Flu, cancer, HIV: after Covid success, what next for mRNA vaccines?

The technology was viewed with scepticism before the pandemic but there is now growing confidence about its use

It is one of the most remarkable success stories of the pandemic: the unproven technology that delivered the Moderna and Pfizer/BioNTech vaccines in record time, helping to turn the tide on Covid-19. The vaccines are based on mRNA, the molecule that instructs our cells to make specific proteins. By injecting synthetic mRNA, our cells are turned into on-demand vaccine factories, pumping out any protein we want our immune system to learn to recognise and destroy.

Pre-pandemic, the technology was viewed with scepticism – a clever concept, but not guaranteed to deliver. Now there is growing confidence that mRNA vaccines could have far-reaching applications in tackling diseases from flu to malaria.

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UK government paves way to bring in tough ‘plan B’ Covid rules

Councils consulted over support for measures such as vaccine passports amid warnings by senior doctors that NHS faces winter illness ‘triple whammy’

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New evidence has emerged that the government is paving the way to implement “plan B” measures in England to combat the spread of Covid-19, amid warnings from health chiefs that a “vortex of pressures” is encircling the NHS.

In the clearest sign to date that Whitehall is actively considering additional measures, the Observer has learnt that the UK Health Security Agency (UKHSA) contacted local authorities on Friday to canvass their level of support for the “immediate rollout of the winter plan – plan B”.

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Fears for Covid vaccine drive if second doses clash with boosters

Risk that low take-up by young will lead to crunch as older people get third shot

Health experts have warned the government that it needs to increase efforts to ensure more young adults are vaccinated against Covid-19 – as a matter of urgency.

They fear the current low take-up of jabs among 18- to 25-year-olds could lead to a pile-up of vaccine campaigns in September, when other groups are scheduled to get booster injections and also to be inoculated against influenza. In addition, they argue that vaccines also have a crucial role to play in protecting young adults against long Covid, which is now recognised as a serious problem associated with the disease.

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Why living with Covid would not be the same as flu

Analysis: coronavirus is more contagious and more lethal than influenza, and we lack the same global protection mechanism

As England prepares to ease coronavirus restrictions further, the messaging from ministers has changed. We have reached, it seems, a tipping point in the pandemic where rules will be replaced by personal decisions. The mantra now is about living with coronavirus, much as we do with seasonal flu.

The pandemic has invited countless comparisons between coronavirus and influenza and the diseases do have some features in common. Both are contagious, potentially lethal respiratory viruses. They can spread through aerosols, droplets and contaminated surfaces. And they share some of the same symptoms in the form of fever, cough, headaches and fatigue. In the winter ahead, one challenge the NHS faces is separating the Covid patients from the flu cases.

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What were some of the collateral effects of lockdowns? | David Spiegelhalter and Anthony Masters

Hospital waiting lists rose, but traffic accidents fell – Covid-19’s consequences will emerge in time, but it’s not all quantifiable
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In early 2020, there were bans on most social contact, international travel stopped, workplaces and schools shut. Lockdown had arrived. These policies may have limited the spread of the virus, but what collateral harms and benefits on physical health were there?

Despite recommendations to continue to seek help, normal healthcare endured severe disruption. In England, waiting lists for hospital treatment now exceed 5m, up more than 500,000 from before the pandemic. During the first wave, nearly 90,000 joint replacement surgeries were cancelled, leaving many struggling with pain. Cancer investigations and diagnoses fell and although there is no sign yet of any excess cancer deaths, this may only become apparent in subsequent years.

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Covid distancing may have weakened children’s immune system, experts say

End of social distancing and mask-wearing could leave children vulnerable to common bugs

Scientists are concerned that measures to combat Covid-19 have weakened the immune systems of young children who have not been able to build up resistance to common bugs, leaving them vulnerable when mask-wearing and social distancing eventually end.

Contact with viral pathogens happens on a fairly regular basis and although it does not always lead to sickness, the exposure helps shore the immune system against the threat should the bugs be encountered again.

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Doctors in South Korea call for flu vaccinations to be paused after 25 deaths

Authorities say programme will continue after finding no direct links between the deaths and the vaccines

South Korean officials refused on Thursday to suspend a seasonal influenza inoculation effort, despite growing calls for a halt, including an appeal from a key group of doctors, after the deaths of at least 25 of those vaccinated. Health authorities said they found no direct links between the deaths and the vaccines.

At least 22 of the dead, including a 17-year-old boy, were part of a campaign to inoculate 19 million teenagers and senior citizens for free, the Korea Disease Control and Prevention Agency (KDCA) said.

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Flu vaccine shortages hit China after rush to avoid ‘twindemic’

Long queues and inflated prices amid fears that flu could complicate anti-Covid effort

A surge in demand for flu shots in Chinese cities has caused shortages, long lines and triple markups on vaccines by scalpers selling them online.

Residents, afraid of the possibility of catching both the flu and Covid-19 – what some have called a “twindemic”, have rushed to clinics since China began its flu vaccine campaign in September.

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Southern hemisphere has record low flu cases amid Covid lockdowns

Data offers hope as winter looms in north and raises viability of eliminating future flu pandemics

Health systems across the southern hemisphere were bracing a few months ago for their annual surge in influenza cases, which alongside Covid-19 could have overwhelmed hospitals. They never came.

Many countries in the southern half of the globe have instead experienced either record low levels of flu or none at all, public health specialists in Australia, New Zealand and South America have said, sparing potentially tens of thousands of lives and offering a glimmer of hope as winter approaches in the northern hemisphere.

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Boris Johnson says ‘anti-vaxxers are nuts’

Prime minister makes comments while promoting extension of free winter flu jabs

Boris Johnson has said people opposed to vaccinations are “nuts” as he promotes an expanded programme of flu jabs that ministers hope will ease pressure on the NHS if there is a second wave of coronavirus this winter.

Visiting a doctors’ surgery in London on Friday, the prime minister said to staff: “There’s all these anti-vaxxers now. They are nuts, they are nuts.”

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What happens when flu meets Covid-19?

How seasonal viruses interact with the coronavirus is unknown – it may lessen or sharpen the pandemic – so flu vaccinations are vital

Optimists had hoped Covid-19 might not withstand the blistering heat of a British summer. However those hopes have faded: the virus staged a recent resurgence in Iran amid actual blistering temperatures, and has had no trouble persisting in sultry Singapore.

But what happens to Covid-19, and us, when the rain and chill – and flu and sniffles – of autumn set in? Especially, how will the annual winter flu epidemic play out amid a Covid-19 pandemic?

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How Spanish flu nearly ripped apart Australia’s fledgling federation | Paul Daley

A nation supposedly forged in the hellfire of war almost crumbled in the face of a virulent threat at home

Newly federated Australia, with its population not yet 5 million, was still enduring shocking fatalities on the European western front when its authorities began paying attention to the virulent strain of pneumonic influenza sweeping Britain.

Early Australian awareness of the “Spanish influenza” – an epidemic in Britain by mid to late 1918 – came with an acknowledgment that the new states grown of old colonies would need to stick together should the virus reach this isolated continent.

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Melbourne girl, 13, dies from the flu as national death toll nears 300

Crystal-lee Wightley dies at her family’s home three days after getting sick

A Melbourne family say they are heartbroken after a 13-year-old girl died from the flu late last week, as the national death toll nears 300.

Crystal-lee Wightley had the flu for three days before she died at her family’s home.

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