Coronavirus live news: Macron says worst of French second wave over; death tolls in Italy and Spain surge

French president says lockdown to ease; Italy reports most daily deaths since late March; Spain’s daily deaths highest of second wave

Scientists have warned the UK’s Christmas coronavirus plans, which will allow up to three households form a “bubble” to meet over the festive period, will cause the virus to spread and lead to further deaths.

Martin McKee, the professor of European public health at the London School of Hygiene and Tropical Medicine, said: “We know that the virus spreads easiest where people mix together, close to each other, for long periods of time indoors. These are exactly the conditions the government seems to be encouraging.”

Brazil registered a further 31,100 confirmed Covid-19 cases over the last 24 hours and 630 deaths, the health ministry said.

The South American nation has now registered 6,118,708 cases since the pandemic began and the official death toll has risen to 170,115, according to ministry data.

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China launches Chang’e-5 mission to bring back rocks from moon

Lunar landing is due in about eight days and entire mission is scheduled to last 23 days

China has launched a robotic spacecraft to bring back rocks from the moon – the first such attempt by any country since the 1970s.

The Long March-5, China’s largest carrier rocket, blasted off at 4.30am Beijing time on Tuesday from Wenchang space launch centre on the island of Hainan carrying the Chang’e-5 spacecraft.

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Vaccine results bring us a step closer to ending Covid, says Oxford scientist

Latest breakthrough comes as PM says he hopes most at-risk could be immunised by Easter

The world is moving a step closer to ending the coronavirus pandemic, the scientist behind Britain’s first vaccine has declared, as Boris Johnson said he hoped the majority of those most at-risk could be immunised by Easter.

Successful trial results for the Oxford University/AstraZeneca vaccine, suggesting it could protect up to 90% of people, are the third set of promising findings in as many weeks. Before this year, there had never been a vaccine for a coronavirus.

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Oxford AstraZeneca vaccine to be sold to developing countries at cost price

Jab that is part of global initiative to distribute doses will remain at low price ‘in perpetuity’

The coronavirus vaccine produced by Oxford University and AstraZeneca will be available on a non-profit basis “in perpetuity” to low- and middle-income countries in the developing world.

The details of arrangements to supply poorer countries came as AstraZeneca revealed the interim results of a phase 3 trial of the vaccine, which is being heralded as the first to meet the more challenging requirements of the developing world.

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Oxford AstraZeneca Covid vaccine has up to 90% efficacy, data reveals

Vaccine developed in UK by AstraZeneca and Oxford University ‘will save many lives’, says scientist

A coronavirus vaccine developed in the UK can prevent 70.4% of people from getting Covid-19 and up to 90% if a lower dose is used, according to data.

Oxford University and AstraZeneca have announced their jab is effective in preventing many people getting ill and it has been shown to work in different age groups, including the elderly. There are early indications it might also help stop the spread of the disease.

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Ice Bucket Challenge co-creator Patrick Quinn dies aged 37

Quinn credited with boosting ‘greatest social media campaign in history’, raising more than $220m for ALS research

Patrick Quinn, whose personal battle with Lou Gehrig’s disease helped power the Ice Bucket Challenge fundraising campaign, has died aged 37, seven years after his diagnosis, according to the ALS Association and his supporters on Facebook.

Quinn, who was born and grew up in Yonkers, New York, was co-founder of the campaign that raised more than $220m for medical research into amyotrophic lateral sclerosis (ALS), more commonly known as Lou Gehrig’s disease. He was diagnosed with ALS on 8 March 2013.

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Mass Covid-19 testing to start in England to head off Tory revolt

Proposals include plans to limit self-isolation and to allow household mixing at Christmas

A programme of mass, instant coronavirus testing is to be rolled out to areas of England with the highest infection rates after lockdown is lifted next month, the prime minister has announced, as the government faces an unprecedented internal rebellion over Covid measures.

Among the plans, which will rely on the ability to massively expand rapid testing systems across the country, is a scheme to stop people who have come into close contact with someone who has coronavirus from having to isolate for 14 days, if tests show they have not contracted it.

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France to ease Covid rules as Asian countries consider stricter action

WHO says Europe faces third wave early in 2021 if nations repeat their failures to prepare

France is preparing to ease its Covid-19 lockdown rules in the weeks leading up to Christmas with new daily caseloads falling and pressure building from retailers to allow the annual shopping season to go ahead.

But parts of east Asia that were thought to be controlling the disease have raised the possibility of new restrictions.

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Is this the beginning of an mRNA vaccine revolution? | Adam Finn

No one knew whether mRNA technology would work against this virus – but it does. It’s an extraordinary moment for science

The past few months have brought a number of scientific terms to public attention. We’ve had to digest R (a virus’s reproduction number) and PCR (the polymerase chain reaction method of testing). And now there’s mRNA. This last one has featured heavily in recent news reports because of the spectacular results of two new mRNA vaccines against coronavirus. It stands for “messenger ribonucleic acid”, a label familiar enough if you studied biology at O-level or GCSE, but otherwise hardly a household name. Even in the field of vaccine research, if you had said as recently as 10 years ago that you could protect people from infections by injecting them with mRNA, you would have provoked some puzzled looks.

Essentially, mRNA is a molecule used by living cells to turn the gene sequences in DNA into the proteins that are the building blocks of all their fundamental structures. A segment of DNA gets copied (“transcribed”) into a piece of mRNA, which in turn gets “read” by the cell’s tools for synthesising proteins. In the case of an mRNA vaccine, the virus’s mRNA is injected into the muscle, and our own cells then read it and synthesise the viral protein. The immune system reacts to these proteins – which can’t by themselves cause disease – just as if they’d been carried in on the whole virus. This generates a protective response that, we hope, lasts for some time. It’s so beautifully simple it almost seems like science fiction. But last week we learned that it was true.

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Hackers ‘try to steal Covid vaccine secrets in intellectual property war’

Agencies point finger at state-sponsored hackers from China, Russia, Iran and North Korea

State-sponsored hackers from China, Russia, Iran and North Korea are engaged in concerted attempts to steal coronavirus vaccine secrets in what security experts describe as “an intellectual property war”.

They accuse hostile-state hackers of trying to obtain trial results early and seize sensitive information about mass production of drugs, at a time when a range of vaccines are close to being approved for the public.

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Which countries and hackers are targeting Covid vaccine developers?

The states and their hackers that security experts believe are targeting vaccine developers

Russia’s best-known hacker groups – Fancy Bear and Cozy Bear – are considered to be linked to the country’s intelligence organisations, according to western security agencies.

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Why the race to find Covid-19 vaccines is far from over

Despite the promising news from Pfizer and Moderna, other efforts – which may be even more effective – continue around the world

While everyone celebrated this month’s news that not one but two experimental vaccines against Covid-19 have proved at least 90% effective at preventing disease in late-stage clinical trials, research into understanding how the Sars-CoV-2 virus, which causes Covid-19, interacts with the human immune system never paused.

There are plenty of questions still to answer about the Pfizer/BioNTech and Moderna vaccines: how well will they protect the elderly, for example, and how long for? Which aspects of the immune response that they elicit are protective and which aren’t? Can even better results be achieved, with vaccines that target different parts of the immune system?

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Coronavirus live: UK lab-confirmed cases pass 1.5m; Gaza’s clinics could soon be overwhelmed

Infections up in UK by more than 18,000 on Sunday; warning over Gaza Strip infections; G20 leaders agree to fund fair distribution of vaccines

Experts have urged Americans against travelling for family gatherings at Thanksgiving this week even though millions were set to defy the advice, as the US crossed the threshold of more than 12m cases of coronavirus.

Ominous warnings came as Donald Trump appeared to admit that coronavirus is “running wild” across the US, in contrast with his statements throughout the election campaign that the virus would simply “go away” or “disappear” and, more recently, that the country was “rounding the turn” on the pandemic.

Related: Millions of Americans set to ignore warnings against Thanksgiving travel

The Palestinian health ministry has recommended strict limits on Christmas celebrations in Bethlehem this year due to the coronavirus outbreak.

Celebrations in the biblical town revered by Christians as Jesus’ birthplace are usually attended by thousands of people from around the world, but this year the ministry has recommended the upcoming tree lighting ceremony in Manger Square be limited to 50 people, throughout the festive season.

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Boris Johnson under pressure as scientists back tight rules for Christmas

PM set to announce end to lockdown before trying to broker national agreement on family gatherings

Boris Johnson will meet his cabinet remotely on Sunday to decide how people will be able to gather with loved ones at Christmas, before the announcement of a new Covid winter plan.

The prime minister, who is self-isolating, will then confirm by video to parliament on Monday that national restrictions will end on 2 December and be replaced by the three-tier regional system, with even tighter controls in some areas.

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Meave Leakey: ‘Definitely, Africa is where it all began’

The renowned fossil hunter on the anti-African prejudice in palaeontology, her dream discovery, and bathing her daughter beside a baby hippo

For over 50 years, British-born palaeoanthropologist Meave Leakey has been unearthing fossils of our early ancestors in Kenya’s Turkana Basin. Her discoveries have changed how we think about our origins. Instead of a tidy ape-to-human progression, her work suggests different pre-human species living simultaneously. Leakey’s new memoir, The Sediments of Time: My Lifelong Search for the Past, co-written with her daughter Samira, reflects on her life in science and pieces together what we now understand about the climate-driven evolution of our species.

Leakey is part of a famous family of palaeoanthropologists. Her husband, Richard Leakey, and his parents, Louis and Mary, are known for their discoveries of early hominins.

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Michael J Fox: ‘Every step now is a frigging math problem, so I take it slow’

After living with Parkinson’s for 30 years, the actor still counts himself a lucky man. He reflects on what his diagnosis has taught him about hope, acting, family and medical breakthroughs

The last time I spoke to Michael J Fox, in 2013, in his office in New York, he was 90% optimistic and 10% pragmatic. The former I expected; the latter was a shock. Ever since 1998, when Fox went public with his diagnosis of early-onset Parkinson’s disease, he has made optimism his defining public characteristic, because of, rather than despite, his illness. He called his 2002 memoir Lucky Man, and he told interviewers that Parkinson’s is a gift, “albeit one that keeps on taking”.

During our interview, surrounded by the memorabilia (guitars, Golden Globes) he has accrued over the course of his career, he talked about how it had all been for the best. Parkinson’s, he said, had made him quit drinking, which in turn had probably saved his marriage. Being diagnosed at the heartbreakingly young age of 29 had also knocked the ego out of his career ambitions, so he could do smaller things he was proud of – Stuart Little, the TV sitcom Spin City – as opposed to the big 90s comedies, such as Doc Hollywood, that were too often a waste of his talents. To be honest, I didn’t entirely buy his tidy silver linings, but who was I to cast doubt on whatever perspective Fox had developed to make a monstrously unjust situation more bearable? So the sudden dose of pragmatism astonished me. Finding a cure for Parkinson’s, he said, “is not something that I view will happen in my lifetime”. Previously, he had talked about finding “a cure within a decade”. No more. “That’s just the way it goes,” he said quietly. It was like a dark cloud had partly obscured the sun.

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Covid vaccine technology pioneer: ‘I never doubted it would work’

Katalin Karikó’s mRNA research helped pave way for Pfizer/BioNTech and Moderna’s successful work

The Hungarian-born biochemist who helped pioneer the research behind the mRNA technology used in the two Covid-19 vaccines showing positive results believes it was always a no-brainer.

“I never doubted it would work,” Katalin Karikó told the Guardian. “I had seen the data from animal studies, and I was expecting it. I always wished that I would live long enough to see something that I’ve worked on be approved.”

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Coronavirus live news: Brazil passes 6m cases as South Australia reports new case

Donald Trump Jr tests positive for Covid; South Australia makes pizza worker scapegoat for failures; German doctor arrested on suspicion of killing two Covid patients. Follow latest updates

via Reuters

Mexico’s confirmed coronavirus death toll has risen to 100,823, according the the country’s health ministry.

In case you missed it earlier:

In Australia, New South Wales has reached two weeks – one complete infection cycle – without a single locally transmitted coronavirus case, AAP reports.

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Coronavirus live news: UK records 341 more deaths; Russia reports record new cases and deaths

Donald Trump Jr tests positive for Covid; South Australia lockdown to end at midnight on Saturday; global cases pass 57.5m. Follow latest updates

The number of Covid-19 cases in the United States was on track to surpass 12 million on Saturday, just days ahead of the Thanksgiving holiday that health experts have warned could fuel the surging spread of infection around the country.

The milestone marks a worsening of the country’s Covid-19 epidemic, which has claimed a quarter of a million lives across America, more than in any other nation.

Turkey on Saturday reported its highest daily number of new coronavirus patients since the outbreak started.

Figures from the health ministry showed that 5,532 people had been diagnosed with Covid-19 symptoms in the previous 24 hours.

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Scientists race to find ‘warm’ Covid vaccine to solve issue of cold storage

With potential injectable vaccines estimated to be out of reach for two-thirds of world’s population, scientists hope to find less-heat-sensitive formulations

News that one of the potential coronavirus vaccines had at least a 90% efficacy rate was a “victory for science”, said K Srinath Reddy, a cardiologist and president of the Public Health Foundation of India. But it meant little to his country’s 1.3 billion citizens.

“For us, the Pfizer vaccine is more of a scientific curiosity than a practical possibility,” Reddy said.

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