Bowel disease breakthrough as researchers make ‘holy grail’ discovery

Scientists pinpoint driver of IBD and other disorders with work under way to adapt existing drugs to treat patients

Researchers have discovered a major driver of inflammatory bowel disease (IBD) and several other immune disorders that affect the spine, liver and arteries, raising hopes for millions of people worldwide.

The breakthrough is particularly exciting because the newly found biological pathway can be targeted by drugs that are already used, with work under way to adapt them to patients with IBD and other conditions.

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Mounjaro is second obesity drug to be approved for use in England

Those with BMI of 35 and a comorbidity can now be prescribed tirzepatide and Nice says it is more effective than Wegovy

The medical treatment regulator for England has approved a second drug to combat obesity, giving patients and doctors what it says is a more effective alternative to semaglutide.

The National Institute for Health and Care Excellence (Nice) issued draft guidance on Tuesday recommending that very obese people should be prescribed tirzepatide, which is marketed in the UK as Mounjaro.

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China’s lunar probe on way back to Earth from far side of the moon

Uncrewed Chang’e-6 lander is carrying rock and soil samples in ‘very important achievement’ after lunar liftoff

China’s uncrewed Chang’e-6 probe is on its way back to Earth carrying the first samples from the far side of the moon, in a major achievement for Beijing’s space programme.

The probe landed on the lunar surface on Sunday, within one of the oldest craters on the moon – the South Pole-Aitken (SPA) basin – then spent two days gathering rock and soil samples using its drill and robotic arm.

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China’s Chang’e-6 probe lands on far side of the moon

Spacecraft to collect samples from rarely explored area after landing heralded as ‘enormous technical achievement’

China has landed its uncrewed Chang’e-6 lunar probe on the far side of the moon, marking an important step in the country’s 53-day mission to retrieve rock and soil samples from the “dark” lunar hemisphere, in what would be a world first.

The landing elevates China’s space power status in a global rush to the moon, where countries including the US are hoping to exploit lunar minerals to sustain long-term astronaut missions and moon bases within the next decade.

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Predictive blood test hailed as ‘incredibly exciting’ breast cancer breakthrough

New ‘liquid biopsy’ will act as an early warning sign to anticipate risk of tumours returning

A new blood test can predict the risk of breast cancer returning three years before any tumours show up on scans in an “incredibly exciting” breakthrough that could help more women beat the disease for good.

More than 2 million women are diagnosed every year with breast cancer, the most prevalent type of the disease. Although treatment has improved in recent decades, the cancer often returns, and if it does, it is usually at a more advanced stage.

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Climate deniers like DeSantis hurt most vulnerable communities, scientists say

On first day of predicted intense Atlantic hurricane season, Nature Conservancy urges action and warns against misinformation

Misinformation spread by climate deniers such as Florida’s extremist Republican governor, Ron DeSantis, increases the “vulnerability” of communities in the path of severe weather events, scientists are warning.

The message comes on Saturday, the first day of what experts fear could be one of the most intense and dangerous Atlantic hurricane seasons on record, threatening a summer of natural disasters across the US.

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Trial results for new lung cancer drug are ‘off the charts’, say doctors

More than half of patients with advanced forms of disease who took lorlatinib were still alive after five years with no progression

Doctors are hailing “off the chart” trial results that show a new drug stopped lung cancer advancing for longer than any other treatment in medical history.

Lung cancer is the world’s leading cause of cancer death, accounting for about 1.8m deaths every year. Survival rates in those with advanced forms of the disease, where tumours have spread, are particularly poor.

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$10m prize launched for team that can truly talk to the animals

AI expected to help researchers unlock two-way communication, say team that includes Tel Aviv University

In the Dr Dolittle books and films, the ability to “talk to the animals” captured the imagination. Now scientists are being offered a $10m prize to create real conversations.

The Coller Dolittle Challenge for Interspecies Two-Way Communication has been launched by the Jeremy Coller Foundation and Tel Aviv University. While the use of AI is not obligatory, the team say the technology can boost almost all proposals.

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Meet the Chinese army’s latest weapon: the gun-toting dog

China shows off mechanical canine with an automatic rifle on its back at joint military drills with Cambodia

The Chinese army has debuted its latest weapon: a gun-toting robotic dog.

The mechanical canine, which has an automatic rifle on its back, was front and centre of recent joint military drills with Cambodia, according to footage from the state broadcaster CCTV.

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Babbling babies may be warming up for speech, say scientists

Squeals and growls tend to occur in groups, finds study of infants aged up to 13 months

It might sound like a stream of jolly nonsense, but the peculiar sounds babies produce could be an attempt to practise the vocal control necessary for speech, researchers have suggested.

A study analysing the sounds made by infants during their first year of life has found squeals and growls tend to occur in groups.

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Remains of horses buried 2,000 years ago found in central France

Archaeologists trying to determine whether animals were killed in battle or buried as part of a ritual

French archaeologists have uncovered nine large graves containing the remains of horses from up to 2,000 years ago, in a find described as “extraordinary”.

The 28 stallions, all around six years old, had been buried shortly after they died, each placed in pits on their right side with their head facing south. Nearby a grave contained the remains of two dogs, heads facing west.

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Drawings depicting gladiators among latest discoveries at Pompeii

Charcoal graffiti believed to have been sketched by children uncovered at ancient Roman city

Drawings of gladiators believed to have been made by children inspired by watching battles at Pompeii’s amphitheatre are among the latest discoveries in the ruins of the ancient Roman city.

The charcoal drawings were found during excavations at I’Insula dei Casti Amanti, a cluster of homes in Pompeii’s archaeological park that opened to the public for the first time on Tuesday.

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‘A catastrophe’: Greenpeace blocks planting of ‘lifesaving’ Golden Rice

Thousands of children could die after court backs campaign group over GM crop in Philippines, scientists warn

Scientists have warned that a court decision to block the growing of the genetically modified (GM) crop Golden Rice in the Philippines could have catastrophic consequences. Tens of thousands of children could die in the wake of the ruling, they argue.

The Philippines had become the first country – in 2021 – to approve the commercial cultivation of Golden Rice, which was developed to combat vitamin A deficiency, a major cause of disability and death among children in many parts of the world.

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Potentially habitable planet size of Earth discovered 40 light years away

Queensland- and Scotland-based PhD students co-lead team celebrating ‘Eureka moment’ spotting Gliese 12b

An Australian university student has co-led the discovery of an Earth-sized, potentially habitable planet just 40 light years away.

Shishir Dholakia, a PhD candidate in astrophysics at the University of Southern Queensland, is part of an international team that published the discovery in the Monthly Notices of the Royal Astronomical Society.

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Huge number of deaths linked to superbugs can be avoided, say experts

Models suggest deaths in poorer countries could be cut by 18% – or about 750,000 a year – with preventive measures

Every year 750,000 deaths linked to drug-resistant superbugs could be prevented through better access to clean water and sanitation, infection control and childhood vaccinations, research suggests.

Antimicrobial resistance, or AMR, is a huge global challenge, with the evolution of drug-resistant superbugs, driven by factors including inappropriate and excessive antibiotic use, raising the prospect of a future where modern medicine fails.

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Eagles shifting flight paths to avoid Ukraine conflict, scientists find

Vulnerable birds deviating from migratory routes by up to 155 miles, which could affect breeding

Eagles that have migratory routes through Ukraine have shifted their flight paths to avoid areas affected by the conflict, researchers have found.

GPS data has revealed that greater spotted eagles not only made large detours after the invasion began, but also curtailed pitstops to rest and refuel, or avoided making them altogether.

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Scientists make potential breast cancer breakthrough after preserving tissue in gel

Ability to preserve tissue in a special gel solution for at least a week will help doctors identify most effective drug treatments

Scientists say they have a made a potentially “gamechanging” breakthrough in breast cancer research after discovering how to preserve breast tissue outside the body for at least a week.

The study, which was funded by the Prevent Breast Cancer charity, found tissue could be preserved in a special gel solution, which will help scientists identify the most effective drug treatments for patients.

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Scientists find buried branch of the Nile that may have carried pyramids’ stones

Discovery of the branch, which ran alongside 31 pyramids, could solve mystery of blocks’ transportation

Scientists have discovered a long-buried branch of the Nile River that once flowed alongside more than 30 pyramids in Egypt, potentially solving the mystery of how ancient Egyptians transported the massive stone blocks to build the monuments.

The 40-mile-long (64km) river branch, which ran by the Giza pyramid complex among other wonders, was hidden under desert and farmland for millennia, according to a study revealing the find on Thursday.

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Great Ormond Street hoping to license gene therapy for ‘bubble baby’ syndrome

Hospital to take unprecedented step after drug firm pulled out despite successful trial of treatment

When Great Ormond Street hospital (Gosh) published the results of its gene therapy trial for “bubble baby” syndrome it was hailed as a medical breakthrough. The treatment had a more than 95% success rate for treating the life-threatening disorder in which children have no immune system. But less than a year later, the therapy had been dropped by the pharmaceutical company that planned to bring it to market.

Now, Gosh is taking the unprecedented step of attempting to license the therapy itself on a non-profit basis and without industry involvement, in order to make it more widely available to babies and children worldwide.

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Pig kidney ‘xenotransplant’ patient dies two months later

No indication that Richard ‘Rick’ Slayman’s receipt of genetically modified kidney caused his death, says Massachusetts transplant team

The first recipient of a genetically modified pig kidney transplant has died about two months later, with the hospital that performed the surgery saying it did not have any indication the transplant was the cause.

Richard “Rick” Slayman had the transplant at Massachusetts general hospital in March at the age of 62. Surgeons said they believed the pig kidney would last for at least two years. On Saturday, his family and the hospital that performed the surgery confirmed Slayman’s death.

Associated Press contributed reporting

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