Experts condemn US tobacco firm’s sponsorship of doctor training as ‘grotesque’

Philip Morris International has supported non-smoking programmes around the world ‘to advance its own interests’, say health professionals

The tobacco company Philip Morris has sponsored courses for doctors in multiple countries, in what critics have called a “grotesque” strategy.

Medical education programmes on quitting smoking and harm reduction in South Africa, the Middle East and the US have been supported by Philip Morris International (PMI) or its regional subsidiaries, according to advertising material seen by the Guardian.

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Global eradication of polio ‘tantalisingly close’ with UK urged to keep up funding

After no reported cases of wild polio for 19 weeks, vaccination efforts boosted at last endemic spots in Pakistan and Afghanistan

The world is “tantalisingly close” to eradicating polio – with no confirmed cases of wild polio anywhere so far this year. But experts warn that vaccination efforts – and funding – must not falter if the world is to rid itself of a human infectious disease for the second time in history, after smallpox.

There have been no reported cases of wild polio infection in people for the last 19 weeks. Figures from the World Health Organization reveal that the last confirmed cases were on the borders of Pakistan and Afghanistan in October and September 2023 respectively; these are the last nations on Earth where polio is endemic.

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Indigenous people sue over alleged Canadian secret medical experiment

First Nation members say in lawsuit that radiologists subjected them to a secret study without their knowledge or consent

Members of a First Nation in Canada have launched a lawsuit alleging they were subjected to a secret medical experiment without their consent that left them feeling “violated and humiliated”.

The class-action lawsuit, which was certified by the Nova Scotia supreme court in early February, revives the painful history of Canada conducting medical experiments on Indigenous peoples and the persistent discrimination they continue to face within the country’s healthcare system.

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US regulators approve two gene therapies for sickle cell disease

Blood disorder that can lead to premature death affects estimated 100,000 people in the United States, most of whom are Black

The US Food and Drug Administration has approved a pair of gene therapies for sickle cell disease, including the first treatment based on the breakthrough Crispr gene-editing technology, opening up two “transformative therapy” avenues for some patients.

The FDA approved Lyfgenia from Bluebird Bio, and a separate treatment called Casgevy by partners Vertex Pharmaceuticals and Crispr Therapeutics. Both therapies are made from the patients’ own blood stem cells and were approved for people aged 12 and older.

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Female doctors vulnerable to sexual assault due to hospital work environments, expert says

Dr Louise Stone says victims have spoken of ‘enforced closeness’ of long sessions in operating rooms and the ‘boys’ club culture’ of industry

Female doctors who have experienced sexual assault have spoken of work conditions they felt made them more vulnerable to harm from senior colleagues, an Australian researcher says.

“[They described] the enforced closeness that can occur in long sessions in operating theatres,” said Dr Louise Stone, an associate professor at the Australian National University.

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Patients dying daily due to poor ‘soft skills’ among Australian surgeons, experts warn

Nearly all avoidable deaths in surgery exhibit a breakdown in communication and cooperation, research shows, as doctors call for system reform

More than 1,000 Australians die unnecessarily in hospital each year due to avoidable failures by surgeons, according to experts calling for a senate inquiry.

Graham Beaumont, PhD, and Dr John North are both long-term members of audit committees that review surgical mortality in Australia.

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More monkeypox cases detected in UK ‘on daily basis’, says scientist

Twenty cases confirmed in UK amid reports of child being admitted to intensive care in London hospital

More monkeypox cases are being detected in Britain “on a daily basis”, a senior doctor has warned, amid reports that a child has been admitted to intensive care with the disease.

Dr Susan Hopkins, a chief medical adviser to the UK Health Security Agency (UKHSA), said an update on confirmed cases would be released on Monday as efforts continue to contain the outbreak using contact tracing, testing and vaccination.

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Whistleblower warns baffling neurological illness affects growing number of young adults

Several new cases in New Brunswick involve caretakers of those afflicted, suggesting a possible environmental trigger

A whistleblower in the Canadian province of New Brunswick has warned that a progressive neurological illness that has baffled experts for more than two years appears to be affecting a growing number of young people and causing swift cognitive decline among some of the afflicted.

Speaking to the Guardian, an employee with Vitalité Health Network, one of the province’s two health authorities, said that suspected cases are growing in number and that young adults with no prior health triggers are developing a catalog of troubling symptoms, including rapid weight loss, insomnia, hallucinations, difficulty thinking and limited mobility.

One suspected case involved a man who was developing symptoms of dementia and ataxia. His wife, who was his caregiver, suddenly began losing sleep and experiencing muscle wasting, dementia and hallucinations. Now her condition is worse than his.

A woman in her 30s was described as non-verbal, is feeding with a tube and drools excessively. Her caregiver, a nursing student in her 20s, also recently started showing symptoms of neurological decline.

In another case, a young mother quickly lost nearly 60 pounds, developed insomnia and began hallucinating. Brain imaging showed advanced signs of atrophy.

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How biodiversity loss is jeopardising the drugs of the future

From willow bark to mosquitoes, nature has been a source of vital medications for centuries. But species die-off caused by human activity is putting this at risk

What will biodiversity loss mean for drug discovery?
Traditionally used as a painkiller for headaches, snowdrops are now known to slow the onset of dementia. In the 1950s, a natural alkaloid called galantamine was extracted from the bulbs. Today, a synthesised version of this is used to treat Alzheimer’s disease and scientists are investigating further to see if snowdrops might also be effective in the treatment of HIV.

However, over-harvesting has resulted in many snowdrop species becoming threatened. The snowdrop isn’t alone – plants are an abundant source of potential new medicines, often providing us with chemical templates for the design of novel drugs. Yet scientists across the globe say unsustainable use of wild medicinal plants is contributing to biodiversity loss and could limit opportunities to source medicines from nature in the future.

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Some US patients waiting for organ transplants must get Covid vaccine or be removed from list

Transplant patients take immune-suppressing drugs and non-vaccinated recipients are more likely to die of infection

Health systems in Colorado and Washington are removing unvaccinated patients from organ transplant lists, given research that unprotected recipients are much more likely to die from Covid-19.

UCHealth in Colorado told a patient on the kidney transplant waiting list that she needed to get vaccinated in the next 30 days or she would be removed from the list. Leilani Lutali told 9News that she was the patient in question, and she hasn’t been vaccinated yet because of her religious views.

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‘Excited delirium’: term linked to police restraint in UK medical guide condemned

Public health bodies and families say term carries racial bias and is used to justify lethal use of force by police

Public health bodies, charities and the families of men who died after being restrained by police have condemned the inclusion of a controversial medical term in one of the UK’s leading medical handbooks.

Acute behavioural disturbance (ABD), more commonly known as “excited delirium”, a contentious expression used in fatal cases of police violence, has recently been added to the Maudsley Prescribing Guidelines (MPG).

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The Lancet’s editor: ‘The UK’s response to coronavirus is the greatest science policy failure for a generation’

Richard Horton does not hold back in his criticism of the UK’s response to the pandemic and the medical establishment’s part in backing fatal government decisions

There is a school of thought that says now is not the time to criticise the government and its scientific advisers about the way they have handled the Covid-19 pandemic. Wait until all the facts are known and the crisis has subsided, goes this thinking, and then we can analyse the performance of those involved. It’s safe to say that Richard Horton, the editor of the influential medical journal the Lancet, is not part of this school.

An outspoken critic of what he sees as the medical science establishment’s acquiescence to government, he has written a book that he calls a “reckoning” for the “missed opportunities and appalling misjudgments” here and abroad that have led to “the avoidable deaths of tens of thousands of citizens”. 

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Doctors call for tighter control of traditional Chinese medicine

Exclusive: European experts fear WHO recognition will encourage use of unproven therapies

Europe’s leading doctors are to call for tighter regulation of traditional Chinese medicine, anxious that recent recognition by the World Health Organization will encourage the use of unproven therapies that can sometimes be harmful.

The Federation of European Academies of Medicine (FEAM) and the European Academies’ Science Advisory Council will issue a joint statement on Thursday urging the WHO to clarify how traditional Chinese medicine and other complementary therapies should be used.

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Edinburgh gives female medical students their degrees – 150 years late

Victorian women who were prevented from qualifying as doctors are finally recognised

Seven women who were among the first females to be admitted to a British university have been awarded posthumous degrees 150 years after they started their studies.

The group, known collectively as the Edinburgh Seven, enrolled to study medicine at the University of Edinburgh in 1869. But they faced substantial resistance from their male peers and were ultimately prevented from graduating and qualifying as doctors.

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The drugs don’t work: what happens after antibiotics?

Antibiotic resistance is growing so fast that routine surgery could soon become impossible. But scientists are fighting back in the battle against infection

The first antibiotic that didn’t work for Debbi Forsyth was trimethoprim. In March 2016, Forsyth, a genial primary care counsellor from Morpeth, Northumberland, contracted a urinary tract infection. UTIs are common: more than 150 million people worldwide contract one every year. So when Forsyth saw her GP, they prescribed the usual treatment: a three-day course of antibiotics. When, a few weeks later, she fainted and started passing blood, she saw her GP again, who again prescribed trimethoprim.

Three days after that, Forsyth’s husband Pete came home to find his wife lying on the sofa, shaking, unable to call for help. He rushed her to A&E. She was put on a second antibiotic, gentamicin, and treated for sepsis, a complication of the infection that can be fatal if not treated quickly. The gentamicin didn’t work either. Doctors sent Forsyth’s blood for testing, but such tests can take days: bacteria must be grown in cultures, then tested against multiple antibiotics to find a suitable treatment. Five days after she was admitted to hospital, Forsyth was diagnosed with an infection of multi-drug-resistant E coli, and given ertapenem, one of the so-called “last resort” antibiotics.

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Elizabeth Warren’s DNA claim inflames some Native Americans

The DNA test that Sen. Elizabeth Warren used to try to rebut the ridicule of President Donald Trump angered some Native Americans, who complained that the genetic analysis cheapens the identities of tribal members with deeper ties to the Indian past. Warren was born in Oklahoma, which is home to 39 tribes and where more than 7 percent of the population identifies as Native American, one of the highest proportions in the nation.

‘Disease’ vs. ‘Difference’: A Question of Eugenics?

Just 100 years ago in the United States, eugenics was the law. From 1907 to 1931, Indiana, California, and 28 other states carried out the forced sterilization of more than 64,000 people who were deemed "unfit"-including the "intellectually disabled," immigrants, people of color, poor people, unmarried mothers, the physically disabled, and the mentally ill.

Here are the special interests that have given the most to Robert Menendez

U.S. Sen. Robert Menendez first ran for the U.S. House in 1992 and has been raising money for his campaigns ever since. He has brought in more than $50 million during that time, according to the Center for Responsive Politics , a Washington research group.