Brazil’s president casts doubts on Covid vaccine as second wave hits – video

Jair Bolsonaro, who has said he will personally refuse any Covid-19 vaccine, has cast doubt on the effectiveness and safety of a vaccination that will be rolled out in Brazil as the country's death toll passed 200,000 this week.

Manaus, the capital of Brazil's largest state, Amazonas, has been put under a daily 11-hour curfew as it faces a health system breakdown with oxygen shortages and thousands of deaths

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Global immunisation: low-income countries rush to access Covid vaccine supply

Despite efforts to procure Covid vaccine, some nations will only vaccinate 20% of population

There are triumphant scenes as lorries leave a vaccine plant in Pune, India, loaded with boxes that will prevent thousands of deaths. Adar Poonawalla, the owner and chief executive of the Serum Institute of India, poses on the tailgate of a truck, making the most of his company’s “proud and historic” moment as the potential saviour of the nation – and even a large chunk of the world.

Poonawalla’s factory, the largest vaccine manufacturing complex in the world, is the best hope for immunisation for people in Africa and some low-income countries elsewhere – which could save them from the ravages of the coronavirus pandemic. The Serum Institute has been contracted to supply the UN-backed Covax initiative, which subsidises low-income countries, with 200m doses of Covid-19 vaccines with an option on 900m more.

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New year, new outbreak: China rushes to vaccinate 50 million as holiday looms

Drive to immunise 3.5% of the population in weeks comes ahead of the lunar new year festival and as three major cities are locked down

At a Shenzhen hospital, 21-year-old airport worker Wang Shuyue lines up to receive her second shot.

“I feel it’s safe because so many people around the country have taken the vaccine so there shouldn’t be any major problems,” she tells the Guardian. “I think it should be effective otherwise there wouldn’t be so many people taking it.”

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GPs in England say inconsistent supply of Covid vaccine causing roll-out issues

Short notice is making it difficult to book advance appointments, as PM admits regional disparities

Inconsistent vaccine supply is making it difficult for GPs in England to book patient appointments more than a few days in advance, experts have warned, as the prime minister admitted there were significant disparities in local immunisation rates.

Doctors, NHS specialists and MPs told the Guardian that batches of the Pfizer and Oxford/AstraZeneca vaccine frequently arrived with only a couple of days’ notice, requiring last-minute planning and creating uncertainty for patients.

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Australia’s chief medical officer defends AstraZeneca’s Covid vaccine amid efficacy concerns

Australia has secured 54m doses of the vaccine some experts say is inferior to Pfizer’s mRNA vaccine, which Australia has bought just 10m doses of

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  • Australia’s chief medical officer, Prof Paul Kelly, and infectious diseases experts have defended securing 54m doses of a Covid-19 vaccine made by Oxford University and the pharmaceutical company AstraZeneca, amid concerns the vaccine will not be effective enough to achieve herd immunity.

    The president of the Australian and New Zealand Society for Immunology, Prof Stephen Turner, told Nine media that Australia should halt the AstraZeneca vaccine rollout because it has “lower efficacy”.

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    ‘Inheriting a mess’: grim outlook for Biden goal of 100m Covid vaccinations in 100 days

    With more than 22 million Americans currently Covid-19 positive, infrastructure needed to disseminate vaccine is far from complete

    Joe Biden has been promising Americans that “help is on the way” since his election, with a goal of inoculating 100 million people with the Covid-19 vaccine within the first 100 days of his presidency.

    But just days away from his inauguration, Biden is reportedly frustrated with his own coronavirus taskforce, and concerned they might not reach their goal in time, according to Politico.

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    The new UK Covid variant: your questions answered

    You asked us about the fast-spreading coronavirus variant, here are the answers

    How do scientists know the new UK variant is 70% more transmissible, and how certain are they of this figure?

    Our gift to the world: the UK variant of Sars-CoV-2. There are sufficient data to quote 70% greater infectivity, but how was this figure ascertained?” D Moon, Brighton

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    Vaccine scepticism in France reflects ‘dissatisfaction with political class’

    Past medical scandals involving big pharma and public officials have made many suspicious of vaccines

    In France, every child is now obliged to have 11 vaccinations. If parents want their children to attend school, or take part in many extracurricular activities, they must accept. There is no opt-out or concessions made to vaccine doubters.

    On Monday France’s government and health authorities are speeding up the country’s Covid-19 vaccine drive – a process complicated by widespread scepticism about the inoculation that has encompassed the usual global conspiracy theories.

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    Salim Abdool Karim: ‘None of us are safe from Covid if one of us is not. We have mutual interdependence’

    The face of South Africa’s Covid science on why Africa has been hit less hard than Europe, the new variant in the region, and the danger of vaccine nationalism

    The epidemiologist Salim Abdool Karim could be considered South Africa’s Anthony Fauci. As co-chair of the South African Ministerial Advisory Committee on Covid-19, he is the government’s top adviser on the pandemic and has become the country’s face of Covid-19 science. He also sits on the Africa Task Force for Novel Coronavirus, overseeing the continent’s response to the global crisis.

    Karim, who directs the Durban-based Centre for the Aids Programme of Research in South Africa and is a professor at Columbia University’s Mailman School of Public Health, has long advocated for science and speaking truth to power. For three decades, along with his wife and scientific collaborator, Quarraisha Abdool Karim, he has been at the forefront of the fight against South Africa’s substantial HIV and tuberculosis epidemics and in the early 2000s was one of the scientists who spoke out against the government’s Aids denialism.

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    All UK adults will be offered Covid vaccine by autumn, says Matt Hancock – video

    The health secretary promised vaccines would be offered to every adult in the UK ‘by the autumn’. Speaking on the BBC’s The Andrew Marr Show, Hancock said it was ‘very, very important’ that as many people as possible get a vaccine. More than 200,000 people are now being vaccinated each day, he added

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    Now we have the coronavirus vaccine, how soon can we get back to normal life?

    The government has ordered sufficient doses to inoculate the entire population of the UK against Covid-19 but we are in for a long haul

    When will the Covid-19 vaccine begin to have an effect on the nation?

    The government has pledged to offer vaccines to 15 million people – the over-70s, healthcare workers and those required to shield by mid-February, and millions more by spring. This should slowly bring the virus under control although it will take many weeks before we can be sure the vaccine is having an effect. Numbers of daily cases of Covid-19 may drop but that decline could simply be due to impact of current lockdown measures. Only when hospital admissions start to reduce significantly will we be sure the vaccine is having an impact. Then there could be be a slackening of lockdown measures. Few scientists believe that will happen before Easter, however.

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    The Queen and Prince Philip receive first dose of Covid vaccine

    Injections given by royal household doctor at Windsor Castle, where the couple are spending lockdown

    The Queen and the Duke of Edinburgh have been vaccinated against Covid, joining more than a million people in the UK who have been given the jab.

    In an unusual move, Buckingham Palace – which rarely comments on the private health matters of the couple – announced that the 94-year-old head of state and her consort had been given the injection.

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    Covid in the UK: why is it so bad now and when will cases decline? | Nicola Davis and Linda Geddes

    With a major incident declared in London and positive test results surging, experts answer key questions

    The UK is seeing record numbers of people testing positive for coronavirus, with more than 60,000 positive tests reported on three days this week.

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    Why the delay? The nations waiting to see how Covid vaccinations unfold

    Australia, New Zealand, Taiwan and Japan are among those that won’t start vaccinating for months, in part to see how other populations react to the jab

    They are the nations that have been held up as shining examples of coronavirus management. In Australia, New Zealand and Taiwan, daily Covid infections are in the single digits and outbreaks are quickly suppressed.

    But there is one area where these nations lag well behind the pack in vaccination. Countries with some of the most enviable healthcare systems in the world – including Australia, New Zealand, Japan and South Korea – will not begin to inoculate until the end of February or later.

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    ‘We cannot take chances’ with South African Covid variant, says Grant Shapps – video

    The transport secretary said fears that vaccines would not work against the new South African coronavirus strain prompted the introduction of testing for new arrivals into England and Scotland. 'There are concerns ... about how effective the vaccine would be against it, so we simply cannot take chances,' Shapps said

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    Fears Covid vaccines would not work against South Africa variant led to travel curbs

    Minister says extra check on travellers introduced as ‘we simply cannot take chances’

    Fears that Covid vaccines will not work against the new South African strain of the virus have prompted the introduction of testing for new arrivals into England and Scotland from abroad, the transport secretary, Grant Shapps, has said.

    Outlining the new testing regime for England and Scotland, he told Sky News: “This is an extra check and we’re doing this now because there are these variants that we’re very keen to keep out of the country, like the South African variant, for example.

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    Bob Grose obituary

    For some people, the work they do and the life they lead are in perfect alignment. My friend and colleague Bob Grose, who has died aged 71, was one of those people.

    He did historically important work on HIV/Aids for the World Health Organization (WHO) in Africa, and for polio, HIV and leprosy for the Overseas Development Administration (ODA, later DfID) in India. Writing for War on Want in the mid-1980s, Bob was one of the first to predict that truckers would be high-risk vectors for the HIV epidemic in Africa. He was quickly snapped up by the WHO’s Global Programme on Aids (later UNAids) in Geneva, where he worked from 1987 to 1992 as a technical adviser. He was ahead of his time, mobilising community groups in Africa to raise awareness of the epidemic: a focus of UNAids to this day.

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    Europe at tipping point with Covid running rampant, says WHO

    Europe director Hans Kluge says rapid spread of new variant is cause for alarm

    Europe is at a tipping point in the course of the pandemic, the World Health Organization has said, warning that the coronavirus is spreading very fast across the continent and the arrival of a new variant has created an “alarming situation”.

    Related: Coronavirus live news: Japan's PM announces state of emergency for Tokyo; US suffers record daily deaths

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    What’s the scientific basis for delaying the Covid vaccine second dose?

    UK health officials also allowing combining doses from different manufacturers

    UK health officials have decided to delay giving second doses of Covid-19 vaccines and even permit combining doses from different manufacturers, prompting international concern. What is the scientific justification for this decision?

    Why has the UK decided to lengthen the gap between the first and second doses of vaccine?
    The original plan was to offer priority groups an initial shot of vaccine, followed by a second dose three weeks later. But a rapid increase in the number of Covid-19 cases, combined with the emergence of a more transmissible variant and uncertainty about the supply of vaccine stocks, prompted the Joint Committee on Vaccination and Immunisation (JCVI) to consider other options.

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    Misinformation ‘superspreaders’: Covid vaccine falsehoods still thriving on Facebook and Instagram

    Researchers say big Facebook accounts still condemn vaccines while anti-vaxxers banned from Facebook have fled to Instagram

    Conspiracy theories and misinformation about the coronavirus vaccine are still spreading on Facebook and Instagram, more than a month after Facebook pledged it would take them down.

    Under pressure to contain an avalanche of falsehoods, Facebook announced on 3 December that it would ban debunked claims about the safety and efficacy of vaccines now being distributed worldwide. The company said it removed more than 12m pieces of content from Facebook and Instagram between March and October, and that it worked with factcheckers to place labels on 167 million more pieces of content over the same period.

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