Hopes of Covid vaccine for more than 1bn people by end of 2021

Moderna becomes second firm to reveal positive results with nearly 95% protection in trials

More than 1 billion people could be immunised against coronavirus by the end of next year with shots from the first two companies to reveal positive results, after the latest vaccine was shown to be nearly 95% effective in trials.

With the US’s top infectious diseases official, Anthony Fauci, hailing “the light at the end of the tunnel”, the US biotech firm Moderna announced impressive results for its mRNA vaccine on Monday, a week after interim results for a Pfizer/BioNTech vaccine showed 90% effectiveness.

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Latest vaccine success is good news but high price may restrict access

Moderna results show Pfizer success was not flash in the pan, but poorer countries may have to look elsewhere

The success of Moderna’s vaccine against Covid-19 is reason for the whole world to cheer. The results from an interim analysis of the trial data are remarkably similar to those of Pfizer/BioNTech a week ago. Most people – Moderna says 94.5% in its trial, Pfizer said more than 90% – were protected from illness.

It’s fantastic news. It means the concept works. Pfizer’s results were not a flash in the pan. Both vaccines have been developed using a new technology that has never produced a licensed vaccine before, called messenger RNA (mRNA), which some hail as the future of all vaccines. It has the potential to deliver vaccines for all sorts of diseases cheaply and safely, enthusiasts say. And, crucially for the time being, they are likely to help us out of the Covid pandemic.

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What does the Moderna vaccine mean for the fight against Covid?

How does it work and how is it different from the Pfizer/BioNTech jab?

As promising results are released from a second vaccine trial, we take a look at what this could mean in the battle against Covid-19.

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Covid: Boris Johnson and Tory MPs forced to self-isolate after No 10 event

PM says he is in good health and has no coronavirus symptoms ahead of crucial week

A string of Conservative MPs are self-isolating following a meeting inside Downing Street that has forced Boris Johnson to spend a potentially crucial political week holed up inside No 10.

The prime minister, who was seriously ill with coronavirus in April, has insisted he is fine and that his body “is bursting with antibodies” after being ordered to self-isolate following a meeting with northern Tory MPs on Thursday.

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Damage to multiple organs recorded in ‘long Covid’ cases

Exclusive: study of low-risk individuals finds impairments four months after infection

Young and previously healthy people with ongoing symptoms of Covid-19 are showing signs of damage to multiple organs four months after the initial infection, a study suggests.

The findings are a step towards unpicking the physical underpinnings and developing treatments for some of the strange and extensive symptoms experienced by people with “long Covid”, which is thought to affect more than 60,000 people in the UK. Fatigue, brain fog, breathlessness and pain are among the most frequently reported effects.

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Cannabis resin now 25% more potent, global study reveals

Concentrations of intoxicating THC have risen, data from more than 80,000 street drug samples gathered over 50 years shows

Cannabis resin – or “hash” – has increased in strength by nearly 25% over the past half century, a major international study has revealed.

Researchers with the Addiction and Mental Health Group at the University of Bath analysed data from more than 80,000 cannabis street samples tested in the past 50 years in the US, UK, Netherlands, France, Denmark, Italy and New Zealand.

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Coronavirus live news: UK records 26,860 more cases and 462 deaths; US sees record 184,000 new daily cases

Italy has registered 37,255 new coronavirus infections over the past 24 hours, the health ministry announced on Saturday, down from 40,902 on Friday.

The ministry also recorded 544 Covid-related deaths, down from 550 the day before, Reuters reports.

Sixteen people have been arrested after hundreds of protestors attended an anti-lockdown demonstration in Liverpool city centre.

ARRESTS | 25 people have now been arrested in #Liverpool city centre for public order offences and breaches of Coronavirus regulations. A further male has been arrested after a police officer was assaulted. Please read our statement about why it's so important people stay home: pic.twitter.com/XcLXXLpuPH

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Matrix party ‘disguised as film shoot’ to bypass German Covid rules

Keanu Reeves among 200 people at studio party where guests came as extras, says report

German health authorities say they plan to speak to the studio where the latest Matrix film was shot after a party allegedly attended by the Hollywood actor Keanu Reeves was held to mark the end of filming, despite coronavirus restrictions.

About 200 people were at the party disguised as a film shoot, with the guests invited to come as extras in an apparent attempt to bypass health regulations, according to the German tabloid Bild.

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Covid test for mass UK screening could miss up to half of cases, say scientists

Some trials of lateral flow test from US firm Innova found it was much less accurate than the government said it was

The lateral flow test bought by the UK government for mass testing in Liverpool, and potentially the whole country, could miss up to half of those who have Covid-19, according to experts.

The government has great expectations of the Innova test, having signed two contracts with the California-based company behind it. Innova told the Guardian it was now shipping more than one million tests a day to the UK.

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Coronavirus live news: Italy deaths highest since 6 April; France lockdown to last at least two more weeks

Italy registers 636 daily deaths; French PM says no easing of restrictions as cases remain high; Germany seeing tentative signs of flattening curve

Greece reported 3,316 new coronavirus cases on Thursday, its highest daily tally since its first infection surfaced in February, according to health authorities data.

The latest jump in infections brings the total number of cases in the country to 66,637.

Donald Trump’s adviser Corey Lewandowski has become the latest member of the outgoing president’s staff to test positive for coronavirus.

Lewandowski recently traveled to Pennsylvania to assist Trump’s efforts to contest the state’s election results. He said today he believes he was infected in Philadelphia and is not experiencing any symptoms.

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French professor faces disciplinary case over hydroxychloroquine claims

Didier Raoult stands accused of touting drug as a coronavirus treatment without evidence

A French professor who touts the anti-malaria drug hydroxychloroquine as a coronavirus treatment – without evidence, scientists say – will appear before a disciplinary panel charged with ethics breaches, an order of doctors has said.

Marseille-based Didier Raoult stands accused by his peers of spreading false information about the benefits of the drug. His promotion of hydroxychloroquine was taken up by the US and Brazilian presidents, Donald Trump and Jair Bolsonaro, who trumpeted its unproven benefits in a way critics say put people’s lives at risk.

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Pfizer and BioNTech’s vaccine poses global logistics challenge

Europe and US create vast facilities for Covid-19 vaccine but poorer nations lack infrastructure, say experts

Two vast football-pitch-sized facilities equipped with hundreds of large freezers in Kalamazoo, Michigan, and Puurs, Belgium, will be the centres of the huge effort to ship the coronavirus vaccine, developed by US drug giant Pfizer and German biotech firm BioNTech, around the world.

Governments are scrambling to prepare for the rollout of the vaccine, which must be stored at -70C (-94F), after the announcement from the two companies that it was more than 90% effective and had no serious side-effects. The news sparked hopes of a return to normal life and a stock market rally, but now minds are turning to the practicalities of getting the vaccine quickly to populations across the world, in particular to the vulnerable people who need it most.

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6 key questions about the Pfizer/BioNTech Covid-19 vaccine

There are grounds for optimism but also several unknowns around this coronavirus vaccine

Hopes that the end of the coronavirus pandemic has become nearer have soared after the news that a coronavirus vaccine was found to be 90% effective in global trials.

Although there is definite reason to be optimistic, experts have cautioned that the data from the trials conducted by Pfizer and BioNTech are not final, and there remain plenty of unknowns.

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Nearly one in five Covid patients later diagnosed with mental illness – study

US data shows nearly twice as many diagnoses over three months among those testing positive

Nearly one in five people who have had Covid-19 are diagnosed with a psychiatric disorder such as anxiety, depression or insomnia within three months of testing positive for the virus, according to a study that suggests action is needed to mitigate the mental health toll of the pandemic.

The analysis – conducted by researchers from the University of Oxford and NIHR Oxford Health Biomedical Research Centre – also found that people with a pre-existing mental health diagnosis were 65% more likely to be diagnosed with Covid-19 than those without, even accounting for known risk factors such as age, sex, race, and underlying physical conditions.

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Hopes rise for end of pandemic as Pfizer says vaccine is 90% effective

Global stocks surge and experts optimistic as Covid vaccine exceeds expectations

Hopes are soaring that a Covid vaccine is within reach, following news that an interim analysis has shown Pfizer/BioNTech’s candidate was 90% effective in protecting people from transmission of the virus in global trials.

The vaccine performed much better than most experts had hoped for, according to the companies’ analysis, and brings into view a potential end to a pandemic that has killed more than a million people, battered economies and upended daily life worldwide.

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Could a Covid vaccine bring back normality?

With test and trace a shambles, many are pinning their hopes on a jab. But experts warn more measures will be needed to vanquish the coronavirus

England is back in lockdown. It happened not a moment too soon. As of 2 November almost three-quarters of a million new cases have been officially counted since 21 September, when the government’s scientific advisory committee Sage advised lockdown. On that day, Britain had only had about 360,000 cases since Covid arrived. Now the figure is three times that. So many more cases mean it will take longer, and possibly require tougher social restrictions, to get numbers down by imposing lockdown than it would have in September, says James Naismith, head of the Rosalind Franklin Institute in Oxford.

Naismith calculates that we will have 500 deaths per day in two to three weeks because of the cases that occurred over the past week, compared with an average of 144 in the week ending 2 November. But it could be far worse. If we had done nothing for another two weeks, he says, we’d be looking at 1,000 deaths a day by Christmas – and more, if hospitals fill up and not everyone can get optimal treatment.

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Travel to UK from Denmark to be banned amid worries over Covid in mink

Chris Whitty, chief medical officer for England, understood to be concerned by new strain

All travel to the UK from Denmark is being banned amid mounting concern over an outbreak in the country of a mutation of coronavirus linked to mink, the Guardian understands.

Downing Street had already taken action to remove Denmark from the travel corridor, forcing arrivals to quarantine for two weeks from Friday at 4am.

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UK coronavirus live: estimated 618,700 people in England had Covid last week; Liverpool begins mass-testing

Latest updates: ONS figures represent around 1.13% of population; Operation Moonshot trial launches in Liverpool on Friday

A coronavirus passport app promoted by the Olympian Zara Tindall has been reported to a health regulator over concerns it is mis-selling antibody tests.

The V-Health Passport was touted as a “game changer” to get sports fans back into stadiums and major events. It involves spectators getting a rapid antibody test prior to attending an event, with results uploaded on a health passport on an app.

In the advert, Zara and Mike Tindall were being told they don’t have the virus – you can’t say that. This could do harm, with people getting into sporting events with negative results while they are infectious.

I have no problem with the app, it’s the use of the app. A lot of health professionals have seen it with their head in their hands.

Some schools may be sending children home “too readily” amid the pandemic, the chief inspector of Ofsted has said.

Parents of pupils with special educational needs and disabilities (SEND) have been told that schools cannot accommodate their children due to Covid-19 risk assessments, according to Amanda Spielman.

And here, many parents haven’t made an active decision to keep their child at home – they’ve been told that schools can’t accommodate them. Because it’s too difficult, because Covid risk assessments won’t allow it. It’s deeply concerning and, understandably, many parents feel cut adrift.

For the children with SEND that have been able to get back into education, it hasn’t been plain sailing either. We’re hearing that many have suffered setbacks in their communication skills – probably down to having reduced social interaction for such a long time.

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How UK government misrepresented Covid projections – explained

No 10 has admitted an ‘error’ in the way data was presented to make case for second lockdown

The UK Statistics Authority has rebuked the government over its lack of transparency around projected Covid-19 deaths and hospital admissions, saying it could cast doubt over official figures.

A range of estimates were used to make the case for a second English lockdown in a press conference on 31 October. However, the UKSA said “the data and assumptions for this model had not been shared transparently”, potentially undermining confidence in official figures.

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Covid immune response faster and stronger post-infection, scientists say

Strongest evidence yet found of sustained defence in people who recover from coronavirus

Scientists have found the strongest evidence yet that people who recover from Covid may mount a much faster and more effective defence against the infection if they encounter the virus again.

Researchers at Rockefeller University in New York found that the immune system not only remembered the virus but improved the quality of protective antibodies after an infection had passed, equipping the body to unleash a swift and potent attack if the virus invaded a second time.

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