Genetic data on 500,000 volunteers in UK to be released for scientific study

UK BioBank offers up biggest ever cache of whole-genome sequences for medical research

A new era of medical discoveries, treatments and cures is on the horizon, researchers say, following the announcement that an unprecedented trove of genetic information is to be made available to scientists.

Health researchers from around the world can now apply to study the whole genomes of half a million people enrolled in UK Biobank, a biomedical research project that has compiled detailed health and lifestyle records on individuals since it began 20 years ago.

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Hope for new skin cancer therapy as UK cases soar

Researchers discover a technique that can kill melanoma cells with few toxic side effects, but warn there is still no cure

Skin cancer rates are rocketing. Thanks to over-enthusiastic sunbathing in previous decades, melanoma cases have tripled in numbers in the UK since the early 1990s – and scientists predict worse is to come.

The type of cancer once relatively rare in Britain is now its fifth most common. Broadcaster Chris Evans recently revealed he had been diagnosed with the disease.

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Immortal cells: Henrietta Lacks’ family settle lawsuit over HeLa tissue harvested in 1950s

Cells taken without consent from cancer victim can reproduce indefinitely and were sold for unjust profit by Thermo Fisher Scientific, relatives argued

Laboratory equipment maker Thermo Fisher Scientific has settled a lawsuit brought by the estate of Henrietta Lacks, a long-deceased cancer victim whose “immortal” cells have lived on to fuel biomedical research for decades, lawyers for the estate have said.

The story of Lacks, a young African American woman who died in Baltimore in 1951, was made famous in Rebecca Skloot’s 2010 book The Immortal Life of Henrietta Lacks, which became a movie in 2017 featuring Oprah Winfrey.

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Bowel cancer patients could be spared radiotherapy, US study suggests

Doctors found some patients could rely on chemotherapy and surgery alone to treat the disease

Thousands of bowel cancer patients could be spared radiotherapy, a study suggests, after doctors discovered they could rely on chemotherapy and surgery alone to treat their disease.

Radiotherapy has been used to treat bowel cancer patients for decades, but the side-effects can be brutal. It can cause problems that negatively affect quality of life, including infertility, the need for a temporary colostomy, diarrhoea, cramping and bladder problems.

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UK breakthrough on lung cancer helps target patients at risk of relapse

Research programme buys doctors crucial time by spotting returning tumours before symptoms appear

Seven years ago, Kelly Harrop was working at a stables while also running regularly in half marathons and 10k races. Then she began to suffer digestive problems. Scans eventually revealed marks on her lungs. The subsequent diagnosis was direct. “I had lung cancer. It was a shock. I was fit, healthy and had never smoked,” she told the Observer.

Kelly had surgery to remove the tumour, followed by chemotherapy. But doctors knew there was a risk of the tumour reappearing, so they enrolled her in a new research programme, TRACERx. Funded by Cancer Research UK, the £14m project was set up 10 years ago to investigate how lung tumours arise and evolve. A total of 850 patients with early-stage lung cancer were studied and followed from diagnosis to treatment.

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Mary J Blige backs Biden administration’s cancer initiative

The R&B superstar, who has lost numerous family members to the disease, appeared with first lady Jill Biden to announce program

The Biden administration’s initiative to spur the prevention and treatment of cancer got a dose of celebrity support on Monday when singer Mary J Blige joined Jill Biden and the American Cancer Society (ACA) to announce national meetings on breast and cervical cancer.

The ACA pledged to convene the events after US president Joe Biden and the first lady resurrected the “cancer moonshot” initiative this year. The program provides more money for research to, as Jill Biden said, “Help us end cancer as we know it. For good.”

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Obesity-related cancer rates nearly quadruple in Australia over three and a half decades

Researchers call on governments to implement national obesity strategy to help stem further rises in preventable cancers

The rate of obesity-related cancers in Australia has almost quadrupled in a few generations, new research suggests.

Researchers at the Daffodil Centre, a joint venture of Cancer Council New South Wales and the University of Sydney, analysed the rate of 10 obesity-linked cancers between 1983 and 2017.

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Revealed: black and Asian people wait longer for cancer diagnosis in England than white people

Exclusive: Analysis of 126,000 cases over a decade shows ‘deeply worrying’ racial disparities in NHS wait times

Black and Asian people in England have to wait longer for a cancer diagnosis than white people, with some forced to wait an extra six weeks, according to a “disturbing” analysis of NHS waiting times.

A damning review of the world’s largest primary care database by the University of Exeter and the Guardian discovered minority ethnic patients wait longer than white patients in six of seven cancers studied. Race and health leaders have called the results “deeply concerning” and “absolutely unacceptable”.

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New ‘Parp inhibitors’ could prevent certain tumours appearing

Breakthrough research could see some genetic cancers neutralised before they take hold and is already being used for people at risk

Sue Hayward was first diagnosed with ovarian cancer in 2017. Doctors acted swiftly and she was given a hysterectomy followed by sessions of chemotherapy.

But her cancer returned within a year. “I carry a mutated version of a gene known as BRCA1 which makes me susceptible to breast and ovarian cancers,” said Hayward, who works at the John Radcliffe Hospital, Oxford. “It runs in families. My mother died of cancer and we assume her mother did as well.”

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Half of people with possible signs of cancer wait six months to contact a GP

Survey by Cancer Research UK shows poorer people less likely to see their family GP, reducing survival chances

Half of people with possible cancer symptoms in the UK do not contact a GP for at least six months, potentially reducing their chances of survival, research has found.

Poorer people are less likely than the better-off to see their family doctor once they have eventually sought medical help, a survey by Cancer Research UK found.

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Research on ‘molecular drills’ of skin cancer cells offers hope for treatment

Institute of Cancer Research in London isolates gene that allows tumours to spread through the body

Skin cancer cells produce “molecular drills” to penetrate healthy tissues and spread around the body, according to research that raises the prospect of new therapies for the disease.

Researchers used robotic microscopy to capture the formation of the drills by melanoma cells that were being grown in 3D skin-like material in the laboratory.

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HPV vaccine after removal of precancerous cells may cut cervical cancer risk

Study finds reduced risk of cervical cancer recurring after HPV vaccination post-surgery, though further research is needed

Giving women the human papillomavirus (HPV) vaccine when precancerous lesions are removed from their cervix may cut the risk of cells recurring and them getting cervical cancer, a study has found.

Cases of cervical cancer in the UK have fallen hugely since school pupils aged 13 and 14 – first girls and later boys – began being offered HPV jabs in 2008 as protection against the disease.

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Cancer researchers unable to access clinical trial data for top-selling drugs, study finds

Lack of transparency from pharmaceutical companies on anticancer medication has implications for health equity, Australian scientist says

Clinical trial data that saw some of the world’s most widely used cancer drugs approved by the US drugs regulator remains secret, despite a pharmaceutical industry commitment to transparency made in 2014.

The authors of a study published in the journal JAMA Oncology on Friday said the lack of transparency should be concerning to Australia.

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Skin cancer death rates for men in UK have tripled since 1970s

Men 69% more likely to die from melanoma than women, says Cancer Research UK, warning that lack of sun protection is a factor

Skin cancer death rates among men have more than tripled since the 1970s, research reveals, prompting fresh warnings from experts to stay safe in the sun.

Since 1973, death rates from melanoma – the deadliest form of skin cancer – have increased by 219% in men, compared with the rise of 76% in women, Cancer Research UK found. As many as 1,400 men are now dying from the disease each year, in contrast to 980 women. This amounts to a total of six people a day, the charity said.

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Women in England with breast cancer may qualify for drug that buys ‘precious’ time

Nice approves Keytruda, which with chemotherapy can lengthen survival of women with triple negative breast cancer

Women with advanced breast cancer in England will be able to benefit from a new type of immunotherapy on the NHS after a U-turn by the medicines watchdog.

The National Institute for Health and Care Excellence (Nice) has overturned its draft rejection of Keytruda (pembrolizumab) and said women in England can take the drug in combination with chemotherapy.

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Global melanoma rate to increase by 50% by 2040, researchers predict

Australia’s skin cancer rate rising in over 50s, but ‘declining quite steeply’ among younger age groups

New cases of melanoma are set to increase by 50% globally by 2040, with a 68% increase in deaths, according to new research.

An international team of researchers have analysed the global burden of melanoma, which accounts for approximately one in five skin cancers. Data from the International Agency for Research on Cancer estimated that there were 325,000 new melanoma cases and 57,000 deaths in 2020.

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If they could turn back time: how tech billionaires are trying to reverse the ageing process

Jeff Bezos and Peter Thiel are pouring huge sums into startups aiming to keep us all young – or even cheat death. And the science isn’t as far-fetched as you might think

In the summer of 2019, months before the word “coronavirus” entered the daily discourse, Diljeet Gill was double-checking data from his latest experiment. He was investigating what happens when old human skin cells are “reprogrammed” – a process used in labs around the world to turn adult cells (heart, brain, muscle and the like) – into stem cells, the body’s equivalent of a blank slate.

Gill, a PhD student at the Babraham Institute near Cambridge, had stopped the reprogramming process midway to see how the cells responded. Sure of his findings, he took them to his supervisor, Wolf Reik, a leading authority in epigenetics. What Gill’s work showed was remarkable: the aged skin had become more youthful – and by no small margin. Tests found that the cells behaved as if they were 25 years younger. “That was the real wow moment for me,” says Reik. “I fell off my chair three times.”

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Third person apparently cured of HIV using novel stem cell transplant

Patient is mixed-race woman treated in New York using umbilical cord blood, in technique raising chances of finding suitable donors

Scientists appear to have cured a third person, and the first woman, of HIV using a novel stem cell transplant method, American researchers in Denver, Colorado, said on Tuesday.

The patient, a woman of mixed race, was treated using a new method that involved umbilical cord blood, which is more readily available than the adult stem cells which are often used in bone marrow transplants, according to the New York Times.

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How DNA link could unlock mystery of cancer patients ‘wasting away’

New research into sudden weight loss finds a possible cause of cachexia in cancer patients and Cockayne syndrome in children

One of the most serious impacts of cancer is the sudden loss of weight, appetite, and muscle that can hit some patients in the later stages of the disease. This wasting syndrome is known as cachexia and it can be triggered in other serious conditions, including heart disease and HIV.

In addition, an inherited version of extreme wasting syndromes can affect children. Known as Cockayne syndrome, it causes them to suffer severe malnutrition and wasting that parallels the effect of cachexia.

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Flu, cancer, HIV: after Covid success, what next for mRNA vaccines?

The technology was viewed with scepticism before the pandemic but there is now growing confidence about its use

It is one of the most remarkable success stories of the pandemic: the unproven technology that delivered the Moderna and Pfizer/BioNTech vaccines in record time, helping to turn the tide on Covid-19. The vaccines are based on mRNA, the molecule that instructs our cells to make specific proteins. By injecting synthetic mRNA, our cells are turned into on-demand vaccine factories, pumping out any protein we want our immune system to learn to recognise and destroy.

Pre-pandemic, the technology was viewed with scepticism – a clever concept, but not guaranteed to deliver. Now there is growing confidence that mRNA vaccines could have far-reaching applications in tackling diseases from flu to malaria.

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