Spring breakers flock to Covid hotspot Florida to party like it’s 2019

A combination of students who feel they are at little risk and a governor who has lifted restrictions has experts worried, leading some schools to cancel spring break altogether

Covid-19 and spring break have never mixed well. Last March one young, shirtless man in Miami wearing a backwards-facing green cap went “viral” in the pre-pandemic sense when he told a reporter: “If I get corona, I get corona,” he said. “I’m not going to let it stop me from partying.”

A year later, even after Covid has killed over 500,000 Americans, and the Centers for Disease Control and Prevention has recommended against all travel, similar pictures and videos of spring breakers – no masks or social distancing in sight – are being seen again this year.

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Wales set to ease Covid lockdown restrictions from Saturday

First minister to announce ‘stay local’ will replace ‘stay home’ rule among other changes

Some semblance of normal life will begin again in Wales from Saturday, with the country’s first minister, Mark Drakeford, expected to announce a change from the current “stay home” restrictions to more lenient “stay local” requirements.

Drakeford is expected to say: “We are taking a phased approach to unlocking each sector – starting with schools. We will make step-by-step changes each week to gradually restore freedoms. We will monitor each change we make, so we know what impact each change has had on Wales’s public health situation.”

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Coronavirus live: highest new cases in Turkey this year after curbs eased; France reports 30,303 new infections

Turkish cases rise after curbs eased; France cases above 30,000 for first time in fortnight; nothing to suggest vaccination behind deaths in Austria, EMA says

US President Joe Biden’s $1.9 trillion Covid-19 relief bill secured enough votes in the U.S. House of Representatives to pass on Wednesday.

The Senate has already approved the legislation.

Here is a quick recap of recent Covid related events from around the world:

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Vitamin D supplements may offer no Covid benefits, data suggests

Two studies fail to find evidence to support claims supplements protect against coronavirus

The idea that vitamin D supplements can reduce susceptibility to, and the severity of, Covid-19 is seductive – it offers a simple, elegant solution to a very complex and lethal problem. But analyses encompassing large European datasets suggest the enthusiasm for the sunshine vitamin may be misplaced.

Two still to be peer-reviewed papers looked at the link between vitamin D levels and Covid-19 and both reached the same conclusion: evidence for a direct link between vitamin D deficiency and Covid outcomes is lacking.

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House will vote Wednesday morning on $1.9tn Covid relief bill – live

Progressive congresswoman Bonnie Watson Coleman said she will vote for the coronavirus relief bill, despite serious concerns about the changes made by the Senate.

“While I will continue to pressure my party to live up to its banner as the party of the people, I cannot ignore the immediate need for relief,” Watson Coleman said in a statement.

pic.twitter.com/VODEIHERDU

This trend is outrageous:

Eliminating $15/hr
Reducing thresholds for payments (cutting off ~400k New Jerseyans)
Cuts to weekly payments

What are we doing here? I'm frankly disgusted with some of my colleagues and question whether I can support this bill.

1/ https://t.co/r9dqZpuCbU

Okay, now it’s official: the House will hold its final vote on the $1.9 trillion coronavirus relief package tomorrow, not today.

House majority leader Steny Hoyer said moments ago that the House will take up the bill at 9 am ET tomorrow morning, per C-SPAN.

Hoyer this morning in his weekly pen and pad announced the potential timing of House vote on final $1.9T COVID-19 relief bill: “Our expectation is, maybe late this afternoon we would adopt the rule...We will then tomorrow at 9am consider the American Rescue Plan and pass that.”

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Coronavirus live news: death toll in Italy goes past 100,000; vaccinated people can meet indoors, says US

Italian PM reiterates pledge to speed up the vaccination programme; fully-vaccinated Americans can meet indoors without social distancing or masks

Here the latest key developments at a glance:

More than half of secondary schools and colleges in England have seen nearly all their students opt in for voluntary on-site coronavirus tests as they returned to class, a survey suggests.

PA reports:

Nearly three in four (73%) secondary school heads said more than 90% of pupils had complied with face covering policies in classrooms, according to the snap poll by the Association of School and College Leaders (ASCL).

But some heads reported lower compliance with masks, with 2% saying it was below 70%.

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Face masks safe to use during intense exercise, research suggests

‘Limited’ cardiology research also shows mask wearing likely to reduce spread of coronavirus in indoor gyms

Face masks can be worn safely during intense exercise, and could reduce the risk of Covid-19 spreading at indoor gyms, preliminary findings suggests.

Scientists from the Monzino Cardiology Centre (CCM) in Milan and the University of Milan tested the breathing rate, heart rate, blood pressure and oxygen levels of six women and men on exercise bikes, with and without a mask.

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Auckland emerges from strict weeklong Covid lockdown

Officials say no new local cases on Sunday, though masks still required on public transport

Auckland has come out of a weeklong lockdown imposed after a community cluster of the more contagious UK coronavirus variant.

There were no new local Covid-19 cases recorded on Sunday, health officials said, allowing for the restrictions to ease. If no community cases are confirmed during the rest of Sunday it would make a full seven days since the last community case.

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Coronavirus live news: UK still not out of the woods, expert says; Dalai Lama gets first Covid vaccine dose

Contradictory death figures in Russia; WHO warns against relaxing guard due to vaccines

India’s federal government has asked local authorities to prioritise vaccinations in several districts of eight states, including New Delhi, that have seen a spike in coronavirus cases in recent weeks.

Reuters reports:

More than 60 districts across New Delhi, Haryana, Andhra Pradesh, Odisha, Himachal Pradesh, Uttarakhand, Goa and Chandigarh, “continue to be of concern”, the government said.

“These districts are seeing a decrease in total tests being conducted, low share of (tests), increase in weekly positivity and low number of contact tracing of the COVID positive cases,” it added, citing a risk of transmission to neighbouring regions.

More than 1,000 people in north-east England have been checked for coronavirus in the first day of surge testing after a variant from South Africa was discovered in their area.

The BBC reports that everyone aged over 16 living in Stockton’s TS19 postcode area was being urged to get tested even if asymptomatic. The local council said the variant was “more infectious” and cases needed to be identified “as quickly as possible”. Early studies indicate that this variant could be much more resistant to vaccines than the original strain.

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From Pfizer to Moderna: who’s making billions from Covid-19 vaccines?

The companies in line for the biggest gains – and the shareholders who have already made fortunes

The arrival of Covid-19 vaccines promises a return to more normal life – and has created a global market worth tens of billions of dollars in annual sales for some pharmaceutical companies.

Among the biggest winners will be Moderna and Pfizer – two very different US pharma firms which are both charging more than $30 per person for the protection of their two-dose vaccines. While Moderna was founded just 11 years ago, has never made a profit and employed just 830 staff pre-pandemic, Pfizer traces its roots back to 1849, made a net profit of $9.6bn last year and employs nearly 80,000 staff.

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‘There’s a lot of nasty stuff’: the people living with long Covid

Sufferers say they have had little specialist help despite NHS England setting up dedicated clinics

“It’s not that I feel I have been abandoned, I think that is perfectly obvious,” says Rachel Pope. “If you speak to any long Covid patient, they have been abandoned.”

Until exactly a year ago – 5 March 2020 – Pope was “an incredibly fit woman”. A senior lecturer in European prehistory at the University of Liverpool, her work and lifestyle were very active. But after falling ill to Covid, she spent four months unable to walk, then three more when she could manage little more than “a sort of shuffle”.

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Pollution fears over mink buried after Covid culling in Denmark

Signs of pollution detected at burial sites but no water contamination, says environmental agency

Mink carcasses that were buried hastily after a mass culling sparked by fears over a mutated coronavirus strain are causing pollution, Denmark’s environmental protection agency has said.

The government agency, which published results of a preliminary environmental study, added, however, that there was no risk of drinking water becoming contaminated.

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Cyprus will allow vaccinated British tourists from 1 May

Visitors would need vaccine approved by EMA administered at least seven days before travel

Cyprus will allow British tourists who have been fully vaccinated against Covid-19 into the country without restrictions from 1 May, a tourism minister has said.

British visitors are the largest market for the country’s tourism industry, which has suffered during the coronavirus pandemic. Arrivals and earnings from the sector, which represents about 13% of the Cypriot economy, plunged on average 85% in 2020.

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Coronavirus live news: modified vaccines for variants to be fast-tracked, say UK and Australia regulators

Agencies in Canada, Singapore and Switzerland will also back plan for modified vaccines to be rolled out without new approval

Authorised vaccines that are modified to protect against new variants will not need to start a new approval process or undergo in-depth clinical studies, regulators in the UK, Australia, Canada, Singapore and Switzerland have said.

Manufacturers will need to provide “robust evidence that the modified vaccine produces an immune response, but time-consuming clinical studies that do not add to the regulatory understanding of a vaccine’s safety, quality or effectiveness would not be needed”, bringing the process into line with that already used for updated flu jabs.

Alongside data on the immune response, the vaccine manufacturer would also be expected to provide evidence showing the modified vaccine is safe and is of the expected quality. In addition, data from the original robust clinical trials and the ongoing studies on real-world use in millions of people could be used to support any decision by the regulators.

This approach is based on the tried and tested regulatory process used for seasonal flu vaccines, for which annual modifications are needed to match the strains circulating each year.

Our priority is to get effective vaccines to the public in as short a time as possible, without compromising on safety. Should any modifications to authorised Covid-19 vaccines be necessary, this regulatory approach should help to do just that.

The announcement today also demonstrates the strength of our international partnerships with other regulators and how our global work can help ensure faster access to life-saving vaccines in the UK and around the world.

While worrisome coronavirus variants identified in Brazil, South Africa, and California have mutations that might help them resist antibody treatments and vaccines, the immune system’s T cell responses to the variants are unaffected in recovered patients and in people who have received the Moderna Inc or Pfizer Inc/BioNTech vaccines, new data show.

Reuters: The T cells induced by vaccines can recognise pieces of the virus spike protein, while T cells induced by previous infection recognise multiple parts of the virus, including the spike and other proteins, said Alessandro Sette of the La Jolla Institute for Immunology.

“These pieces are largely not changed/mutated in the variants,” he explained. “This means that the T cell responses recognise the ‘ancestral’ sequence and the variants equally well.”

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Vaccines tweaked for Covid variants will be fast-tracked safely, says UK regulator

Approach will be similar to how flu vaccine is modified each year to deal with new strains without fresh approval

Coronavirus vaccines tweaked to deal with variants will be fast-tracked without compromising on safety or effectiveness, the UK’s regulator has said.

The approach will be similar to the regulatory process for the modified flu vaccine, to deal with new strains each year, with a brand new approval not required.

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Covid deaths high in countries with more overweight people, says report

Governments urged to prioritise obese people for vaccinations over greater risk of death from coronavirus

Countries with high levels of overweight people, such as the UK and the US, have the highest death rates from Covid-19, a landmark report reveals, prompting calls for governments to urgently tackle obesity, as well as prioritising overweight people for vaccinations.

About 2.2 million of the 2.5 million deaths from Covid were in countries with high levels of overweight people, says the report from the World Obesity Federation. Countries such as the UK, US and Italy, where more than 50% of adults are overweight, have the biggest proportions of deaths linked to coronavirus.

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How elimination versus suppression became Covid’s cold war | Laura Spinney

Getting rid of the virus completely now seems an impossible project. But there are powerful arguments in its favour

A year ago, when the World Health Organization published a report showing that China had shut down a highly contagious virus in a city of 11 million people, epidemiologist Michael Baker assumed that the international body would advise the rest of the world to follow China’s example. When to his amazement it didn’t, he decided that New Zealand (population 5 million) should go its own way, and started lobbying the government to pursue an elimination strategy.

He found some unexpected allies in New Zealand’s billionaires who, hearing what he was proposing, got on the phone to cabinet ministers too. On 23 March, New Zealand shut down and seven weeks later, its citizens emerged into a virus-free country. Baker, who estimates that the move saved about 8,000 lives, later asked the billionaires why they backed him: “They said, ‘We didn’t get filthy rich by not being good at assessing and managing risk.’ They were in it for the long haul.”

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Northern Ireland’s five steps out of Covid lockdown: key points

Plan for moving from lockdown to relaxation of restrictions will be guided by data

Northern Ireland’s deputy first minister, Michelle O’Neill, has unveiled a cautious five-step plan to ease the region’s Covid-19 lockdown. The plan has no hard dates and will be led by data, notably the reproductive rate of the virus, O’Neill told the Stormont assembly on Tuesday.

The 28-page plan, titled Moving Forward: the Executive’s Pathway out of Restrictions, envisages a five-stage process moving from lockdown to relaxation of restrictions for nine different sectors.

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CDC chief warns of ‘potential fourth surge’ of coronavirus in US – video

The director of the federal Centers for Disease Control and Prevention (CDC), Rochelle Walensky, warned that a recent increase in coronavirus cases indicated a fourth surge could occur before a majority of the US had been vaccinated.

According to Johns Hopkins University, the US has recorded more than 28.5m Covid-19 cases and nearly 513,000 deaths. Daily case numbers fell steeply after a peak in January but have started to increase again, boosted by the spread of new variants 

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Brazil variant evaded up to 61% of immunity in previous Covid cases

Scientists call for more genetic sequencing of emerging variants like P1 to bring pandemic under control

The coronavirus variant originally found in Manaus in Brazil and detected in six cases in the UK was able to infect 25% to 61% of the people in the Amazonian city who might have expected to be immune after a first bout of Covid, researchers say.

The extent to which P1 can evade the immune system, and potentially vaccines, emerged as the UK health secretary said the hunt for one person who tested positive for P1 – but did not leave contact details – had narrowed to 379 households in the south-east of England.

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