Life savers: the amazing story of the Oxford/AstraZeneca Covid vaccine

A year ago, two scientists began work on the response to a new virus. Now, as their vaccine is being given to millions, they tell of their incredible 12 months

Exactly a year ago, Oxford University scientists launched a joint enterprise that is set to have a profound impact on the health of our planet. On 11 February, research teams led by Professor Andy Pollard and Professor Sarah Gilbert – both based at the Oxford Vaccine Centre – decided to combine their talents to develop and manufacture a vaccine that could protect people from the deadly new coronavirus that was beginning to spread across the world.

A year later that vaccine is being administered to millions across Britain and other nations and was last week given resounding backing by the World Health Organization. The head of the WHO’s department of immunisation, vaccines and biologicals, Professor Kate O’Brien, described the jab as “efficacious” and “an important vaccine for the world”.

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Nelson urged mistress to give their baby girl ‘new’ smallpox vaccine

Naval hero praises Jenner’s cowpox jab in a newly found love letter to Emma Hamilton, written as he prepared for war

He is best remembered as the one-armed hero who defeated Napoleon, rewrote the rules of naval warfare and died at sea, in battle, onboard HMS Victory.

Now, the “chance discovery” of a 220-year-old love letter from Admiral Horatio Nelson to Lady Emma Hamilton, his mistress, reveals how open-minded and ahead of his time the formidable captain was about a radical new scientific breakthrough: the smallpox vaccine. In the letter, dated July 1801, Nelson appears to advocate the use of the brand new vaccine on his own baby daughter.

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Boris Johnson ‘optimistic’ about easing some England lockdown measures

Prime minister says priority is to reopen schools on 8 March once 15m in priority groups vaccinated

Boris Johnson has said he is optimistic about announcing the easing of some lockdown measures soon as the government nears its target of offering vaccines to 15 million people in priority groups.

Speaking on Saturday at a visit to the Fujifilm Diosynth Biotechnologies plant in Billingham, Teesside, where the new Novavax vaccine will be manufactured, the prime minister said his first priority remained opening schools in England from 8 March, to be followed by other sectors.

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Wales is first UK nation to offer Covid jab to top four priority groups

Everyone in top four categories has been offered first vaccine dose, says first minister

Wales has become the first UK nation to have offered a Covid jab to everyone in the top four priority groups, the first minister, Mark Drakeford has announced.

Last month, Drakeford was forced to defend Wales’s vaccination programme after criticism of delays from opposition parties and doctors. But at a press conference on Friday, he said that 66 days after people in Wales first began getting the jab, the key target had been achieved.

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Ursula von der Leyen admits failings in EU Covid vaccine rollout

European commission leader says bloc late to authorise jabs and ‘not where it wants to be’

The EU is “not where it wants to be” with its coronavirus immunisation programme, Ursula von der Leyen has conceded, as she faced MEPs in the European parliament amid mounting criticism of the bloc’s slow deployment of vaccines.

“We were late to authorise,” the European commission president said. “We were too optimistic when it came to massive production, and perhaps too confident that what we ordered would actually be delivered on time. We need to ask ourselves why that is the case.”

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Europe’s oldest person survives Covid and set to celebrate 117th birthday

French nun Sister Andrée tested positive in her retirement home in Toulon but had no symptoms

A French nun who is Europe’s oldest person has recovered from Covid-19 after it swept through a nursing home in the south of France, and will celebrate her 117th birthday this week.

Sister Andrée, born Lucile Randon in 1904, tested positive for the coronavirus last month at the Sainte-Catherine Labouré home near Toulon where 81 of the 88 residents contracted the virus – 10 of whom died.

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How can Covid vaccines be tweaked to tackle new variants?

Drugmakers are looking at ways to improve their vaccines so they are ready for mutations of the virus

Emerging variants of the virus that causes Covid-19 have triggered concerns that the vaccines developed to date will not provide the high level of protection seen in clinical trials. Concerning variants have been identified in California, South Africa, Brazil and the UK.

But not every variant needs a new vaccine, since vaccines produce a broad immune response that will probably cover many mutations. Here’s what needs to be done to assess whether a vaccine needs to be tweaked, and how to tweak it.

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Study shows Oxford Covid vaccine has less protection against South African variant

Researchers say vaccines’ focus must shift to protecting people from hospitalisation and death

The Oxford/AstraZeneca vaccine will not stop people becoming ill if they contract the South African variant of Covid-19, researchers have confirmed, warning that vaccines’ focus needs to shift from population immunity to protecting individuals from hospitalisation and death.

The small study in 2,000 people aged 31, who are less likely to become severely ill, adds to evidence from big trials of other vaccines carried out after the variant appeared in South Africa. Trial data from the Janssen and Novavax vaccines showed efficacy in South Africa was up to 60% against the variant, substantially lower than against the original virus.

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When will Britain’s Covid lockdown be lifted? Three scenarios

At best, vaccines and lockdown could make life more normal by May. But at worst, a new mutation could undo any progress

Hopes are rising that Britain may soon put the worst of Covid-19 behind it. After a year in which the disease has paralysed the nation, killed more than 100,000 people, closed schools and universities, and brought the NHS to its knees, there are now signs of hope emerging.

Most optimism stems from Britain’s vaccination programme, which has resulted in the inoculation of more than 10 million people in the past two months alone, and which aims to have vaccinated the entire adult population later this year.

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Oxford Covid jab less effective against South African variant, study finds

University of the Witwatersrand and Oxford University research shows vaccine has reduced efficacy against mutation

British drugmaker AstraZeneca said on Saturday that its vaccine developed with the University of Oxford appeared to offer only limited protection against mild disease caused by the South African variant of Covid-19, based on early data from a trial.

The study from South Africa’s University of the Witwatersrand and Oxford University showed the vaccine had significantly reduced efficacy against the South African variant, according to a Financial Times report published earlier in the day.

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Oxford Covid vaccine almost as effective against Kent variant, trials suggest

Scientists say it offers only slightly lower protection compared with original Covid

The Covid vaccine developed by the University of Oxford and AstraZeneca is nearly as effective against the Kent variant as it is against older forms of the virus, according to preliminary research results.

Researchers analysed swabs from trial volunteers who developed asymptomatic or symptomatic infections to determine which variant of the virus they had caught after receiving the vaccine or a control jab.

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What are Covid variants – and should we be worried?

In the UK, all eyes are on South African, Brazilian and Kent variants - with mutations transmitting among the population

With the discovery of new coronavirus variants in parts of the UK, prompting intensive testing, we take a look at what the variants are and how concerned we should be.

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Gout drug could reduce Covid hospital stays, new research finds

Colchicine also found to reduce need for extra oxygen and has potential to be used in outpatient settings

A cheap drug normally used to treat gout has been found to have the potential to significantly reduce hospital stays among Covid-19 patients and the need for extra oxygen.

The results of new research into colchicine conducted in Brazil come after an international trial published on Wednesday found that it reduced hospitalisations and deaths among Covid-19 patients by more than 20%.

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UK minister announces launch of mix-and-match Covid jab trial – video

The UK vaccine deployment minister, Nadhim Zahawi, says volunteers are being sought for a world-first trial giving a first dose of one vaccine type and a second dose of another.  Run by the University of Oxford, it will recruit 820 people over the age of 50 to receive a first dose of either the Oxford/AstraZeneca or Pfizer/BioNTech vaccine

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Covid: Oxford trial to test efficacy of mix of vaccines for individuals

Scientists aim to establish level of immunity in trial of 820 people, giving some a substitute vaccine at second appointment

Volunteers are being sought for a world-first trial to establish the efficacy of giving people a first dose of one vaccine and a second dose of a different vaccine.

The trial, which is being run by Oxford University and is funded by the government’s vaccine taskforce, has been described by ministers as “hugely important”.

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UK passes 10m Covid vaccination milestone

About 15% of population has been offered first jab, as experts call for focus on hotspots

Britain has given a first dose of a coronavirus vaccine to more than 10 million people, as public health experts call on ministers to target future vaccinations in hotspots where the disease is threatening to run out of control.

Official figures from across the UK’s four nations showed that 374,756 people received a jab on Tuesday, taking the headline total to 10.02 million, less than two months after the programme began.

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Israel opens coronavirus vaccines to all over-16s

New age group eligible from Thursday while focus remains on older at-risk people

Israel’s health ministry has said it will offer coronavirus vaccines to anyone over the age of 16, as part of a rapid campaign in which the majority of older and vulnerable people have already received shots.

The ministry has told healthcare providers they can start booking appointments for the new age group starting on Thursday.

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Sputnik V vaccine has 91.6% efficacy against symptomatic Covid, Russian trial suggests

Preliminary findings based on analysis of data from more than 20,000 participants

The Sputnik V vaccine, which has been the subject of scepticism since Russia began using it last year before trials had ended, is 91.6% effective against symptomatic Covid according to data published in one of the world’s leading medical journals.

Results in the Lancet from 20,000 trial participants suggest Sputnik’s efficacy is on a par with that of some of the leading vaccines now in use. There was good efficacy in older adults, who are at highest risk for death, but little diversity, since most participants were white males.

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Even with vaccines, we still need treatments for Covid. So what works?

Analysis: death rates in intensive care are falling as doctors identify more ways to help those with the disease

Vaccines may have been described as the great escape route from the Covid pandemic – but treatments, which are bringing down death rates, will be needed as much as ever in the era of jabs because the virus is not expected to go away in the foreseeable future, experts say.

“It’s going to take a long time to vaccinate the world,” said Peter Horby of Oxford University, chief investigator of the Recovery trial into Covid treatments and chair of the New and Emerging Respiratory Virus Threats Advisory Group (Nervtag). “I don’t know what the estimates are, but we’ve already seen issues with manufacturing scale-up and difficulties in delivering at scale.

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Covid mortality down dramatically since start of pandemic

New research shows global death rates among patients in intensive care have fallen from 60% to 36%

Death rates among people who end up in intensive care with Covid-19 have improved dramatically since the start of the pandemic thanks to advances in treatment, new research has found.

The proportion of those worst affected by the disease who die from it has fallen from 60% when it first appeared early last year to 36% by October, the study of global trends shows.

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