First US trachea transplant offers hope to Covid patients with windpipe damage

  • Social worker, 56, treated at Mt Sinai hospital in New York
  • Some patients left with serious damage from ventilators

Surgeons in New York City have performed the first windpipe transplant in the US, giving a woman who suffered severe asthma a new trachea, the tube that transports air from the mouth to the lungs.

Doctors say such operations could help Covid-19 patients left with serious windpipe damage from breathing machines.

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Bat catchers fight the next pandemic – in pictures

Researchers at the University of the Philippines Los Baños aim to catch thousands of bats to develop a Japanese-funded simulation model over the next three years that they believe could help avert potential pandemics. They hope the bats will help in predicting the dynamics of a coronavirus outbreak by analysing factors such as climate, temperature and ease of spread

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Global rollout of vaccines is no longer a guarantee of victory over Covid-19 | Susan Michie, Chris Bullen, et al

New variants of concern have changed the game, spreading worldwide and threatening to derail pandemic control efforts

At the end of 2020, there was a strong hope that high levels of vaccination would see humanity finally gain the upper hand over Sars-CoV-2, the virus that causes Covid-19. In an ideal scenario, the virus would then be contained at very low levels without further societal disruption or significant numbers of deaths.

But since then, new “variants of concern” have emerged and spread worldwide, putting current pandemic control efforts, including vaccination, at risk of being derailed.

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The ‘elite controllers’ who can naturally suppress HIV

Research into how some HIV-positive people keep the virus at bay promises to yield new treatment possibilities, from vaccines to gene therapies

The year was 1998 when Joel Blankson encountered a patient he would never forget. Blankson was working in the HIV clinic at John Hopkins School of Medicine, Baltimore, when an HIV-positive woman in her mid-40s arrived for some routine tests.

Blankson gave her a PCR test, intending to prescribe a newly developed combination of medicines called antiretroviral therapies to suppress the infection, and prevent her developing Aids.

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Brazil records 70,238 new cases; Netherlands halts AstraZeneca jab for under 60s – as it happened

Country has registered more than 12.9 million cases; 10,000 appointments scrapped, reports Dutch news agency citing Netherlands health ministry

That’s it from the global blog team for now. Thanks for following our coverage, a new blog will be going live in a few hours.

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Pandemic 2020 review – a masterly mapping of the Covid outbreak

The team behind Once Upon a Time in Iraq has compiled a moving and sometimes hopeful three-parter that offers a global perspective on the crisis

Like the virus itself, the programmes about it have moved from localised subjects to a slightly wider field and now have expanded to take in a global view. It hasn’t been a perfectly linear progression, of course, but most of the first documentaries were composed largely of footage recorded by medical professionals themselves, at work and then – exhausted and tearful – at home.

After that came socially distanced films recording the impact on local communities and bereaved families, the experiences of survivors and the long-term consequences for those who do not make a full recovery. Alongside that have come considerations and critiques of the UK response to the crisis and comparisons – not generally favourable – with that of other countries.

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About half of people in UK now have antibodies against coronavirus

Study by Office for National Statistics based on data from blood test results

Half of people in the UK now have antibodies against coronavirus, either through infection or vaccination, tests conducted by the Office for National Statistics (ONS) show.

According to the most recent coronavirus infection survey, an estimated 54.7% of the population in England would have tested positive for antibodies to coronavirus from a blood sample in the week ending 14 March 2021.

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Mystery brain disorder baffles Canadian doctors

Spasms, memory loss and hallucinations among symptoms of 43 patients in Acadian region of New Brunswick province

Doctors in Canada are concerned they could be dealing with a previously unknown brain disease amid a string of cases involving memory loss, hallucinations and muscle atrophy.

Politicians in the province of New Brunswick have demanded answers, but with so few cases, experts say there are far more questions than answers and have urged the public not to panic.

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Coronavirus live news: India pauses AstraZeneca vaccine exports; Belgium, Iceland and France tighten restrictions

No exports were made on Thursday; Belgium imposes fresh lockdown; Iceland imposes three-week shutdown; France locks down more areas

AstraZeneca has dismissed as “inaccurate” a report in the Italian press that 29m doses of its Covid-19 vaccine found in factory near Rome were destined for the UK.

La Stampa reported on Wednesday that the doses – almost twice the amount the EU has so far received from AstraZeneca – were found “hidden” in the factory following a search by Italian police on Saturday at the request of the European commission, and that they were probably destined for the UK.

Related: AstraZeneca dismisses claim 29m vaccine doses in Italy were bound for UK

Luxembourg has announced a partial reopening of its hospitality industry, with cafés and restaurants able to serve customers again in outdoor areas from 7 April.

The European country’s venues have been closed since the end of November.

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Covid-19: what happens next? – podcast

On 23 March 2020, the UK prime minister, Boris Johnson, announced the first lockdown in response to the growing number of cases of Covid-19. At the same time, countries around the world began to close their schools, restaurants, and offices and ask citizens to physically distance from one another. In the 12 months since, more than 2 million people have died, viral variants have emerged, and we have developed safe and effective vaccines.

One year into the pandemic, Science Weekly is asking: what happens next? Ian Sample talks to the professors Martin Landray, Mike Tildesley, and Deborah Dunn-Walters about Covid treatments, vaccines and what the next 12 months may hold

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Dexamethasone hailed as lifesaver for up to a million Covid patients worldwide

Results of Recovery drug trial also credited with successful treatment of 22,000 people in the UK, says NHS England

Dexamethasone – the inexpensive steroid that quickly emerged as a highly effective Covid therapy thanks to a large drug testing programme pioneered by UK scientists – has so far saved the lives of an estimated million people globally, including 22,000 in the UK, according to NHS England.

Called Recovery, the world’s largest randomised Covid-19 drug trial commenced in March 2020 to evaluate the suitability of a suite of different drugs to help hospitalised Covid patients. The study has since been carried out by thousands of doctors and nurses on tens of thousands of patients in hospitals across Britain.

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Can the UK avoid a third wave of Covid?

Analysis: as lockdown restrictions ease, the country now faces a race between vaccination and infection

Britain’s latest lockdown has dramatically reduced cases of coronavirus, and the number of people being admitted to hospital and dying from the disease. What the country faces now is essentially a race between vaccination and infection: can we protect people faster than the virus spreads as restrictions are eased?

This was always going to be a balancing act. The UK vaccination strategy of prioritising the most vulnerable people and moving down the age groups is intended to save lives first and slow transmission second. This means that as the country unlocks, infections are likely to rise, primarily in younger people who have more social contacts and have not yet been vaccinated. Hospitalisations and deaths are expected to rise too, though not as sharply: even though vaccine coverage has been high in vulnerable groups and older people, not everyone has the vaccine and it will not protect all those who do.

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Covid: AstraZeneca vaccine 79% effective with no increased blood clot risk – US trial

Study of over 32,000 people included review of risks of cerebral venous sinus thrombosis

The Covid-19 vaccine developed by Oxford University and AstraZeneca was 79% effective in preventing symptomatic illness in a large trial in the US, Chile and Peru, the company said on Monday, paving the way for it to apply for US approval.

The vaccine was 100% effective against severe or critical disease and hospitalisation and was safe, the drugmaker said on Monday, releasing results of the late-stage human trial study of more than 32,000 volunteers across all age groups.

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Covid: why has the fall in UK infection rate stalled despite vaccinations?

Hospital admissions and deaths are declining as priority groups vaccinated but number of new diagnoses has stabilised

The UK’s Covid-19 statistics remain encouraging despite continuing rows over vaccine deliveries in Europe. Admissions to hospital and daily deaths from the disease continue to decline with numbers in the latter category now down to double digits while the former have dropped to around a 10th of their total two months ago.

However, one other category – numbers of new diagnoses a day – has reached a plateau with cases, having plunged from 60,000, stabilising at around 5,000 to 6,000. So why has this figure apparently stalled while deaths and hospitalisations continue to decline?

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Doctors suggest Covid-19 could cause diabetes

More than 350 clinicians report suspicions of Covid-induced diabetes, both type 1 and type 2

A cohort of scientists from across the world believe that there is a growing body of evidence that Covid-19 can cause diabetes in some patients.

Prof Francesco Rubino, from King’s College London, is leading the call for a full investigation into a possible link between the two diseases. Having seen a rise in both type 1 and type 2 diabetes in people who have caught coronavirus, some doctors are even considering the possibility that the virus ‒ by disrupting sugar metabolism ‒ could be inducing an entirely new form of diabetes.

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Clot theory curdles into junkets for migrants on Isle of Man

PM welcomes vaccine safety vow, then spots new offshore home for folk trafficked here under false pretence – of getting a welcome

After a morning spent painting flowers at a primary school in his Uxbridge constituency, Britain’s prize clot returned to Downing Street to lead a press conference on clots. Blood clots to be precise.

Following the decision of some countries to suspend their Oxford AstraZeneca vaccination programmes over concerns of blood clot side-effects, Boris Johnson was happy to report that the UK’s Medicines and Healthcare products Regulatory Agency had declared the Oxford/AstraZeneca vaccine to be absolutely safe.

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Matt Hancock confirms dip in UK Covid vaccine supply for April

Health secretary says stocks will be affected by need to retest 1.7m doses and delay from India

Matt Hancock has said there will be a significant dip in vaccine supply in April, confirming supplies have been hit by a need to retest 1.7m doses and a delay in arrival of imports from India.

Speaking in the House of Commons, Hancock stressed the overall target timetable for vaccinations would not change but said he wanted to give more information, following the “speculation we’ve seen overnight”, after he was criticised for a press conference on Wednesday where the drop in supply went unexplained.

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Lack of skin-to-skin care for small and premature babies hits survival rates

Life-saving techniques fall out of favour on maternity wards in developing countries over Covid fears

Small and sick babies are at increased risk of dying due to disruptions in care caused by coronavirus, a survey of health workers across 62 mainly developing countries has found.

Every year, 2.5 million babies die within 28 days of birth, and more than 80% of them have low birth weight. A technique for premature and small babies known as kangaroo mother care (KMC), involving early prolonged skin-to-skin contact with their mothers and breastfeeding, can help reduce mortality.

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Scientists form human cell clumps that act like early-stage embryos

Cultured stem cells turn into blastoid ‘balls’, like natural blastocysts after egg fertilisation

Scientists have made clumps of human tissue that behave like early-stage embryos, a feat that promises to transform research into the first tentative steps of human development.

The clumps of cells, named blastoids, are less than a millimetre across and resemble structures called blastocysts, which form within a few days of an egg being fertilised. Typically blastocysts contain about 100 cells, which give rise to every tissue in the body.

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China to only allow foreign visitors who have had Chinese-made vaccine

Move raises questions as China’s vaccines not approved in many countries to which it is opening travel

China is resuming visa processing for foreigners from dozens of countries, but only if they have been inoculated against Covid-19 with a Chinese-made vaccine.

The move has raised questions about the motivations behind the demand, given China’s vaccines are not approved in many of the countries to which it has opened travel and that it will not accept foreign vaccines made elsewhere, including those approved by the World Health Organization.

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