Mexico deaths pass 100,000 as fragments found in Victorian sewage

Obrador rejects criticism as political attacks; Canada fears big rise in cases could overwhelm hospitals; Italy records 37,242 new cases

This blog is now closed. Follow our continuing coronavirus coverage here

Marshall is asked if he admits there have been shortcomings in South Australia’s hotel quarantine system.

“Not at all. There will be a thorough investigation but what we have said since day one is this is a highly contagious disease ... we know that, very highly trained nurses and with all of their PPE, they have been able to contract the disease, so we know there is a risk associated with every time we bring somebody into this country,” he says.

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US to shut down famed huge Arecibo space telescope in Puerto Rico jungle

The observatory has played a key part in space exploration – and a few movies – but two accidents have rendered the 305m-wide instrument unsafe

A huge US space telescope nestled deep in the Puerto Rican jungle will be shut down after suffering two destructive mishaps in recent months, ending 57 years of astronomical discoveries.

Operations at the Arecibo observatory, one of the largest in the world, were halted in August when one of its supportive cables slipped loose from its socket, falling and gashing a 30-metre (100ft) hole in its 305m-wide (1,000ft) reflector dish.

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Coronavirus is evolving. Whether it gets deadlier or not may depend on us | Laura Spinney

There’s now evidence that ignoring social distancing rules could help more lethal strains of Covid-19 to win out

Letting the virus that causes Covid-19 circulate more-or-less freely is dangerous not only because it risks overwhelming hospitals and so endangering lives unnecessarily, but also because it could delay the evolution of the virus to a more benign form and potentially even make it more lethal.

Though the data is still sketchy and the measures crude, this effect may already be influencing the difference in death rates between Sweden – which took a relaxed approach to containment until recently – and Norway, whose measures have been much stricter. Sweden has more than three times as many deaths per 100 cases as its neighbour.

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Coronavirus live news: Russia exceeds 2m cases; Danish mink Covid mutation ‘most likely extinct’

Russia passes landmark number as 23,610 new cases reported; Denmark says no further cases of mutation since mid-September

The UK will be urged to reconsider its opposition to waiving intellectual property rights for Covid-19 vaccines and treatments at a World Trade Organization meeting on Friday, a move that would allow mass production of treatments and inoculations against the disease and could significantly shorten the length of the pandemic, campaigners say.

India and South Africa have proposed that WTO member states be allowed to waive patents and other intellectual property (IP) rights on any treatments and tools related to Covid-19 until the end of the pandemic, including for the Moderna and Pfizer/BionNTech vaccines that are set to be approved for use in the coming weeks.

Related: UK faces calls to drop opposition to patent-free Covid vaccines

More mink mutation news: a number of cases of Covid-19 have been found in people who work in the mink industry in Sweden.

In a statement the Swedish Public Health Agency said it and “the Swedish Veterinary Institute, the Swedish Board of Agriculture and local infection control units are jointly investigating whether there is any connection between the cases and their contact with minks.”

Flera myndigheter utreder fall av covid-19 inom minknäringen. https://t.co/TRDin3ZZHG

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Covid-19 mink variants discovered in humans in seven countries

Denmark has already launched a nationwide cull of its farmed mink herd after concerns for vaccine efficacy

Seven countries are now reporting mink-related Sars-CoV-2 mutations in humans, according to new scientific analysis.

The mutations are identified as Covid-19 mink variants as they have repeatedly been found in mink and now in humans as well.

Uncertainty around the implications of the discovery of a Covid-19 mink variant in humans led Denmark, the world’s largest mink fur producer, to launch a nationwide cull earlier this month.

The cull was sparked by research from Denmark’s public health body, the Statens Serum Institut (SSI), which showed that a mink variant called C5 was harder for antibodies to neutralise and posed a potential threat to vaccine efficacy.

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Covid-19 antibodies reduce faster in men than women – study

Finding has implications for one-size-fits-all approach to vaccine development

Antibody levels against the virus that causes Covid-19 appear to fall faster in men than in women, a study suggests – a finding that could have implications for vaccine research.

Historically, medical research has often taken a one-size-fits-all approach, lumping women and men together despite growing evidence that the sexes differ in how they catch and fight disease. Covid-19 seems to be a case in point, with women more likely to be infected but men thought to be up to twice as likely to die from the virus.

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Coronavirus live news: US doctors urge Trump to share Covid data; record cases in Tokyo

Medical establishment says cooperation can save lives; UK pressed to open transatlantic travel corridors; South Australia locks down for 6 days

I am handing over the blog to my colleague Alexandra Topping in the UK.

Thanks for reading but if you’re just joining, here are the main developments of the past few hours:

Businesses in the Japanese capital, Tokyo, could be asked to shorten their opening hours in order to contain an outbreak of the virus that has seen cases in the city reach a record daily high of 472 on Wednesday.

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Covid: near-lockdown curbs imposed on west of Scotland

Eleven local authorities to enter level 4 – highest of Scotland’s five-tier system of virus controls

More than 2.7 million Scots will face near-lockdown restrictions for three weeks after Nicola Sturgeon imposed the country’s highest level of Covid restrictions across the west of Scotland.

Following a cabinet meeting on Tuesday morning, Scotland’s first minister told MSPs that 11 local authority areas would enter level 4 – the highest of Scotland’s five-tier system of virus controls – from 6pm this Friday for a limited period.

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Dolly Parton partly funded Moderna Covid vaccine research

The country music icon’s $1m donation supported the latest breakthrough by Moderna and several research papers

It’s truly the greatest gift of all: a $1m donation by Dolly Parton to coronavirus vaccine research supported the development of the Moderna vaccine, which shows 95% protection from the virus.

In April, Parton donated £800,000 to research after her friend Dr Naji Abumrad of the Vanderbilt Institute for Infection, Immunology and Inflammation at Vanderbilt University in Tennessee told her that they were making “some exciting advancements” in the search for a cure for the virus. Abumrad and Parton became friends in 2014 after the singer was involved in a car accident and treated at Vanderbilt.

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UK, Italy and Spain record highest daily death totals since spring – as it happened

This blog is closing now but you can follow our continuing live coverage here. Thanks for reading.

Related: Coronavirus live news: senator Chuck Grassley tests positive; airlines offer Covid testing

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Blinking hell: how to keep tired eyes healthy during a pandemic

Are you worried your vision has grown worse this year? You’re definitely not alone. But from the 20-20-20 rule to changing the size of your text, there are simple ways to address it

In the pandemic, our eyes are working harder than ever. With the majority of our communication nonverbal, and all but the upper third of our faces covered by masks, we are more reliant on them to express tone, emotion and even individuality, with a recent explosion in online tutorials for “mask makeup looks” emphasising long lashes, bright eyeshadows and statement liner.

Yet as we rely on our eyes to do the talking, we may also be putting them under greater strain. In June, a survey by the College of Optometrists, the professional body in the UK, found that 22% of people polled believed their vision had worsened during lockdown. The reason why they might feel this way is obvious: when the mask comes off, most of the time our gaze is trained on a screen.

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Scents of history: study hopes to recreate smells of old Europe

Researchers plan library of scents from plague repellents to early tobacco

From the pungent scent of a cigar to the gentle fragrance of roses, smells can transport us to days gone by. Now researchers are hoping to harness the pongs of the past to do just that.

Scientists, historians and experts in artificial intelligence across the UK and Europe have announced they are teaming up for a €2.8m project labelled “Odeuropa” to identify and even recreate the aromas that would have assailed noses between the 16th and early 20th centuries.

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Researchers confirm human-to-human transmission of rare virus in Bolivia

Chapare virus, which causes haemorrhagic fevers, was transmitted to health workers in La Paz and resulted in three deaths

Researchers with the US Centers for Disease Control and Prevention have discovered human-to-human transmission of a rare virus in Bolivia belonging to a family of viruses that can cause haemorrhagic fevers, such as Ebola.

The news is a reminder that scientists are working to identify new viral threats to humankind, even as countries around the world battle a new wave of Covid-19 outbreaks.

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Hopes of Covid vaccine for more than 1bn people by end of 2021

Moderna becomes second firm to reveal positive results with nearly 95% protection in trials

More than 1 billion people could be immunised against coronavirus by the end of next year with shots from the first two companies to reveal positive results, after the latest vaccine was shown to be nearly 95% effective in trials.

With the US’s top infectious diseases official, Anthony Fauci, hailing “the light at the end of the tunnel”, the US biotech firm Moderna announced impressive results for its mRNA vaccine on Monday, a week after interim results for a Pfizer/BioNTech vaccine showed 90% effectiveness.

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Moderna vaccine’s effectiveness bodes well for Oxford/AstraZeneca jab

Phase 3 success rate of 95% for US firm’s treatment is promising for UK vaccine trial

Hopes are rising for the Covid jab being developed by Oxford University, after Moderna became the second company to reveal impressive results from its vaccine trials.

Interim results from phase 3 clinical trials of the Covid vaccine from US company Moderna has revealed it to be almost 95% effective at preventing the disease. The news followed an announcement last week from Germany-based Pfizer and BioNTech that their vaccine was more than 90% effective.

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Latest vaccine success is good news but high price may restrict access

Moderna results show Pfizer success was not flash in the pan, but poorer countries may have to look elsewhere

The success of Moderna’s vaccine against Covid-19 is reason for the whole world to cheer. The results from an interim analysis of the trial data are remarkably similar to those of Pfizer/BioNTech a week ago. Most people – Moderna says 94.5% in its trial, Pfizer said more than 90% – were protected from illness.

It’s fantastic news. It means the concept works. Pfizer’s results were not a flash in the pan. Both vaccines have been developed using a new technology that has never produced a licensed vaccine before, called messenger RNA (mRNA), which some hail as the future of all vaccines. It has the potential to deliver vaccines for all sorts of diseases cheaply and safely, enthusiasts say. And, crucially for the time being, they are likely to help us out of the Covid pandemic.

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What does the Moderna vaccine mean for the fight against Covid?

How does it work and how is it different from the Pfizer/BioNTech jab?

As promising results are released from a second vaccine trial, we take a look at what this could mean in the battle against Covid-19.

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Coronavirus live news: Japan may reimpose state of emergency; Sweden limits public gatherings to eight people

Moderna is latest to reveal impressive vaccine results; Sweden cuts public gatherings limit from 300 as it blames fall in adherence to rules

South Africa has recorded 1,245 new coronavirus cases and 73 further deaths.

The caseload stands at 752,269 , while 20,314 people have died.

#COVID19 Statistics in SA as at 16 November.

Use the COVID Alert SA app to protect yourself, your loved ones and your community. Start using this privacy preserving app today. Add your phone to the fight! Download the Covid Alert SA app now! https://t.co/8YKEqaiiRF pic.twitter.com/MwMJovMXA9

The Australian state of Victoria has recorded its 18th day without a new coronavirus case or death.

Yesterday there were 0 new cases, 0 lives lost. Three active cases remain, 0 with an unknown source. #EveryTestHelps and thanks to all who were tested, there were 17,412 results received. https://t.co/pcll7ySEgz#StaySafeStayOpen #COVID19Vic pic.twitter.com/k0HwjYcBrE

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Coronavirus live news: Russia and Iran report worst daily increase; Merkel to push for tougher curbs in Germany

Russia confirms over 22,000 new cases; Iran sees 13,053 new cases; German chancellor wants masks in all schools and more contact restrictions

We have more from Reuters on the tough new measures expected to be agreed in Germany, in a meeting between state leaders and the chancellor, Angela Merkel, later on Monday.

Earlier we reported how they would include compulsory mask-wearing at schools and drastic restrictions on household gatherings. A draft document of the measures, seen by Reuters, also said people would be urged to avoid private parties completely in coming weeks.

Hullo! This is Damien Gayle taking the reins on the live blog now for the rest of the working day here in the UK.

If you have any interesting coronavirus-related news, suggestions or comments from your part of the world, that you think is worth our including on the blog, please drop me a line, either via email to damien.gayle@theguardian.com, or via Twitter DM to @damiengayle.

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Covid: Boris Johnson and Tory MPs forced to self-isolate after No 10 event

PM says he is in good health and has no coronavirus symptoms ahead of crucial week

A string of Conservative MPs are self-isolating following a meeting inside Downing Street that has forced Boris Johnson to spend a potentially crucial political week holed up inside No 10.

The prime minister, who was seriously ill with coronavirus in April, has insisted he is fine and that his body “is bursting with antibodies” after being ordered to self-isolate following a meeting with northern Tory MPs on Thursday.

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