AstraZeneca overtakes Pfizer as crunch week for UK pharma looms

Driven by a revamped drug portfolio, AstraZeneca is expected to report revenues of $10.7bn in its latest quarterly results

Nearly a decade after AstraZeneca fended off a hostile takeover approach from US rival Pfizer, the British drug firm has overtaken the Viagra maker in terms of market value, marking a significant moment in its turnaround – and for UK plc.

In a week when AstraZeneca and Britain’s second-biggest pharma firm GSK release their latest quarterly results and the main industry body, the Association of the British Pharmaceutical Industry holds its annual conference, all eyes will be on what pharma executives say about the UK as a place to operate and invest in.

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Asking price of properties popular with UK first-time buyers hits record

Average of £224,963 for homes with one or two bedrooms is 2% higher than a year ago, says Rightmove

Those people hoping to get on to the UK housing ladder are facing record asking prices, as calm returns to the sector after last autumn’s mini-budget spooked the markets.

Rightmove, the property portal, reports that the average asking price of properties popular with first-time buyers – those with one or two bedrooms – has hit a record price of £224,963 in the last month. That is 2% higher than a year ago, even though higher mortgage rates have made homes less affordable.

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Credit Suisse says £55bn left bank in lead-up to rescue by UBS

Results reported for what is likely to be the last time as lender’s takeover by Swiss rival nears completion

Credit Suisse said customers pulled more than 61bn Swiss francs (£55bn) worth of assets from the bank at the start of the year, laying bare the scale of the panic that contributed to its failure and emergency takeover by its rival UBS last month.

The Swiss lender said the “significant withdrawals” were partly to blame for its poor financial performance in the first quarter, with its adjusted pre-tax loss ballooning to 1.3bn Swiss francs for the first three months of the year. That compares with a profit of 300m Swiss francs during the same period in 2022.

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Descendants of UK slave owners call on government to apologise

Heirs of Slavery body wants restorative justice to tackle ‘ongoing consequences of this crime against humanity’

The descendants of some of Britain’s wealthiest slave owners have launched an activist movement, calling on the government both to apologise for slavery and begin a programme of reparative justice in recognition of the “ongoing consequences of this crime against humanity”.

A second cousin of King Charles and a direct descendant of the Victorian prime minister William Gladstone have joined journalists, a publisher, a schoolteacher and a retired social worker, to create the Heirs of Slavery campaigning body, which will lobby the UK government to acknowledge and atone for its role in the transportation of 3.1 million enslaved African people across the Atlantic.

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Half of UK public fear family would not be well looked after in care homes

Survey also reveals nine out of 10 older people believe there are not enough care staff in the country

Trust in care homes has slumped, leaving half of the British public lacking confidence that friends or family would be well looked after.

Nationwide polling for the Guardian revealed nine out of 10 older people believe there are not enough care staff, and half have lost confidence in the standard of care homes since the start of the pandemic.

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Care home where staff were filmed abusing 88-year-old is still breaking rules

Inspectors find lack of trained staff at Reigate Grange and medicines not being administered properly

A £2,400-a-week care home where staff were secretly filmed abusing 88-year-old Ann King is still breaking Care Act regulations despite a public outcry over her treatment.

Recent inspections of Reigate Grange revealed there were still not enough trained staff, medicines were not being administered properly and the home to 74 people was “not always safe” and “not always well led”. The “luxury” home is marketed as offering the “highest possible standards of assisted living with the best possible care”.

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UK medical bodies ‘gravely concerned’ over Rwanda deportation scheme

Hundreds of healthcare professionals fear plan will cause ‘catastrophic mental and physical harm’ to refugees

More than 830 UK health professionals and representatives from leading medical bodies have signed a letter to the prime minister expressing “grave concerns” that the government’s plan to send asylum seekers to Rwanda will cause “catastrophic mental and physical harm” to people seeking safety, in advance of a court of appeal hearing on the policy on Monday.

Signatories to the letter include the BMA and the Royal College of Obstetrics and Gynaecologists.

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Defence spending in western and central Europe tops last year of cold war

Stockholm International Peace Institute’s annual report finds UK was region’s biggest spender in 2022 at $68.5bn

Defence spending in western and central Europe has surpassed that of the last year of the cold war, an annual report has found, as military expenditure across the world hit an all-time high of $2.24tn (£1.8tn) last year.

The outbreak of war in Ukraine has triggered the steepest increase in military expenditure in Europe in three decades, according to the Stockholm International Peace Institute (Sipri).

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Emergency alert test UK: phone alarm sounds early for some users but others don’t receive it – live updates

At 3pm BST, every phone in Britain was due to receive a loud alarm as a test for future emergencies

Boston-based Everbridge is one of the companies providing the technology behind today’s alert. Lorenzo Marchetti, the company’s public affairs manager, explained the requirements of any such system:

A public alerting system should encompass three key elements– communication, synchronisation and analysis of data. For example, information might come from a weather forecast, a traffic report or through social media. Analysis of this data gives authorities a broad picture of what could occur and allows them to communicate and synchronise their actions. They can then disseminate this across specific locations or to an entire nation while ensuring that they reach the targeted people in the area. This means that effective public warning platforms can integrate several delivery methods such as radio or TVs, depending on the context of the deployment, in addition to the cell broadcast capacity.

Emergency alerts don’t just benefit citizens but are also essential for giving information and directions to the emergency services, helping them understand where to go and how to direct people away from danger.

If you are concerned you could:

Avoid wearing headphones during the test

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UK armed forces evacuate British diplomats from Sudan after threats

Rishi Sunak says ‘complex and rapid’ operation carried out, amid fears for remaining UK nationals

The UK has evacuated its diplomatic staff and their dependants from Khartoum, the British prime minister and foreign secretary said on Sunday, but UK nationals still living in Sudan remained in the country.

Announcing the evacuation, Rishi Sunak said British armed forces had carried out “a complex and rapid” military operation. The evacuation involved members of UK special forces and the Parachute Regiment.

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Labour cuts ties with CBI and says lobby group needs ‘root and branch reform’

Flood of Confederation of British Industry members have quit since allegations reported by the Guardian

The Labour party has cut all ties with the Confederation of British Industry after the Guardian’s revelations about alleged sexual misconduct by male employees at the lobbying group.

The CBI experienced an exodus of major member businesses at the end of last week, including the insurer Aviva, the retailer John Lewis, the manufacturer Jaguar Land Rover and the banking firm Natwest Group. Companies said the lobby group was unable to carry out its role effectively following the allegations, after a second woman alleged to the Guardian that she was raped by two male colleagues when she worked at the CBI.

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UK evacuates British embassy staff and families from Sudan in wake of ‘significant threats’ – as it happened

Foreign secretary says efforts to support British nationals trapped in Sudan currently ‘severely limited’

Oliver Dowden is often viewed as one of the safest pairs of Conservative party hands in media performances, but he’s had a tricky couple of minutes here where Sophy Ridge has first challenged him over concerns about appointments to the BBC raised with him when he was at the DCMS, and is struggling to answer on whether he thinks it would be embarrassing if Boris Johnson appointed his own father to the House of Lords.

Sophy Ridge has pointed out to Oliver Dowden that there have been nine justice ministers in the last few years, and that the backlog in crown court cases is not diminishing. He tried to pin the backlog on Covid, to which she said: “That’s not true, the backlog started before the pandemic.”

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Infected blood victims and families urge UK government to drop defence

Exclusive: Claimants say government can no longer defend treatment disaster in light of inquiry’s damning interim report

More than 500 people taking the government to court over the contaminated blood scandal are urging it to concede the case in light of evidence heard by a public inquiry and an interim report produced by its chair.

The claim, which began in 2017 but was stayed pending the inquiry into what has been described as the biggest treatment disaster in the history of the NHS, alleges the Department of Health – now the Department of Health and Social Care (DHSC) – breached a duty to take reasonable care to prevent personal injury or loss, amounting to misfeasance in public office.

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Rise in school absences since Covid driven by anxiety and lack of support, say English councils

Evidence to MPs claims parents more cautious about sending children to school with minor ailments

Increased anxiety and lack of mental health support are driving a steep increase in children missing school since the Covid pandemic, with some children “struggling to leave home”, according to councils in England.

Local authorities are also highlighting budget pressures that have forced cuts in school support staff, with some schools trying to “manage” students out of classrooms or disguising their attendance records, while others are “off-rolling” students to artificially boost school exam results.

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Western and other nations escalate plans to evacuate diplomats from Sudan

Death toll passes 420, including 264 civilians, and more than 3,700 wounded as ceasefires fail to hold

Western and other nations have intensified increasingly desperate efforts to evacuate diplomats and their dependents from Khartoum, as battles raged in the centre of the Sudanese capital and in its twin city of Omdurman.

With a series of ceasefires failing to hold, the death toll has now passed 420, including 264 civilians, and more than 3,700 have been wounded, according to local and international NGOs. However, most analysts believe the true total of fatalities and injuries in more than nine days of fighting is much higher.

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Labour suspends Diane Abbott in attempt to stifle fresh antisemitism row

MP loses party whip after writing letter suggesting Jewish, Irish, and Gypsy, Roma and Traveller people had not experienced racism

Labour has sought to head off a fresh antisemitism storm by suspending the party whip from Diane Abbott, after the former shadow home secretary played down suggestions of racism against Jewish people.

In comments that were swiftly condemned by senior Conservatives and faith groups, the MP argued that minority groups – such as Jewish people, as well as Gypsy, Roma and Traveller people – faced similar levels of prejudice to people with red hair.

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Eurostar urged to carry adrenaline injectors in first-aid kit after medical alert

A doctor was shocked to find no anti-allergy pens on board the train, though operator says law forbids it at present

A junior doctor is calling for lifesaving adrenaline auto-injectors to be carried on Eurostar after caring for a young child who suffered an allergic reaction on the service.

Dr Raphaelle Debray, 26, who is French and works for the NHS, was en route to Paris when she responded to an appeal for a doctor. She requested the onboard medical kit and found it contained only some plasters and a defibrillator. In contrast, international guidelines state that commercial airlines should carry emergency medical kits, with equipment and medication including adrenaline. British Airways and easyJet said they carried adrenaline auto-injectors (AAIs) on all flights.

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Goodnight possum! Tributes to Dame Edna creator Barry Humphries

World mourns ‘unique wit’ of Australian star and inventor of vivid stage personas, who has died aged 89

Like bouquets of appropriately lurid gladioli, colourful tributes to the memory of Barry Humphries piled up this weekend as his many fans adjusted to a dimmer world without Dame Edna Everage.

Mourning Humphries, who was taken ill in Sydney last week with complications after hip surgery, means saying goodbye to his charismatic, hyper-real fictional personas: not only “the Australian housewife and superstar” Dame Edna, with her radiant, rinsed hairdo, trademark sparkling spectacles and bright gladioli, but also to the revolting Australian cultural attaché, Sir Les Patterson, and the irrepressibly dull Sandy Stone. Over decades, each of these stage characters has mischievously shaped the world’s view of Australians, satirising the stereotypical lack of taste that British “pommies” enjoy looking down on.

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Last remaining Gurkha Victoria Cross recipient dies in Nepal aged 83

Rambahadur Limbu was awarded Britain’s highest military honour in 1966 for an act of gallantry

The last remaining Gurkha recipient of Britain’s Victoria Cross has died in Nepal at the age of 83.

Rambahadur Limbu was awarded Britain’s highest military decoration by Queen Elizabeth II at Buckingham Palace in 1966 for gallantry during an attack on Indonesian troops on the island of Borneo during which he rescued two fellow soldiers.

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Chris Packham calls for ‘every last person who cares’ to join XR

Wildlife presenter urges people to join action on climate crisis during mass protest supported by more than 200 organisations

Wildlife presenter Chris Packham has made a rallying call for “every last person who cares” about the planet to join Extinction Rebellion after thousands took part in a demonstration on Saturday.

The 61-year-old broadcaster spoke to the crowd from a stage close to Parliament Square, Westminster, during the second day of a mass protest the climate group has called The Big One.

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