Oxford AstraZeneca vaccine to be sold to developing countries at cost price

Jab that is part of global initiative to distribute doses will remain at low price ‘in perpetuity’

The coronavirus vaccine produced by Oxford University and AstraZeneca will be available on a non-profit basis “in perpetuity” to low- and middle-income countries in the developing world.

The details of arrangements to supply poorer countries came as AstraZeneca revealed the interim results of a phase 3 trial of the vaccine, which is being heralded as the first to meet the more challenging requirements of the developing world.

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The Covid vaccine results are great news, but it’s not all over yet

Oxford/AstraZeneca findings have certain advantages over those from other versions

Within weeks, the prospects of an end to the pandemic have changed utterly, with three vaccines against Covid-19 reporting good results in final clinical trials and at least one likely to be used before Christmas. But there are still huge challenges ahead.

The results from the Oxford University/AstraZeneca vaccine, which is absolutely central to the UK’s vaccination strategy, may at first glance look not as good as those of Pfizer/BioNTech and Moderna – the two mRNA vaccines that have both reported 95% efficacy.

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US vaccine expert predicts life could be back to normal around May

Operation Warp Speed chief says if immunization plan goes well enough Americans should be vaccinated by May

As the number of Covid-19 cases in the United States passed 12 million, the Trump administration’s vaccine program adviser predicted that life in America could be back to normal around May of 2021 as immunization is set to begin.

The note of optimism came even as millions of Americans were expected to travel for the upcoming Thanksgiving holiday this week and many appeared to be ignoring warnings from health officials about furthering the spread of the infectious disease.

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France to ease Covid rules as Asian countries consider stricter action

WHO says Europe faces third wave early in 2021 if nations repeat their failures to prepare

France is preparing to ease its Covid-19 lockdown rules in the weeks leading up to Christmas with new daily caseloads falling and pressure building from retailers to allow the annual shopping season to go ahead.

But parts of east Asia that were thought to be controlling the disease have raised the possibility of new restrictions.

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Is this the beginning of an mRNA vaccine revolution? | Adam Finn

No one knew whether mRNA technology would work against this virus – but it does. It’s an extraordinary moment for science

The past few months have brought a number of scientific terms to public attention. We’ve had to digest R (a virus’s reproduction number) and PCR (the polymerase chain reaction method of testing). And now there’s mRNA. This last one has featured heavily in recent news reports because of the spectacular results of two new mRNA vaccines against coronavirus. It stands for “messenger ribonucleic acid”, a label familiar enough if you studied biology at O-level or GCSE, but otherwise hardly a household name. Even in the field of vaccine research, if you had said as recently as 10 years ago that you could protect people from infections by injecting them with mRNA, you would have provoked some puzzled looks.

Essentially, mRNA is a molecule used by living cells to turn the gene sequences in DNA into the proteins that are the building blocks of all their fundamental structures. A segment of DNA gets copied (“transcribed”) into a piece of mRNA, which in turn gets “read” by the cell’s tools for synthesising proteins. In the case of an mRNA vaccine, the virus’s mRNA is injected into the muscle, and our own cells then read it and synthesise the viral protein. The immune system reacts to these proteins – which can’t by themselves cause disease – just as if they’d been carried in on the whole virus. This generates a protective response that, we hope, lasts for some time. It’s so beautifully simple it almost seems like science fiction. But last week we learned that it was true.

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Why the race to find Covid-19 vaccines is far from over

Despite the promising news from Pfizer and Moderna, other efforts – which may be even more effective – continue around the world

While everyone celebrated this month’s news that not one but two experimental vaccines against Covid-19 have proved at least 90% effective at preventing disease in late-stage clinical trials, research into understanding how the Sars-CoV-2 virus, which causes Covid-19, interacts with the human immune system never paused.

There are plenty of questions still to answer about the Pfizer/BioNTech and Moderna vaccines: how well will they protect the elderly, for example, and how long for? Which aspects of the immune response that they elicit are protective and which aren’t? Can even better results be achieved, with vaccines that target different parts of the immune system?

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Michael J Fox: ‘Every step now is a frigging math problem, so I take it slow’

After living with Parkinson’s for 30 years, the actor still counts himself a lucky man. He reflects on what his diagnosis has taught him about hope, acting, family and medical breakthroughs

The last time I spoke to Michael J Fox, in 2013, in his office in New York, he was 90% optimistic and 10% pragmatic. The former I expected; the latter was a shock. Ever since 1998, when Fox went public with his diagnosis of early-onset Parkinson’s disease, he has made optimism his defining public characteristic, because of, rather than despite, his illness. He called his 2002 memoir Lucky Man, and he told interviewers that Parkinson’s is a gift, “albeit one that keeps on taking”.

During our interview, surrounded by the memorabilia (guitars, Golden Globes) he has accrued over the course of his career, he talked about how it had all been for the best. Parkinson’s, he said, had made him quit drinking, which in turn had probably saved his marriage. Being diagnosed at the heartbreakingly young age of 29 had also knocked the ego out of his career ambitions, so he could do smaller things he was proud of – Stuart Little, the TV sitcom Spin City – as opposed to the big 90s comedies, such as Doc Hollywood, that were too often a waste of his talents. To be honest, I didn’t entirely buy his tidy silver linings, but who was I to cast doubt on whatever perspective Fox had developed to make a monstrously unjust situation more bearable? So the sudden dose of pragmatism astonished me. Finding a cure for Parkinson’s, he said, “is not something that I view will happen in my lifetime”. Previously, he had talked about finding “a cure within a decade”. No more. “That’s just the way it goes,” he said quietly. It was like a dark cloud had partly obscured the sun.

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Covid vaccine technology pioneer: ‘I never doubted it would work’

Katalin Karikó’s mRNA research helped pave way for Pfizer/BioNTech and Moderna’s successful work

The Hungarian-born biochemist who helped pioneer the research behind the mRNA technology used in the two Covid-19 vaccines showing positive results believes it was always a no-brainer.

“I never doubted it would work,” Katalin Karikó told the Guardian. “I had seen the data from animal studies, and I was expecting it. I always wished that I would live long enough to see something that I’ve worked on be approved.”

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Scientists race to find ‘warm’ Covid vaccine to solve issue of cold storage

With potential injectable vaccines estimated to be out of reach for two-thirds of world’s population, scientists hope to find less-heat-sensitive formulations

News that one of the potential coronavirus vaccines had at least a 90% efficacy rate was a “victory for science”, said K Srinath Reddy, a cardiologist and president of the Public Health Foundation of India. But it meant little to his country’s 1.3 billion citizens.

“For us, the Pfizer vaccine is more of a scientific curiosity than a practical possibility,” Reddy said.

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Coronavirus is evolving. Whether it gets deadlier or not may depend on us | Laura Spinney

There’s now evidence that ignoring social distancing rules could help more lethal strains of Covid-19 to win out

Letting the virus that causes Covid-19 circulate more-or-less freely is dangerous not only because it risks overwhelming hospitals and so endangering lives unnecessarily, but also because it could delay the evolution of the virus to a more benign form and potentially even make it more lethal.

Though the data is still sketchy and the measures crude, this effect may already be influencing the difference in death rates between Sweden – which took a relaxed approach to containment until recently – and Norway, whose measures have been much stricter. Sweden has more than three times as many deaths per 100 cases as its neighbour.

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Covid-19 antibodies reduce faster in men than women – study

Finding has implications for one-size-fits-all approach to vaccine development

Antibody levels against the virus that causes Covid-19 appear to fall faster in men than in women, a study suggests – a finding that could have implications for vaccine research.

Historically, medical research has often taken a one-size-fits-all approach, lumping women and men together despite growing evidence that the sexes differ in how they catch and fight disease. Covid-19 seems to be a case in point, with women more likely to be infected but men thought to be up to twice as likely to die from the virus.

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Dolly Parton partly funded Moderna Covid vaccine research

The country music icon’s $1m donation supported the latest breakthrough by Moderna and several research papers

It’s truly the greatest gift of all: a $1m donation by Dolly Parton to coronavirus vaccine research supported the development of the Moderna vaccine, which shows 95% protection from the virus.

In April, Parton donated £800,000 to research after her friend Dr Naji Abumrad of the Vanderbilt Institute for Infection, Immunology and Inflammation at Vanderbilt University in Tennessee told her that they were making “some exciting advancements” in the search for a cure for the virus. Abumrad and Parton became friends in 2014 after the singer was involved in a car accident and treated at Vanderbilt.

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Covid: chemicals found in everyday products could hinder vaccine

Researchers worry PFAS, commonly found in the bodies of Americans, will reduce the immunization’s effectiveness

The successful uptake of any vaccine for Covid-19, a crucial step in returning a sense of normalcy after a year ravaged by the coronavirus pandemic, could be hindered by widespread contamination from a range of chemicals used in everyday products.

Small amounts of per- and polyfluoroalkyl (or PFAS) chemicals are commonly found in the bodies of people in the US, as well as several other countries. These man-made chemicals, used in everything from non-stick pans to waterproof clothes to pizza boxes, have been linked to an elevated risk of liver damage, decreased fertility and even cancer.

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Researchers confirm human-to-human transmission of rare virus in Bolivia

Chapare virus, which causes haemorrhagic fevers, was transmitted to health workers in La Paz and resulted in three deaths

Researchers with the US Centers for Disease Control and Prevention have discovered human-to-human transmission of a rare virus in Bolivia belonging to a family of viruses that can cause haemorrhagic fevers, such as Ebola.

The news is a reminder that scientists are working to identify new viral threats to humankind, even as countries around the world battle a new wave of Covid-19 outbreaks.

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Hopes of Covid vaccine for more than 1bn people by end of 2021

Moderna becomes second firm to reveal positive results with nearly 95% protection in trials

More than 1 billion people could be immunised against coronavirus by the end of next year with shots from the first two companies to reveal positive results, after the latest vaccine was shown to be nearly 95% effective in trials.

With the US’s top infectious diseases official, Anthony Fauci, hailing “the light at the end of the tunnel”, the US biotech firm Moderna announced impressive results for its mRNA vaccine on Monday, a week after interim results for a Pfizer/BioNTech vaccine showed 90% effectiveness.

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Latest vaccine success is good news but high price may restrict access

Moderna results show Pfizer success was not flash in the pan, but poorer countries may have to look elsewhere

The success of Moderna’s vaccine against Covid-19 is reason for the whole world to cheer. The results from an interim analysis of the trial data are remarkably similar to those of Pfizer/BioNTech a week ago. Most people – Moderna says 94.5% in its trial, Pfizer said more than 90% – were protected from illness.

It’s fantastic news. It means the concept works. Pfizer’s results were not a flash in the pan. Both vaccines have been developed using a new technology that has never produced a licensed vaccine before, called messenger RNA (mRNA), which some hail as the future of all vaccines. It has the potential to deliver vaccines for all sorts of diseases cheaply and safely, enthusiasts say. And, crucially for the time being, they are likely to help us out of the Covid pandemic.

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What does the Moderna vaccine mean for the fight against Covid?

How does it work and how is it different from the Pfizer/BioNTech jab?

As promising results are released from a second vaccine trial, we take a look at what this could mean in the battle against Covid-19.

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Covid: Boris Johnson and Tory MPs forced to self-isolate after No 10 event

PM says he is in good health and has no coronavirus symptoms ahead of crucial week

A string of Conservative MPs are self-isolating following a meeting inside Downing Street that has forced Boris Johnson to spend a potentially crucial political week holed up inside No 10.

The prime minister, who was seriously ill with coronavirus in April, has insisted he is fine and that his body “is bursting with antibodies” after being ordered to self-isolate following a meeting with northern Tory MPs on Thursday.

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Damage to multiple organs recorded in ‘long Covid’ cases

Exclusive: study of low-risk individuals finds impairments four months after infection

Young and previously healthy people with ongoing symptoms of Covid-19 are showing signs of damage to multiple organs four months after the initial infection, a study suggests.

The findings are a step towards unpicking the physical underpinnings and developing treatments for some of the strange and extensive symptoms experienced by people with “long Covid”, which is thought to affect more than 60,000 people in the UK. Fatigue, brain fog, breathlessness and pain are among the most frequently reported effects.

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Cannabis resin now 25% more potent, global study reveals

Concentrations of intoxicating THC have risen, data from more than 80,000 street drug samples gathered over 50 years shows

Cannabis resin – or “hash” – has increased in strength by nearly 25% over the past half century, a major international study has revealed.

Researchers with the Addiction and Mental Health Group at the University of Bath analysed data from more than 80,000 cannabis street samples tested in the past 50 years in the US, UK, Netherlands, France, Denmark, Italy and New Zealand.

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