Officials say no new local cases on Sunday, though masks still required on public transport
Auckland has come out of a weeklong lockdown imposed after a community cluster of the more contagious UK coronavirus variant.
There were no new local Covid-19 cases recorded on Sunday, health officials said, allowing for the restrictions to ease. If no community cases are confirmed during the rest of Sunday it would make a full seven days since the last community case.
Continue reading...Contradictory death figures in Russia; WHO warns against relaxing guard due to vaccines
India’s federal government has asked local authorities to prioritise vaccinations in several districts of eight states, including New Delhi, that have seen a spike in coronavirus cases in recent weeks.
Reuters reports:
More than 60 districts across New Delhi, Haryana, Andhra Pradesh, Odisha, Himachal Pradesh, Uttarakhand, Goa and Chandigarh, “continue to be of concern”, the government said.
“These districts are seeing a decrease in total tests being conducted, low share of (tests), increase in weekly positivity and low number of contact tracing of the COVID positive cases,” it added, citing a risk of transmission to neighbouring regions.
More than 1,000 people in north-east England have been checked for coronavirus in the first day of surge testing after a variant from South Africa was discovered in their area.
The BBC reports that everyone aged over 16 living in Stockton’s TS19 postcode area was being urged to get tested even if asymptomatic. The local council said the variant was “more infectious” and cases needed to be identified “as quickly as possible”. Early studies indicate that this variant could be much more resistant to vaccines than the original strain.
Continue reading...The companies in line for the biggest gains – and the shareholders who have already made fortunes
The arrival of Covid-19 vaccines promises a return to more normal life – and has created a global market worth tens of billions of dollars in annual sales for some pharmaceutical companies.
Among the biggest winners will be Moderna and Pfizer – two very different US pharma firms which are both charging more than $30 per person for the protection of their two-dose vaccines. While Moderna was founded just 11 years ago, has never made a profit and employed just 830 staff pre-pandemic, Pfizer traces its roots back to 1849, made a net profit of $9.6bn last year and employs nearly 80,000 staff.
Continue reading...Sufferers say they have had little specialist help despite NHS England setting up dedicated clinics
“It’s not that I feel I have been abandoned, I think that is perfectly obvious,” says Rachel Pope. “If you speak to any long Covid patient, they have been abandoned.”
Until exactly a year ago – 5 March 2020 – Pope was “an incredibly fit woman”. A senior lecturer in European prehistory at the University of Liverpool, her work and lifestyle were very active. But after falling ill to Covid, she spent four months unable to walk, then three more when she could manage little more than “a sort of shuffle”.
Continue reading...Signs of pollution detected at burial sites but no water contamination, says environmental agency
Mink carcasses that were buried hastily after a mass culling sparked by fears over a mutated coronavirus strain are causing pollution, Denmark’s environmental protection agency has said.
The government agency, which published results of a preliminary environmental study, added, however, that there was no risk of drinking water becoming contaminated.
Continue reading...Visitors would need vaccine approved by EMA administered at least seven days before travel
Cyprus will allow British tourists who have been fully vaccinated against Covid-19 into the country without restrictions from 1 May, a tourism minister has said.
British visitors are the largest market for the country’s tourism industry, which has suffered during the coronavirus pandemic. Arrivals and earnings from the sector, which represents about 13% of the Cypriot economy, plunged on average 85% in 2020.
Continue reading...Agencies in Canada, Singapore and Switzerland will also back plan for modified vaccines to be rolled out without new approval
Authorised vaccines that are modified to protect against new variants will not need to start a new approval process or undergo in-depth clinical studies, regulators in the UK, Australia, Canada, Singapore and Switzerland have said.
Manufacturers will need to provide “robust evidence that the modified vaccine produces an immune response, but time-consuming clinical studies that do not add to the regulatory understanding of a vaccine’s safety, quality or effectiveness would not be needed”, bringing the process into line with that already used for updated flu jabs.
Alongside data on the immune response, the vaccine manufacturer would also be expected to provide evidence showing the modified vaccine is safe and is of the expected quality. In addition, data from the original robust clinical trials and the ongoing studies on real-world use in millions of people could be used to support any decision by the regulators.
This approach is based on the tried and tested regulatory process used for seasonal flu vaccines, for which annual modifications are needed to match the strains circulating each year.
Our priority is to get effective vaccines to the public in as short a time as possible, without compromising on safety. Should any modifications to authorised Covid-19 vaccines be necessary, this regulatory approach should help to do just that.
The announcement today also demonstrates the strength of our international partnerships with other regulators and how our global work can help ensure faster access to life-saving vaccines in the UK and around the world.
While worrisome coronavirus variants identified in Brazil, South Africa, and California have mutations that might help them resist antibody treatments and vaccines, the immune system’s T cell responses to the variants are unaffected in recovered patients and in people who have received the Moderna Inc or Pfizer Inc/BioNTech vaccines, new data show.
Reuters: The T cells induced by vaccines can recognise pieces of the virus spike protein, while T cells induced by previous infection recognise multiple parts of the virus, including the spike and other proteins, said Alessandro Sette of the La Jolla Institute for Immunology.
“These pieces are largely not changed/mutated in the variants,” he explained. “This means that the T cell responses recognise the ‘ancestral’ sequence and the variants equally well.”
Continue reading...Approach will be similar to how flu vaccine is modified each year to deal with new strains without fresh approval
Coronavirus vaccines tweaked to deal with variants will be fast-tracked without compromising on safety or effectiveness, the UK’s regulator has said.
The approach will be similar to the regulatory process for the modified flu vaccine, to deal with new strains each year, with a brand new approval not required.
Continue reading...Governments urged to prioritise obese people for vaccinations over greater risk of death from coronavirus
Countries with high levels of overweight people, such as the UK and the US, have the highest death rates from Covid-19, a landmark report reveals, prompting calls for governments to urgently tackle obesity, as well as prioritising overweight people for vaccinations.
About 2.2 million of the 2.5 million deaths from Covid were in countries with high levels of overweight people, says the report from the World Obesity Federation. Countries such as the UK, US and Italy, where more than 50% of adults are overweight, have the biggest proportions of deaths linked to coronavirus.
Continue reading...Getting rid of the virus completely now seems an impossible project. But there are powerful arguments in its favour
A year ago, when the World Health Organization published a report showing that China had shut down a highly contagious virus in a city of 11 million people, epidemiologist Michael Baker assumed that the international body would advise the rest of the world to follow China’s example. When to his amazement it didn’t, he decided that New Zealand (population 5 million) should go its own way, and started lobbying the government to pursue an elimination strategy.
He found some unexpected allies in New Zealand’s billionaires who, hearing what he was proposing, got on the phone to cabinet ministers too. On 23 March, New Zealand shut down and seven weeks later, its citizens emerged into a virus-free country. Baker, who estimates that the move saved about 8,000 lives, later asked the billionaires why they backed him: “They said, ‘We didn’t get filthy rich by not being good at assessing and managing risk.’ They were in it for the long haul.”
Continue reading...Plan for moving from lockdown to relaxation of restrictions will be guided by data
Northern Ireland’s deputy first minister, Michelle O’Neill, has unveiled a cautious five-step plan to ease the region’s Covid-19 lockdown. The plan has no hard dates and will be led by data, notably the reproductive rate of the virus, O’Neill told the Stormont assembly on Tuesday.
The 28-page plan, titled Moving Forward: the Executive’s Pathway out of Restrictions, envisages a five-stage process moving from lockdown to relaxation of restrictions for nine different sectors.
Continue reading...The director of the federal Centers for Disease Control and Prevention (CDC), Rochelle Walensky, warned that a recent increase in coronavirus cases indicated a fourth surge could occur before a majority of the US had been vaccinated.
According to Johns Hopkins University, the US has recorded more than 28.5m Covid-19 cases and nearly 513,000 deaths. Daily case numbers fell steeply after a peak in January but have started to increase again, boosted by the spread of new variants
Scientists call for more genetic sequencing of emerging variants like P1 to bring pandemic under control
The coronavirus variant originally found in Manaus in Brazil and detected in six cases in the UK was able to infect 25% to 61% of the people in the Amazonian city who might have expected to be immune after a first bout of Covid, researchers say.
The extent to which P1 can evade the immune system, and potentially vaccines, emerged as the UK health secretary said the hunt for one person who tested positive for P1 – but did not leave contact details – had narrowed to 379 households in the south-east of England.
Continue reading...Both countries urged to take action to avoid pile-up of unused AstraZeneca vaccine doses
Authorities in Germany and France are under pressure to come up with creative solutions to shift the AstraZeneca vaccine at higher speed in order to avoid a pile-up of unused doses over the coming weeks.
On Monday, France’s medical regulator reversed its advice not to use the AstraZeneca jab on over-65s, and Germany’s vaccination committee is coming under increasing pressure to follow suit or even scrap prioritisation altogether.
Continue reading...Anal swabs cause ‘great psychological pain’, says Japan’s chief cabinet secretary
Tokyo has requested Beijing to stop taking anal swab tests for Covid-19 on Japanese citizens because the procedure causes psychological pain, a government spokesperson has said.
Japan’s chief cabinet secretary, Katsunobu Kato, said the government had not received a response that Beijing would change the testing procedure, so Japan would continue to ask China to alter the way of testing.
Continue reading...Analysis: P1 strain believed to transmit more easily and may reduce vaccine effectiveness
Public Health England is facing a needle-in-a-haystack hunt for a person who tested positive for the “concerning” Brazilian Covid variant but did not leave their name and address with their test.
There are a few clues to go on. Public Health England thinks it knows when the test in question was taken and so is asking people who were tested on 12 or 13 February but have not received any test result to get in touch.
Continue reading...As hotels and gyms reopen in Israel, governments elsewhere are considering a similar certificate scheme – raising ethical concerns
As the UK and other governments consider whether to give Covid-vaccinated people certificates that allow entry to bars, hotels, and swimming pools, one country, Israel, has already deployed its “green pass”.
The state of 9 million, which has administered jabs to half its population, released an app a week ago that shows whether people have been fully inoculated against the coronavirus or if they have presumed immunity after contracting the disease.
Continue reading...Scientists emphasise safety but younger women still hesitant
Amy Taylor was chatting to friends over a Zoom drink when the conversation took an unexpected turn. One of the group – all in their early 30s, mostly university-educated and in professional jobs – mentioned that she had concerns about the Covid vaccine because she wanted to try for a baby in the next year or two.
“I was surprised when others said they were also a bit anxious. Then I started thinking maybe I should be worried too – even though I’m pro-vaccinations and I know this is the way out of the pandemic,” said Taylor*. “This really plays into the fertility insecurity that lots of women in their 30s have anyway – have I left it too late, will I need IVF, should I freeze my eggs? We don’t want anything else that could interfere with our chances of motherhood.”
Continue reading...Government data shows 19.6m get first jab and up to 770,000 inoculated a second time
More than 20 million people in the UK have received at least a first dose of coronavirus vaccine, with under 4% of those given as second doses.
Government data shows that of the 20.5m jabs given in the UK up to 26 February, 19.6m were first doses.
Continue reading...Regulator concedes process had ‘somehow gone wrong’ and could soon approve vaccine
Germany could soon authorise the use of the AstraZeneca vaccine for seniors after the head of the country’s vaccination committee said his body’s advice to give the Oxford-developed vaccine only to those under 65 had “somehow gone wrong”.
Unlike the European Medicines Agency or Britain’s MHRA, Germany’s Standing Committee on Vaccination (Stiko) last month recommended against the use of the AstraZeneca vaccine on seniors, citing a lack of conclusive trial data to prove its efficacy in that age group.
Continue reading...