Synthetic opioids: warning issued in NSW after nitazenes cause cluster of overdoses

NSW Health investigating after powerful drugs detected in samples related to overdoses in Nepean Blue Mountains local health district

A cluster of 20 drug overdoses in New South Wales has prompted the state’s health department to issue a public warning about the danger of synthetic opioids, which are often substantially more powerful than heroin.

Called nitazenes, the drugs are often mixed into other substances such as MDMA and heroin without the user’s knowledge.

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Doctors fighting US opioid epidemic say insurance barrier impedes treatment

Prior authorization requires permission to be sought before prescribing critical drugs, which could cost lives, doctors say

In the midst of the worst overdose epidemic in US history, addiction medicine specialists say a bureaucratic hurdle is adding to the difficulty of getting people in treatment: an insurance industry tactic called “prior authorization”.

Loathed by doctors of all stripes, prior authorization requires healthcare providers to seek permission from insurance companies before they prescribe a treatment. Doctors in addiction medicine said the requirement is both unnecessarily burdensome and could cost lives.

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Nan Goldin named art world’s most influential figure

Photographer and campaigner against Sackler family tops ArtReview Power 100 list

Nan Goldin, the pioneering photographer and campaigner against the billionaires who fuelled the US opioid epidemic, has topped an annual ranking of the contemporary art world’s most influential people and organisations.

Goldin, 70, took the number one spot on the ArtReview Power 100 list. This year, for the first time, the top 10 is made up entirely of artists who use their work and platforms to intervene in the pressing social and political issues of the current moment.

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Opioid crisis: US and China at odds over influx of fentanyl

Antony Blinken speaks at launch of US-led coalition to address synthetic drug threats

Who is responsible for the United States’ opioid epidemic? According to the US secretary of state, Antony Blinken, the culprits are “transnational criminal enterprises” who need to be tackled via international law enforcement operations.

But according to Chinese state media, “the fentanyl crisis in the United States is demand-driven”, primarily by “the users themselves”.

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Walgreens reaches $230m settlement with San Francisco over opioids crisis

Company averts a trial to determine damages as drug-related deaths surged by 41% in the city in the first quarter of this year

San Francisco has reached a $230m settlement with Walgreens over the corporation’s role in the city’s unprecedented opioid crisis.

The settlement is the largest ever awarded to a local government amid years of continuing, nationwide opioid-centered litigation, according to San Francisco’s city attorney.

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Mexican president bemoans ‘rude’ US fentanyl pressure in plea to Xi Jinping

Andrés Manuel López Obrador asks China to curb exports of opioid after lengthy denunciation of similar calls from US

Mexico’s president has written to his Chinese counterpart, Xi Jinping, urging him to help control shipments of fentanyl, while also complaining of “rude” US pressure to curb the drug trade.

President Andrés Manuel López Obrador has previously said that fentanyl is the US’s problem and is caused by “a lack of hugs” in US families. On Tuesday he read out the letter to Xi dated 22 March in which he defended efforts to curb supply of the deadly drug, while rounding on US critics.

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FDA approves overdose-reversing Narcan for sale without prescription

Move seen as a key strategy to control the US overdose crisis, which has been linked to more than 100,000 deaths a year

The US Food and Drug Administration on Wednesday approved selling naloxone without a prescription, setting the overdose-reversing drug on course to become the first opioid treatment drug to be sold over counters in the US.

It is a move some advocates have long sought as a way to improve access to a life-saving drug, though the exact impact will not be clear immediately.

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Amount of fentanyl seized in US this year ‘enough to kill every American’

DEA says more than 379m deadly doses of opioid with strength from one and a half to 50 times stronger than heroin were seized

The US Drug Enforcement Administration (DEA) has said it seized enough fentanyl in 2022 to kill every person in America.

In a statement on Tuesday, the DEA said it had seized 50.6m fentanyl-laced fake prescription pills and more than 10,000lb of fentanyl powder this year – seizures that in total represent more than 379m deadly doses.

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Campaigners celebrate as V&A severs Sackler links over opioids cash

London museum bows to years of pressure and removes signs acknowledging the family behind the OxyContin crisis

Campaigners calling for the name Sackler to be dropped from cultural landmarks are celebrating this weekend. Their smiles mark five years of demonstrations and dramatic stunts as another major arts institution – London’s Victoria and Albert Museum – takes down signs acknowledging the financial contribution from this wealthy family.

The museum is dropping it controversial ties with the Sackler family, descendants of US makers of addictive opioid prescription drugs. It’s a victory for the campaign group Sackler P.A.I.N, which staged a dramatic public protest at the gallery in November 2019. The group, led by American artist Nan Goldin, argued that donations from the family that founded now-bankrupt Purdue Pharma, maker of the painkiller OxyContin, were a moral stain on cultural institutions that accepted them.

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Five of seven people involved in Florida fentanyl-cocaine overdose are West Point cadets

Six men and a woman were taken to hospitals on Thursday in an incident that highlights a two-year trend in suspected opioid overdoses

Police have made an arrest in connection with fentanyl overdoses that involved five cadets from the US Military Academy at a Florida vacation home during spring break this week.

Wilton Manors police said six men and a woman overdosed on fentanyl-laced cocaine and were taken to hospitals on Thursday. Authorities said late on Friday they had made an arrest, but did not offer specifics.

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OxyContin victims fight for their share in Purdue bankruptcy case

The Sacklers want protection from future suits. Victims’ families want them to ‘know what their greed has caused’

Stephanie and Troy Lubinski met when they were teenagers, and they were married for three decades. Troy was big-hearted, kind, the best fisherman around, a devoted father who cared for the kids during the day after long night shifts as a firefighter.

But he had back pain that began when he worked in construction and then grew worse over the years. His doctor prescribed OxyContin, and that was the beginning of the end.

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J&J and distributors to pay $26bn to settle claims they fuelled US opioid crisis

Settlements represent largest of opioid-related cases in epidemic that has killed more than 500,000 Americans over two decades

Drugmaker Johnson & Johnson and three major distributors finalized nationwide settlements over their role in the opioid addiction crisis Friday, an announcement that clears the way for $26bn to flow to nearly every state and local government in the US.

Taken together, the settlements are the largest to date among the many opioid-related cases that have been playing out across the country. They’re expected to provide a significant boost to efforts aimed at reversing the crisis in places that have been devastated by it, including many parts of rural America.

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Purdue Pharma owners willing to pay up to $6bn to settle opioid suits

Members of Sackler family would contribute sum over 18 years under latest proposal

Members of the Sackler family who own OxyContin maker Purdue Pharma, maker of OxyContin, are willing to kick in more money – up to $6bn in total – to settle thousands of lawsuits over the toll of opioids as the company tries to work out a deal with state attorneys general who torpedoed an earlier settlement.

The offer was detailed in a report filed on Friday in US bankruptcy court by a federal mediator who asked the court to let her have until the end of the month to broker a new settlement.

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US could loosen some restrictions on prescribing opioids

CDC considers rolling back limits on which doses can be prescribed and for how many days in cases of acute pain

The US could see loosened guidance around prescribing opioids, as the US Centers for Disease Control and Prevention (CDC) considers relaxing some of its guidelines in a move that could signal a new direction for managing chronic pain.

The CDC last Thursday released proposed changes to its guidance on prescribing opioids, rolling back limits on which doses can be prescribed and for how many days in cases of acute pain.

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New strategy urgently needed to tackle devastating opioids crisis, US told

Bipartisan commission makes 76 recommendations to confront crisis that has caused 1m overdose deaths since 1999

The US urgently needs a smarter, multi-pronged strategy and cabinet-level leadership to tackle an escalating overdose epidemic which poses an unacceptable threat to national security and the economy, a bipartisan congressional commission has found.

The long awaited report by the Commission on Combating Synthetic Opioid Trafficking calls for a major shift in policy to combat rising fatal overdoses, with much greater focus on reducing demand through public health measures.

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I was shooting coke between chapters of Dostoevsky – but eventually books would save me from addiction

At first, I could hardly get through a novel. But slowly reading – and writing – saved me from a life of drugs, rehab and jail

When I was in tenth grade in Tampa, Florida, I was, like millions of other high school students, assigned to read The Catcher in the Rye for English class. Like millions of other high school students, I was extremely fragile. I was holding on by a thread. I was 15 and spent much of my time at school, on the days I would go, doing OxyContin, Xanax, cocaine and speed in the bathroom. I jittered and itched through class, and my internal life was, to say the least, stifled. It would continue to be stifled for the next few years, until it became so claustrophobic that I attempted suicide. Needless to say, I was pretty hit or miss with school assignments. But I had always liked to read. I decided to crack Salinger’s book and read a chapter or two. I stayed up all night and finished it. I came into class the next day wired, eyes wide: it felt as if I had been hooked up to a car battery. I remember walking into the classroom and saying to my English teacher, “What the hell was that?”

I didn’t know anything about the book. I didn’t know that the men who shot John Lennon and Ronald Reagan were both obsessed with it. I didn’t know that it was the subject of endless think pieces debating the ethical ramifications of Holden Caulfield’s character. I didn’t know Salinger stormed the beaches on D-Day, carried scars from his years in war. I just got sucked in. It is a funny, polarising little book. I remember my girlfriend at the time saying she hated it, that she couldn’t get through it. But my teacher told me that every year at least one person does what I did, gets hooked up to the car battery. Looking back, it makes sense that someone in my particular situation would have this reaction to it. In fact, it is almost embarrassing just how cliched it is. But that’s what happened. And, in what would become a theme of my life, what stuck with me more than any of the particular content of the book was the feeling of being sucked in, of losing time trapped in someone else’s words and turbulent emotions.

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A treasured letter to Uncle Bob in Malta | Brief letters

Postal wonder | Corruption | Sacklers | Platinum pudding | Polar prayers

As a five-year-old in the 1950s, I wrote a letter with my Toytown writing set to my favourite uncle, who was in the navy. Before posting, I chose the shade of Noddy stamp to best complement the matching paper and envelope, then addressed it to “Uncle Bob, Malta” (Letters, 11 January). He received it, along with a hefty excess postage fee, but carried it with him in his wallet long afterwards as a cherished memory of home.
Andrea Clarkson
Barrow-in-Furness, Cumbria

• You report that “the British foreign secretary, Liz Truss, insists the UK has some of the toughest anti-corruption laws in the world” (MPs to re-examine UK response to dirty money from Russia, 10 January). But laws and acts of parliament are just pieces of paper until their implementation is monitored.
Marika Sherwood
Oare, Kent

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Killed by a pill bought on Snapchat: the counterfeit drugs poisoning US teens

Accidental deaths soar among young people amid a proliferation of fentanyl-filled pharmaceuticals

Fourteen-year-old Alondra Salinas had set out her new white sneakers and packed her backpack the night before the first day of in-person high school when police say she responded to an offer on Snapchat for blue pills, which turned out to be deadly fentanyl. Her mother couldn’t wake her the next morning.

Seventeen-year-old Zachary Didier was waiting to hear back on his college applications when a fake Percocet killed him. Sammy Berman Chapman, a 16-year-old straight-A student, died in his bedroom after taking what he thought was a single Xanax.

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Is medical cannabis really a magic bullet?

Research increasingly suggests that extracts from the plant are effective in treating pain, anxiety, epilepsy and more, but experts still preach caution around recreational use

In 2017, Mikael Sodergren, a liver and pancreatic cancer surgeon at Imperial College healthcare NHS trust, was finding himself becoming increasingly interested in the potential role of medical cannabis in treating pain, especially the discomfort experienced by patients after complex operations.

“I hope that I do a lot of good, but unfortunately in the short term, I inflict a lot of pain with cancer surgery,” says Sodergren. “So we’re reliant on pretty nasty painkillers, such as high-strength intravenous opioids, which we’re trying to move away from. They slow patients down and they cause complications.”

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‘Johnson & Johnson helped fuel this fire’ – now it’s out of the opioids business

Whether the pharmaceutical giant jumped or was pushed, its New York deal is a significant sign of the way the wind is blowing

Johnson & Johnson said it had already jumped. New York’s attorney general suggested the pharmaceutical giant was pushed.

Either way, the American drug maker is the first to formally agree to get out of the multibillion-dollar business of selling the powerful narcotic painkillers that drove the US opioid epidemic.

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