US could loosen some restrictions on prescribing opioids

CDC considers rolling back limits on which doses can be prescribed and for how many days in cases of acute pain

The US could see loosened guidance around prescribing opioids, as the US Centers for Disease Control and Prevention (CDC) considers relaxing some of its guidelines in a move that could signal a new direction for managing chronic pain.

The CDC last Thursday released proposed changes to its guidance on prescribing opioids, rolling back limits on which doses can be prescribed and for how many days in cases of acute pain.

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New strategy urgently needed to tackle devastating opioids crisis, US told

Bipartisan commission makes 76 recommendations to confront crisis that has caused 1m overdose deaths since 1999

The US urgently needs a smarter, multi-pronged strategy and cabinet-level leadership to tackle an escalating overdose epidemic which poses an unacceptable threat to national security and the economy, a bipartisan congressional commission has found.

The long awaited report by the Commission on Combating Synthetic Opioid Trafficking calls for a major shift in policy to combat rising fatal overdoses, with much greater focus on reducing demand through public health measures.

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I was shooting coke between chapters of Dostoevsky – but eventually books would save me from addiction

At first, I could hardly get through a novel. But slowly reading – and writing – saved me from a life of drugs, rehab and jail

When I was in tenth grade in Tampa, Florida, I was, like millions of other high school students, assigned to read The Catcher in the Rye for English class. Like millions of other high school students, I was extremely fragile. I was holding on by a thread. I was 15 and spent much of my time at school, on the days I would go, doing OxyContin, Xanax, cocaine and speed in the bathroom. I jittered and itched through class, and my internal life was, to say the least, stifled. It would continue to be stifled for the next few years, until it became so claustrophobic that I attempted suicide. Needless to say, I was pretty hit or miss with school assignments. But I had always liked to read. I decided to crack Salinger’s book and read a chapter or two. I stayed up all night and finished it. I came into class the next day wired, eyes wide: it felt as if I had been hooked up to a car battery. I remember walking into the classroom and saying to my English teacher, “What the hell was that?”

I didn’t know anything about the book. I didn’t know that the men who shot John Lennon and Ronald Reagan were both obsessed with it. I didn’t know that it was the subject of endless think pieces debating the ethical ramifications of Holden Caulfield’s character. I didn’t know Salinger stormed the beaches on D-Day, carried scars from his years in war. I just got sucked in. It is a funny, polarising little book. I remember my girlfriend at the time saying she hated it, that she couldn’t get through it. But my teacher told me that every year at least one person does what I did, gets hooked up to the car battery. Looking back, it makes sense that someone in my particular situation would have this reaction to it. In fact, it is almost embarrassing just how cliched it is. But that’s what happened. And, in what would become a theme of my life, what stuck with me more than any of the particular content of the book was the feeling of being sucked in, of losing time trapped in someone else’s words and turbulent emotions.

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A treasured letter to Uncle Bob in Malta | Brief letters

Postal wonder | Corruption | Sacklers | Platinum pudding | Polar prayers

As a five-year-old in the 1950s, I wrote a letter with my Toytown writing set to my favourite uncle, who was in the navy. Before posting, I chose the shade of Noddy stamp to best complement the matching paper and envelope, then addressed it to “Uncle Bob, Malta” (Letters, 11 January). He received it, along with a hefty excess postage fee, but carried it with him in his wallet long afterwards as a cherished memory of home.
Andrea Clarkson
Barrow-in-Furness, Cumbria

• You report that “the British foreign secretary, Liz Truss, insists the UK has some of the toughest anti-corruption laws in the world” (MPs to re-examine UK response to dirty money from Russia, 10 January). But laws and acts of parliament are just pieces of paper until their implementation is monitored.
Marika Sherwood
Oare, Kent

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Killed by a pill bought on Snapchat: the counterfeit drugs poisoning US teens

Accidental deaths soar among young people amid a proliferation of fentanyl-filled pharmaceuticals

Fourteen-year-old Alondra Salinas had set out her new white sneakers and packed her backpack the night before the first day of in-person high school when police say she responded to an offer on Snapchat for blue pills, which turned out to be deadly fentanyl. Her mother couldn’t wake her the next morning.

Seventeen-year-old Zachary Didier was waiting to hear back on his college applications when a fake Percocet killed him. Sammy Berman Chapman, a 16-year-old straight-A student, died in his bedroom after taking what he thought was a single Xanax.

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Is medical cannabis really a magic bullet?

Research increasingly suggests that extracts from the plant are effective in treating pain, anxiety, epilepsy and more, but experts still preach caution around recreational use

In 2017, Mikael Sodergren, a liver and pancreatic cancer surgeon at Imperial College healthcare NHS trust, was finding himself becoming increasingly interested in the potential role of medical cannabis in treating pain, especially the discomfort experienced by patients after complex operations.

“I hope that I do a lot of good, but unfortunately in the short term, I inflict a lot of pain with cancer surgery,” says Sodergren. “So we’re reliant on pretty nasty painkillers, such as high-strength intravenous opioids, which we’re trying to move away from. They slow patients down and they cause complications.”

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‘Johnson & Johnson helped fuel this fire’ – now it’s out of the opioids business

Whether the pharmaceutical giant jumped or was pushed, its New York deal is a significant sign of the way the wind is blowing

Johnson & Johnson said it had already jumped. New York’s attorney general suggested the pharmaceutical giant was pushed.

Either way, the American drug maker is the first to formally agree to get out of the multibillion-dollar business of selling the powerful narcotic painkillers that drove the US opioid epidemic.

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‘Ground zero of the opioid epidemic’: West Virginia puts drug giants on trial

A series of federal cases over the pharmaceutical industry’s push to sell narcotic painkillers which created the worst drug epidemic in US history

The trial of the three biggest US drug distributors for illegally flooding West Virginia with hundreds of millions of prescription opioid pills, and driving the highest overdose rate in the country, is due to open on Monday.

Related: Empire of Pain review: the Sacklers, opioids and the sickening of America

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Empire of Pain review: the Sacklers, opioids and the sickening of America

Patrick Radden Keefe delivers a damning account of Purdue Pharma, Oxycontin and a family that grew rich

By 2016, opioids had torn a piece out of Appalachia and the rust belt. The deep drop in life expectancy among white Americans without four-year degrees would no longer be ignored. OxyContin, Purdue Pharma’s highly addictive painkiller, helped elect Donald Trump.

Related: George Floyd's girlfriend shared his opioids pain – Derek Chauvin refused to see it

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George Floyd’s girlfriend shared his opioids pain – Derek Chauvin refused to see it

Courteney Ross’s testimony showed how police departments fail in their duty to protect those who battle addiction

Of all the accounts of George Floyd’s life and death heard in a Minneapolis courtroom this week, perhaps the least expected was his girlfriend’s description of their shared struggle with opioid addiction.

Courteney Ross’s wrenching testimony gave a very human glimpse into the remorseless search for a fix and a mutual fight to shake off drug dependency.

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‘We need prison time’: Purdue’s belated guilty plea gets skeptical reaction

While the guilty plea was welcomed, there was also anger over the US justice department’s failure to prosecute executives

Lawyers and public relations firms for the Sackler family who own Purdue Pharma have spent months pushing an aggressive campaign to deny that the company’s powerful painkiller, OxyContin, unleashed the devastating US opioid epidemic.

They manipulated statistics and attacked critics to paint the company and the Sacklers as victims of an unwarranted smear campaign driven by a sensationalist media and grasping addicts trying to lay their hands on the billions of dollars of profits generated by a legitimate drug.

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‘So much sadness’: more British Columbians dying from overdoses than Covid

Morgan Goodridge was one of 900 British Columbians to die of an overdose this year, more than four times the number killed by coronavirus

Kathleen Radu thought her son was getting better.

After three stints in private drug treatment programs, Morgan Goodridge was stable again. His prescription drug-replacement treatments seemed to be working. He had just bought his first car, and hadn’t used street drugs in five months.

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Opioid vending machine opens in Vancouver

MySafe scheme for addicts aims to help reduce overdose deaths in Canadian city

A vending machine for powerful opioids has opened in Canada as part of a project to help fight the Canadian city’s overdose crisis.

The MySafe project, which resembles a cash machine, gives addicts access to a prescribed amount of medical quality hydromorphone, a drug about twice as powerful as heroin.

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Purdue payments to Sackler family surged after OxyContin fine

Family started taking far more money out of firm after it was fined for misleading marketing of drug

The wealthy owners of OxyContin maker Purdue Pharma started taking far more money out of the company after it was fined for misleading marketing of the powerful prescription painkiller.

Purdue made payments for the benefit of members of the Sackler family totalling $10.7bn (£8bn) from 2008 through to 2017, a court filing made by the company on Monday evening shows.

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Canada: nearly 14,000 people die from opioid overdoses in four years

More than 17,000 have been hospitalized in what officials say is mounting crisis

Nearly 14,000 people in Canada have died from opioid overdoses in the last four years and more than 17,000 have been hospitalized in what officials say is a mounting crisis that shows few signs of relief.

In a report titled Opioid-related harms in Canada released this week, Canada’s public health agency outlined the scope of the crisis.

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US effort to curb fentanyl behind brief arrest of El Chapo’s son, says minister

  • Ovidio Guzmán was wanted on allegations of smuggling drug
  • Sinaloa cartel appears to have moved into production of opioid

US efforts to curb the opioid fentanyl were behind the brief arrest of a son of imprisoned kingpin Joaquín “El Chapo” Guzmán last month, Mexico’s security minister has said.

After the US requested his extradition, Ovidio Guzmán was briefly arrested, then freed by outnumbered officials who feared a bloody confrontation with cartel henchmen.

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US states fight back against Purdue Pharma’s bid to stop opioid lawsuits

Twenty-four states and DC say Purdue and Sackler members should not be allowed to use bankruptcy filing to shield assets

US state officials launched a legal counter-attack on Friday against Purdue Pharma’s attempt to shield itself and its controlling Sackler family members from thousands of lawsuits claiming the maker of the OxyContin prescription painkiller helped fuel the opioid epidemic.

Related: Top universities in US and UK took millions from Sackler family

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US attack on WHO ‘hindering morphine drive in poor countries’

Claims have hurt efforts to help people around world in acute pain, say palliative care experts

An attack on the World Health Organization (WHO) by US politicians accusing it of being corrupted by drug companies is making it even more difficult to get morphine to millions of people dying in acute pain in poor countries, say experts in the field.

Representatives of the hospice and palliative care community said they were stunned by the Congress members’ report, which they said made false accusations and would affect people suffering in countries where almost no opioids were available.

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OxyContin maker Purdue Pharma files for bankruptcy

Move is partly aimed at halting more than 2,000 lawsuits filed against drug firm

US drug-maker Purdue Pharma has filed for bankruptcy and announced a $10bn (£8bn) plan to settle thousands of lawsuits that accuse the company’s prescription painkiller, OxyContin, of fuelling the deadly opioids crisis.

The company, owned by the billionaire Sackler family, faces more than 2,000 lawsuits, including actions from nearly all US states and many local governments, which allege Purdue falsely promoted OxyContin by downplaying the risk of addiction. The public health crisis claimed the lives of nearly 400,000 people between 1999 and 2017, according to the latest US data.

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US opioid crisis: experts say payouts from drug makers ‘highly questionable’

Two potential payouts from Johnson & Johnson and Purdue Pharma have provoked varied responses

Efforts to get compensation for the US opioid crisis with two multimillion-dollar drug manufacturer payouts have been met by leading activists and addiction experts with a range of responses from incredulity to cautious optimism.

On Tuesday, the wealthy Sackler family and their embattled drugmaker, Purdue Pharma, makers of two opioids that triggered the crisis, Oxycontin and MSContin, reportedly backed a proposal to resolve all opioid lawsuits against themselves and the company for more than $11bn.

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