How race to track mystery gene with links to three cancers saved millions

25 years ago, a mutation was discovered that makes some people susceptible to the disease, and now it has transformed treatment

Ten years ago, Tony Herbert developed a lump on the right side of his chest. The clump of tissue grew and became painful and he was tested for breast cancer. The result was positive.

“I had surgery and chemotherapy and that worked,” he said last week. But how had Herbert managed to develop a condition that is so rare in men? Only about 400 cases of male breast cancer are diagnosed every year in the UK compared with around 55,000 in women. A genetic test revealed the answer. Herbert had inherited a pathogenic version of a gene called BRCA2 and this mutation had triggered his condition.

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Now we have the coronavirus vaccine, how soon can we get back to normal life?

The government has ordered sufficient doses to inoculate the entire population of the UK against Covid-19 but we are in for a long haul

When will the Covid-19 vaccine begin to have an effect on the nation?

The government has pledged to offer vaccines to 15 million people – the over-70s, healthcare workers and those required to shield by mid-February, and millions more by spring. This should slowly bring the virus under control although it will take many weeks before we can be sure the vaccine is having an effect. Numbers of daily cases of Covid-19 may drop but that decline could simply be due to impact of current lockdown measures. Only when hospital admissions start to reduce significantly will we be sure the vaccine is having an impact. Then there could be be a slackening of lockdown measures. Few scientists believe that will happen before Easter, however.

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Why the delay? The nations waiting to see how Covid vaccinations unfold

Australia, New Zealand, Taiwan and Japan are among those that won’t start vaccinating for months, in part to see how other populations react to the jab

They are the nations that have been held up as shining examples of coronavirus management. In Australia, New Zealand and Taiwan, daily Covid infections are in the single digits and outbreaks are quickly suppressed.

But there is one area where these nations lag well behind the pack in vaccination. Countries with some of the most enviable healthcare systems in the world – including Australia, New Zealand, Japan and South Korea – will not begin to inoculate until the end of February or later.

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Which countries have reported the new UK Covid variant?

The visuals show 13 countries have recorded community transmission of UK variant, as 24 experience rising case rates

Forty-five countries have so far identified the UK coronavirus variant, with experts warning that more countries could report sharp increases in cases in the coming weeks.

Thirteen of these nations have recorded community transmission of the B117 variant, which spreads faster and has helped pushed England into a third lockdown.

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Fears Covid vaccines would not work against South Africa variant led to travel curbs

Minister says extra check on travellers introduced as ‘we simply cannot take chances’

Fears that Covid vaccines will not work against the new South African strain of the virus have prompted the introduction of testing for new arrivals into England and Scotland from abroad, the transport secretary, Grant Shapps, has said.

Outlining the new testing regime for England and Scotland, he told Sky News: “This is an extra check and we’re doing this now because there are these variants that we’re very keen to keep out of the country, like the South African variant, for example.

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Food for thought? French bean plants show signs of intent, say scientists

Many botanists dispute idea of plant sentience, but study of climbing beans sows seed of doubt

They’ve provided us with companionship and purpose during the darkest days of lockdown, not to mention brightening our Instagram feeds. But the potted cacti, yucca, and swiss cheese plants we’ve welcomed into our homes are entirely passive houseguests. Aren’t they?

Research suggests that at least one type of plant – the french bean – may be more sentient than we give it credit for: namely, it may possess intent.

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Europe at tipping point with Covid running rampant, says WHO

Europe director Hans Kluge says rapid spread of new variant is cause for alarm

Europe is at a tipping point in the course of the pandemic, the World Health Organization has said, warning that the coronavirus is spreading very fast across the continent and the arrival of a new variant has created an “alarming situation”.

Related: Coronavirus live news: Japan's PM announces state of emergency for Tokyo; US suffers record daily deaths

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What’s the scientific basis for delaying the Covid vaccine second dose?

UK health officials also allowing combining doses from different manufacturers

UK health officials have decided to delay giving second doses of Covid-19 vaccines and even permit combining doses from different manufacturers, prompting international concern. What is the scientific justification for this decision?

Why has the UK decided to lengthen the gap between the first and second doses of vaccine?
The original plan was to offer priority groups an initial shot of vaccine, followed by a second dose three weeks later. But a rapid increase in the number of Covid-19 cases, combined with the emergence of a more transmissible variant and uncertainty about the supply of vaccine stocks, prompted the Joint Committee on Vaccination and Immunisation (JCVI) to consider other options.

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Change in the weather: German storm names to be more diverse

Symbolic #WeatherCorrection is part of campaign for inclusivity in society

Move over, Siegfried. Ahmet is on the way.

A journalists’ group has named a low pressure system bringing low temperatures, dark clouds and snow to Germany after the boy’s name of Turkish origin in an effort to increase the visibility of the country’s increasingly diverse population.

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Covid lockdown in England likely in place until March, Gove warns

Minister says time needed for vaccine to take effect means restrictions cannot definitely be lifted in mid-February

The third national lockdown imposed in England to try to deal with the huge increase in Covid-19 cases is likely to remain in place into March at least, with some measures lasting even longer, the government has indicated.

The cabinet secretary, Michael Gove, said he hoped the gradual lifting of restrictions could begin in mid-February, but that the time it took for the vaccines to take effect meant it was likely to be at least another couple of weeks before measures could start to be eased.

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21 things to look forward to in 2021 – from meteor showers to the Olympics

From finally seeing the back of Donald Trump to being in a football stadium – the new year is full of promise

You probably found a few things to enjoy about last year: you rediscovered your bicycle, perhaps, or your family, or even both, and learned to love trees. And don’t forget the clapping. Plus some brilliant scientists figured out how to make a safe and effective vaccine for a brand new virus in record time.

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UK to move to highest coronavirus alert level as full lockdowns loom

Boris Johnson to make TV announcement on Monday night after pressure to tackle soaring infection rate

The government is expected to announce new steps to control the spread of coronavirus, as the chief medical officers recommended that the UK move to the highest coronavirus alert level.

Boris Johnson is due to make a TV address on Monday evening where he is set to announce mass school closures and tight lockdown restrictions. MPs will be recalled to parliament from Wednesday.

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Analysis: is it wise for England to mix and match Covid vaccines?

US experts warn against plan to give different second jab if supplies run low

The UK is setting the pace around the world in the approval and use of Covid vaccines but, while other countries watch intently, not all are yet prepared to embrace what looks like public health pragmatism rather than strict adherence to evidence.

Britain is the first country in the world to approve and use the Oxford/AstraZeneca vaccine, just as it was first with Pfizer/BioNTech’s. In a further trailblazing decision, it is giving everyone a first shot of either of those vaccines, with the second shot delayed to 12 weeks afterwards instead of the three- or four-week interval in the trials.

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Keir Starmer calls for immediate lockdown in England as Covid cases soar

Labour leader urges prime minister to impose new nationwide restrictions within next 24 hours

The Labour leader, Keir Starmer, has urged Boris Johnson to avoid delay by imposing new nationwide restrictions in England within the next 24 hours to tackle the “out of control” virus.

After the prime minister earlier on Sunday raised the prospect of tougher Covid-19 restrictions amid concerns over pressure on the NHS, Starmer intervened to argue action must be taken immediately and that it was no good hinting at curbs to come in future.

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India’s approval of covid vaccines triggers mass immunisation drive

Green light for Oxford vaccine alongside domestic Covaxin hailed as ‘decisive turning point’ by PM

India has granted emergency approval to both the Oxford/AstraZeneca coronavirus vaccine and the domestically developed Covaxin, signalling the start of one of the largest Covid-19 immunisation drives in the world.

At a press conference on Sunday, the drugs controller general of India said the decision to approve both the Oxford vaccine and Covaxin, which is produced by the Indian company Bharat Biotech and was part-funded by the government, had come after “careful examination” of the data.

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I lived like an astronaut for months in isolation

Kate Greene had a headstart in coping with lockdown cabin fever after living inside a geodesic dome at 8,000ft, as part of a space experiment

Once upon a time I lived on Mars. Or the closest thing to it. At the time I was a science journalist and not necessarily an obvious choice for the mission. And yet I found myself on it. This was 2012 and Kim Binsted, professor of information and computer sciences at the University of Hawaii, along with Jean Hunter, professor of biological and environmental engineering at Cornell, had put out a call for “almost” astronauts to participate in a four-month “Mars” mission.

Binsted and Hunter wanted a crew who could technically qualify for space flight, according to Nasa, in terms of education and experience. They were also looking for astronaut-like personalities who, according to Binsted, feature “thick skin, a long fuse and an optimistic outlook”. Nearly 700 people applied worldwide.

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Jane Goodall: ‘Change is happening. There are many ways to start moving in the right way’

The primatologist and ecological activist on why population isn’t the cause of climate change, and why she’s encouraging optimism

Jane Goodall is a primatologist who is regarded as one of the world’s leading authorities on chimpanzees. She has spent 60 years studying the chimps that live in the Gombe Stream national park and she is a prominent advocate, via several foundations, of protecting the great apes and their habitats. She has been presented with awards by the UN and various governments for her conservation and environmental work. She appears in the Netflix documentary The Beginning of Life 2.

You warned last June that humanity will be finished if we don’t make drastic changes in response to the coronavirus pandemic and the climate crisis. Have you seen any indication of that drastic change?
The window is closing. Business as usual – using up natural resources faster and faster – can’t carry on. In some cases, we are already using resources faster than they can be replenished. And we can see the consequences. Look at climate change. It is not something that might happen in the future; we are already seeing terrible hurricanes and floods and fires. It is building up into an inferno. When you think globally like that, it is very, very depressing.

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Finding time for creativity will give you respite from worries

Drawing, singing, writing, knitting… lose yourself in something creative to find inner calm. You might also come up with solutions to problems

When the first lockdown began in March, my son developed a persistent cough. I was anxious and when I couldn’t sleep I would write. Inspired by the author Elizabeth Gilbert, whose soothing Instagram I would turn to in the ungodly hours, and reassured by her pragmatic take on creative endeavours, I poured my anxiety on to the page and lost myself in my story.

My son’s cough wasn’t Covid-19 as it turned out, but writing about it had helped me manage my fears around the pandemic and given me direction. Now it’s New Year, and lockdown, in some shape or another, is still a reality while most of us wait for the vaccine. There is light at the end of the tunnel, but until we get there, I have a strong feeling that making something might just help.

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Dr Anthony Fauci says US will not delay second doses of Covid vaccine

American infectious disease expert disagrees with UK’s plans to prioritise first doses

The American infectious disease expert Dr Anthony Fauci has said he does not agree with the UK’s approach of delaying the second dose of the Pfizer/BioNTech vaccine.

On Friday, Dr Fauci told CNN that the United States would not be following in the UK’s footsteps and would follow Pfizer and BioNTech’s guidance to administer the second dose of its vaccine three weeks after the first.

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