Covid linked to risk of mental illness and brain disorder, study suggests

One in eight people who get coronavirus also have first psychiatric or neurological illness within six months, research finds

One in eight people who have had Covid-19 are diagnosed with their first psychiatric or neurological illness within six months of testing positive for the virus, a new analysis suggests, adding heft to an emerging body of evidence that stresses the toll of the virus on mental health and brain disorders cannot be ignored.

The analysis – which is still to be peer-reviewed – also found that those figures rose to one in three when patients with a previous history of psychiatric or neurological illnesses were included.

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I’ve had my first vaccine jab. It gives me hope of liberation… but not yet

Exactly a year after his first story about coronavirus, our science editor received the Pfizer injection last week. Here he reflects on a remarkable scientific achievement

I marked a grim anniversary in an unexpected manner last week. On 18 January last year, I wrote my first story about a mysterious disease that had struck Wuhan, in China, and which was now spreading around the world. More than two million individuals have since died of Covid-19, almost 100,000 of them in the UK.

Remarkably, 12 months to the day that the Observer published my story, I was given my first dose of Covid-19 vaccine, allowing me to follow nearly six million other newly immunised UK residents who are set to gain protection against a disease that has brought the planet to a standstill. It was a rare, comforting experience after a year of unremitting sadness and gloom.

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Reasons why Covid variant could kill more people are uncertain

Whatever the answer, everyone has to try even harder not to catch it in the first place

Those who may have been comforted in recent weeks by the evolutionary theory of virus mutation – that the more transmissible they become, the less lethal they are – may now be pondering the news that the variant that originated in Kent not only spreads more easily but may kill more people too.

Britain’s chief scientific adviser, Sir Patrick Vallance, at the Downing Street press briefing, said it could be that in people over 60 with Covid, 13 or 14 might die in every 1000, instead of 10 as has been the case. The reasons still seem to be uncertain.

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Covid vaccines: what are the implications of new variants of virus?

UK, South Africa and Brazil variants indicate changes may be needed

In common with others, the virus that causes Covid-19 mutates as it spreads. Most mutations have little or no effect, but some can change the behaviour of the virus. Mutations in a variant found in the UK in September has helped the virus spread more easily and potentially more dangerously. Further changes in variants that emerged in South Africa and Brazil may help the virus resist antibodies induced by vaccines and Covid infections from the first wave.

Why would the vaccines be updated?
If scientists spot new variants of coronavirus that are resistant to current vaccines then the vaccines will need to be redesigned to make them effective again. The more people who have immunity, either through vaccination or past infection, the more evolutionary pressure there is on the virus to evolve around that immunity. And when there’s lot of virus around, as there is now, there are more opportunities for resistant variants to emerge.

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I’m in a UK Covid vaccine trial – should I also accept a ‘real’ jab?

My turn for an AstraZeneca dose has come up, so I need to decide whether to drop out of Novavax tests

I had two excellent pieces of news this week. They left me feeling utterly wretched.

First, my turn came up for the AstraZeneca vaccine against Covid. I was told I could have my first jab on Thursday.

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Wear medical-grade masks if you can’t socially distance, Britons told

As new Covid variants emerge, scientists advise use of FFP masks that filter inflow and outflow of air

Scientists have urged Britons to wear medical-grade masks when they cannot physically distance, amid growing concerns of faster-spreading Covid-19 variants – but said that any face covering is better than none at all.

This week French health officials advised people to wear surgical masks rather than homemade fabric ones as these afford greater protection against highly contagious new variants.

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Indian hesitancy sets back world’s biggest Covid vaccination drive

Low uptake fuelled by fears over safety of vaccine and spread of misinformation

India’s Covid-19 vaccine drive has been hampered by turnout as low as 22% in some states, as fears over the safety of the vaccine and the spread of misinformation has fuelled widespread hesitancy.

On Saturday, India launched the world’s largest vaccination programme as it began the massive task of vaccinating its 1.3 billion citizens against coronavirus.

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Talking can spread Covid as much as coughing, says research

Tiny aerosols of the virus emitted when speaking linger in air for longer than larger droplets from a cough

Speaking to a friend when infected with the coronavirus could be as dangerous as coughing near them thanks to lingering particles, research has suggested.

Covid can be spread through a number of routes, including virus-containing droplets emitted when an infected person breaths, speaks or coughs – a factor experts said could help to explain why Covid seems to spread more easily in indoor settings.

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Single Covid vaccine dose in Israel ‘less effective than we thought’

Surge in infections dampens optimism over country’s advanced immunisation programme

Israel’s coronavirus tsar has warned that a single dose of the Pfizer/BioNTech vaccine may be providing less protection than originally hoped, as the country reported a record 10,000 new Covid infections on Monday.

In remarks reported by Army Radio, Nachman Ash said a single dose appeared “less effective than we had thought”, and also lower than Pfizer had suggested.

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Sri Lankan holy man’s ‘miracle’ potion for Covid turns sour

Minister who publicly drank syrup touted as coronavirus cure tests positive

A self-styled Sri Lankan holy man’s supposed miracle potion to prevent Covid-19 has turned sour after a minister who publicly drank it was taken to hospital with the virus.

Thousands defied public gathering restrictions to swamp a village in central Sri Lanka last month to get the syrup made by Dhammika Bandara.

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Covid-19: how do you tweak a vaccine?

The emergence of more infectious variants of Sars-CoV-2 has raised questions about just how long our vaccines will remain effective for. Although there is little evidence that the current vaccines won’t work against the new variants, as the virus continues to mutate scientists are preparing themselves for having to make changes to the vaccines in response. Speaking to Dr Katrina Pollock, science correspondent Linda Geddes asks how we can tweak the vaccines against new variants, and how likely it is we’ll end up in a game of cat and mouse with the virus

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Almost 30% of Covid patients in England readmitted to hospital after discharge – study

Readmission rate for Covid patients 3.5 times greater, and death rate seven times higher, than for other hospital patients

Nearly a third of people who were discharged from hospitals in England after being treated for Covid-19 were readmitted within five months – and almost one in eight died, a study suggests.

The research, which is still to be peer-reviewed, also found a higher risk of problems developing in a range of organs after hospital discharge in those younger than 70 and ethnic minority individuals.

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‘We need answers’: why are people living near Dutch goat farms getting sick?

A decade after an outbreak of Q fever killed 95 people in the Netherlands, scientists fear the emergence of a new disease

In early 2008, Jeannette van de Ven began to see a slightly higher rate of miscarriages among the goats on her dairy farm in the south of the Netherlands.

“We sent the samples to the veterinary authority. Nine out of 10 results showed no explanation. Only maybe toxoplasmosis from cats. We had no cats,” she says.

Van de Ven, who keeps a herd of around 1,700 dairy goats in Noord-Brabant, a province densely populated with goat farms, kept sending samples. Finally, in May 2008 an outbreak of the respiratory infection Q fever was confirmed. It infects livestock including goats, sheep and cattle, and is found in placenta, amniotic fluid, urine, faeces and milk.

The disease turned into a nightmare for the Netherlands after thousands of people also became infected during the outbreak, which lasted from 2007 to 2010. The Dutch government culled more than 50,000 dairy goats on 55 farms in an effort to stop the spread of the disease.

About half of the humans infected ended up developing complications, such as heart failure, and 95 people died.

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‘We are worried’: Indians hopeful but anxious as vaccination drive begins

India launches bid to vaccinate 300m people amid fears over efficacy of domestically produced vaccine

Emerging from Holy Family hospital in New Delhi, Ram Verma, a sanitation worker, breathed a deep sigh of relief. As one of the first in India to receive a coronavirus vaccine on Saturday – marking the start of the world’s largest vaccination programmes – he had been feeling a little jittery.

“I must admit I was nervous,” said Verma, who had received his Covaxin jab in a centre set up in the hospital car park. “A lot of us were. I thought I might faint or have side-effects. After all, it is something totally new. But I’m fine. There is nothing to worry about.”

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Turn it down: how to silence your inner voice

Your internal monologue shapes mental wellbeing, says psychologist Ethan Kross. He has the tools to improve your mind’s backchat

As Ethan Kross, an American experimental psychologist and neuroscientist, will cheerfully testify, the person who doesn’t sometimes find themselves listening to an unhelpful voice in their head probably doesn’t exist. Ten years ago, Kross found himself sitting up late at night with a baseball bat in his hand, waiting for an imaginary assailant he was convinced was about to break into his house – a figure conjured by his frantic mind after he received a threatening letter from a stranger who’d seen him on TV. Kross, whose area of research is the science of introspection, knew that he was overreacting; that he had fallen victim to what he calls “chatter”. But telling himself this did no good at all. At the peak of his anxiety, his negative thoughts running wildly on a loop, he found himself, somewhat comically, Googling “bodyguards for academics”.

Kross runs the wonderfully named Emotion and Self Control Lab at Michigan University, an institution he founded and where he has devoted the greater part of his career to studying the silent conversations people have with themselves: internal dialogues that powerfully influence how they live their lives. Why, he and his colleagues want to know, do some people benefit from turning inwards to understand their feelings, while others are apt to fall apart when they engage in precisely the same behaviour? Are there right and wrong ways to communicate with yourself, and if so, are there techniques that might usefully be employed by those with inner voices that are just a little too loud?

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Experts remain divided over merits of mass Covid tests in schools

Analysis: some say lateral flow tests could help cut outbreaks, but others argue they offer false reassurance

The education secretary, Gavin Williamson, has put mass testing for coronavirus at the heart of his strategy to reopen schools after the lockdown. It is a controversial strategy that has divided scientists. Some believe mass testing can help reduce outbreaks at schools, while others argue it could make matters worse by giving teachers and pupils false reassurance.

Mass testing relies on lateral flow tests, or LFTs, which contain antibodies that bind to the virus. When a nasal swab is tested in an LFT, any virus present in the sample sticks to the antibodies and produces a dark band, a bit like a pregnancy test’s indicator. LFTs are not as accurate as the standard NHS lab-based PCR tests, but they are cheap and produce results fast – within 30 minutes.

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What are the new coronavirus variants and how do we monitor them? – podcast

Over the course of the pandemic, scientists have been monitoring emerging genetic changes to Sars-Cov-2. Mutations occur naturally as the virus replicates but if they confer an advantage – like being more transmissible – that variant of the virus may go on to proliferate. This was the case with the ‘UK’ or B117 variant, which is about 50% more contagious and is rapidly spreading around the country. So how does genetic surveillance of the virus work? And what do we know about the new variants? Ian Sample speaks to Dr Jeffrey Barrett, the director of the Covid-19 genomics initiative at the Wellcome Sanger Institute, to find out

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The new UK Covid variant: your questions answered

You asked us about the fast-spreading coronavirus variant, here are the answers

How do scientists know the new UK variant is 70% more transmissible, and how certain are they of this figure?

Our gift to the world: the UK variant of Sars-CoV-2. There are sufficient data to quote 70% greater infectivity, but how was this figure ascertained?” D Moon, Brighton

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One in five in England have had Covid, modelling suggests

Analysis shows 12.4 million people infected since start of pandemic, against 2.4 million detected by test and trace

One in five people in England may have had coronavirus, new modelling suggests, equivalent to 12.4 million people, rising to almost one in two in some areas.

It means that across the country as a whole the true number of people infected to date may be five times higher than the total number of known cases according to the government’s dashboard.

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Salim Abdool Karim: ‘None of us are safe from Covid if one of us is not. We have mutual interdependence’

The face of South Africa’s Covid science on why Africa has been hit less hard than Europe, the new variant in the region, and the danger of vaccine nationalism

The epidemiologist Salim Abdool Karim could be considered South Africa’s Anthony Fauci. As co-chair of the South African Ministerial Advisory Committee on Covid-19, he is the government’s top adviser on the pandemic and has become the country’s face of Covid-19 science. He also sits on the Africa Task Force for Novel Coronavirus, overseeing the continent’s response to the global crisis.

Karim, who directs the Durban-based Centre for the Aids Programme of Research in South Africa and is a professor at Columbia University’s Mailman School of Public Health, has long advocated for science and speaking truth to power. For three decades, along with his wife and scientific collaborator, Quarraisha Abdool Karim, he has been at the forefront of the fight against South Africa’s substantial HIV and tuberculosis epidemics and in the early 2000s was one of the scientists who spoke out against the government’s Aids denialism.

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