‘Over-supplied’ US faces pressure to send Covid vaccine doses to less wealthy countries

US bought enough doses to vaccinate whole eligible population twice, but continues to resist sharing in effort to ‘over-prepare’

The US is under increasing pressure to share Covid-19 vaccine doses with less wealthy nations, as advocates call for prevention of an emerging “vaccine apartheid” and point to the strategic and diplomatic importance of sharing essential medicines.

Calls to share vaccine doses grew louder this week after the Biden administration announced an additional purchase of 100 million vaccine doses from Johnson & Johnson. The American government has now bought enough doses of vaccines from Moderna, Pfizer and Johnson & Johnson to vaccinate 500 million people – nearly the entire eligible population twice over.

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Australia news live: Morrison defends tourism package; WA election campaign enters final day

The PM has rejected claims of favouring Coalition and marginal seats through subsidised flights; and WA opposition leader Zak Kirkup insists he has no regrets as he prepares for landslide defeat. Follow all the latest updates, live

Good news for NSW residents in Auckland, they will once again be allowed to return to Australia without quarantine, as the New Zeland cluster dies out with no more new cases reported in the recent Auckland cluster since 28 February.

NSW health released a statement last night confirming the (one-way) travel bubble will reopen:

People who have been in Auckland in the past 14 days will be exempt from hotel quarantine provided that they seek testing for Covid-19 after arriving in NSW. They must self-isolate in their accommodation until they receive a negative result.

NSW Health will follow up arrivals from Auckland if a negative test is not recorded for them, to inform them of their obligations.

The OECD has so far been unable to find a clear winner in the contest between former Australian finance minister Mathias Cormann and former European trade commissioner Cecilia Malmström – so the decision may not be finalised until later this month.

Cormann and Malmström, the Swedish candidate, are the final two nominees for the role of secretary general of the Paris based OECD. The selection process is based on seeking to find consensus among OECD member states.

Following discussion with the Selection Committee, the Chair’s conclusions were finalised and these were communicated first to the nominating ambassadors, and then to the Heads of Delegations in plenary. Following these consultations, the Chair has been unable to identify which candidate has the most support. Further steps will be taken in March, with the aim of concluding the process.

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‘It’s the right thing to do’: Londoners receive first jabs at new mass vaccination centre – video

A north London business centre previously used to host almost a million people across hundreds of events each year has reopened as an NHS  Covid-19  mass vaccination centre. Up to 4,000 people a day will receive shots in dozens of private booths at the Business Design Centre in Islington, treated by trained staff and an army of volunteers. Patients arriving on its opening day expressed excitement and hope that the vaccine programme could eventually end lockdowns

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Delaying second Pfizer dose leaves cancer patients at risk, say researchers

Covid vaccination policy review urged after study finds 12-week gap leaves patients vulnerable

Delaying the second dose of the Pfizer/BioNTech vaccine must be urgently reviewed for cancer patients after a single shot was found to offer inadequate protection, researchers have said.

A study from King’s College London and the Francis Crick Institute – which has not yet been peer reviewed – found that three weeks after the first jab antibody responses were found in 39% of people with solid cancers and 13% of people with blood cancer.

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EMA says AstraZeneca vaccine can continue to be used during investigation

Several countries suspend inoculations but regulator says vaccine benefits outweigh its risks

The European Medicines Agency has said the Oxford/AstraZeneca Covid vaccine can continue to be used during an investigation into cases of blood clots that have prompted several European countries to pause their use of the shot.

The EMA said 30 cases of “thromboembolic events” or blood clots had been reported among 5 million people who had received the jab in Europe so far. “The vaccine’s benefits continue to outweigh its risks,” the regulator said in a statement.

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Israeli real-world data on Pfizer vaccine shows high Covid protection

Jab has 97% efficacy against disease and death and 94% against infection without symptoms

The Pfizer/BioNTech vaccine appears to give high protection against asymptomatic Covid-19, according to data from Israel – a finding that will boost hopes that mass vaccination can stop the spread of the virus.

The top line of the real-world results, issued by the Israeli ministry of health and the companies but not yet peer-reviewed by scientists, is efficacy of 97% against disease and death and 94% against infection without symptoms.

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Vaccine row: EU has exported 34m doses – including 9m to the UK

Internal figures leaked amid tit-for-tat with Boris Johnson over claims UK had export ban in place

A total of 34m doses of coronavirus vaccine have been exported from the EU despite shortages for people living in the bloc, including 9m sent to the UK and 1m to the US, which has a ban on sales abroad.

The internal figures were leaked as the EU was embroiled in a tit-for-tat with Boris Johnson over claims that the UK had an export ban in place.

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Israel says 600 children given Covid jab had no serious side-effects

Exclusive: hopes raised for vaccine safety, although children, some of whom have cystic fibrosis, were not part of a clinical trial

Hundreds of children between the ages of 12 and 16 who have been given the Pfizer/BioNtech vaccination in Israel experienced no serious side-effects, a senior official has told the Guardian, one of the first signs that Covid-19 inoculations could be safe for minors before clinical trial results.

Israel’s health ministry has recommended vaccinating some teenagers if they suffer from underlying conditions that make them vulnerable to coronavirus.

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Russia’s Sputnik V Covid vaccine gaining acceptance in Europe

Jab has already been ordered or used in some EU countries, and Italy could start producing vaccine in July

Russia’s Sputnik V vaccine appears to be gaining acceptance in the European Union, as the head of Germany’s regulatory authority publicly praised the Covid-19 jab and Italy could become the first European country to produce the vaccine from the summer.

Thomas Mertens, the head of Germany’s standing commission on vaccination, described Sputnik V in an interview on Wednesday as “a good vaccine that will presumably also be approved in the EU at some point”.

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Coronavirus live: highest new cases in Turkey this year after curbs eased; France reports 30,303 new infections

Turkish cases rise after curbs eased; France cases above 30,000 for first time in fortnight; nothing to suggest vaccination behind deaths in Austria, EMA says

US President Joe Biden’s $1.9 trillion Covid-19 relief bill secured enough votes in the U.S. House of Representatives to pass on Wednesday.

The Senate has already approved the legislation.

Here is a quick recap of recent Covid related events from around the world:

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Australia urged to back plan to let poor countries make cheap copies of Covid vaccines

Exclusive: union, health and aid groups plead with the Morrison government to support a WTO proposal to suspend vaccine patents during the pandemic

International aid groups, health organisations and unions are pleading with the Morrison government to support a World Trade Organization proposal designed to allow developing countries to make and sell cheap copies of patented vaccines, to achieve a quicker end to the global pandemic.

The WTO proposal would suspend Covid vaccine patents for successful jab formulas invented by pharmaceutical giants for the duration of the pandemic so poorer countries could acquire more affordable doses faster.

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Whitty: revising plan to ease England lockdown would risk fresh Covid surge

Chief medical officer tells MPs lifting rules more quickly would lead to more hospitalisations and deaths

England’s chief medical officer has warned MPs that revising the government’s roadmap to emerge from lockdown sooner than planned would risk a more serious third wave of Covid infections.

Prof Chris Whitty said he expected a surge of infections once restrictions were lifted but that exiting lockdown faster, when fewer people are vaccinated, would send more people into hospital and lead to more deaths.

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From Pfizer to Moderna: who’s making billions from Covid-19 vaccines?

The companies in line for the biggest gains – and the shareholders who have already made fortunes

The arrival of Covid-19 vaccines promises a return to more normal life – and has created a global market worth tens of billions of dollars in annual sales for some pharmaceutical companies.

Among the biggest winners will be Moderna and Pfizer – two very different US pharma firms which are both charging more than $30 per person for the protection of their two-dose vaccines. While Moderna was founded just 11 years ago, has never made a profit and employed just 830 staff pre-pandemic, Pfizer traces its roots back to 1849, made a net profit of $9.6bn last year and employs nearly 80,000 staff.

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Dalai Lama urges people to get Covid vaccine after having first dose

Tibetan spiritual leader, 85, receives jab at hospital in north Indian city of Dharamshala

The Dalai Lama, the 85-year-old Tibetan spiritual leader, was administered the first shot of the coronavirus vaccine on Saturday at a hospital in the north Indian hill city of Dharamshala.

After receiving the injection, he urged people to be brave and come forward to be vaccinated.

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WHO chief: waive Covid vaccine patents to put world on ‘war footing’

Dr Tedros Adhanom Ghebreyesus says he supports patent waiver to help countries make and sell cheap vaccine copies

Opinion: A ‘me first’ approach to vaccination won’t defeat Covid

The normal rules of business that protect the profits of vaccine manufacturers will have to be set aside if that is what it takes to ensure everybody is immunised against the coronavirus, according to the director general of the World Health Organization.

Writing in the Guardian, Dr Tedros Adhanom Ghebreyesus says the world needs to be “on a war footing”. Before a key meeting of the World Trade Organization next week on the anniversary of the declaration of the pandemic, he supports a patent waiver that would allow countries to make and sell cheap copies of vaccines that were invented elsewhere.

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Australia news live: Scott Morrison speaking after national cabinet meeting

Sex discrimination commissioner to lead review of parliament culture; Italy blocks 250,000 doses of Covid vaccine under the EU’s export authorisation scheme. Follow latest updates

Morrison has moved on from Covid-19, and is being asked about other matters, including Linda Reynolds’ comments about Brittany Higgins.

Minister Reynolds has offered an apology, as she should. And as I said yesterday. And I didn’t find that acceptable, the comments that were made within her office at that time. They weren’t public statements, of course. These were comments made not in a public space... That doesn’t excuse them. And it was relating... she was not talking about the allegations of sexual assault.

Linda Reynolds is returning. She’s currently on leave and will return to her duties when her leave is finished. She maintains my confidence.

Morrison is also asked about the education sector, and whether that was a consideration when discussing international arrival caps and quarantine facilities. In short, no change, but if universities want to reach agreements with government, they’re willing to chat.

No, there’s no change on that front. It would be good if we could get to that point, but at this stage we’re not at that point. The opening of the international borders, we don’t think is wise at this time, and for the period that we’ve suggested, and that’s totally consistent with the medical advice. And we’ve always been happy to work with the international education sector if they want to put in place supplementary self-funded quarantine arrangements and flight arrangements. That has always been there for the international education industry, the large universities and others to go down that path. They haven’t chosen to go down that path. Our focus has remained on the responsibilities we have as a commonwealth.

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Ian Brown pulls out of music festival over Covid vaccination row

Brown, a noted Covid sceptic, has withdrawn from the Neighbourhood Weekender festival in Warrington in September

Ian Brown has pulled out of headlining the Neighbourhood Weekender festival in Warrington this September after claiming that all attendees require proof of vaccination.

Brown is a noted Covid sceptic, frequently using his Twitter account to spread disinformation about the virus and protections against it. “I refuse to accept vaccination proof as condition of entry,” he tweeted yesterday.

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Coronavirus live news: modified vaccines for variants to be fast-tracked, say UK and Australia regulators

Agencies in Canada, Singapore and Switzerland will also back plan for modified vaccines to be rolled out without new approval

Authorised vaccines that are modified to protect against new variants will not need to start a new approval process or undergo in-depth clinical studies, regulators in the UK, Australia, Canada, Singapore and Switzerland have said.

Manufacturers will need to provide “robust evidence that the modified vaccine produces an immune response, but time-consuming clinical studies that do not add to the regulatory understanding of a vaccine’s safety, quality or effectiveness would not be needed”, bringing the process into line with that already used for updated flu jabs.

Alongside data on the immune response, the vaccine manufacturer would also be expected to provide evidence showing the modified vaccine is safe and is of the expected quality. In addition, data from the original robust clinical trials and the ongoing studies on real-world use in millions of people could be used to support any decision by the regulators.

This approach is based on the tried and tested regulatory process used for seasonal flu vaccines, for which annual modifications are needed to match the strains circulating each year.

Our priority is to get effective vaccines to the public in as short a time as possible, without compromising on safety. Should any modifications to authorised Covid-19 vaccines be necessary, this regulatory approach should help to do just that.

The announcement today also demonstrates the strength of our international partnerships with other regulators and how our global work can help ensure faster access to life-saving vaccines in the UK and around the world.

While worrisome coronavirus variants identified in Brazil, South Africa, and California have mutations that might help them resist antibody treatments and vaccines, the immune system’s T cell responses to the variants are unaffected in recovered patients and in people who have received the Moderna Inc or Pfizer Inc/BioNTech vaccines, new data show.

Reuters: The T cells induced by vaccines can recognise pieces of the virus spike protein, while T cells induced by previous infection recognise multiple parts of the virus, including the spike and other proteins, said Alessandro Sette of the La Jolla Institute for Immunology.

“These pieces are largely not changed/mutated in the variants,” he explained. “This means that the T cell responses recognise the ‘ancestral’ sequence and the variants equally well.”

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Vaccines tweaked for Covid variants will be fast-tracked safely, says UK regulator

Approach will be similar to how flu vaccine is modified each year to deal with new strains without fresh approval

Coronavirus vaccines tweaked to deal with variants will be fast-tracked without compromising on safety or effectiveness, the UK’s regulator has said.

The approach will be similar to the regulatory process for the modified flu vaccine, to deal with new strains each year, with a brand new approval not required.

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Interpol warns fake vaccines seized in China and South Africa are ‘tip of iceberg’

Police in China and South Africa have seized thousands of fake doses of Covid-19 vaccine

Police in China and South Africa have seized thousands of fake doses of the Covid-19 vaccine, the global police organisation Interpol said on Wednesday, warning this represented only the “tip of the iceberg” in vaccine-related crime.

The Lyon-based agency Interpol said 400 vials – equivalent to around 2,400 doses – containing the fake vaccine were found at a warehouse in Germiston outside Johannesburg in South Africa, where officers also recovered fake masks and arrested three Chinese and a Zambian national.

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