Cancer treatment during the pandemic is bringing back traumatic memories

I am about to go through an invasive therapy for my cervical cancer. The process has brought me closer to my seven-year-old self

In a large black planner that I keep next to my bed, I mark off each round of chemotherapy and radiation. And after each one, I feel a growing sense of dread.

That’s because every mark means I’m one step closer to brachytherapy, a process that involves doctors sticking radioactive materials into my cervix – or what’s left of it anyway. It’s a way for them to aim high doses of radiation at my tumor, without risking the other nearby organs.

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‘Happy hypoxia’: unusual coronavirus effect baffles doctors

Some patients who appear not in distress are found to have dangerously low oxygen levels

It is a mystery that has left doctors questioning the basic tenets of biology: Covid-19 patients who are talking and apparently not in distress, but who have oxygen levels low enough to typically cause unconsciousness or even death.

The phenomenon, known by some as “happy hypoxia” (some prefer the term “silent”) is raising questions about exactly how the virus attacks the lungs and whether there could be more effective ways of treating such patients.

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North-west overtakes London for number of Covid-19 hospital cases

Latest figures reveal English regional differences in spread and peak of coronavirus

More people are in hospital with coronavirus in the north-west of England than in London, as regional differences in the spread and peak of the pandemic become increasingly apparent.

Latest figures show 2,033 people in London hospitals compared to 2,191 in the north-west, where the peak for hospitalisation appears to have been on 13 April, compared to 8 April in the capital.

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Fearful Britons remain strongly opposed to lifting lockdown

Just one in five want schools, pubs and restaurants to be reopened, according to new poll by Opinium
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Fewer than one in five of the British public believe the time is right to consider reopening schools, restaurants, pubs and stadiums. The findings, in a new poll for the Observer, suggest Boris Johnson will struggle to convince people to return their lives to normal if he tries to ease the lockdown soon.

The poll by Opinium, taken between Wednesday and Friday last week, found 17% of people think the conditions have been met to consider reopening schools, against 67% who say they have not been, and that they should stay closed.

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No leadership and no plan: is Trump about to fail the US on coronavirus testing?

Declarations of false victory and a vacuum of federal leadership have undermined testing as experts warn reopening the US could result in disaster

A broad coalition of US health systems has mobilized to ramp up coronavirus testing in a national effort on a scale not seen since the second world war. But declarations of false victory by the Trump administration and a vacuum of federal leadership have undermined the endeavor, leading experts to warn that reopening the US could result in a disaster.

Related: The missing six weeks: how Trump failed the biggest test of his life

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‘Truly shocking’: the area of the UK worst-affected by Covid-19

Coronavirus has hit the London borough of Newham – one of the UK’s most deprived areas – harder than anywhere else

Kamrul Islam doesn’t dare visit his local supermarket. Over the last few weeks, he said three of his closest friends fell ill with the coronavirus shortly after shopping there. One friend’s mother became seriously unwell after contracting the virus and sadly died.

The 40-year-old former cab driver says a day doesn’t go by when he isn’t aware of a death or infection of someone he knows. While the coronavirus has spread widely across the UK, the pandemic has taken a huge toll on the area where Islam lives, the east London borough of Newham, which has recorded the worst mortality rate in England and Wales.

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Is 100,000 tests a day an effective strategy against coronavirus?

UK government has been accused of inflating tally to hit goal for Covid-19 testing

The government has been accused of counting some tests prematurely, reportedly expanding its daily count to include tests that have been sent out in the post, rather than those actually carried out in labs. While it denies the charge, regardless of whether the 100,000 target has been met, countries that have taken a “test, trace, isolate” approach are running a far higher proportion of tests to positive cases than the UK. Germany, which is down to fewer than 1,000 daily positive cases, is performing nearly 1m tests per week. South Korea is doing 15,000 tests per day, but has had no more than 100 daily cases since the beginning of April. So, for a robust “test, trace, isolate” regime in the UK, the number of tests would need to be vastly increased or we would need to wait for the number of cases in the community to fall significantly.

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Why BAME people may be more at risk from coronavirus – video explainer

NHS staff from black, Asian and minority ethnic backgrounds may be given roles away from the frontline under plans to reduce their disproportionately high death rate from Covid-19.

The Guardian revealed last week that minority groups were over-represented by as much as 27% in the overall Covid-19 death toll. Additionally, 63% of the first 106 health and social care staff known to have died from the virus were black or Asian, according to the Health Service Journal.

Senior reporter Haroon Siddique looks at the figures and explains why BAME people may be more at risk.

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Sudan to outlaw female genital mutilation

Campaigners welcome move to criminalise those carrying out FGM, but warn it will take time to eradicate practice entirely

Sudan looks set to outlaw female genital mutilation (FGM), in a significant move welcomed by campaigners.

Anyone found carrying out FGM will face up to three years in prison, according to a document seen by the Guardian.

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US germ warfare research leads to new early Covid-19 test

Exclusive: test has potential to identify carriers before they become infectious

Scientists working for the US military have designed a new Covid-19 test that could potentially identify carriers before they become infectious and spread the disease, the Guardian has learned.

In what could be a significant breakthrough, project coordinators hope the blood-based test will be able to detect the virus’s presence as early as 24 hours after infection – before people show symptoms and several days before a carrier is considered capable of spreading it to other people. That is also around four days before current tests can detect the virus.

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Coronavirus Australia live updates: Scott Morrison labels Twiggy Forrest’s comments on Covid-19 origin ‘nonsense’ – latest news

Sydney aged care home reports 13th coronavirus-related death as three more residents test positive, while Tasmania to lift north-west lockdown. Follow live

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WA premier Mark McGowan is due to give an update at 2pm Perth time today, which is 4pm on the east coast.

So, working backwards, we can expect an update from the prime minister on today’s national cabinet meeting some time between now and 4pm.

I’m going to leave you for the day. Thanks for reading. Calla Wahlquist will take over from here.

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‘With restrictions easing, how do we tell someone we don’t want them in our bubble?’

This is a rare moment when excluding people doesn’t have to mean we don’t like them, writes advice columnist Eleanor Gordon-Smith – so handle your approach with grace

Now that lockdown restrictions are easing a little bit in my area, my family’s been getting a few requests for playdates and dinner visits. It’s exciting but we don’t want to turn our lives into a rotating door of visits and visitors, because there is still risk out there. One of the people who’s been quite persistent in inviting us over lives nearby, and volunteers for the same organisation as me. But geography is where the closeness ends – we don’t have that much in common and, face to face, our conversations are often awkward. If we’re going to expand our small circle we want to prioritise people we like better. Is there a polite way of telling someone we don’t want them in our bubble?

Eleanor says: I’ve been waiting for this moment, the one where our reaction to the risk starts to change, even though the risk itself stays more or less the same. In normal circumstances we expect our reactions to have a half-life: when there’s a fact we can’t change, like “she left me” or “I didn’t get the promotion”, there’s a point when we’re meant to move on.

But when the fact is an ongoing risk, instead of something that recedes into the past, it’s not clear how long our reactions should last. We don’t know what the half-life of fear is meant to be. To some of us it feels as though the fear should be dissolving by now: we’ve had the big reaction, we’ve processed the horror and, like any other grief or upheaval, there’s a point where we need to return to normalcy.

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Covid-19 could mark a deadly turn in Ghana’s fight against fake drugs

With substandard medicines already in wide circulation, fears are growing that coronavirus could create a lethal ‘parallel crisis’

When Joana Opoku-Darko’s daughter Anna was 18 months old, she came down with malaria, a disease common in Ghana and especially deadly for children.

She bought medication from a pharmacy in Ghana’s capital, Accra; when Anna’s fever didn’t subside she took her to a hospital, where they ran some tests.

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More cases of rare syndrome in children reported globally

Nearly 100 cases of the unusual illness linked to Covid-19 have emerged in at least six countries

Doctors around the world have reported more cases of a rare but potentially lethal inflammatory syndrome in children that appears to be linked to coronavirus infections.

Nearly 100 cases of the unusual illness have emerged in at least six countries, with doctors in Britain, the US, France, Italy, Spain and Switzerland now reported to be investigating the condition.

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NHS staff coronavirus inquests told not to look at PPE shortages

Exclusive: guidance to avoid examining systemic failures is ‘very worrying’, says Labour

Inquests into coronavirus deaths among NHS workers should avoid examining systemic failures in provision of personal protective equipment (PPE), coroners have been told, in a move described by Labour as “very worrying”.

The chief coroner for England and Wales, Mark Lucraft QC, has issued guidance that “an inquest would not be a satisfactory means of deciding whether adequate general policies and arrangements were in place for provision of PPE to healthcare workers”.

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The toxic chemicals in our homes could increase Covid-19 threat | Leonardo Trasande and Akhgar Ghassabian

Everyday hormone-disrupting chemicals could affect our immune system’s defenses against infections

During the rare moments you’ve ventured outside these days, you’ve probably noticed clearer skies and the benefits of reductions in air pollution.

Long-term exposure to air pollution increases the danger associated with four of the biggest Covid-19 mortality risks: diabetes, hypertension, coronary artery disease and asthma. It also can make the immune system overreact, exaggerating the inflammatory response to common pathogens.

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The questions No 10 needs to answer over Covid-19 response

From lockdown to PPE, the government is under pressure to provide more clarity

No 10 has promised “maximum transparency” on its coronavirus response in the coming days. Here are just some of the areas where the government is under pressure to provide detailed answers – or risk being accused of a whitewash.

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‘Calamitous’: domestic violence set to soar by 20% during global lockdown

Data from the UN population fund, outlining increases in abuse, FGM and child marriage, predicts a grim decade for many women

At least 15m more cases of domestic violence are predicted around the world this year as a result of pandemic restrictions, according to new data that paints a bleak picture of life for women over the next decade.

The UN Population Fund (UNFPA) has also calculated that tens of millions of women will not be able to access modern contraceptives this year, and millions more girls will undergo female genital mutilation or be married off by 2030.

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NHS warns of rise in children with new illness that may be linked to coronavirus

Doctors alerted to possibly fatal syndrome, which gives the small number of sufferers stomach pain and inflamed heart

Children are falling ill with a new and potentially fatal combination of symptoms apparently linked to Covid-19, including a sore stomach and heart problems.

The children affected appear to have been struck by a form of toxic shock syndrome. Some have been left so seriously unwell that they have had to be treated in intensive care. At least one has undergone extra corporeal membrane oxygenation (ECMO) treatment, which is used when someone’s life is at risk because they can no longer breathe for themselves.

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A rise in deaths from preventable diseases must not be part of Covid-19’s legacy

The world may be faced with a new foe, but old ones lie in wait if lockdowns disrupt existing vaccination programmes

In The Conjurer, a 16th-century painting by Dutch artist Hieronymus Bosch, a spectator stands in rapt attention as a magic trick is performed. He bends forward, wholly absorbed by the spectacle, blissfully unaware of the man behind him casually picking his pocket.

As we mark World Immunisation Week 2020, all eyes are on Covid-19. Across the globe, researchers have responded with remarkable speed and ingenuity. More than 100 vaccine candidates are in development, and several human clinical trials have begun. Though significant hurdles lie ahead, we can be optimistic that a vaccine will emerge from the fray.

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