Lupus patients in England in remission after pioneering NHS trial of GM therapy

Doctors say therapy that genetically modifies person’s T-cells could offer cure for chronic autoimmune disease

Five lupus patients in England are in remission after being treated with a revolutionary therapy that genetically modifies their own cells, in a medical breakthrough that could offer people a cure, doctors have said.

CAR (chimeric antigen receptor) T-cell therapy involves removing a type of white blood cell also called T lymphocytes, which are crucial for hunting out infected or damaged cells, and engineering them to spot and destroy disease. The T-cells are then fed back into the patient via an infusion to reset their immune system.

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Millions of homes in London, Essex and Kent at risk of sinking as climate crisis worsens

Analysis pinpoints areas most vulnerable to hotter, drier weather causing ground to shrink and drag foundations down

Millions of homes are at risk from climate-related subsidence, according toan analysis by the British Geological Survey (BGS).

As hotter, drier summers driven by global heating become more frequent, the ground under houses can shrink and drag down a property’s foundations. The most vulnerable areas include London, Essex, Kent and a tranche of land from Oxford up to the Wash on England’s east coast, according to scientists, who say mitigation measures will be needed.

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Weight-loss drug users save more than £400 a year on food as take-up triples

Research suggests households that include a GLP-1 user collectively spent £780m less on grocery bills

Weight-loss drugs are saving users’ households more than £400 a year on grocery bills, according to a survey, which found use of GLP-1s has nearly tripled in the past two years to 1.9 million adults.

More than 6.3% of households in Great Britain now include at least one GLP-1 user, according to the research by Worldpanel by Numerator. This marks a sharp rise from 4.1% of households in 2025 and 2.3% in 2024.

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‘Earth’s first starfleet’: Nasa reveals Artemis III crew and project’s next steps

Luca Parmitano to pilot all-male crew of four paving way for planned first human landing on Artemis IV in 2028

Jared Isaacman, the Nasa administrator, hailed the creation of “Earth’s first starfleet” on Tuesday as he revealed the Artemis III crew and details of the next stages of the space agency’s project to return humans to the moon.

An Italian astronaut, Luca Parmitano of the European Space Agency (ESA), will be the pilot of the planned two-week mission to lower Earth orbit next year that will test lunar landers from private companies Blue Origin and SpaceX.

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‘Osprey cam’ streams life of nesting seabirds perched at tip of 55 metre-long Queensland rainforest canopy crane

Researchers believe the same pair of birds have been mating and nesting in the unusual spot in the Daintree Rainforest for 15 consecutive years

It started by chance – but it should have come as no surprise that two ospreys would pick a hi-tech research facility to make their home.

James Cook University’s 47-metre tall crane towers over the far-north Queensland rainforest canopy, making it the perfect nesting place for the seabird.

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Richard Scolyer, cancer researcher and former Australian of the year, dies aged 59

Scolyer, who did pioneering work on immunotherapy, was diagnosed with inoperable brain cancer in 2023

Prof Richard Scolyer, the world-renowned cancer researcher and former Australian of the year, has died at the age of 59.

Scolyer’s family shared a statement the eminent pathologist and melanoma expert penned before his final stages of illness.

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Scientists make sourdough bread using yeast found in 5,000-year-old mummy

Team now plans to see if they can use yeast strains harvested from Ötzi the Iceman to brew beer too

Scientists have baked a sourdough loaf of bread using yeast strains harvested from a 5,000-year-old mummy and now plan to see if they can use them to brew beer too.

The yeast came from Ötzi the Iceman, a famous corpse remarkably preserved by being frozen in Alpine ice near the Italy-Austria border until he was discovered in 1991. Ötzi has been the subject of intense study since he was found and has shed much light on pre-historic European people and their way of life.

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Lord Howe Island got rid of its rats and mice – now its ‘wonderful’ insect life is back

Invasive vermin decimated the island’s native flora and fauna – but its unique cockroaches and beetles are thriving once again

In the summer months, Lord Howe Island’s unique stag beetle, with wing cases that appear forged from iridescent green metal, fly around the ancient tree tops looking for a mate.

“That’s really something wonderful,” said Ian Hutton, a naturalist and nature guide on the World Heritage-listed island.

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Stephen Hawking’s father worried his son ‘does not study much’, diaries reveal

Exclusive: New biography uncovers Frank Hawking’s papers in which he lamented that his son had ‘little initiative’

In exploring the physics and geometry of the universe, Stephen Hawking became a world-renowned pioneer of black hole theory, writing the bestselling book A Brief History of Time, which has sold more than 13m copies, and inspiring people to “look up at the stars and not down at your feet”.

But, during Hawking’s student years and as he approached adulthood, his father was deeply concerned about how his son would turn out. Frank Hawking lamented that “he hangs round the house with little initiative and does not study much”, according to previously unknown diaries that he had written partly in code.

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SpaceX launches its biggest rocket yet in test flight from Texas

The launch is the 12th test flight of the mega-rocket that CEO Elon Musk is building to get people to Mars one day

SpaceX launched its biggest, most powerful Starship yet on a test flight Friday, an upgraded version that Nasa is counting on to land astronauts on the moon.

The redesigned mega-rocket made its debut two days after SpaceX CEO Elon Musk announced he’s taking the company public. It blasted off from the southern tip of Texas, carrying 20 mock Starlink satellites for release halfway around the world.

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Infectious diseases such as hantavirus and Ebola becoming more frequent and damaging, say experts

Pandemic report warns of growing global threat as health teams in Africa move to contain Ebola outbreak

The world is becoming less resilient to outbreaks of infectious diseases, experts have warned, as health authorities in the Democratic Republic of the Congo and Uganda scramble to contain an outbreak of Ebola.

The Global Preparedness Monitoring Board (GPMB) said in a report published on Monday that “as infectious disease outbreaks become more frequent they are also becoming more damaging”, warning that pandemic risk is outpacing investments in preparedness and “the world is not yet meaningfully safer”.

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Signs of ‘feeding’ ritual at dingo burial site shed new light on bond between First Nations people and canines

Never documented archaeologically before, evidence points to First Nations people caring for and nursing the animal

The discovery of a millennium-old dingo burial site in western New South Wales, including evidence of a “feeding” ritual never before documented archaeologically, has shed new light on the longstanding relationship between the canines and First Nations people.

The dingo was buried along the Baaka, or Darling River, in Kinchega national park near the Menindee Lakes.

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‘We’re not ready’: US lags on pandemic preparedness after Covid, experts say

Experts say slashed funding and growing misinformation are some of the greatest challenges facing public health

The hantavirus outbreak, while unlikely to spark the next big pandemic, is shining a spotlight on the ways public health has deteriorated in the US: its ability to test for rare diseases, its expertise on outbreak prevention and response, its ability to battle misinformation and restore trust.

“Assuming everything goes well in containing this outbreak, which I hope it does, the takeaway from that should not be ‘we’re fine,’” said Stephanie Psaki, former White House global health security coordinator. “We’re not ready for this type of threat.”

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Labor accused of ‘robbing Peter to pay Paul’ for axing $760m research program to fund other science measures

Researchers say budget decision to cut commercialisation program to fund the CSIRO and other science initiatives undermines the government’s own priorities

The federal government has been accused of “robbing Peter to pay Paul” over the budget axing of a $760m research commercialisation program in order to fund other science initiatives.

The budget includes a $387.4m boost to “support the financial sustainability” of the beleaguered national science agency CSIRO, as well as $273m for the National Measurement Institute.

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David Pocock applauds $387m in extra funding for CSIRO after tens of thousands sign petition

Analysis commissioned by independent senator found national science agency’s funding is at its lowest since 1978

The Albanese government will boost funding to CSIRO by $387.4m in a bid to meet the long-term costs of the national science agency.

It follows months of advocacy by scientists and staff after hundreds of job cuts and cost-cutting measures.

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Up to 2cm a month: Nasa keeps track as Mexico City sinks into the ground

Powerful radar system is providing new data on city’s subsidence, which experts hope will draw more attention to it

Walking into Mexico City’s sprawling central Zócalo is a dizzying experience. At one end of the plaza, the capital’s cathedral, with its soaring spires, slumps in one direction. An attached church, known as the Metropolitan Sanctuary, tilts in the other. The nearby National Palace also seems off-kilter.

The teetering of many of the capital’s historic buildings is the most visible sign of a phenomenon that has been ongoing for more than a century: Mexico City is sinking at an alarming rate.

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Man produces sperm from testicular tissue frozen as a child in breakthrough trial

Exclusive: Sperm re-transplant offers hope that boys left infertile by chemotherapy could have biological children one day

In a groundbreaking fertility trial, a man whose testicular tissue was frozen before he underwent chemotherapy as a child to be re-transplanted 16 years later has been able to produce sperm.

It is the first time a transplant of cryopreserved prepubertal testicular tissue has been demonstrated to restore sperm production in an adult patient. The 27-year-old man had the sample frozen when he was 10, before undergoing potent chemotherapy as part of treatment for sickle cell disease.

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‘They know they’re safe’: beagles saved from US research facility after protests

Big Dog Ranch Rescue made deal to buy 1,500 dogs from Ridglan Farms, a Wisconsin breeding and research facility

The first beagles removed from a Wisconsin dog breeding and research facility that was the site of recent protests seemed to know right away that they were safe.

“They started within an hour or so coming up to us, wanting attention. Some crawled in people’s laps. Every single one of them are super sweet,” Lauree Simmons, the president and founder of Big Dog Ranch Rescue, said on Sunday. “I think they are loving the attention. I just know they know they’re safe.”

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German museum to return rare Irritator dinosaur skull to Brazil

Spinosaurid fossil bought by Stuttgart institution in 1991 has been the subject of a long restitution campaign

It is a 113-million-year-old bone of contention.

After Stuttgart’s museum of natural history bought a fossilised dinosaur skull in 1991, researchers found it was the most complete spinosaurid skull known to date, belonging to a previously unknown genus of the huge meat-eating dinosaurs.

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First malaria drug for babies is approved in ‘major public health milestone’

WHO prequalification of Coartem Baby means newborns can be safely treated rather than using medication for older children

The first malaria treatment for babies has been approved by the World Health Organization, opening the door to widespread use around the globe.

In parts of Africa, up to 18% of children under six months will be infected with malaria, but there has historically been no safe treatment for the smallest of them. There were 610,000 deaths from malaria in 2024, about three quarters of which were under-fives in Africa.

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