Covid vaccine side-effects: what are they, who gets them and why? | Nicola Davis

Most side-effects are mild and short-lived, and some groups are more likely to get them than others

According to Public Health England, most side-effects from the Covid vaccines – Pfizer/BioNTech and Oxford/AstraZeneca – are mild and short-lived. These include soreness where the jab was given, feeling tired or achy and headaches. Uncommon side-effects include having swollen lymph nodes.

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Matt Hancock confirms dip in UK Covid vaccine supply for April

Health secretary says stocks will be affected by need to retest 1.7m doses and delay from India

Matt Hancock has said there will be a significant dip in vaccine supply in April, confirming supplies have been hit by a need to retest 1.7m doses and a delay in arrival of imports from India.

Speaking in the House of Commons, Hancock stressed the overall target timetable for vaccinations would not change but said he wanted to give more information, following the “speculation we’ve seen overnight”, after he was criticised for a press conference on Wednesday where the drop in supply went unexplained.

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Space oddity Oumuamua probably shard of Pluto-like world, scientists say

Interstellar visitor likely made of frozen nitrogen, cookie-shaped rather than cigar, and not a comet or asteroid – while some stick to alien theory

Our solar system’s first known interstellar visitor is neither a comet nor asteroid as first suspected and looks nothing like a cigar. A new study says the mystery object is likely a remnant of a Pluto-like world and shaped like a cookie.

Arizona State University astronomers report the strange 45-metre (148ft) object appears to be made of frozen nitrogen, just like the surface of Pluto, and Neptune’s largest moon, Triton.

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Older people more likely to catch Covid a second time

Study finds under-65s have about 80% protection from virus for at least six months but over-65s only 47%

Older people who have recovered from Covid cannot assume they are immune from a second attack, according to a new study that shows the under-65s are much less susceptible to reinfection.

The study carried out in Denmark found that the under-65s had about 80% protection for at least six months from catching Covid a second time. But the over-65s had only 47% protection.

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Scientists form human cell clumps that act like early-stage embryos

Cultured stem cells turn into blastoid ‘balls’, like natural blastocysts after egg fertilisation

Scientists have made clumps of human tissue that behave like early-stage embryos, a feat that promises to transform research into the first tentative steps of human development.

The clumps of cells, named blastoids, are less than a millimetre across and resemble structures called blastocysts, which form within a few days of an egg being fertilised. Typically blastocysts contain about 100 cells, which give rise to every tissue in the body.

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Coronavirus live news: AstraZeneca jab is safe, says UK health secretary; Trump urges people to get vaccinated

Matt Hancock says vaccine is ‘saving lives right now’; former US president addresses ‘a lot of people that don’t want to get it, and a lot of those people voted for me’

China will allow foreign visitors who have had Chinese-made vaccine to enter the country, Helen Davidson reports.

Related: China to allow foreign visitors who have had Chinese-made vaccine

Poland has reported 25,052 daily coronavirus cases, its highest rate since November, Reuters reports.

In total, the country of 38 million has reported 1,956,974 cases and 48,032 deaths.

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China to only allow foreign visitors who have had Chinese-made vaccine

Move raises questions as China’s vaccines not approved in many countries to which it is opening travel

China is resuming visa processing for foreigners from dozens of countries, but only if they have been inoculated against Covid-19 with a Chinese-made vaccine.

The move has raised questions about the motivations behind the demand, given China’s vaccines are not approved in many of the countries to which it has opened travel and that it will not accept foreign vaccines made elsewhere, including those approved by the World Health Organization.

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Covid outbreak has reached my hospital in Papua New Guinea. People could soon be dying in the parking lot | Glen Mola

Port Moresby General Hospital is one of the few safe places for women to give birth, but 30% of our workforce has Covid-19 and we may have to shut our doors

At Port Moresby General Hospital, about 20% of women presenting in labour have symptoms of Covid-19. Of these, about one-third (four to five women a day) test positive.

We get the test results back about two to three hours after we take the swabs, so often by the time the woman is delivering her baby it is too late to transfer her to the Covid isolation ward for the birth and staff have attended to her and been exposed to the virus, without being able to don the appropriate level of PPE and practice other precautionary measures to protect themselves.

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Oxford/AstraZeneca vaccine: which countries have paused jab and why

Analysis: Germany, France, Spain and Italy head an expanding list of EU countries to have put its use on hold

A host of European countries have put all vaccinations with this jab on hold, including Germany, France, Spain, Italy, Denmark, Norway and Ireland. Some others such as Estonia and Austria have suspended vaccinations from particular batches of the vaccine.

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AstraZeneca jab: EU regulator ‘firmly convinced’ benefits outweigh risks

Agency says there are ‘no indications’ the vaccine causes blood clots, but the risk may be higher for some groups

The EU’s medicines regulator has said it remains “firmly convinced” the benefits of the Oxford/AstraZeneca Covid vaccine outweigh the risks, but isolated cases of blood clots “are a serious concern and need serious and detailed scientific evaluation”.

Emer Cooke, the head of the European Medicines Agency (EMA), said there was no indication that the shot had caused any of the incidents, but the agency was investigating them thoroughly and would report it conclusions on Thursday.

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For crying out loud: Dutch scientists grow human tear glands

Creation of mini-organs using stem cells will help research into tear-related disorders

Stop your sobbing – because scientists can do it for you. Using stem cells, Dutch researchers have grown miniature human tear glands capable of “crying”.

Initially, when scientists were looking at developing this technology, their first port of call was the inner lining of the gut, because it replaces itself every five days. They took a tiny piece of gut tissue filled with stem cells and fed it proteins called growth factors to stimulate cell growth, expecting the stem cells to rapidly proliferate.

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Dead Sea scroll fragments and ‘world’s oldest basket’ found in desert cave

Six-millennia-old skeleton of child also unearthed during dig in Judean Desert by Israeli archeologists

Israeli archaeologists have unearthed two dozen Dead Sea scroll fragments from a remote cave in the Judean Desert, the first discovery of such Jewish religious texts in more than half a century.

“For the first time in approximately 60 years, archaeological excavations have uncovered fragments of a biblical scroll,” the Israel Antiquities Authority (IAA) said in a statement.

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Coronavirus live news: ‘no indication’ AstraZeneca vaccine has caused blood clots, says Europe health authority

European Medicines Agency says number of blood clots in vaccinated people ‘seems not to be higher than that seen in the general population’

Russia’s Covid vaccines have proven effective against new variants of the coronavirus in trials, a scientist with Moscow’s consumer regulator has said, after the agency reported its first cases of a variant first detected in South Africa (see 10.02am).

Reuters has the story:

In fact, trials have already been done in Russia and we can say with confidence that the [Sputnik V and EpiVacCoriona] vaccines registered in Russia also work against new strains,” Alexander Gorelov, deputy head of research at Rospotrebnadzor’s Institute of Epidemiology, said on state television.

Gorelov gave no details on trials that had tested vaccines against variants first discovered abroad. Researchers conducting trials under the review ordered by Putin said on 27 February that results were looking strong when volunteers were re-vaccinated with Sputnik V against new mutations of the virus.

Public health experts in the US have called for access to vaccines to be widened to better cater for Latino migrants – among the groups hardest hit by Covid-19.

Zackary Berger and Kathleen Page, both associate professors at the Johns Hopkins School of Medicine, and Alicia Fernández, a professor of medicine at the University of California, San Francisco, write:

Current vaccine priority algorithms are inequitable, particularly those that focus on age. Almost 90% of deaths among whites have been in people over 65, but, as CDC data clearly indicate, among Latinos and African Americans more than one-third of those dying of Covid-19 have been younger than 65. And although shared living spaces have undoubtedly fueled the rapid transmission of Covid-19 in immigrant communities, living in a crowded house does not qualify people for the vaccine.

As for essential workers, it’s one thing for a hospital employee to prove they are a healthcare worker, but another thing entirely for a day laborer getting paid in cash to show proof of occupation. Finally, while people all over the country are struggling with poorly designed websites and busy call centers, these approaches are particularly insurmountable for low-income Latino workers who lack the digital skills, language capabilities and time to overcome these barriers.

Related: Latino immigrants need vaccines – and aren't getting them. Here's why | Kathleen Page, Alicia Fernández and Zackary Berger

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Climate crisis: recent European droughts ‘worst in 2,000 years’

Study of tree rings dating back to Roman empire concludes weather since 2014 has been extraordinary

The series of severe droughts and heatwaves in Europe since 2014 is the most extreme for more than 2,000 years, research suggests.

The study analysed tree rings dating as far back as the Roman empire to create the longest such record to date. The scientists said global heating was the most probable cause of the recent rise in extreme heat.

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There’s no proof the Oxford vaccine causes blood clots. So why are people worried? | David Spiegelhalter

It’s human nature to spot patterns in data. But we should be careful about finding causal links where none may exist

Stories about people getting blood clots soon after taking the Oxford/AstraZeneca vaccine have become a source of anxiety among European leaders. After a report on a death and three hospitalisations in Norway, which found serious blood clotting in adults who had received the vaccine, Ireland has temporarily suspended the jab. Some anxiety about a new vaccine is understandable, and any suspected reactions should be investigated. But in the current circumstances we need to think slow as well as fast, and resist drawing causal links between events where none may exist.

As Ireland’s deputy chief medical officer, Ronan Glynn, has stressed, there is no proof that this vaccine causes blood clots. It’s a common human tendency to attribute a causal effect between different events, even when there isn’t one present: we wash the car and the next day a bird relieves itself all over the bonnet. Typical. Or, more seriously, someone is diagnosed with autism after receiving the MMR vaccine, so people assume a causal connection – even when there isn’t one. And now, people get blood clots after having a vaccine, leading to concern over whether the vaccine is what caused the blood clots.

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What price a child’s life? India’s quest to make rare disease drugs affordable

Parents whose only hope was finding foreign sponsorship or a clinical trial are now looking for homegrown breakthroughs

For three years, Vidya tried to find the cause of her son’s recurrent fevers and low cognitive development. When she found out, she was devastated.

Vineeth, 10, has an incurable illness – mucopolysaccharidosis type 2 – that affects his organs. Afflicting just one in a million, the enzyme-replacement medication that can help stop the illness getting any worse costs £100,000 a year, far beyond the reach of even a wealthier Indian parent.

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Coronavirus live news: 4,618 new cases and 52 more deaths in UK; Irish regulator hopes to lift AstraZeneca vaccine pause

Prof Karina Butler says Irish health authority recommendation after unproven reports of blood clotting is down to ‘an abundance of caution’

Brazil has reported 1,127 further Covid-19 deaths in the past 24 hours and 43,812 new cases of the coronavirus, the health ministry said as the pandemic’s most lethal week for the country comes to an end.

The South American country has now registered a total of 11,483,370 cases, Reuters reports.

France must do everything to avoid another lockdown as pressure on hospitals grows, prime minister Jean Castex has said as the country added more than 26,000 new cases to its tally.

Rather than send the country into a third national lockdown, the French government has implemented a 6pm nationwide curfew and weekend lockdowns in two hotspot regions while shutting shopping centres.

We have to use all weapons available to avoid a lockdown. I’ve never hid it, let’s vaccinate, protect ourselves, get tested,” Castex said on Sunday.

The situation is not getting better, there is a higher and higher number of infections and hospitals are very burdened with many patients, whose average age is getting lower and who don’t always have comorbidities.”

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Covid death on Isle of Man deals a blow after tough lockdown

Manx government has run strict regime to keep island virus-free but isolation exemption for ferry workers causes anger

On Friday, the chief minister of the Isle of Man announced some bad news. A patient in the island’s Noble’s hospital had died from coronavirus, he said, the first Manx Covid death since 5 November.

Howard Quayle said he knew the news would “come as a blow” to the Isle of Man’s 85,000 residents. “The death of a member of our island community is a painful reminder of how dangerous this virus is,” he added.

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