Crab blood to remain big pharma’s standard as industry group rejects substitute

Animal rights groups have been pushing a synthetic alternative to horseshoe crab blood in drug safety testing

Horseshoe crabs’ icy-blue blood will remain the drug industry’s standard for safety tests after a powerful US group ditched a plan to give equal status to a synthetic substitute pushed by Swiss biotech Lonza and animal welfare groups.

The crabs’ copper-rich blood clots in the presence of bacterial endotoxins and has long been used in tests to detect contamination in shots and infusions.

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SpaceX successfully launches Nasa astronauts into orbit

  • Donald Trump and Mike Pence witness launch in Florida
  • First attempt was cancelled minutes from blast-off

A rocketship named Dragon breathed new fire into America’s human spaceflight programme on Saturday, carrying two astronauts on a much-anticipated adventure.

Related: Trump wants America looking at the stars as he drags it through the gutter

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Could nearly half of those with Covid-19 have no idea they are infected?

As studies confirm many infected people show no symptoms, contact tracing and face masks assume even greater importance

When Noopur Raje’s husband fell critically ill with Covid-19 in mid-March, she did not suspect that she too was infected with the virus.

Raje, an oncologist at Massachusetts General Hospital in Boston, had been caring for her sick husband for a week before driving him to an emergency centre with a persistently high fever. But after she herself had a diagnostic PCR test – which looks for traces of the Sars-CoV-2 virus DNA in saliva – she was astounded to find that the result was positive.

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Ruby Princess passengers warned after crew member tests positive to tuberculosis

Scientists prepare to examine sewage in attempt to try to find the source of a Covid-19 infection that killed Nathan Turner

Passengers on the ill-fated Ruby Princess cruise ship have been sent another warning from the New South Wales health department, that they could have been exposed to tuberculosis.

The Ruby Princess voyage that arrived in Sydney on 19 March is responsible for about 10% of all coronavirus infections in Australia, and the bungled management of the outbreak has sparked two separate inquiries.

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Coronavirus live news: deaths surge in Brazil and Russia as Trump says US is quitting WHO

Afghanistan similarly reports worst day yet; Angela Merkel said she will not attend G7 if Trump insists on holding it. All the developments live

Colombia issued new measures to control the spread of coronavirus in three of its most affected cities on Saturday, including the capital Bogota, as the rest of the country prepares for quarantine rules to start lifting, Reuters reports.

The country has reported more than 26,600 coronavirus cases and 853 deaths.

Italy’s total number of confirmed coronavirus cases rose to 232,664 on Saturday, as daily new infections fell to 416, down from 516 on Friday, the Civil Protection Agency said.

The country’s overall Covid-19 death toll rose by 111 to 33,340, a slight increase from the 87 deaths reported in the 24 hours to Friday. On Thursday, 70 deaths were reported.

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SpaceX’s Starship rocket prototype explodes during test

  • 394ft rocket designed to carry humans and cargo to moon and Mars
  • No immediate indication of injuries after explosion in Texas

A prototype of SpaceX’s upcoming heavy-lift rocket, Starship, exploded on Friday during ground tests in south Texas as Elon Musk’s space company pursued an aggressive development schedule to fly the launch vehicle for the first time.

The testing explosion was unrelated to SpaceX’s upcoming launch of two Nasa astronauts from Florida’s Kennedy Space Center using a different rocket system, the Falcon 9 with the Crew Dragon capsule fixed on top.

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Coronavirus live news: Paris no longer a Covid-19 ‘red zone’ as France moves into new lockdown phase

France prepares to enter phase two of lockdown relaxation; South Korean officials re-implement lockdown measures in Seoul; Kenya records highest one-day case rise

France announced further easing of lockdown restrictions on Thursday, with life slowly returning to normal for much of the country, writes Kim Willsher, the Guardian’s Paris correspondent. However, certain restrictions will remain in the Paris area and the overseas territories Mayotte and Guyane for at least the next three weeks.

In a 90 minute press conference, the prime minister, Édouard Philippe, said the Covid-19 figures in the country were better than expected, but urged the French to continue respecting the rules and remain careful and vigilant.

French PM Édouard Philippe has arrived for the press conference on Phase 2 of the easing of the lockdown. (I will be trying to translate and type as he speaks, so please forgive lapses in translation and grammar!).

The governor of New York, Andrew Cuomo, has said he would sign an executive order allowing businesses to deny entry to customers who are not wearing masks, the Guardian US coronavirus blog reports.

“That store owner has a right to protect himself,” Cuomo said of the order. “That store owner has a right to protect the other patrons in that store.”

Today I am signing an Executive Order authorizing businesses to deny entry to those who do not wear masks or face-coverings. No mask - No entry.

Related: Coronavirus US live: Cuomo to sign 'no mask, no entry' order for businesses

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UK coronavirus live: groups of six people can meet outside in England from Monday; No 10 backs Cummings

Johnson unveils lockdown relaxation measures; Durham police say they won’t take further against against Cummings; UK death toll rises by 377 to 37,837

Q. In Northern Ireland the R has been increasing and is barely below 1 – should that cause alarm?

Vallance says the R remains below 1 everywhere but may be very close to 1 in some places.

Q. Do you really have the capacity to trace all the contacts of infected people?

Q. Why is the UK still only listing three symptoms for the disease compared to other countries?

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SpaceX-Nasa launch scrubbed due to poor weather

The first crewed flight from US soil since 2011 was called off 16 minutes before lift off; the next opportunity is on Saturday

The United States’ long-anticipated return to human spaceflight will have to wait a few more days after poor weather forced mission managers to scrub Wednesday’s planned launch of a SpaceX Falcon 9 rocket from Florida.

The first crewed flight from US soil since 2011 was called off 16min 53sec before the scheduled 4.33pm lift-off time, with SpaceX and Nasa officials blaming “strength of electric fields in the atmosphere”, translating to lightning near the launchpad.

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Ancient Roman mosaic floor discovered under vines in Italy

Pristine ‘archaeological treasure’ near Verona may date to 3rd century AD, say experts

A perfectly preserved ancient Roman mosaic floor has been discovered near the northern Italian city of Verona.

Archaeologists were astonished by the find as it came almost a century after the remains of a villa, believed to date to the 3rd century AD, were unearthed in a hilly area above the town of Negrar di Valpolicella.

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Coronavirus live news: WHO sounds alarm over surge of Covid-19 cases in Latin America

Longest official mourning period in Spain’s democracy; unrest grows in UK PM’s party over Dominic Cummings lockdown breach; WHO says Americas are new Covid-19 epicentre. Follow the latest updates

There have now been 118,000 confirmed cases of coronavirus across the 54 nations of Africa, according to the World Health Organization’s regional office for the continent.

So far, about 48,000 people in Africa who have tested positive for the virus have recovered, while 3,500 have died, according to the latest updated from WHO African region on Wednesday morning.

Over 118,000 confirmed #COVID19 cases on the African continent - with more than 48,000 recoveries & 3,500 deaths. View country figures & more with the WHO African Region COVID-19 Dashboard: https://t.co/V0fkK8dYTg pic.twitter.com/W1hbvugno1

Hi, this is Damien Gayle taking the reins of the live blog now, bringing you the latest headlines and stories, and the best of the Guardian’s coverage, from the coronavirus pandemic around the world.

If you have any comments, tips or suggestions for coverage please drop me a line, either via email to damien.gayle@gmail.com, or via Twitter direct message to @damiengayle.

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Coronavirus live news: US deaths from Covid-19 have passed 100,000

Qatar Covid-19 app ‘exposed 1m people’s personal details’; WHO sounds alarm over surge of Covid-19 cases in Latin America

Tom McCarthy writes that one of the key problems facing American efforts to emerge from the Covid-19 crisis is the population’s aversion to vaccines.

Only about half of Americans say they would get a Covid-19 vaccine if available, according to a poll, as a top US government scientist tempered claims by Donald Trump that the United States would be able to invent, manufacture and administer hundreds of millions of vaccine doses by the end of the year.

Related: Just half of Americans plan on getting Covid-19 vaccine, poll shows

Further to our story at 20.29, data from Johns Hopkins University shows that the United States has recorded more than 100,000 deaths from Covid-19, moving past a grim milestone even as many states relax mitigation measures to stop the spread of the novel coronavirus.

The US has recorded more deaths from the disease than any other country in the pandemic, and almost three times as many as the second-ranking country, Britain, which has recorded more than 37,000 Covid-19 deaths.

Related: US passes 100,000 coronavirus deaths as states relax lockdown measures

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How South Africa’s action on Covid-19 contrasts sharply with its response to Aids

Country’s swift response is distinct from the handling of the HIV crisis 20 years ago. Have lessons been learnt?

Twenty years ago Nelson Mandela made an impassioned plea for international cooperation on “one of the greatest threats humankind has faced”.

Aids was ravaging lives and overwhelming health systems, at its peak killing up to 1,000 people a day in South Africa.

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‘The human fingerprint is everywhere’: Met Office’s alarming warning on climate

Exclusively compiled data from the Hadley Centre’s supercomputer shows alarming climate trajectory

The human fingerprint on the climate is now unmistakable and will become increasingly evident over the coming decades, the UK Met Office has confirmed after 30 years of pioneering study.

Since the 1990s, global temperatures have warmed by half a degree, Arctic sea ice has shrunk by almost 2 million km2, sea-levels have risen by about 10cm and carbon dioxide in the atmosphere has increased by 60 parts per million (17%), according to figures exclusively compiled for the Guardian to mark the 30th anniversary of the Met Office’s Hadley Centre for climate science and services.

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‘The big show’: US poised to return to human spaceflight with historic launch

Elon Musk’s SpaceX, in partnership with Nasa, to launch Falcon 9 rocket from Florida carrying two American astronauts

In a historic moment a decade in the making, the skies above Florida will light up on Wednesday when the launch of a rocket born from a groundbreaking public-private partnership returns the United States to the business of human spaceflight.

Not since the retirement of Nasa’s space shuttle fleet in 2011 has the US possessed the capability to send its own astronauts into orbit, and the success of this week’s mission, formally known as SpaceX Demo-2, is likely to shape the direction of the space agency’s near-Earth ambitions for a generation.

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Experts sound alarm over lack of Covid-19 test kits in Africa

Global competition for kits and national constraints cause concern as lockdowns ease

Public health experts have warned about the risks of low supplies of coronavirus test kits as lockdowns in African countries begin to ease and urban populations become more mobile.

Different countries on the continent have adopted a range of testing strategies, but international competition for test kits and a lack of global coordination of resources have meant many African countries are testing with significantly limited reach.

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Coronavirus live news: Putin says Russia past peak of outbreak despite highest daily death toll

WHO warns of second peak as global cases pass 5.5m; Irish taoiseach Leo Varadkar denies picnic with friends was rule breach; world health leaders urge green recovery

I’m handing over to my esteemed colleague Kevin Rawlinson shortly, so I’ll leave you with a summary of today’s main global developments on the coronavirus pandemic:

A diplomatic rift has broken out between Tanzania and the US. The East African nation said it had summoned the top official at the US embassy to object to an advisory that warned of “exponential growth” of Covid-19 cases in the country.

Tanzania’s divisive leader John Magufuli has repeatedly played down the gravity of the coronavirus pandemic, appearing to model his response on the early approach taken by Donald Trump in the US.

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Why glass frogs have see-through skin becomes clear in study

While colour of body changes little, legs are more translucent to help amphibians to blend in

The mystery of why glass frogs have see-through skin has been solved, scientists say: the unusual feature is a type of camouflage.

Glass frogs are found in tropical Central and South America, and get their name from their skin.

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WHO halts hydroxychloroquine trial for coronavirus amid safety fears

Malaria drug taken by Trump could raise risk of death and heart problems, study shows

The World Health Organization has said it will temporarily drop hydroxychloroquine — the malaria drug Donald Trump said he is taking as a precaution — from its global study into experimental coronavirus treatments after safety concerns.

The WHO’s director-general Tedros Adhanom Ghebreyesus said in light of a paper published last week in the Lancet that showed people taking hydroxychloroquine were at higher risk of death and heart problems than those who were not, it would pause the hydroxychloroquine arm of its solidarity global clinical trial.

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