Cranberry juice won’t cut it: UTIs and the potential for repurposing drugs

The winning essay in the Max Perutz science writing award 2021, published below, was written by Vicky Bennett from the department of biology and biochemistry at Bath University

In May, PhD students who are funded by the Medical Research Council (MRC) were invited to enter the Max Perutz science writing award 2021 and write a compelling piece about their research for the non-scientific reader.

From the many entries received, the 10 that made the shortlist covered diverse topics, including dementia, childhood adversity, the role of genes in schizophrenia and the use of hypnosis to treat psychosis.

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UK is first to approve oral antiviral pill to treat Covid

Pill can be taken twice daily at home and priority will be given to elderly patients and those with health vulnerabilities

The UK medicines regulator has become the first in the world to approve an oral antiviral pill for Covid in a move that paves the way for tens of thousands of vulnerable patients to receive the treatment from this winter.

Nearly half a million doses of molnupiravir, a pill that can be taken twice daily at home, are due for delivery from mid-November and will be given as a priority to elderly Covid patients and those with particular vulnerabilities, such as weakened immune systems. The drug will initially be given to patients through a national study run by the NHS.

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‘He was adamant he didn’t want it’: the pro-vax parents with vaccine-hesitant kids

Among under-18s, vaccine uptake is low, and there is a growing issue with misinformation spread on social media and at school. Is there anything a concerned caregiver can do?

Throughout the pandemic, Anna has worked for the NHS. She has seen the effects of Covid-19 first-hand and, although she worked remotely because she was in a vulnerable group, other colleagues – she is a physiotherapist – were deployed to Covid wards at the height of hospital admissions. “At the trust I work for, they’re setting up a long-Covid service,” she says. She comes home and her son Sam, 16, listens to her talk about it – and yet he is adamant that the coronavirus isn’t happening or that, if it is, it’s not serious. “You know: ‘Covid is a load of rubbish – it’s all about control’,” she says. “It’s all very conspiracy theory, a lot of his stuff.” He was adamant from the start that he wouldn’t be having the vaccine if and when it became available for his age group, and he has stuck to it. “He is very resistant,” says Anna. “He is pretty determined not to conform anyway. Part of it, I think, is him being a teenager, and the other bit of it is conspiracy theory: ‘It’s all a big con.’” His main source of information since the start of the pandemic has been social media, says Anna. “He watches a lot of YouTube.”

Just over a month ago, YouTube announced it would remove videos that spread misinformation about all vaccines, and would ban the accounts of anti-vax activists; it had already banned content with false claims about Covid vaccines last year. Facebook did the same in February this year, though a quick search reveals misinformation is still easy to find (one post I found within minutes claimed 80% of vaccinated women had miscarriages). On TikTok, “unvaxxed” content racks up hundreds of thousands of views. Last month, NewsGuard, an organisation that rates the credibility of news organisations and monitors misinformation, found Covid conspiracy theories were being viewed by millions on TikTok, and, in its research, children under 13 – the lower age limit – were able to access the app.

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Covid has caused 28m years of life to be lost, study finds

Oxford researchers arrive at virus’s toll in 31 countries by looking at deaths and age they occurred

Covid has caused the loss of 28m years of life, according to the largest-ever survey to assess the scale of the impact of the pandemic.

The enormous toll was revealed in research, led by the University of Oxford, which calculated the years of life lost (YLL) in 37 countries. The study measured the number of deaths and the age at which they occurred, making it the most detailed assessment yet of the impact of Covid-19.

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Covid-19 virus does not infect human brain cells, study suggests

Exclusive: study raises hopes that Covid-related damage to sense of smell may be more superficial than previously feared

The virus that causes Covid-19 does not infect human brain cells, according to a study published in the journal Cell. The findings will raise hopes that the damage caused by Sars-CoV-2 might be more superficial and reversible than previously feared.

The study contradicts earlier research that suggested the virus infects neurons in the membrane that lines the upper recesses of the nose.

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Flu, cancer, HIV: after Covid success, what next for mRNA vaccines?

The technology was viewed with scepticism before the pandemic but there is now growing confidence about its use

It is one of the most remarkable success stories of the pandemic: the unproven technology that delivered the Moderna and Pfizer/BioNTech vaccines in record time, helping to turn the tide on Covid-19. The vaccines are based on mRNA, the molecule that instructs our cells to make specific proteins. By injecting synthetic mRNA, our cells are turned into on-demand vaccine factories, pumping out any protein we want our immune system to learn to recognise and destroy.

Pre-pandemic, the technology was viewed with scepticism – a clever concept, but not guaranteed to deliver. Now there is growing confidence that mRNA vaccines could have far-reaching applications in tackling diseases from flu to malaria.

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Fresh air or foul odour? How Covid can distort the sense of smell

Coronavirus-induced parosmia is surprisingly common and the sensory confusion can have profound effects

Deirdre likens her body odour to raw onions; Deepak says his favourite aftershave smells foul, and coffee like cleaning products; Julie thinks coffee and chocolate both smell like burnt ashes.

Most people are aware that a cardinal symptom of Covid-19 is loss of smell, or anosmia. It may last for weeks or even months. Increasingly though, those who have recovered subsequently develop another disorienting symptom, parosmia, or a distorted sense of smell. This typically results in things that once smelled pleasant smelling bad or rotten.

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Call for action on TB as deaths rise for first time in decade

Tuberculosis campaigners tell G20 leaders $1bn is needed annually for vaccine research to reverse decades of underfunding

A group of tuberculosis survivors are calling for more funding and action to find new vaccines, after the numbers dying of the infection rose for the first time in 10 years.

In 2020, 1.5 million were killed by TB and 10 million infected, according to the World Health Organization. Campaigners want world leaders to invest $1bn (£730m) every year into vaccine research, spurred on by the momentum from the Covid jab development.

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The world was woefully unprepared for a pandemic. Let’s be ready for the next one | Elhadj As Sy

The Global Preparedness Monitoring Board is calling for a coherent action plan to counter future health emergencies

Two years ago, three months before coronavirus erupted, the Global Preparedness Monitoring Board (GPMB) issued a warning to the international community that a pandemic was only a matter of time, and that the world was not prepared. Tragically, we were proved right.

After 20 months of Covid-19, with nearly five million directly attributed deaths and economic devastation, we say again that the world is not prepared. It has neither the capacity to end the current pandemic in the near future, nor to prevent the next one.

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Covid testing failures at UK lab ‘should have been flagged within days’

Senior scientists say problems at Immensa site show private firms should not be carrying out PCR tests

Health officials should have known about major failings at a private Covid testing lab within days of the problem arising, rather than taking weeks to shut down operations at the site, senior scientists say.

About 43,000 people, mostly in south-west England, are believed to have wrongly been told they did not have the virus by Immensa Health Clinic’s laboratory in Wolverhampton in a debacle described as one of the worst scandals in the UK’s Covid crisis.

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Without Covid-19 jab, ‘reinfection may occur every 16 months’

Reports grow of repeat infection as experts warn prevalence among school pupils puts older people at risk

As Covid-19 infections surge in England, people are increasingly reporting catching Sars-CoV-2 for a second or even third time.

New analysis has suggested that unvaccinated individuals should expect to be reinfected with Covid-19 every 16 months, on average.

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Offshoot of Covid Delta variant on the rise in England

UK Health Security Agency monitoring AY.4.2 as daily cases at highest level since late July

A newly detected coronavirus variant is on the rise in England, with the virus believed to be an offshoot of Delta.

According to a briefing from the UK Health Security Agency, released on Friday, “a Delta sublineage newly designated as AY.4.2 is noted to be expanding in England”, with the body adding that the variant is being monitored and assessed.

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Valneva Covid vaccine could be as effective as Oxford jab, study suggests

Vaccine produced by French company uses inactivated Sars-CoV-2 virus and can be stored in fridge

A coronavirus jab based on traditional vaccine technology might be as effective as the Oxford/AstraZeneca vaccine, data suggests, offering new hope for global vaccination efforts.

Vaccines currently approved for use in the UK deliver instructions for producing the coronavirus “spike” protein to cells in order, which triggers an immune response. However, the jab produced by the French pharmaceutical company Valneva involves delivering the whole – but inactivated – Sars-CoV-2 virus.

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How my ivermectin research led to Twitter death threats | Dr Andrew Hill

I was sent images of coffins and hanged Nazi war criminals after finding medical fraud in clinical trials

The story of online threats and abuse is very dark. In early 2021, my research team was analysing a new drug called ivermectin. In the first clinical trials, this drug seemed to prevent new infections and improve survival. When I first wrote about this, I started getting regular threats on Twitter, demanding that ivermectin should be approved worldwide and questioning the safety of vaccines.

In March 2021, I received my first vaccine dose and posted a photo on Twitter from the clinic. Within minutes I was receiving strange messages: “Why would you do that?”, “not safe”, “why not use ivermectin instead”, “you are paid by the Gates Foundation”. One person even sent a link to a suction device to remove the vaccine fluid from my arm. Any message I sent promoting the benefits of vaccines led to threats and abuse.

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Local Covid vaccines fill gap as UN Covax scheme misses target

India, Egypt and Cuba among first states to develop and make their own vaccines as Covax falls behind

Developing countries are increasingly turning to homegrown Covid vaccinations as the UN-backed Covax programme falls behind.

While western countries roll out booster jabs to their own populations, Covax, which was set up by UN agencies, governments and donors to ensure fair access to Covid-19 vaccines for low- and middle-income countries, has said it will miss its target to distribute 2bn doses globally by the end of this year.

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New treatment destroys head and neck cancer tumours in trial

Exclusive: combination of drugs causes tumours to vanish in some terminally ill patients, study finds

A new cancer treatment can wipe out tumours in terminally ill head and neck cancer patients, scientists have discovered.

In a landmark trial, a cocktail of immunotherapy medications harnessed patients’ immune systems to kill their own cancer cells and prompted “a positive trend in survival”, according to researchers at the Institute of Cancer Research (ICR), London, and the Royal Marsden NHS foundation trust.

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Covid by numbers: 10 key lessons separating fact from fiction

To make sense of coronavirus data, the Observer asked David Spiegelhalter and Anthony Masters of the Royal Statistical Society Covid taskforce to write a column. That column has now inspired a book. Here are some of its insights

Genomic sequencing has identified more than 1,000 different seeds of Sars-CoV-2 introduced in early 2020. Instead of one central outbreak, reverberating outwards like an explosion, we now know there were many erupting simultaneously across the country. There were far more imports of Sars-CoV-2 from France, Italy and Spain than from China – viruses can take indirect flights. The peak was early March, after the school half-term, but a popular holiday time for adults. At the Champions League football match at Anfield between Liverpool and Atlético Madrid on 10 March, 49,000 local supporters mixed with 3,000 fans of the opposing team, while schools in Madrid were shut and supporters could not attend matches. To add insult to injury, Liverpool lost 3–2, and 4–2 on aggregate.

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Could the global Covid death toll be millions higher than thought?

A data scientist and economics student joined forces in search of the real pandemic death toll – and the results are startling

For the past 18 months, hunkered down in his Tel Aviv apartment, Ariel Karlinsky has scoured the web for data that could help him calculate the true death toll of Covid-19.

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WHO endorses use of world’s first malaria vaccine in Africa

World Health Organization’s director general hails ‘historic day’ in fight against parasitic disease

The World Health Organization has recommended the widespread rollout of the first malaria vaccine, in a move experts hope could save tens of thousands of children’s lives each year across Africa.

Hailing “an historic day”, the WHO’s director general, Dr Tedros Adhanom Ghebreyesus, said that after a successful pilot programme in three African countries the RTS,S vaccine should be made available more widely.

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‘Covid toe’ may be side-effect of immune response, says study

Chilblain-like inflammation causes redness on hands and feet and can last for months

The skin condition known as Covid toe may be a side-effect of the immune system’s response to fighting off the virus, according to a study.

The symptom results in chilblain-like inflammation and redness on the hands and feet, with the condition sometimes lasting for months at a time. It typically develops within a week to four weeks of being infected and can result in toes and fingers becoming swollen or changing colour.

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