Countdown to ecstasy: how music is being used in healing psychedelic trips

Jon Hopkins timed his upcoming album to the length of a ketamine high, while apps are using AI music to tailor drug experiences. Welcome to a techno-chemical new frontier

Two hundred psychedelic enthusiasts have converged in Austin, Texas for a “ceremonial concert” on the autumn equinox. People sprawl on yoga mats around a circular stage as staffers pace the candlelit warehouse, jingling bells and spritzing essential oils. While psychedelic drugs are prohibited, some attenders seem in an altered state, lying on their backs and breathing heavily as rumbles of bass from Jon Hopkins’ upcoming album, Music for Psychedelic Therapy, shakes the hushed space.

This is the first time Hopkins – known for acclaimed solo electronic albums as well as production for Coldplay and Brian Eno – has played his new record in public, and the crowd is visibly moved. As recordings of spiritual guru Ram Dass’s teachings fill the room on the final song, the woman next to me begins silently weeping.

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‘My life in the mafia’s shadow’: Italy’s most hunted author, Robert Saviano

Since 2006, the acclaimed writer has lived in fear for his life, following publication of his exposé on the criminal gangs. The Observer takes a trip back to Naples with him and his minders

On a Friday in autumn 2006, local newspapers and prosecutors in Italy’s south-western region of Campania received the same anonymous letter. Computer-typed and delivered by hand in the early morning, it detailed the Neapolitan Mafia’s plan to execute a 26-year-old Italian writer. His name was Roberto Saviano and his book, Gomorrah, a devastating denunciation of the Camorra’s criminal activity, was on its way to becoming a bestseller.

The unpublished letter, seen by the Observer, refers to a meeting held in a betting office in Casal di Principe, Saviano’s hometown, in which local bosses, known as some of the most violent in the Camorra, decreed that Saviano must die, saying that his murder would take place “when the waters are calm”.

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Coronavirus treatments: the potential ‘game-changers’ in development

After positive clinical trials for antiviral drug Molnupiravir, it joins other medicines that have shown promise

The first clinical trial results showing a positive effect for a pill that can be taken at home has been hailed as a potential gamechanger that could provide a new way to protect the most vulnerable people from the worst effects of Covid-19. Molnupiravir joins a growing list of medicines that have shown promise. Here are some of the main developments in treatments so far.

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Hydroxychloroquine sales spiked almost 100% in Australia at start of Covid pandemic, study finds

There was also a rise in prescriptions for ivermectin being filled, despite no evidence either drug is effective against the virus

The amount of hydroxychloroquine and ivermectin dispensed from Australian pharmacies increased significantly in 2020 as the Covid pandemic took hold, according to new research.

Analysis of six publicly subsidised drugs – including hydroxychloroquine, ivermectin, corticosteroids and the common antibiotic azithromycin – found Covid-related changes in prescription patterns in Australia.

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‘Psychedelics renaissance’: new wave of research puts hallucinogenics forward to treat mental health

In what’s been described as a ‘paradigm shifter’ for psychiatry, Australian clinical trials are exploring the therapeutic benefits of illegal substances

It was out of desperation that Michael Raymond found himself sitting in a remote retreat in the Peruvian Andes, sipping a cup of bitter tea.

Raymond had reached breaking point. His 16-year career as an electrical engineer in high–security situations for the Australian air force had seen him deal with near-death experiences, crashes, casualties and “the aftermath of human remains”.

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Religious rehab centres fill gap as Nigeria grapples with soaring drug use

With poverty deepening, state services are failing to cope with rising rates of addiction

Kola* was in secondary school in Nigeria when he started smoking cigarettes. He soon graduated to cannabis, heroin and eventually to crack cocaine. Access to drugs was easy and he felt the pressure of friends to participate.

In 2002, when he was 39, he was introduced to a private drug rehabilitation centre in Ibadan, in the south-west of the country, where he spent 90 days weaning himself off his addiction.

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Ministers told to bar EU from UK trial data in vaccines row

England’s deputy medical chief asked for data to be withheld unless British vaccine guinea pigs allowed to travel abroad

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England’s deputy chief medical officer asked ministers to withhold all UK clinical trial data from the EU if European countries continued to deny entry to British vaccine trial volunteers, the Observer can reveal.

Jonathan Van-Tam made the extraordinary proposal after months of uncertainty for the 19,000 volunteers who are effectively unable to travel to Europe to see family, work or go on holiday because they took part in trials of Novavax and Valneva.

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Ivermectin: Australian regulator bans drug as Covid treatment after sharp rise in prescriptions

Therapeutic Goods Administration concerned people taking controversial medication instead of seeking proper treatment or vaccine

Australia’s drug regulator has banned medical practitioners from prescribing the anti-parasitic drug ivermectin for “off-label” uses, such as for treating Covid-19.

The move comes after prescriptions for the drug increased between three and four times in Australia in recent months.

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Priti Patel orders review into effects of nitrous oxide

Possession could be criminalised as home secretary vows to ‘take tough action’ on use of laughing gas

Possession of nitrous oxide, one of the most popular drugs among 16- to 24-year-olds, could be criminalised after the home secretary ordered experts to review its effects.

Priti Patel said she was ready to “take tough action” on the widespread use of laughing gas, which is taken mostly through balloons filled from small metal cylinders often seen littering areas around nightclubs and music festivals.

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‘Swazi gold’: grandmothers in Eswatini growing cannabis to make ends meet

In the poverty-stricken kingdom, an older generation rely on growing marijuana to feed children orphaned by Aids epidemic

In Nhlangano, in the south of Eswatini (formerly Swaziland), the illegal farming of the mountainous kingdom’s famous “Swazi gold” is a risk many grandmothers are ready to take.

In what is known locally as the “gardens of Eden”, a generation of grandparents are growing cannabis, many of them sole carers for some of the many children orphaned by the HIV/Aids epidemic that gripped southern Africa.

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Sydney Covid patient in Westmead hospital after overdosing on ivermectin and other online ‘cures’

Patient, who suffered vomiting and diarrhoea, part of trend hospital is seeing of people taking unproven substances

A Covid-positive person in Sydney was admitted to Westmead hospital suffering from vomiting and diarrhoea after overdosing on ivermectin and other drugs ordered online, as Australia’s chief medical officer pleads with the public not to take unproven medicine.

Westmead hospital’s toxicologist, Naren Gunja, said the case was part of a growing trend the hospital was seeing of people taking unproven online cures for Covid. The patient didn’t get severe toxicity from taking the ivermectin cocktail, “but it didn’t help their Covid either”, he said.

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Spanish couple arrested over toad-venom and ayahuasca rituals

Pair allegedly charged €150 for ‘ancestral’ ceremonies involving psychotropic substances

Spanish police have arrested a couple over accusations they were carrying out rituals – billed online as “international ancestral medicine” – involving an array of banned substances ranging from toad venom to ayahuasca.

The couple, aged 42 and 38, allegedly ran an association that performed ceremonies involving psychotropic substances for as much as €150 (£129) a session. Weekend retreats were also on offer at a cost of up to €350 (£300).

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Born to be wild: India’s first captive-bred endangered vultures are set free

Numbers of the country’s carrion-loving birds dropped by over 97% in the 1990s. Now, a successful breeding scheme is giving them a boost

In February, the doors of an aviary in West Bengal’s Buxa tiger reserve were flung open. Eight critically endangered captive-bred white-rumped vultures cautiously emerged and within minutes were mingling with wild vultures, devouring the meat of carcasses left out by a team of researchers from the Bombay Natural History Society (BNHS).

The birds were raised in a nearby breeding centre by BNHS, led by assistant director Sachin Ranade, as part of efforts to save India’s Gyps vultures. Gradually, some of the released vultures perched on trees with their wild cousins, while others returned to the wire-mesh aviary where they had spent the previous few months getting acclimatised to their surroundings.

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Drug poisoning deaths in England and Wales reach record high

Charities warn of a public health emergency after data shows 4,561 deaths in 2020 – up 3.8% on previous year

Deaths due to drug poisoning in England and Wales have reached a record high, with a growing number of people dying after using cocaine and opiates, data shows.

Charities warned the figures showed there was a public health emergency, with the pandemic negatively affecting those with addiction problems. In 2020, 4,561 died from drug poisoning– the equivalent of 79.5 deaths per million people. This is 3.8% higher than figures for 2019 and the highest number since records began in 1993.

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Barcelona cannabis clubs face closure in new legal setback

Police and city authorities agree that ‘pioneering’ model has reduced street dealing and consumption

Barcelona’s 200 cannabis clubs face closure after the supreme court shut a legal loophole that has seen the city become Spain’s marijuana capital.

It is the latest in a series of setbacks for the asociaciónes, as they are popularly known. In 2017, the court overruled a law passed by the Catalan parliament which said “private consumption of cannabis by adults … is part of the exercise of the fundamental right to free personal development and freedom of conscience”.

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Is medical cannabis really a magic bullet?

Research increasingly suggests that extracts from the plant are effective in treating pain, anxiety, epilepsy and more, but experts still preach caution around recreational use

In 2017, Mikael Sodergren, a liver and pancreatic cancer surgeon at Imperial College healthcare NHS trust, was finding himself becoming increasingly interested in the potential role of medical cannabis in treating pain, especially the discomfort experienced by patients after complex operations.

“I hope that I do a lot of good, but unfortunately in the short term, I inflict a lot of pain with cancer surgery,” says Sodergren. “So we’re reliant on pretty nasty painkillers, such as high-strength intravenous opioids, which we’re trying to move away from. They slow patients down and they cause complications.”

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The top journalist, the mafia boss and the gunman: Dutch fear the rise of ‘narco crime’

While Peter R de Vries fights for life in an Amsterdam hospital the nation reflects on how to end the grip of drug gangs

Five gunshots blasted like fireworks on a sunny evening, just behind Amsterdam’s busy Leidseplein. To the horror of the Netherlands, a cold-blooded shooting has left prominent Dutch crime journalist Peter R de Vries fighting for his life in hospital.

Everyone from European leaders to the Dutch king Willem-Alexander and Amsterdam mayor Femke Halsema have expressed their shock at the ambush of “national hero” De Vries as he walked back to his car on Tuesday after recording a chatshow, on a busy street in broad daylight.

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My summer of love: ‘Under the spell of ecstasy, strangers went straight to limitless intimacy’

We danced in water features, stupefied with drugs. And while my big crush was unrequited, the whole season was irresistible fun

A summer of love is predicted when – if – we emerge from the Babylonian captivity of lockdown in a frenzy of courting. It will be the third summer of love in recent years. The first occurred, in a cloud of hashish and patchouli, around San Francisco in 1967. I was five and living on the outskirts of Kettering, untouched by those events, although I have heard it said the Skew Bridge Ski Club could get quite racy.

The second summer of love I can talk about because I was in it. It was 1990, I was 28, and recently retired from pop music. It arrived on the back of a new party drug, ecstasy. I had come across E – more properly MDMA – in the United States, in the clubs of the east and west coasts, where enterprising leisure professionals realised that its effect on the neurotransmitters responsible for the experience of pleasure could make every venue a Xanadu of irresistible fun.

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Coastguard seizes half a tonne of cocaine floating off Algeria coast

Fishermen alerted authorities to ‘suspicious’ items floating in the sea

The Algerian coastguard has seized almost half a tonne of cocaine after fishers alerted authorities to “suspicious” items floating off the north-west coast.

The coastguard fished out 490kg (1,080 pounds) of cocaine split up into 442 packages from the water six nautical miles (11 kilometres) off Oran’s Cap Carbon on Saturday evening, a defence ministry statement said on Monday.

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