About half of people in UK now have antibodies against coronavirus

Study by Office for National Statistics based on data from blood test results

Half of people in the UK now have antibodies against coronavirus, either through infection or vaccination, tests conducted by the Office for National Statistics (ONS) show.

According to the most recent coronavirus infection survey, an estimated 54.7% of the population in England would have tested positive for antibodies to coronavirus from a blood sample in the week ending 14 March 2021.

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Mystery brain disorder baffles Canadian doctors

Spasms, memory loss and hallucinations among symptoms of 43 patients in Acadian region of New Brunswick province

Doctors in Canada are concerned they could be dealing with a previously unknown brain disease amid a string of cases involving memory loss, hallucinations and muscle atrophy.

Politicians in the province of New Brunswick have demanded answers, but with so few cases, experts say there are far more questions than answers and have urged the public not to panic.

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Coronavirus live news: India pauses AstraZeneca vaccine exports; Belgium, Iceland and France tighten restrictions

No exports were made on Thursday; Belgium imposes fresh lockdown; Iceland imposes three-week shutdown; France locks down more areas

AstraZeneca has dismissed as “inaccurate” a report in the Italian press that 29m doses of its Covid-19 vaccine found in factory near Rome were destined for the UK.

La Stampa reported on Wednesday that the doses – almost twice the amount the EU has so far received from AstraZeneca – were found “hidden” in the factory following a search by Italian police on Saturday at the request of the European commission, and that they were probably destined for the UK.

Related: AstraZeneca dismisses claim 29m vaccine doses in Italy were bound for UK

Luxembourg has announced a partial reopening of its hospitality industry, with cafés and restaurants able to serve customers again in outdoor areas from 7 April.

The European country’s venues have been closed since the end of November.

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Covid-19: what happens next? – podcast

On 23 March 2020, the UK prime minister, Boris Johnson, announced the first lockdown in response to the growing number of cases of Covid-19. At the same time, countries around the world began to close their schools, restaurants, and offices and ask citizens to physically distance from one another. In the 12 months since, more than 2 million people have died, viral variants have emerged, and we have developed safe and effective vaccines.

One year into the pandemic, Science Weekly is asking: what happens next? Ian Sample talks to the professors Martin Landray, Mike Tildesley, and Deborah Dunn-Walters about Covid treatments, vaccines and what the next 12 months may hold

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Dexamethasone hailed as lifesaver for up to a million Covid patients worldwide

Results of Recovery drug trial also credited with successful treatment of 22,000 people in the UK, says NHS England

Dexamethasone – the inexpensive steroid that quickly emerged as a highly effective Covid therapy thanks to a large drug testing programme pioneered by UK scientists – has so far saved the lives of an estimated million people globally, including 22,000 in the UK, according to NHS England.

Called Recovery, the world’s largest randomised Covid-19 drug trial commenced in March 2020 to evaluate the suitability of a suite of different drugs to help hospitalised Covid patients. The study has since been carried out by thousands of doctors and nurses on tens of thousands of patients in hospitals across Britain.

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Can the UK avoid a third wave of Covid?

Analysis: as lockdown restrictions ease, the country now faces a race between vaccination and infection

Britain’s latest lockdown has dramatically reduced cases of coronavirus, and the number of people being admitted to hospital and dying from the disease. What the country faces now is essentially a race between vaccination and infection: can we protect people faster than the virus spreads as restrictions are eased?

This was always going to be a balancing act. The UK vaccination strategy of prioritising the most vulnerable people and moving down the age groups is intended to save lives first and slow transmission second. This means that as the country unlocks, infections are likely to rise, primarily in younger people who have more social contacts and have not yet been vaccinated. Hospitalisations and deaths are expected to rise too, though not as sharply: even though vaccine coverage has been high in vulnerable groups and older people, not everyone has the vaccine and it will not protect all those who do.

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Covid: AstraZeneca vaccine 79% effective with no increased blood clot risk – US trial

Study of over 32,000 people included review of risks of cerebral venous sinus thrombosis

The Covid-19 vaccine developed by Oxford University and AstraZeneca was 79% effective in preventing symptomatic illness in a large trial in the US, Chile and Peru, the company said on Monday, paving the way for it to apply for US approval.

The vaccine was 100% effective against severe or critical disease and hospitalisation and was safe, the drugmaker said on Monday, releasing results of the late-stage human trial study of more than 32,000 volunteers across all age groups.

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Covid: why has the fall in UK infection rate stalled despite vaccinations?

Hospital admissions and deaths are declining as priority groups vaccinated but number of new diagnoses has stabilised

The UK’s Covid-19 statistics remain encouraging despite continuing rows over vaccine deliveries in Europe. Admissions to hospital and daily deaths from the disease continue to decline with numbers in the latter category now down to double digits while the former have dropped to around a 10th of their total two months ago.

However, one other category – numbers of new diagnoses a day – has reached a plateau with cases, having plunged from 60,000, stabilising at around 5,000 to 6,000. So why has this figure apparently stalled while deaths and hospitalisations continue to decline?

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Doctors suggest Covid-19 could cause diabetes

More than 350 clinicians report suspicions of Covid-induced diabetes, both type 1 and type 2

A cohort of scientists from across the world believe that there is a growing body of evidence that Covid-19 can cause diabetes in some patients.

Prof Francesco Rubino, from King’s College London, is leading the call for a full investigation into a possible link between the two diseases. Having seen a rise in both type 1 and type 2 diabetes in people who have caught coronavirus, some doctors are even considering the possibility that the virus ‒ by disrupting sugar metabolism ‒ could be inducing an entirely new form of diabetes.

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Clot theory curdles into junkets for migrants on Isle of Man

PM welcomes vaccine safety vow, then spots new offshore home for folk trafficked here under false pretence – of getting a welcome

After a morning spent painting flowers at a primary school in his Uxbridge constituency, Britain’s prize clot returned to Downing Street to lead a press conference on clots. Blood clots to be precise.

Following the decision of some countries to suspend their Oxford AstraZeneca vaccination programmes over concerns of blood clot side-effects, Boris Johnson was happy to report that the UK’s Medicines and Healthcare products Regulatory Agency had declared the Oxford/AstraZeneca vaccine to be absolutely safe.

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Matt Hancock confirms dip in UK Covid vaccine supply for April

Health secretary says stocks will be affected by need to retest 1.7m doses and delay from India

Matt Hancock has said there will be a significant dip in vaccine supply in April, confirming supplies have been hit by a need to retest 1.7m doses and a delay in arrival of imports from India.

Speaking in the House of Commons, Hancock stressed the overall target timetable for vaccinations would not change but said he wanted to give more information, following the “speculation we’ve seen overnight”, after he was criticised for a press conference on Wednesday where the drop in supply went unexplained.

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Lack of skin-to-skin care for small and premature babies hits survival rates

Life-saving techniques fall out of favour on maternity wards in developing countries over Covid fears

Small and sick babies are at increased risk of dying due to disruptions in care caused by coronavirus, a survey of health workers across 62 mainly developing countries has found.

Every year, 2.5 million babies die within 28 days of birth, and more than 80% of them have low birth weight. A technique for premature and small babies known as kangaroo mother care (KMC), involving early prolonged skin-to-skin contact with their mothers and breastfeeding, can help reduce mortality.

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Scientists form human cell clumps that act like early-stage embryos

Cultured stem cells turn into blastoid ‘balls’, like natural blastocysts after egg fertilisation

Scientists have made clumps of human tissue that behave like early-stage embryos, a feat that promises to transform research into the first tentative steps of human development.

The clumps of cells, named blastoids, are less than a millimetre across and resemble structures called blastocysts, which form within a few days of an egg being fertilised. Typically blastocysts contain about 100 cells, which give rise to every tissue in the body.

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China to only allow foreign visitors who have had Chinese-made vaccine

Move raises questions as China’s vaccines not approved in many countries to which it is opening travel

China is resuming visa processing for foreigners from dozens of countries, but only if they have been inoculated against Covid-19 with a Chinese-made vaccine.

The move has raised questions about the motivations behind the demand, given China’s vaccines are not approved in many of the countries to which it has opened travel and that it will not accept foreign vaccines made elsewhere, including those approved by the World Health Organization.

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Oxford/AstraZeneca vaccine: which countries have paused jab and why

Analysis: Germany, France, Spain and Italy head an expanding list of EU countries to have put its use on hold

A host of European countries have put all vaccinations with this jab on hold, including Germany, France, Spain, Italy, Denmark, Norway and Ireland. Some others such as Estonia and Austria have suspended vaccinations from particular batches of the vaccine.

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For crying out loud: Dutch scientists grow human tear glands

Creation of mini-organs using stem cells will help research into tear-related disorders

Stop your sobbing – because scientists can do it for you. Using stem cells, Dutch researchers have grown miniature human tear glands capable of “crying”.

Initially, when scientists were looking at developing this technology, their first port of call was the inner lining of the gut, because it replaces itself every five days. They took a tiny piece of gut tissue filled with stem cells and fed it proteins called growth factors to stimulate cell growth, expecting the stem cells to rapidly proliferate.

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What price a child’s life? India’s quest to make rare disease drugs affordable

Parents whose only hope was finding foreign sponsorship or a clinical trial are now looking for homegrown breakthroughs

For three years, Vidya tried to find the cause of her son’s recurrent fevers and low cognitive development. When she found out, she was devastated.

Vineeth, 10, has an incurable illness – mucopolysaccharidosis type 2 – that affects his organs. Afflicting just one in a million, the enzyme-replacement medication that can help stop the illness getting any worse costs £100,000 a year, far beyond the reach of even a wealthier Indian parent.

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Covid death on Isle of Man deals a blow after tough lockdown

Manx government has run strict regime to keep island virus-free but isolation exemption for ferry workers causes anger

On Friday, the chief minister of the Isle of Man announced some bad news. A patient in the island’s Noble’s hospital had died from coronavirus, he said, the first Manx Covid death since 5 November.

Howard Quayle said he knew the news would “come as a blow” to the Isle of Man’s 85,000 residents. “The death of a member of our island community is a painful reminder of how dangerous this virus is,” he added.

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Ireland suspends AstraZeneca Covid vaccine over blood clot concerns

Deployment of Oxford vaccine temporarily deferred after latest reports from Norway

Ireland is suspending use of the Oxford/AstraZeneca coronavirus vaccine as a precautionary measure following further reports of blood clots in people who have received it, this time from Norway.

The deputy chief medical officer, Dr Ronan Glynn, said Ireland’s advisory body on vaccines had recommended that deployment of the AstraZeneca jab should be “temporarily deferred” with immediate effect. He stressed, though, that there was no proof that the vaccine had caused blood clots.

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Wales set to ease Covid lockdown restrictions from Saturday

First minister to announce ‘stay local’ will replace ‘stay home’ rule among other changes

Some semblance of normal life will begin again in Wales from Saturday, with the country’s first minister, Mark Drakeford, expected to announce a change from the current “stay home” restrictions to more lenient “stay local” requirements.

Drakeford is expected to say: “We are taking a phased approach to unlocking each sector – starting with schools. We will make step-by-step changes each week to gradually restore freedoms. We will monitor each change we make, so we know what impact each change has had on Wales’s public health situation.”

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