Michael J Fox: ‘Every step now is a frigging math problem, so I take it slow’

After living with Parkinson’s for 30 years, the actor still counts himself a lucky man. He reflects on what his diagnosis has taught him about hope, acting, family and medical breakthroughs

The last time I spoke to Michael J Fox, in 2013, in his office in New York, he was 90% optimistic and 10% pragmatic. The former I expected; the latter was a shock. Ever since 1998, when Fox went public with his diagnosis of early-onset Parkinson’s disease, he has made optimism his defining public characteristic, because of, rather than despite, his illness. He called his 2002 memoir Lucky Man, and he told interviewers that Parkinson’s is a gift, “albeit one that keeps on taking”.

During our interview, surrounded by the memorabilia (guitars, Golden Globes) he has accrued over the course of his career, he talked about how it had all been for the best. Parkinson’s, he said, had made him quit drinking, which in turn had probably saved his marriage. Being diagnosed at the heartbreakingly young age of 29 had also knocked the ego out of his career ambitions, so he could do smaller things he was proud of – Stuart Little, the TV sitcom Spin City – as opposed to the big 90s comedies, such as Doc Hollywood, that were too often a waste of his talents. To be honest, I didn’t entirely buy his tidy silver linings, but who was I to cast doubt on whatever perspective Fox had developed to make a monstrously unjust situation more bearable? So the sudden dose of pragmatism astonished me. Finding a cure for Parkinson’s, he said, “is not something that I view will happen in my lifetime”. Previously, he had talked about finding “a cure within a decade”. No more. “That’s just the way it goes,” he said quietly. It was like a dark cloud had partly obscured the sun.

Continue reading...

Covid vaccine technology pioneer: ‘I never doubted it would work’

Katalin Karikó’s mRNA research helped pave way for Pfizer/BioNTech and Moderna’s successful work

The Hungarian-born biochemist who helped pioneer the research behind the mRNA technology used in the two Covid-19 vaccines showing positive results believes it was always a no-brainer.

“I never doubted it would work,” Katalin Karikó told the Guardian. “I had seen the data from animal studies, and I was expecting it. I always wished that I would live long enough to see something that I’ve worked on be approved.”

Continue reading...

Scientists race to find ‘warm’ Covid vaccine to solve issue of cold storage

With potential injectable vaccines estimated to be out of reach for two-thirds of world’s population, scientists hope to find less-heat-sensitive formulations

News that one of the potential coronavirus vaccines had at least a 90% efficacy rate was a “victory for science”, said K Srinath Reddy, a cardiologist and president of the Public Health Foundation of India. But it meant little to his country’s 1.3 billion citizens.

“For us, the Pfizer vaccine is more of a scientific curiosity than a practical possibility,” Reddy said.

Continue reading...

Coronavirus is evolving. Whether it gets deadlier or not may depend on us | Laura Spinney

There’s now evidence that ignoring social distancing rules could help more lethal strains of Covid-19 to win out

Letting the virus that causes Covid-19 circulate more-or-less freely is dangerous not only because it risks overwhelming hospitals and so endangering lives unnecessarily, but also because it could delay the evolution of the virus to a more benign form and potentially even make it more lethal.

Though the data is still sketchy and the measures crude, this effect may already be influencing the difference in death rates between Sweden – which took a relaxed approach to containment until recently – and Norway, whose measures have been much stricter. Sweden has more than three times as many deaths per 100 cases as its neighbour.

Continue reading...

Covid-19 antibodies reduce faster in men than women – study

Finding has implications for one-size-fits-all approach to vaccine development

Antibody levels against the virus that causes Covid-19 appear to fall faster in men than in women, a study suggests – a finding that could have implications for vaccine research.

Historically, medical research has often taken a one-size-fits-all approach, lumping women and men together despite growing evidence that the sexes differ in how they catch and fight disease. Covid-19 seems to be a case in point, with women more likely to be infected but men thought to be up to twice as likely to die from the virus.

Continue reading...

Dolly Parton partly funded Moderna Covid vaccine research

The country music icon’s $1m donation supported the latest breakthrough by Moderna and several research papers

It’s truly the greatest gift of all: a $1m donation by Dolly Parton to coronavirus vaccine research supported the development of the Moderna vaccine, which shows 95% protection from the virus.

In April, Parton donated £800,000 to research after her friend Dr Naji Abumrad of the Vanderbilt Institute for Infection, Immunology and Inflammation at Vanderbilt University in Tennessee told her that they were making “some exciting advancements” in the search for a cure for the virus. Abumrad and Parton became friends in 2014 after the singer was involved in a car accident and treated at Vanderbilt.

Continue reading...

Covid: chemicals found in everyday products could hinder vaccine

Researchers worry PFAS, commonly found in the bodies of Americans, will reduce the immunization’s effectiveness

The successful uptake of any vaccine for Covid-19, a crucial step in returning a sense of normalcy after a year ravaged by the coronavirus pandemic, could be hindered by widespread contamination from a range of chemicals used in everyday products.

Small amounts of per- and polyfluoroalkyl (or PFAS) chemicals are commonly found in the bodies of people in the US, as well as several other countries. These man-made chemicals, used in everything from non-stick pans to waterproof clothes to pizza boxes, have been linked to an elevated risk of liver damage, decreased fertility and even cancer.

Continue reading...

Researchers confirm human-to-human transmission of rare virus in Bolivia

Chapare virus, which causes haemorrhagic fevers, was transmitted to health workers in La Paz and resulted in three deaths

Researchers with the US Centers for Disease Control and Prevention have discovered human-to-human transmission of a rare virus in Bolivia belonging to a family of viruses that can cause haemorrhagic fevers, such as Ebola.

The news is a reminder that scientists are working to identify new viral threats to humankind, even as countries around the world battle a new wave of Covid-19 outbreaks.

Continue reading...

Hopes of Covid vaccine for more than 1bn people by end of 2021

Moderna becomes second firm to reveal positive results with nearly 95% protection in trials

More than 1 billion people could be immunised against coronavirus by the end of next year with shots from the first two companies to reveal positive results, after the latest vaccine was shown to be nearly 95% effective in trials.

With the US’s top infectious diseases official, Anthony Fauci, hailing “the light at the end of the tunnel”, the US biotech firm Moderna announced impressive results for its mRNA vaccine on Monday, a week after interim results for a Pfizer/BioNTech vaccine showed 90% effectiveness.

Continue reading...

Latest vaccine success is good news but high price may restrict access

Moderna results show Pfizer success was not flash in the pan, but poorer countries may have to look elsewhere

The success of Moderna’s vaccine against Covid-19 is reason for the whole world to cheer. The results from an interim analysis of the trial data are remarkably similar to those of Pfizer/BioNTech a week ago. Most people – Moderna says 94.5% in its trial, Pfizer said more than 90% – were protected from illness.

It’s fantastic news. It means the concept works. Pfizer’s results were not a flash in the pan. Both vaccines have been developed using a new technology that has never produced a licensed vaccine before, called messenger RNA (mRNA), which some hail as the future of all vaccines. It has the potential to deliver vaccines for all sorts of diseases cheaply and safely, enthusiasts say. And, crucially for the time being, they are likely to help us out of the Covid pandemic.

Continue reading...

What does the Moderna vaccine mean for the fight against Covid?

How does it work and how is it different from the Pfizer/BioNTech jab?

As promising results are released from a second vaccine trial, we take a look at what this could mean in the battle against Covid-19.

Continue reading...

Covid: Boris Johnson and Tory MPs forced to self-isolate after No 10 event

PM says he is in good health and has no coronavirus symptoms ahead of crucial week

A string of Conservative MPs are self-isolating following a meeting inside Downing Street that has forced Boris Johnson to spend a potentially crucial political week holed up inside No 10.

The prime minister, who was seriously ill with coronavirus in April, has insisted he is fine and that his body “is bursting with antibodies” after being ordered to self-isolate following a meeting with northern Tory MPs on Thursday.

Continue reading...

Damage to multiple organs recorded in ‘long Covid’ cases

Exclusive: study of low-risk individuals finds impairments four months after infection

Young and previously healthy people with ongoing symptoms of Covid-19 are showing signs of damage to multiple organs four months after the initial infection, a study suggests.

The findings are a step towards unpicking the physical underpinnings and developing treatments for some of the strange and extensive symptoms experienced by people with “long Covid”, which is thought to affect more than 60,000 people in the UK. Fatigue, brain fog, breathlessness and pain are among the most frequently reported effects.

Continue reading...

Cannabis resin now 25% more potent, global study reveals

Concentrations of intoxicating THC have risen, data from more than 80,000 street drug samples gathered over 50 years shows

Cannabis resin – or “hash” – has increased in strength by nearly 25% over the past half century, a major international study has revealed.

Researchers with the Addiction and Mental Health Group at the University of Bath analysed data from more than 80,000 cannabis street samples tested in the past 50 years in the US, UK, Netherlands, France, Denmark, Italy and New Zealand.

Continue reading...

Coronavirus live news: UK records 26,860 more cases and 462 deaths; US sees record 184,000 new daily cases

Italy has registered 37,255 new coronavirus infections over the past 24 hours, the health ministry announced on Saturday, down from 40,902 on Friday.

The ministry also recorded 544 Covid-related deaths, down from 550 the day before, Reuters reports.

Sixteen people have been arrested after hundreds of protestors attended an anti-lockdown demonstration in Liverpool city centre.

ARRESTS | 25 people have now been arrested in #Liverpool city centre for public order offences and breaches of Coronavirus regulations. A further male has been arrested after a police officer was assaulted. Please read our statement about why it's so important people stay home: pic.twitter.com/XcLXXLpuPH

Continue reading...

Matrix party ‘disguised as film shoot’ to bypass German Covid rules

Keanu Reeves among 200 people at studio party where guests came as extras, says report

German health authorities say they plan to speak to the studio where the latest Matrix film was shot after a party allegedly attended by the Hollywood actor Keanu Reeves was held to mark the end of filming, despite coronavirus restrictions.

About 200 people were at the party disguised as a film shoot, with the guests invited to come as extras in an apparent attempt to bypass health regulations, according to the German tabloid Bild.

Continue reading...

Covid test for mass UK screening could miss up to half of cases, say scientists

Some trials of lateral flow test from US firm Innova found it was much less accurate than the government said it was

The lateral flow test bought by the UK government for mass testing in Liverpool, and potentially the whole country, could miss up to half of those who have Covid-19, according to experts.

The government has great expectations of the Innova test, having signed two contracts with the California-based company behind it. Innova told the Guardian it was now shipping more than one million tests a day to the UK.

Continue reading...

Coronavirus live news: Italy deaths highest since 6 April; France lockdown to last at least two more weeks

Italy registers 636 daily deaths; French PM says no easing of restrictions as cases remain high; Germany seeing tentative signs of flattening curve

Greece reported 3,316 new coronavirus cases on Thursday, its highest daily tally since its first infection surfaced in February, according to health authorities data.

The latest jump in infections brings the total number of cases in the country to 66,637.

Donald Trump’s adviser Corey Lewandowski has become the latest member of the outgoing president’s staff to test positive for coronavirus.

Lewandowski recently traveled to Pennsylvania to assist Trump’s efforts to contest the state’s election results. He said today he believes he was infected in Philadelphia and is not experiencing any symptoms.

Continue reading...

French professor faces disciplinary case over hydroxychloroquine claims

Didier Raoult stands accused of touting drug as a coronavirus treatment without evidence

A French professor who touts the anti-malaria drug hydroxychloroquine as a coronavirus treatment – without evidence, scientists say – will appear before a disciplinary panel charged with ethics breaches, an order of doctors has said.

Marseille-based Didier Raoult stands accused by his peers of spreading false information about the benefits of the drug. His promotion of hydroxychloroquine was taken up by the US and Brazilian presidents, Donald Trump and Jair Bolsonaro, who trumpeted its unproven benefits in a way critics say put people’s lives at risk.

Continue reading...

Pfizer and BioNTech’s vaccine poses global logistics challenge

Europe and US create vast facilities for Covid-19 vaccine but poorer nations lack infrastructure, say experts

Two vast football-pitch-sized facilities equipped with hundreds of large freezers in Kalamazoo, Michigan, and Puurs, Belgium, will be the centres of the huge effort to ship the coronavirus vaccine, developed by US drug giant Pfizer and German biotech firm BioNTech, around the world.

Governments are scrambling to prepare for the rollout of the vaccine, which must be stored at -70C (-94F), after the announcement from the two companies that it was more than 90% effective and had no serious side-effects. The news sparked hopes of a return to normal life and a stock market rally, but now minds are turning to the practicalities of getting the vaccine quickly to populations across the world, in particular to the vulnerable people who need it most.

Continue reading...