In today’s newsletter: A major new attack on territory known for Kyiv’s biggest victory has led to a sense of Ukraine’s prospects viciously unravelling, town by town

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Good morning. In September 2022, Kharkiv province was the site of the greatest Ukrainian victory of the war so far: the lightning counteroffensive that liberated at least 12,000 square kilometres from Russian control, pushed Moscow’s artillery out of range of Kharkiv city and provided real hope that Vladimir Putin could not just be slowed down, but defeated.

Over the past few days, Kharkiv has been the location of a very different shift. This time, it is the Russians who have made larger daily advances than at almost any other point in the war, and are now moving further forwards. Civilians who had come home are fleeing once more in their thousands, and even Kyiv admits that the situation is “difficult”. Further attacks could draw sparse Ukrainian resources from along the frontline, deal a heavy blow to Ukrainian morale and redraw the map before the resources belatedly provided by the US last month are in place to do anything about it.

Medical research | A weight loss injection could reduce the risk of heart attacks and benefit the cardiovascular health of millions of adults in what could be the largest medical breakthrough since statins, according to a study. Trial participants who took semaglutide, sold as Wegovy and Ozempic, had a 20% lower risk of heart attack, stroke, or death due to cardiovascular disease.

Housing | Rent rises should be capped for millions of people struggling to afford soaring rates, according to a landmark report commissioned by Labour. Leaked proposals from the independent report will put pressure on Keir Starmer to adopt measures that could ease pressure on tenants who saw an average 9% increase in rates last year.

Donald Trump | Donald Trump told his one-time fixer Michael Cohen only weeks before the 2016 election to bury Stormy Daniels’s account of an alleged sexual liaison, demanding that he “just take care of it”, Cohen told the former president’s trial on Monday. In hours of testimony, Cohen linked Trump to a $130,000 hush money payment and said: “Everything required Mr Trump’s sign-off.”

Gaza | Israeli settlers attacked an aid convoy headed into Gaza on Monday, throwing packages of food into the road and setting fire to vehicles. The incident, condemned by the US as “a total outrage”, came as Israeli troops continued their offence across Gaza in the most intensive round of fighting for weeks.

Women’s health | Women in labour have been mocked, ignored, fobbed off with paracetamol and left with permanent damage by midwives and doctors, a damning report by MPs has found. The UK’s first inquiry into birth trauma called for the appointment of a maternity commissioner and the creation of new specialist postnatal services to address the problems.