The Oxford vaccine: the trials and tribulations of a world-saving jab

Amid bemusement from scientists at the deluge of often undeserved criticism, the Guardian pieces together the story behind the vaccine’s successes and failures

In January 2020, when most of the world slept soundly in ignorance of the pandemic coming its way, a group of scientists at Oxford University got to work on a vaccine to save the planet. They wanted it to be highly effective, cheap, and easy to use in even the poorest countries.

Prof Sarah Gilbert, Prof Andrew Pollard and others pulled it off. With speed crucial, they designed it and launched into trials before bringing in a business partner. The giant Anglo-Swedish pharmaceutical company AstraZeneca would manufacture it, license it around the world – and not make a profit until the pandemic was over.

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NSW Covid outbreaks: Gladys Berejiklian locks down Sydney, Central Coast, Blue Mountains and Wollongong

New South Wales premier says lockdown will last two weeks and new restrictions will be in place for rest of state

All of greater Sydney, the Central Coast, the Blue Mountains and Wollongong regions will enter a two-week coronavirus lockdown until 9 July and new restrictions will be in place for the remainder of New South Wales.

The NSW premier, Gladys Berejiklian, announced the expanded lockdown – the first lockdown of greater Sydney since last year – would commence at 6pm Saturday, following crisis talks due to the growing number of exposure sites associated with the Sydney outbreak of the Delta Covid-19 variant.

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Fossilised bones found in Israel could belong to mystery extinct humans

Remains with combination of Neanderthal and early human features date back 100,000 years

Fossilised bones recovered from an ancient sinkhole in Israel may belong to a previously unknown group of extinct humans that lived in the Levant more than 100,000 years ago.

Researchers unearthed the bones alongside stone tools and the remains of horses, fallow deer and wild ox during excavations at the Nesher Ramla prehistoric site near the city of Ramla in central Israel.

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Rich countries ‘deliberately’ keeping Covid vaccines from Africa, says envoy

Questions raised over failure of Covax scheme to provide promised doses to the continent

African Union special envoy Strive Masiyiwa has accused the world’s richest nations of deliberately failing to provide enough Covid-19 vaccines to the continent.

Masiyiwa, the union’s special envoy to the African vaccine acquisition task team, said the Covax scheme had failed to keep its promise to secure production of 700 million doses of vaccines in time for delivery by December 2021.

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Scientists identify 29 planets where aliens could observe Earth

Astronomers estimate 29 habitable planets are positioned to see Earth transit and intercept human broadcasts

For centuries, Earthlings have gazed at the heavens and wondered about life among the stars. But as humans hunted for little green men, the extraterrestrials might have been watching us back.

In new research, astronomers have drawn up a shortlist of nearby star systems where any inquisitive inhabitants on orbiting planets would be well placed to spot life on Earth.

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Cloud spraying and hurricane slaying: could geoengineering fix the climate crisis?

Around the world, dozens of ingenious projects are trying to ‘trick’ the ocean into absorbing more CO2. But critics warn of unforeseen consequences

Tom Green has a plan to tackle climate change. The British biologist and director of the charity Project Vesta wants to turn a trillion tonnes of CO2 into rock, and sink it to the bottom of the sea.

Green admits the idea is “audacious”. It would involve locking away atmospheric carbon by dropping pea-coloured sand into the ocean. The sand is made of ground olivine – an abundant volcanic rock, known to jewellers as peridot – and, if Green’s calculations are correct, depositing it offshore on 2% of the world’s coastlines would capture 100% of total global annual carbon emissions.

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Indonesia tightens restrictions as it confirms record new coronavirus infections

The country’s infections, the worst in south-east Asia, have passed two million

Indonesian health authorities are battling a new surge in coronavirus infections, as the National Agency for Disaster Management (BNPB) reported the highest one-day total, with 14,535 cases confirmed in the 24 hours to Monday.

Daily case totals are reaching levels last seen in January, the peak of Indonesia’s fight against the virus.

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Drinking coffee may cut risk of chronic liver disease, study suggests

UK analysis shows people who drank coffee had 49% reduced risk of dying from the condition

From espresso to instant, coffee is part of the daily routine for millions. Now research suggests the brew could be linked to a lower chance of developing or dying from chronic liver disease.

Chronic liver disease is a major health problem around the world. According to the British Liver Trust, liver disease is the third leading cause of premature death in the UK, with deaths having risen 400% since 1970.

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Myanmar reports highest Covid numbers since coup as concerns over health system grow

State hospitals are barely functioning as humanitarian crisis unfolds across the country

Myanmar has reported what is believed to be its highest daily increase in Covid cases since the February coup, as concerns grow over the country’s collapsed health system and the junta’s continued crackdown on medics.

Myanmar’s Covid response was plunged into chaos when the military seized power on 1 February, detaining the elected government of Aung San Suu Kyi.

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ISS astronauts complete six-hour spacewalk to install solar panels

Successful International Space Station installation followed an attempt on Wednesday that ran into several problems

French and American astronauts have completed a six-hour spacewalk as they installed new solar panels to boost power supplies to the International Space Station (ISS), Nasa said.

“It is a huge team effort each time and couldn’t be happier to return with @astro_kimbrough,” Frenchman Thomas Pesquet tweeted on Sunday, referring to his American colleague Shane Kimbrough. Pesquet is with the European Space Agency, Kimbrough with Nasa.

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High stress may make ‘broken heart syndrome’ more likely, study finds

Condition also known as takotsubo cardiomyopathy is brought on by an acute emotional shock

Two molecules associated with high stress levels have been implicated in the development of broken heart syndrome, a condition that mainly affects post-menopausal women and is usually brought on by severe stress, such as the loss of a loved one.

The syndrome, formally known as takotsubo cardiomyopathy, is characterised by weakening of the heart’s main pumping chamber and was first identified in 1990 in Japan. It looks and sounds like a heart attack and is consequently often confused for one.

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‘Two Americas’ may emerge as Delta variant spreads and vaccination rates drop

Biden’s 70% vaccination target by Fourth of July likely to fall short as efforts to entice people to get shots have lost their initial impact

With Covid vaccination penetration in the US likely to fall short of Joe Biden’s 70% by Fourth of July target, pandemic analysts are warning that vaccine incentives are losing traction and that “two Americas” may emerge as the aggressive Delta variant becomes the dominant US strain.

Efforts to boost vaccination rates have come through a variety of incentives, from free hamburgers to free beer, college scholarships and even million-dollar lottery prizes. But of the efforts to entice people to get their shots have lost their initial impact, or failed to land effectively at all.

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Under-18s could be ‘reservoirs’ for virus when all adults are jabbed, expert warns

Unvaccinated children have potential to drive third wave of highly transmissible Delta variant, says virologist

The drive to vaccinate all adults over the age of 18 in the UK could lead to the concentration of Covid-19 cases in schoolchildren, a leading British virologist has warned.

Under-18s would then become reservoirs in which new variants of the virus could arise, said Julian Tang, of Leicester University.

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Giles Yeo: ‘Let’s consider the type of food we eat, and not fixate on calories’

The scientist and broadcaster discusses the drawbacks of calorie-counting and BMI in measuring obesity, and how our growing understanding of genetics is leading to new treatments

Since the dawn of the 20th century, almost all weight loss guidelines have used calories as a simple measure of how much energy we’re consuming from our food. But according to Giles Yeo, a Cambridge University research scientist who studies the genetics of obesity, there’s one problem: not all calories are created equal. In his new book, Why Calories Don’t Count, Yeo explains that what really matters is not how many calories a particular food contains, but how that food is digested and absorbed by your body.

Can you explain why you feel calorie-counting is a flawed approach to weight loss?
There was an American chemist in the 19th century called Wilbur Olin Atwater who calculated the calorie numbers for different foods, by working out the total energy intake you get from them. But his calculations never took into account the energy it takes our cells to metabolise food in order to use it. This is important. It’s why for example a calorie of protein makes you feel fuller than a calorie of fat, because protein is more complex to metabolise. For every 100 calories of protein you eat, you only ever absorb 70.

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Ask Philippa: meet the Observer’s brilliant new agony aunt

As psychotherapist and author Philippa Perry becomes our new agony aunt, she reveals why helping you with your worries will help us all. Plus, a special welcome from Jay Rayner

John Dunton founded the Athenian Mercury in the 1690s. A paper that consisted of readers’ questions and the answers. His idea was that readers could send in dilemmas to be answered by a panel of experts, the Athenian Society. But his great innovation was that they could do so anonymously and this has remained a feature of problem pages ever since. Poor old Dunton could have done with some advice himself, because he ended his days in poverty as he was a better innovator than he was a business person. He blamed his woes on other people rather than taking responsibility for his own failings. I think an agony aunt today might have spotted that for him and possibly saved him from destitution.

His panel of experts, depicted as 12 learned men with him in the centre in an engraving at the top of the pages, were largely fictitious. It was just Dunton and a couple of mates who went through all the letters in a coffee shop.

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Head of Independent Sage to launch international climate change group

Sir David King hopes to emulate success of British Covid advisory body by issuing monthly reports on environmental crisis

Several of the world’s leading scientists plan to launch an independent expert group this week to advise, warn and criticise global policymakers about the climate and nature crises.

The new body has been inspired by Independent Sage – the cluster of British scientists who have held UK ministers and civil servants to account for their lack of transparency and mishandling of the Covid pandemic.

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How a cancer diagnosis inspired a fresh outlook for one young musician

At the age of just 22, the very last thing you want to hear is that you have stage 4 cancer, but for some people the only response is to tackle it head on – which is just what Ellie Edna Rose-Davies did

I barely noticed it at first. A bump on the right side of my neck, small but definite. I was 22 and had no health issues (I’d never even broken a bone), so I didn’t think much of the lump. But my boyfriend was concerned, so I made an appointment to go to the GP.

For the next few months, I would see and feel more lumps spreading up my neck, and even larger ones under my armpits. I went to the doctor three times, where I was told: “It’s not cancer” and that I had “nothing to worry about”.

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Robin Wall Kimmerer: ‘Mosses are a model of how we might live’

The moss scientist and bestselling author reveals the secrets of these primitive plants – and what they might teach us about surviving the climate crisis

Robin Wall Kimmerer can recall almost to the day when she first fell under the unlikely spell of moss. “It’s kind of embarrassing,” she says. “I’ve always been engaged with plants, because I grew up in the countryside. That was my world. But mosses I’d set aside in my mind as not worthy of attention. I was studying to be a forest ecologist. That little green scum on the rocks: how interesting could it really be? Only then there came a point when I’d taken every botany class our university had to offer, except one: the ecology of mosses. I thought I’d do it, just so I could say that I’d taken them all. It was love at first sight. I remember looking with a lens at these big glacial erratic boulders that were covered in moss, and thinking: there’s a whole world here to be discovered.” Ever since, she has rarely left her house for a walk without such a lens on a string around her neck.

Kimmerer, a professor of environmental biology and the director of the Centre for Native Peoples and the Environment at the State University of New York in Syracuse, is probably the most well-known bryologist at work in the world today. She may be, in fact, the only well-known bryologist at work today (bryology is the study of mosses and liverworts), at least among the general public. But her unlikely success – her fans include the writer Robert Macfarlane and the Pulitzer prize-winning novelist Richard Powers, who gives daily thanks for what he calls her “endless knowledge” – hardly arrived overnight. In 2013, Kimmerer, a member of the Citizen Potawatomi Nation of Oklahoma, quietly published a book called Braiding Sweetgrass: Indigenous Wisdom, Scientific Knowledge, and the Teaching of Plants – a (seemingly) niche read from a small US press.

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Covid jabs for billions of humans will earn their makers billions of dollars

We look at the drug firms – led by Pfizer and Moderna – that are set to profit most in an unprecedented global vaccination drive

Drugmakers led by US firms Pfizer and Moderna stand to make tens of billions of dollars from their Covid-19 vaccines this year and next, given G7 governments’ pledge to vaccinate the entire world by the end of 2022, but sales are likely to drop sharply thereafter, according to analysts.

Acclaimed for allowing a return to more normal life, Covid vaccines will also substantially benefit some pharmaceutical companies. The global market for the vaccines is worth $70bn (£50bn) this year, says Karen Andersen of Morningstar.

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