How Covid changed medicine for the future

The global pandemic sparked a huge superhuman effort to control coronavirus. But the billions spent have also had an unexpected impact on medicine and science

When Tom Pooley, 21, became the first person to receive an experimental vaccine against plague as part of a medical trial last summer after tests on mice, he was inspired by the thought that his involvement could help to rid the world of one of the most brutal killers in human history.

“They made it quite clear I was the first human to receive it,” says Pooley, a radiotherapy engineering student. “They didn’t dress it up, but they made it clear it was as safe as possible. There are risks, but they are talented people: it’s a big honour to be the first.” The single-shot, based on the Chadox technology developed by the Oxford Vaccine Group and AstraZeneca, took less than five seconds to painlessly administer, he says. That night, he felt a little unwell, but he was fine within three hours; and the small trial continued apace to combat the centuries-old bacteria threat, which killed 171 in Madagascar as recently as 2017. It uses a weakened, genetically altered version of a common-cold virus from chimpanzees.

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Living with Covid: what are risks of England’s plan to lift restrictions?

As the new plan is set to be announced, here’s what might change, from testing to shielding

As Britain emerges from the Omicron wave, ministers are thrashing out a “living safely with Covid” plan for England expected to be announced next week. The strategy should see freedoms expanded back towards pre-pandemic norms in an attempt to readjust people’s attitudes towards coronavirus.

The decisions taken this weekend in Whitehall will have major repercussions for public health across the country. While vaccines have drastically blunted Covid hospitalisations and deaths, and restrictions came with significant downsides, lifting further measures is unlikely to come without a cost – particularly for those in vulnerable groups.

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Ending all Covid restrictions ‘premature and not based on evidence’, says BMA

Council chair says decision not guided by data or made in consultation with health profession

Ending all Covid restrictions is premature and “not based on current evidence”, the British Medical Association has said, as experts warned dropping testing and self-isolation could lead to a surge in cases.

Boris Johnson told MPs last week that he was preparing to lift the legal requirement in England to self-isolate on 24 February, a month earlier than originally planned, with a formal announcement expected on Monday.

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Six African countries to begin making mRNA vaccines as part of WHO scheme

Egypt, Kenya, Nigeria, Senegal, South Africa and Tunisia first countries to be assisted by global mRNA hub

Six African countries – Egypt, Kenya, Nigeria, Senegal, South Africa and Tunisia – will be the first on the continent to receive the technology needed to produce their own mRNA vaccines from a scheme headed by the World Health Organization.

The groundbreaking project aims to assist low- and middle-income countries in manufacturing mRNA vaccines at scale and according to international standards, with the aim of ending much of the reliance of African countries on vaccine manufacturers outside the continent.

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US has suffered more than 1m excess deaths during pandemic, CDC finds

The latest statistic hints at the breadth of Covid-19’s impact on health in the United States

There have been more than 1m excess deaths in the US during the pandemic, according to the US Centers for Disease Control and Prevention (CDC).

The deaths are mainly attributable to Covid-19, as well as conditions that may have resulted from delayed medical care and overwhelmed health systems.

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Brains do not slow down until after age of 60, study finds

Findings go against the assumption that mental processing speed declines from a peak at age 20

It is widely accepted as one of life’s bleak but unavoidable facts: as we get older, our brains get slower. But now a study, based on data from more than 1 million people, suggests that mental processing speed remains almost constant until the age of 60.

The analysis puts perceived reductions in speed down to people becoming more cautious as they get older. This could account for the large body of research that has concluded that mental processing speed peaks at about the age of 20 and undergoes a steady decline from that point onwards.

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US parents of under-fives clamor for off-label use over Covid vaccine delays

Authorities warn against surreptitious use of authorized vaccines for younger children due to no safety and efficacy data

As news broke recently that the Covid vaccine for children under five would be delayed in the US amid ongoing clinical trials, a call to make the vaccines off-label for use among those children gained force – but officials caution against vaccinating young children without any safety or efficacy data for this age group.

When providers sign an agreement to provide Covid-19 vaccine shots, they also agree not to give the vaccine off-label, or use it for purposes other than what it was approved to do.

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If they could turn back time: how tech billionaires are trying to reverse the ageing process

Jeff Bezos and Peter Thiel are pouring huge sums into startups aiming to keep us all young – or even cheat death. And the science isn’t as far-fetched as you might think

In the summer of 2019, months before the word “coronavirus” entered the daily discourse, Diljeet Gill was double-checking data from his latest experiment. He was investigating what happens when old human skin cells are “reprogrammed” – a process used in labs around the world to turn adult cells (heart, brain, muscle and the like) – into stem cells, the body’s equivalent of a blank slate.

Gill, a PhD student at the Babraham Institute near Cambridge, had stopped the reprogramming process midway to see how the cells responded. Sure of his findings, he took them to his supervisor, Wolf Reik, a leading authority in epigenetics. What Gill’s work showed was remarkable: the aged skin had become more youthful – and by no small margin. Tests found that the cells behaved as if they were 25 years younger. “That was the real wow moment for me,” says Reik. “I fell off my chair three times.”

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The ugly truth: beauty’s not just skin deep – gorgeous people may be healthier too

Good-looking people may be better at fighting infections, a study finds, so don’t feel shallow when you swipe right

Name: Gorgeous people.

Age: Considerable. Certainly of greater longevity than poor saps like you who’ve been battered by the ugly stick and, let’s face it, will probably die sooner than hotties like me.

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‘The pleasure of a chancer unmasked’: why we are living in the age of schadenfreude

Watching the misfortunes of Boris Johnson or Novak Djokovic is deliciously satisfying – and unmistakably human. But is it wrong to submit to our basest instincts?

No one is especially shy about the anger they feel about the partygate shambles in Downing Street, nor should they be. We are all a bit more discreet, though, about how enjoyable it is to watch the prime minister’s downfall. It hits every base of funny, from the slapstick to the surreal; a comedy home run. But there is something delicious here that is richer than humour. To see a chancer unmasked is a very particular pleasure.

Likewise, I would happily give you my thoughts on the international tennis elite and their stance on vaccination. But why it was so droll to see Novak Djokovic detained in and then deported from Australia I would struggle to say; I never had anything against the man.

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‘Every year it astounds us’: the Orkney dig uncovering Britain’s stone age culture

Archaeologists excavating the windswept Ness of Brodgar are unearthing a treasure trove of neolithic villages, tombs, weapons and mysterious religious artefacts, some to be displayed in a blockbuster exhibition

If you happen to imagine that there’s not much left to discover of Britain’s stone age, or that its relics consist of hard-to-love postholes and scraps of bones, then you need to find your way to Orkney, that scatter of islands off Scotland’s north-east coast. On the archipelago’s Mainland, out towards the windswept west coast with its wave-battered cliffs, you will come to the Ness of Brodgar, an isthmus separating a pair of sparkling lochs, one of saltwater and one of freshwater. Just before the way narrows you’ll see the Stones of Stenness rising up before you. This ancient stone circle’s monoliths were once more numerous, but they remain elegant and imposing. Like a gateway into a liminal world of theatricality and magic, they lead the eye to another, even larger neolithic monument beyond the isthmus, elevated in the landscape as if on a stage. This is the Ring of Brodgar, its sharply individuated stones like giant dancers arrested mid-step – as local legend, indeed, has it.

It’s between these two stone circles that archaeologist Nick Card and his team are excavating a huge settlement of neolithic stone buildings. The earliest date from about 3300BC, their walls and hearths crisply intact, their pots and stone tools in remarkable profusion, the whole bounded by six-metre-wide monumental walls. “You could continue for several lifetimes and not get to the bottom of it,” says the neatly white-bearded, laconic Card as we gaze out over the site, presently covered with tarpaulin to protect it from the winter storms. “Every year it never fails to produce something that astounds us.” After nearly two decades of digging, they have excavated only about 10% of its area, and about 5% of its volume. It goes deep: buildings are stacked on the ruins of older ones; the place was in use for 1,000 years. When summer comes, they’ll dig again. When the coverings come off each July, says Card’s colleague, Anne Mitchell, “down you go and you’re among the ghosts of the past”.

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Cook Islands reports first Covid case amid fears of ‘silent transmission’

Hundreds turn out for testing across the Pacific country after a traveller from New Zealand tested positive for the virus

One of the last remaining countries without Covid-19 - the small Pacific nation of Cook Islands - has reported its first case of the virus.

Prime minister Mark Brown said the first case arrived on an international flight from New Zealand on 10 February.

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What will ‘living with Covid’ actually mean?

Last week Boris Johnson announced that all Covid regulations in England, including the requirement to isolate after testing positive, were due to be abolished on 24 February. Whilst the Omicron variant has caused fewer hospitalisations and deaths than many predicted, some scientists say the changes may be going too far, too soon. Madeleine Finlay gets the Guardian science correspondent Hannah Devlin’s view on whether there’s scientific evidence backing up this decision and what the changes could look like

Archive: Daily Mail, Sky News

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Rocket on collision course with the moon ‘built by China not SpaceX’

Astronomers say mistake over object that is due to hit lunar surface in March highlights difficulties of deep space tracking

Astronomy experts say they originally misread the secrets of the night sky: it turns out that a rocket expected to crash into the moon in early March was built by China, not SpaceX.

A rocket will indeed strike the lunar surface on 4 March, but contrary to what had been announced, it was built not by Elon Musk’s company, but by Beijing, experts now say.

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What does your music taste say about you? Nothing actually | Barbara Ellen

A study that finds ‘agreeable’, ‘neurotic’ and ‘open’ types are fans of the same artists misses the point of music – and people

Does music taste reflect personality? A study from the University of Cambridge involving 350,000 participants, from 50 countries, across six continents, posits that people with similar traits across the globe are drawn to similar music genres. So, “extroverts” love Ed Sheeran, Beyoncé and Justin Timberlake. The “open” thrill to Daft Punk, Radiohead and Jimi Hendrix. The “agreeable” are into Marvin Gaye, U2 and Taylor Swift. The “neurotic” enjoy, presumably as much they can, the work of David Bowie, Nirvana, and the Killers. And so on.

While the study doesn’t claim to be definitive, how strange to be allotted only one personality trait/genre each. It sounds like Colour Me Beautiful for music. “What sound best goes with my personality? Did you bring along swatches?” Certainly, back when I worked for the New Musical Express, journalists, musicians and readers alike resisted being wrangled into such rigid categories.

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How DNA link could unlock mystery of cancer patients ‘wasting away’

New research into sudden weight loss finds a possible cause of cachexia in cancer patients and Cockayne syndrome in children

One of the most serious impacts of cancer is the sudden loss of weight, appetite, and muscle that can hit some patients in the later stages of the disease. This wasting syndrome is known as cachexia and it can be triggered in other serious conditions, including heart disease and HIV.

In addition, an inherited version of extreme wasting syndromes can affect children. Known as Cockayne syndrome, it causes them to suffer severe malnutrition and wasting that parallels the effect of cachexia.

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‘Relentless calls and constant abuse’: why Britain’s vets are in crisis

Vets are no strangers to pressure, but Covid and the huge boom in pets means they have never been busier – or experienced so much stress

By the summer of 2020, veterinary practices were beginning to feel the effects of the pandemic pet boom. That was the time that Melanie, a small-animal vet from the southeast of England, realised she no longer wanted to be in the profession. The feeling left her at a loss. All she’d ever done was eat, breathe and sleep veterinary medicine. Like many vets she had been inspired since she was a child: religiously watching TV shows such as Animal Hospital and Vets in Practice, mucking out stables to embellish her university application and completing a five-year degree before finding work at a busy practice. It was a vocation, not a job: she simply loved animals. “Ever since I knew what a vet was, I wanted to be one,” she says. “I don’t remember a time when I didn’t want to do that – until now.”

But for Melanie, the pressure of lockdown was just the start. During the initial mayhem, practices were forced to work within strict Covid restrictions. Many team members were off sick, isolating or furloughed. Melanie worked three shifts on, three shifts off with a skeleton staff, clocking two hours’ overtime every evening out of a sense of duty. The busiest day in the practice calendar was usually Boxing Day. But between March and July 2020, says Melanie, every day felt as if it was Boxing Day “if the toilet was flooded and the lab was on fire”. Staff bounced from the reception to operations, from remote appointments to emergencies, shepherding animals in for treatment from the street while brushing off abuse from stressed-out owners who were unhappy about wearing masks, didn’t want to wait outside or refused to accept that they couldn’t receive a home visit to have their cat’s claws clipped.

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Next Covid strain could kill many more, warn scientists ahead of England restrictions ending

Demands grow for government science chiefs to reveal evidence backing move to lift last protective measures

A future variant of Covid-19 could be much more dangerous and cause far higher numbers of deaths and cases of serious illness than Omicron, leading UK scientists have warned.

As a result, many of them say that caution needs to be taken in lifting the last Covid restrictions in England, as Boris Johnson plans to do next week.

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Dr Julie Smith: ‘Mental health is no different to physical health. No one is immune’

The clinical psychologist has 3 million followers for her self-help TikToks and now her book is a bestseller. She talks about social media, the pandemic and the simple tools that really help

Dr Julie Smith, 37, is a clinical psychologist who has a private practice in Hampshire and has spent 10 years working for the NHS. In November 2019, she started making TikToks containing clear, engaging advice about various mental health issues. She has more than 3 million followers and in January published her first book, Why Has Nobody Told Me This Before?, which has spent four weeks at the top of bestseller lists.

There are a lot of self-help books published; why do you think yours has struck a chord?
I think people like the fact that it’s evidence-based. I’m a clinical psychologist, so the things I’ve put in there have been scrutinised with the latest research and they are things that are taught to people in therapy, depending on what they’re going to therapy for. They are also life skills that we can all use.

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Scientists discover new planet orbiting nearest star to solar system

Proxima d is the third planet to have been spotted circling Proxima Centauri four light years away

Astronomers have found evidence for a new planet circling Proxima Centauri, the nearest star to the sun.

The alien world is only a quarter of the mass of Earth and orbits extremely close to its parent star, at one tenth of the distance between the sun and Mercury, the solar system’s innermost planet.

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