Moderna vaccine’s effectiveness bodes well for Oxford/AstraZeneca jab

Phase 3 success rate of 95% for US firm’s treatment is promising for UK vaccine trial

Hopes are rising for the Covid jab being developed by Oxford University, after Moderna became the second company to reveal impressive results from its vaccine trials.

Interim results from phase 3 clinical trials of the Covid vaccine from US company Moderna has revealed it to be almost 95% effective at preventing the disease. The news followed an announcement last week from Germany-based Pfizer and BioNTech that their vaccine was more than 90% effective.

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Latest vaccine success is good news but high price may restrict access

Moderna results show Pfizer success was not flash in the pan, but poorer countries may have to look elsewhere

The success of Moderna’s vaccine against Covid-19 is reason for the whole world to cheer. The results from an interim analysis of the trial data are remarkably similar to those of Pfizer/BioNTech a week ago. Most people – Moderna says 94.5% in its trial, Pfizer said more than 90% – were protected from illness.

It’s fantastic news. It means the concept works. Pfizer’s results were not a flash in the pan. Both vaccines have been developed using a new technology that has never produced a licensed vaccine before, called messenger RNA (mRNA), which some hail as the future of all vaccines. It has the potential to deliver vaccines for all sorts of diseases cheaply and safely, enthusiasts say. And, crucially for the time being, they are likely to help us out of the Covid pandemic.

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What does the Moderna vaccine mean for the fight against Covid?

How does it work and how is it different from the Pfizer/BioNTech jab?

As promising results are released from a second vaccine trial, we take a look at what this could mean in the battle against Covid-19.

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A vaccine? Trump going? A bit of good news and my optimism has gone bananas

The doom spiral has been interrupted. Could it be that, by the spring, things will actually be better than they are now?

After five years of wanting to move, about two years of having to move and eight months of really urgently needing to move, the kids being so large and teen now that we could all smell each other across two floors of our titchy house, we finally moved. The sheer number of small, troublesome questions this prompted – have we traumatised the rabbit? Will the dog definitely die if he runs on to the A3, and will the resulting pile-up be legally my fault? What’s at the bottom of this pan we packed, oh God no, it’s curdled milk, who moves house without washing up first? Me, that’s who – completely clouded my vision. It was days before I realised something good had happened.

The US elections unfolded at the same time, following the same pattern. Lots of facts, and counting, and more facts, and revised counting, and nebulous fretting, until finally, wait … this is actually good. Something good has happened. This would have been a really fortuitous day to buy a lottery ticket, I thought on Saturday evening; with so much improbable good fortune, the chances of me winning a million quid are probably pretty high. I didn’t follow that up because I was too busy drinking and whatnot. Then two days later, a vaccine.

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Is the vaccine safe? Do I need it if I’ve had Covid? Readers’ questions answered

‘Zero chance’ mRNA can alter genes, says expert, adding that vaccine can ‘top up’ immune response from infection

“The concerted efforts put into developing a vaccine are wonderful but they can’t possibly know about long-term adverse effects. I’ll have it if it’s offered to me, and at my age long-term effects are irrelevant. I just hope it doesn’t turn out to be a latter-day thalidomide.” Jenny Walters, retired teacher, Ashburton

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Measles cases hit 20-year high as Covid disrupts vaccinations, report finds

Number of people dying from the disease also increased by 50% since 2016, according to data from the WHO and CDC

The number of measles cases worldwide surged to nearly 900,000 in 2019, the highest figure in more than two decades, underlining a significant U-turn in global progress to combat the disease.

Data from the World Health Organization (WHO) and US Centers for Disease Control and Prevention (CDC) found that the number of people dying from measles also increased by 50% since 2016, with an estimated 207,500 deaths in 2019 alone.

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‘It came in a locked box’: UK Covid vaccine volunteers – in pictures

Thousands of ordinary people around Britain volunteered to take part in the Imperial College London coronavirus vaccine trial. Who are they, what motivated them to take part, and what’s it been like?

  • These portraits were taken for Team Halo, an initiative that goes behind the scenes with the scientists trying to develop a Covid vaccine
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Scientist behind BioNTech/Pfizer vaccine says it can end pandemic

Exclusive: BioNTech’s CEO Uğur Şahin says he is confident vaccine can ‘bash the virus over the head’

The scientist behind the first Covid-19 vaccine to clear interim clinical trials says he is confident his product can “bash the virus over the head” and put an end to the pandemic that has held the world hostage in 2020.

The German company BioNTech and the US pharmaceutical giant Pfizer announced via a press release on Monday that their jointly developed vaccine candidate had outperformed expectations in the crucial phase 3 trials, proving 90% effective in stopping people from falling ill.

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Totnes Covid concerns reflect UK-wide rise in conspiracy theories

Suspicion in Devon town of face masks and 5G means take-up of vaccine may face resistance

Like many people living in or around Totnes in Devon, David, who is in his 70s, has his own theories about coronavirus and its origins. Sitting in the armchair of his house, he says the pandemic is a secret plot to impose a totalitarian world government and a nefarious effort to crush freedom. He scrolls through Facebook, which he recently signed up to, to show many with similar beliefs.

David came to many of these ideas recently. When the pandemic hit, he started looking for answers. “I’m friends with a few people who are active in researching what is going on. I quickly made contact with others putting posts on the internet.”

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6 key questions about the Pfizer/BioNTech Covid-19 vaccine

There are grounds for optimism but also several unknowns around this coronavirus vaccine

Hopes that the end of the coronavirus pandemic has become nearer have soared after the news that a coronavirus vaccine was found to be 90% effective in global trials.

Although there is definite reason to be optimistic, experts have cautioned that the data from the trials conducted by Pfizer and BioNTech are not final, and there remain plenty of unknowns.

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‘Very early days’: Johnson says UK cannot yet rely on Covid vaccine – video

Boris Johnson has welcomed the promising news about the BioNTech/Pfizer coronavirus vaccine and said the UK was at 'the front of the pack' if and when it becomes available. At a Downing Street briefing, however, the prime minister also cautioned that it was 'very early days'. He said the vaccine still needed to be peer reviewed and clear any potential safety hurdles. 'We cannot rely on this news as a solution,' he said. 'The biggest mistake we could make now would be to slacken our resolve at a critical moment'

UK rollout of Covid vaccine could start before Christmas

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Hopes rise for end of pandemic as Pfizer says vaccine is 90% effective

Global stocks surge and experts optimistic as Covid vaccine exceeds expectations

Hopes are soaring that a Covid vaccine is within reach, following news that an interim analysis has shown Pfizer/BioNTech’s candidate was 90% effective in protecting people from transmission of the virus in global trials.

The vaccine performed much better than most experts had hoped for, according to the companies’ analysis, and brings into view a potential end to a pandemic that has killed more than a million people, battered economies and upended daily life worldwide.

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Pfizer/BioNTech vaccine announcement is cause for cautious celebration

Interim trial results are encouraging as scientists welcome news

It is not yet the end of the pandemic, but the announcement by Pfizer/BioNTech that their vaccine has been 90% successful in the vital large-scale trials has got even the soberest of scientists excited.

These are interim results and the trial will continue into December to collect more data. The two companies – a tiny German biotech with the big idea and the giant pharma company Pfizer with the means to develop it – have not yet published their detailed data, so it is all on trust. And yet, nobody is suggesting the results have been over-egged. It looks as though the vaccine not only works, but works better than anyone hoped.

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Future market for Covid vaccines ‘could be worth more than $10bn a year’

Analysts estimate revenue generated, assuming an annual jab at an average price of $20

The future market for Covid-19 vaccines could be worth more than $10bn (£7.6bn) in annual revenues for pharmaceutical companies, according to industry experts, even though some drugmakers have pledged to provide their vaccines on a not-for-profit basis during this pandemic.

The calculations by analysts at Morgan Stanley and Credit Suisse assume people will need to be vaccinated every year, similar to the traditional flu jab, with an average price of $20 for a Covid-19 vaccine dose. Prices range from $3 a dose to $37.

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Australia news live: Victoria and NSW report no new Covid cases as Queensland pushed to open border

Border restrictions continue to be eased as Australian politicians respond to US election result. Follow latest updates

The best doughnut, is a jam doughnut, followed closely by cinnamon.

Both fresh, of course.

Related: How doughnuts became Australia's symbol of Covid hope

News Hub reports New Zealand’s US ambassador has commented on the election. As government employees, ambassadors are prevented from indicating political views (despite being political appointments) but it looks like Scott Brown, for one, is feeling confident enough in the result to be a little honest.

From News Hub’s report:

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T-cell Covid immunity ‘present in adults six months after first infection’

Study suggests white blood cell levels higher in people who had symptoms

Cellular (T-cell) immunity against the virus that causes Covid-19 is likely to be present within most adults six months after primary infection, with levels considerably higher in patients with symptoms, a study suggests.

The data offers another piece of the puzzle that could be key to understanding whether previous Sars-CoV-2 infections – the virus behind Covid-19 – can prevent reinfection, and if so, for how long.

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‘It’s possible’: the race to approve a Covid vaccine by Christmas

At least three companies close to revealing results of phase three trials, but to be approved for use safety has to be ensured

The race for a Covid vaccine is reaching a crucial stage, with the glimmer of a possibility that one of the leading contenders will be approved by Christmas.

In an interview with the Guardian, Kate Bingham, who heads the UK’s vaccine taskforce, said the UK was in “a very good place”.

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Survey uncovers widespread belief in ‘dangerous’ Covid conspiracy theories

False claims that pandemic is a hoax or was started deliberately are attracting adherents around world

Significant numbers of people around the world believe Covid-19 was created deliberately, has killed far fewer people than reported, or is a hoax and does not actually exist, according to a global survey.

Along with belief in other conspiracy theories – such as that the world is run by a secret cabal – the YouGov-Cambridge Globalism Project, a survey of about 26,000 people in 25 countries designed in collaboration with the Guardian, found widespread and concerning scepticism about vaccine safety.

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Australian production of non-protein Covid-19 vaccine may take an extra year, minister says

Industry minister says, depending on type of vaccine approved, ‘significant work’ may be required before production

It could take up to a year for Australian biotech company CSL to develop the capability to make a Covid-19 vaccine if a non-protein-based version proves safe and effective, the country’s industry minister has said.

Karen Andrews said CSL would be able to immediately start making a protein-based vaccine, but “significant work” would be required if it was another type based on mRNA, or messenger ribonucleic acid.

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At 75, I’ve volunteered for a Covid vaccine trial. It could set people free

Some of my friends think I’m mad but we need to know people my age can go out safely again

There’s a 50% chance that this week I was injected with a vaccine designed to protect me from Covid-19. If not, I got the saltwater placebo instead. I won’t know until the study ends in 13 months, which is a shame. It would be nice to walk the streets without looking balefully around me at young people not wearing masks and thinking: I’m 75, this virus kills people my age.

It killed my chum Mike Pentelow, who was having a lot of fun in his retirement, writing books with titles such as A Pub Crawl Through History, and Mike was a year younger than me. Perhaps he’s the reason I volunteered to be a guinea pig for one of the companies working on a vaccine.

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