellence (Nice), the drugs regulator, said it was recommending rimegepant for preventing migraines in the approximately 145,000 adults where at least three previous preventive treatments had failed.

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Antidepressants ‘should be reduced in stages’ to avoid withdrawal symptoms

UK medicines watchdog advises GPs to ‘taper’ doses for patients who want to stop taking the drugs

GPs whose patients want to stop taking antidepressants should reduce the dose of their medication in stages to lower the risk and severity of withdrawal symptoms, the medicines watchdog has said.

About one in six (16%) adult Britons experience moderate to severe depression, according to the Office for National Statistics. In England alone, 21.4m antidepressant drugs were prescribed between July and September 2022, according to the NHS Business Services Authority.

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Ensure waist size is less than half your height, health watchdog says

Guidance for England and Wales comes amid increasing concern over rate of obesity and cost to NHS

A health watchdog is urging millions of people for the first time to ensure their waist size is less than half their height in order to help stave off serious health problems.

The UK has one of the worst obesity rates in Europe, with two in three adults officially overweight or obese in an escalating crisis that now costs the NHS £6bn a year and wider society £27bn.

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People with type 1 diabetes in England to be given skin sensor to monitor blood sugar

Nice says wearable tech reduces need for finger-prick testing by up to 50%

Hundreds of thousands of people with type 1 diabetes in England are to be offered a hi-tech skin sensor to monitor their blood sugar levels in seconds.

The device, the size of a £2 coin, sits on a patient’s arm and constantly checks their glucose levels. It comes with an app that tells them whethertheir blood sugar levels are at an appropriate level.

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‘Frail’ people like me shouldn’t be denied lifesaving Covid care | Patience Owen

A frailty index is rationing treatment for older and disabled people who catch coronavirus. We are not sacrificial lambs

Lockdown was easy for me, it has become my daily state more frequently throughout my life. I have a debilitating connective tissue disorder that keeps me indoors most days. It was a relief I no longer had to go out and pretend to be normal when wracked with ill-health and hidden pain. Like thousands of others with rare conditions, I’m already in a minority within a minority, marginalised by our NHS, battling increasing disability day by day. So, while many fear a second lockdown over the winter months, I haven’t gone out more often since the first one was lifted because I risk a double jeopardy – catching Covid, then being a low priority for medical care.

Back in March, without consultation and days before the first lockdown, the Clinical Frailty Scale (CFS), a worldwide tool used to swiftly identify frailty in older patients to improve acute care, was adapted by the National Institute for Health and Care Excellence (Nice). It asked NHS staff in England to score the frailty of Covid patients. Rather than aiming to improve care, it seems the CFS – a fitness-to-frailty sheet using scores from one to nine – was used to work out which patients should be denied acute care. Nice’s new guidelines advised NHS trusts to sensitively discuss a possible ‘do not attempt cardiopulmonary resuscitation’ decision with all adults with capacity and an assessment suggestive of increased frailty”.

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