Editor Brian Harrod Provides Comprehensive up-to-date news coverage, with aggregated news from sources all over the world from the Roundup Newswires Network
Matt Hancock has said there will be a significant dip in vaccine supply in April, confirming supplies have been hit by a need to retest 1.7m doses and a delay in arrival of imports from India.
Speaking in the House of Commons, Hancock stressed the overall target timetable for vaccinations would not change but said he wanted to give more information, following the “speculation we’ve seen overnight”, after he was criticised for a press conference on Wednesday where the drop in supply went unexplained.
Life-saving techniques fall out of favour on maternity wards in developing countries over Covid fears
Small and sick babies are at increased risk of dying due to disruptions in care caused by coronavirus, a survey of health workers across 62 mainly developing countries has found.
Every year, 2.5 million babies die within 28 days of birth, and more than 80% of them have low birth weight. A technique for premature and small babies known as kangaroo mother care (KMC), involving early prolonged skin-to-skin contact with their mothers and breastfeeding, can help reduce mortality.
Cultured stem cells turn into blastoid ‘balls’, like natural blastocysts after egg fertilisation
Scientists have made clumps of human tissue that behave like early-stage embryos, a feat that promises to transform research into the first tentative steps of human development.
The clumps of cells, named blastoids, are less than a millimetre across and resemble structures called blastocysts, which form within a few days of an egg being fertilised. Typically blastocysts contain about 100 cells, which give rise to every tissue in the body.
China is resuming visa processing for foreigners from dozens of countries, but only if they have been inoculated against Covid-19 with a Chinese-made vaccine.
The move has raised questions about the motivations behind the demand, given China’s vaccines are not approved in many of the countries to which it has opened travel and that it will not accept foreign vaccines made elsewhere, including those approved by the World Health Organization.
Analysis: Germany, France, Spain and Italy head an expanding list of EU countries to have put its use on hold
A host of European countries have put all vaccinations with this jab on hold, including Germany, France, Spain, Italy, Denmark, Norway and Ireland. Some others such as Estonia and Austria have suspended vaccinations from particular batches of the vaccine.
Creation of mini-organs using stem cells will help research into tear-related disorders
Stop your sobbing – because scientists can do it for you. Using stem cells, Dutch researchers have grown miniature human tear glands capable of “crying”.
Initially, when scientists were looking at developing this technology, their first port of call was the inner lining of the gut, because it replaces itself every five days. They took a tiny piece of gut tissue filled with stem cells and fed it proteins called growth factors to stimulate cell growth, expecting the stem cells to rapidly proliferate.
Parents whose only hope was finding foreign sponsorship or a clinical trial are now looking for homegrown breakthroughs
For three years, Vidya tried to find the cause of her son’s recurrent fevers and low cognitive development. When she found out, she was devastated.
Vineeth, 10, has an incurable illness – mucopolysaccharidosis type 2 – that affects his organs. Afflicting just one in a million, the enzyme-replacement medication that can help stop the illness getting any worse costs £100,000 a year, far beyond the reach of even a wealthier Indian parent.
On Friday, the chief minister of the Isle of Man announced some bad news. A patient in the island’s Noble’s hospital had died from coronavirus, he said, the first Manx Covid death since 5 November.
Howard Quayle said he knew the news would “come as a blow” to the Isle of Man’s 85,000 residents. “The death of a member of our island community is a painful reminder of how dangerous this virus is,” he added.
Ireland is suspending use of the Oxford/AstraZeneca coronavirus vaccine as a precautionary measure following further reports of blood clots in people who have received it, this time from Norway.
The deputy chief medical officer, Dr Ronan Glynn, said Ireland’s advisory body on vaccines had recommended that deployment of the AstraZeneca jab should be “temporarily deferred” with immediate effect. He stressed, though, that there was no proof that the vaccine had caused blood clots.
Some semblance of normal life will begin again in Wales from Saturday, with the country’s first minister, Mark Drakeford, expected to announce a change from the current “stay home” restrictions to more lenient “stay local” requirements.
Drakeford is expected to say: “We are taking a phased approach to unlocking each sector – starting with schools. We will make step-by-step changes each week to gradually restore freedoms. We will monitor each change we make, so we know what impact each change has had on Wales’s public health situation.”
The idea that vitamin D supplements can reduce susceptibility to, and the severity of, Covid-19 is seductive – it offers a simple, elegant solution to a very complex and lethal problem. But analyses encompassing large European datasets suggest the enthusiasm for the sunshine vitamin may be misplaced.
Two still to be peer-reviewed papers looked at the link between vitamin D levels and Covid-19 and both reached the same conclusion: evidence for a direct link between vitamin D deficiency and Covid outcomes is lacking.
Face masks can be worn safely during intense exercise, and could reduce the risk of Covid-19 spreading at indoor gyms, preliminary findings suggests.
Scientists from the Monzino Cardiology Centre (CCM) in Milan and the University of Milan tested the breathing rate, heart rate, blood pressure and oxygen levels of six women and men on exercise bikes, with and without a mask.
Forty years after the mutant genes that cause the deadliest cancers were discovered, drugs that target them could be approved
In the early 1980s, Channing Der was just beginning his career as a scientist at Harvard Medical School when he happened upon a discovery that would change the course of cancer research. At the time, the holy grail of cancer biology was discovering so-called oncogenes – genetic switches that can turn a normal cell into a cancer cell – in the genomes of tumours. But while teams of scientists had thrown everything at it for the best part of a decade, their efforts had proved fruitless. One by one, they were beginning to accept that it might be a dead end.
Der found himself assigned to test 20 different genes that had been identified as possible oncogene candidates. His question was simple: did any of them actually exist in tumours in a form that was different from normal cells?
The arrival of Covid-19 vaccines promises a return to more normal life – and has created a global market worth tens of billions of dollars in annual sales for some pharmaceutical companies.
Among the biggest winners will be Moderna and Pfizer – two very different US pharma firms which are both charging more than $30 per person for the protection of their two-dose vaccines. While Moderna was founded just 11 years ago, has never made a profit and employed just 830 staff pre-pandemic, Pfizer traces its roots back to 1849, made a net profit of $9.6bn last year and employs nearly 80,000 staff.
Authorised vaccines that are modified to protect against new variants will not need to start a new approval process or undergo in-depth clinical studies, regulators in the UK, Australia, Canada, Singapore and Switzerland have said.
Manufacturers will need to provide “robust evidence that the modified vaccine produces an immune response, but time-consuming clinical studies that do not add to the regulatory understanding of a vaccine’s safety, quality or effectiveness would not be needed”, bringing the process into line with that already used for updated flu jabs.
Alongside data on the immune response, the vaccine manufacturer would also be expected to provide evidence showing the modified vaccine is safe and is of the expected quality. In addition, data from the original robust clinical trials and the ongoing studies on real-world use in millions of people could be used to support any decision by the regulators.
This approach is based on the tried and tested regulatory process used for seasonal flu vaccines, for which annual modifications are needed to match the strains circulating each year.
Our priority is to get effective vaccines to the public in as short a time as possible, without compromising on safety. Should any modifications to authorised Covid-19 vaccines be necessary, this regulatory approach should help to do just that.
The announcement today also demonstrates the strength of our international partnerships with other regulators and how our global work can help ensure faster access to life-saving vaccines in the UK and around the world.
While worrisome coronavirus variants identified in Brazil, South Africa, and California have mutations that might help them resist antibody treatments and vaccines, the immune system’s T cell responses to the variants are unaffected in recovered patients and in people who have received the Moderna Inc or Pfizer Inc/BioNTech vaccines, new data show.
Reuters: The T cells induced by vaccines can recognise pieces of the virus spike protein, while T cells induced by previous infection recognise multiple parts of the virus, including the spike and other proteins, said Alessandro Sette of the La Jolla Institute for Immunology.
“These pieces are largely not changed/mutated in the variants,” he explained. “This means that the T cell responses recognise the ‘ancestral’ sequence and the variants equally well.”
Coronavirus vaccines tweaked to deal with variants will be fast-tracked without compromising on safety or effectiveness, the UK’s regulator has said.
The approach will be similar to the regulatory process for the modified flu vaccine, to deal with new strains each year, with a brand new approval not required.
Countries with high levels of overweight people, such as the UK and the US, have the highest death rates from Covid-19, a landmark report reveals, prompting calls for governments to urgently tackle obesity, as well as prioritising overweight people for vaccinations.
About 2.2 million of the 2.5 million deaths from Covid were in countries with high levels of overweight people, says the report from the World Obesity Federation. Countries such as the UK, US and Italy, where more than 50% of adults are overweight, have the biggest proportions of deaths linked to coronavirus.
Northern Ireland’s deputy first minister, Michelle O’Neill, has unveiled a cautious five-step plan to ease the region’s Covid-19 lockdown. The plan has no hard dates and will be led by data, notably the reproductive rate of the virus, O’Neill told the Stormont assembly on Tuesday.
The coronavirus variant originally found in Manaus in Brazil and detected in six cases in the UK was able to infect 25% to 61% of the people in the Amazonian city who might have expected to be immune after a first bout of Covid, researchers say.
The extent to which P1 can evade the immune system, and potentially vaccines, emerged as the UK health secretary said the hunt for one person who tested positive for P1 – but did not leave contact details – had narrowed to 379 households in the south-east of England.
Authorities in Germany and France are under pressure to come up with creative solutions to shift the AstraZeneca vaccine at higher speed in order to avoid a pile-up of unused doses over the coming weeks.
On Monday, France’s medical regulator reversed its advice not to use the AstraZeneca jab on over-65s, and Germany’s vaccination committee is coming under increasing pressure to follow suit or even scrap prioritisation altogether.