Category Archives: Microbiology

When will Britain’s Covid lockdown be lifted? Three scenarios

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At best, vaccines and lockdown could make life more normal by May. But at worst, a new mutation could undo any progress

Hopes are rising that Britain may soon put the worst of Covid-19 behind it. After a year in which the disease has paralysed the nation, killed more than 100,000 people, closed schools and universities, and brought the NHS to its knees, there are now signs of hope emerging.

Most optimism stems from Britain’s vaccination programme, which has resulted in the inoculation of more than 10 million people in the past two months alone, and which aims to have vaccinated the entire adult population later this year.

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What are Covid variants – and should we be worried?

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In the UK, all eyes are on South African, Brazilian and Kent variants - with mutations transmitting among the population

With the discovery of new coronavirus variants in parts of the UK, prompting intensive testing, we take a look at what the variants are and how concerned we should be.

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UK passes 10m Covid vaccination milestone

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About 15% of population has been offered first jab, as experts call for focus on hotspots

Britain has given a first dose of a coronavirus vaccine to more than 10 million people, as public health experts call on ministers to target future vaccinations in hotspots where the disease is threatening to run out of control.

Official figures from across the UK’s four nations showed that 374,756 people received a jab on Tuesday, taking the headline total to 10.02 million, less than two months after the programme began.

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Israel opens coronavirus vaccines to all over-16s

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New age group eligible from Thursday while focus remains on older at-risk people

Israel’s health ministry has said it will offer coronavirus vaccines to anyone over the age of 16, as part of a rapid campaign in which the majority of older and vulnerable people have already received shots.

The ministry has told healthcare providers they can start booking appointments for the new age group starting on Thursday.

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Sputnik V vaccine has 91.6% efficacy against symptomatic Covid, Russian trial suggests

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Preliminary findings based on analysis of data from more than 20,000 participants

The Sputnik V vaccine, which has been the subject of scepticism since Russia began using it last year before trials had ended, is 91.6% effective against symptomatic Covid according to data published in one of the world’s leading medical journals.

Results in the Lancet from 20,000 trial participants suggest Sputnik’s efficacy is on a par with that of some of the leading vaccines now in use. There was good efficacy in older adults, who are at highest risk for death, but little diversity, since most participants were white males.

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What we know about the South African variant of Covid

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Experts say 501Y.V2 variant is more infectious and resistant to vaccines, though there are no signs that it leads to more severe disease

The South African variant, like the new UK variant, contains a mutation known as N501Y which is believed to make the virus more contagious than older variants. The South African variant also contains other mutations of concern, including E484K and K417N. These two mutations are thought to explain why the South African variant appears to be better able to evade neutralising antibody responses by the body.

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Why experts say there is no basis to claims in Germany about efficacy of AstraZeneca vaccine

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Analysis: Drug company and scientific partners at Oxford University have strongly pushed back against German press report

A row has broken out after German newspapers suggested the Oxford/AstraZeneca vaccine might have a lower efficacy among the over-65s. Below we take a look at the claims, and whether we should be concerned.

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I’ve had my first vaccine jab. It gives me hope of liberation… but not yet

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Exactly a year after his first story about coronavirus, our science editor received the Pfizer injection last week. Here he reflects on a remarkable scientific achievement

I marked a grim anniversary in an unexpected manner last week. On 18 January last year, I wrote my first story about a mysterious disease that had struck Wuhan, in China, and which was now spreading around the world. More than two million individuals have since died of Covid-19, almost 100,000 of them in the UK.

Remarkably, 12 months to the day that the Observer published my story, I was given my first dose of Covid-19 vaccine, allowing me to follow nearly six million other newly immunised UK residents who are set to gain protection against a disease that has brought the planet to a standstill. It was a rare, comforting experience after a year of unremitting sadness and gloom.

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Covid vaccines: what are the implications of new variants of virus?

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UK, South Africa and Brazil variants indicate changes may be needed

In common with others, the virus that causes Covid-19 mutates as it spreads. Most mutations have little or no effect, but some can change the behaviour of the virus. Mutations in a variant found in the UK in September has helped the virus spread more easily and potentially more dangerously. Further changes in variants that emerged in South Africa and Brazil may help the virus resist antibodies induced by vaccines and Covid infections from the first wave.

Why would the vaccines be updated?
If scientists spot new variants of coronavirus that are resistant to current vaccines then the vaccines will need to be redesigned to make them effective again. The more people who have immunity, either through vaccination or past infection, the more evolutionary pressure there is on the virus to evolve around that immunity. And when there’s lot of virus around, as there is now, there are more opportunities for resistant variants to emerge.

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I’m in a UK Covid vaccine trial – should I also accept a ‘real’ jab?

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My turn for an AstraZeneca dose has come up, so I need to decide whether to drop out of Novavax tests

I had two excellent pieces of news this week. They left me feeling utterly wretched.

First, my turn came up for the AstraZeneca vaccine against Covid. I was told I could have my first jab on Thursday.

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Indian hesitancy sets back world’s biggest Covid vaccination drive

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Low uptake fuelled by fears over safety of vaccine and spread of misinformation

India’s Covid-19 vaccine drive has been hampered by turnout as low as 22% in some states, as fears over the safety of the vaccine and the spread of misinformation has fuelled widespread hesitancy.

On Saturday, India launched the world’s largest vaccination programme as it began the massive task of vaccinating its 1.3 billion citizens against coronavirus.

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Talking can spread Covid as much as coughing, says research

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Tiny aerosols of the virus emitted when speaking linger in air for longer than larger droplets from a cough

Speaking to a friend when infected with the coronavirus could be as dangerous as coughing near them thanks to lingering particles, research has suggested.

Covid can be spread through a number of routes, including virus-containing droplets emitted when an infected person breaths, speaks or coughs – a factor experts said could help to explain why Covid seems to spread more easily in indoor settings.

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Sri Lankan holy man’s ‘miracle’ potion for Covid turns sour

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Minister who publicly drank syrup touted as coronavirus cure tests positive

A self-styled Sri Lankan holy man’s supposed miracle potion to prevent Covid-19 has turned sour after a minister who publicly drank it was taken to hospital with the virus.

Thousands defied public gathering restrictions to swamp a village in central Sri Lanka last month to get the syrup made by Dhammika Bandara.

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Covid-19: how do you tweak a vaccine?

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The emergence of more infectious variants of Sars-CoV-2 has raised questions about just how long our vaccines will remain effective for. Although there is little evidence that the current vaccines won’t work against the new variants, as the virus continues to mutate scientists are preparing themselves for having to make changes to the vaccines in response. Speaking to Dr Katrina Pollock, science correspondent Linda Geddes asks how we can tweak the vaccines against new variants, and how likely it is we’ll end up in a game of cat and mouse with the virus

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What are the new coronavirus variants and how do we monitor them? – podcast

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Over the course of the pandemic, scientists have been monitoring emerging genetic changes to Sars-Cov-2. Mutations occur naturally as the virus replicates but if they confer an advantage – like being more transmissible – that variant of the virus may go on to proliferate. This was the case with the ‘UK’ or B117 variant, which is about 50% more contagious and is rapidly spreading around the country. So how does genetic surveillance of the virus work? And what do we know about the new variants? Ian Sample speaks to Dr Jeffrey Barrett, the director of the Covid-19 genomics initiative at the Wellcome Sanger Institute, to find out

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WHO’s Covid mission to Wuhan: ‘It’s not about finding China guilty’

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Scientists express caution about what they may find and the political sensitivity around investigation

When the scientists on the World Health Organization’s mission to research the origins of Covid-19 touch down in China as expected on Thursday at the beginning of their investigation they are clear what they will – and what they will not – be doing.

They intend to visit Wuhan, the site of the first major outbreak of Covid-19, and talk to Chinese scientists who have been studying the same issue. They will want to see if there are unexamined samples from unexplained respiratory illnesses, and they will want to examine ways in which the virus might have jumped the species barrier to humans.

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The new UK Covid variant: your questions answered

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You asked us about the fast-spreading coronavirus variant, here are the answers

How do scientists know the new UK variant is 70% more transmissible, and how certain are they of this figure?

Our gift to the world: the UK variant of Sars-CoV-2. There are sufficient data to quote 70% greater infectivity, but how was this figure ascertained?” D Moon, Brighton

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Now we have the coronavirus vaccine, how soon can we get back to normal life?

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The government has ordered sufficient doses to inoculate the entire population of the UK against Covid-19 but we are in for a long haul

When will the Covid-19 vaccine begin to have an effect on the nation?

The government has pledged to offer vaccines to 15 million people – the over-70s, healthcare workers and those required to shield by mid-February, and millions more by spring. This should slowly bring the virus under control although it will take many weeks before we can be sure the vaccine is having an effect. Numbers of daily cases of Covid-19 may drop but that decline could simply be due to impact of current lockdown measures. Only when hospital admissions start to reduce significantly will we be sure the vaccine is having an impact. Then there could be be a slackening of lockdown measures. Few scientists believe that will happen before Easter, however.

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Golden ticket: the lucky tourists sitting out coronavirus in New Zealand

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Visitors from UK and North America tell of finding themselves with a pass to one of the best-rated pandemic responses in the world

For Christmas 2019 Efrain Vega de Varona gave his partner plane tickets to New Zealand – her dream holiday destination. It has proved a gift that keeps on giving.

A year later they are still in New Zealand, having decided to stay put at the end of their two-week holiday in mid-March rather than return to Los Angeles. “We’ve been living out of two suitcases for 10 months,” says Vega de Varona from their latest Airbnb rental (number 50-something this year) in Island Bay, Wellington.

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Coronavirus live news: more countries report suspected cases of new Covid variant

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Latest updates: South Africa imposes tighter restrictions amid sharp increase in cases; UK told it must vaccinate 2 million people per week to avoid new wave

India has found six people who returned from the UK in recent weeks with the more infectious strain of the virus that has prompted border closures around the world, Reuters reports.

Nevertheless, the country’s daily increase in cases fell to a six-month low.

Hello and thank you for reading our live coverage. I’ll be with you for the next few hours. Here’s a brief summary of where we stand:

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