The great project: how Covid changed science for ever

The emergence of a novel coronavirus prompted a wave of global collaboration that has led to vaccines, treatments and the promise of new discoveries

For scientists, 5 January was a turning point in the fight against the coronavirus. That day, a team led by Prof Yong-Zhen Zhang at Fudan University in Shanghai sequenced the genetic code of the virus behind Wuhan’s month-long pneumonia outbreak. The process took about 40 hours. Having analysed the code, Zhang reported back to the Ministry of Health. The pathogen was a novel coronavirus similar to Sars, the deadly virus that sparked an epidemic in 2003. People should take precautions, he warned.

The Chinese government had imposed an embargo on information about the outbreak and Zhang and his co-workers were under pressure not to publish the code. The blackout couldn’t hold. On 8 January, news broke about the nature of the pathogen and was confirmed a day later by Chinese authorities. To sit on the code now seemed ridiculous.

Continue reading...

‘It made Boris seem like a normal person’: how did Johnson’s Covid change him?

The prime minister’s spell in intensive care underscored the severity of the pandemic. Did it also make him reassess his life?

It was an unexpected twist in what already felt like an excessively dramatic disaster movie. On 6 April, the British prime minister was admitted to the intensive care ward at St Thomas’ hospital in London, after contracting a new and potentially deadly virus. Donald Trump said he was “praying for his good friend”; the French president, Emmanuel Macron, said all his wishes were with the prime minister, his family and the British people in “this difficult time”. The Labour leader, Keir Starmer, described it as “terribly sad news”.

Boris Johnson pulled through, of course, surviving to witness the birth of his son, Wilfred – given the middle name Nicholas, after the doctors, Dr Nick Price and Dr Nick Hart, who saved Johnson’s life. But more than eight months later, could the country still be feeling the impact of this dramatic turn of events?

Continue reading...

New variant of coronavirus identified in UK, Matt Hancock says – video

Health secretary suggests that variant could be linked with the rapid spread of the virus in south-east England, although it was highly unlikely a vaccine would not work against it

Continue reading...

Coronavirus: key moments – timeline

From December 2019, when an unknown virus was found in China, to the release of vaccines for Covid-19 – here are the points where momentum shifted

From December 2019, when an unknown virus was found in China, to the release of vaccines for Covid-19, it has been an extraordinary year. Here’s how the momentum shifted

Continue reading...

Coronavirus live news: Netherlands heading for month-long lockdown; Poland facing ‘third wave’ of Covid

Dutch PM to speak to the nation tonight; ministers to recommend restrictions are extended in Poland

The US has reported 16,113,148 cases of new coronavirus cases since the start of the pandemic, with 1,476,230 cases reported in the last seven days.

The US Centers for Disease Control and Prevention (CDC) said on Monday that 17,184 people had died from Covid-19 in the previous week, taking the total US death toll so far to 298,266.

Turkish president has said Turkey will impose a five-day full lockdown beginning on 31 December, as official data showed new daily coronavirus deaths hit a record 229.

Recep Tayip Erdoğan, speaking after a cabinet meeting, said the stay-home order would begin at 9pm on New Year’s Eve and run to 4 January.

Continue reading...

‘Autoantibodies’ may be driving severe Covid cases, study shows

Scientists find aberrant immune system in patients with virus could also be cause of ‘long Covid’

Dramatic levels of “friendly fire” from the immune system may drive severe Covid-19 disease and leave patients with “long Covid” – when medical problems persist for a significant time after the virus has been beaten – scientists have said.

Researchers at Yale University found that Covid-19 patients had large numbers of misguided antibodies in their blood that targeted the organs, tissues and the immune system itself, rather than fighting off the invading virus.

Continue reading...

Coronavirus live news: Germany to close schools and all non-essential shops; Turkey adds 800,000 cases

Germany introduces new restrictions to combat spread of virus; Turkey changes counting method, almost doubling cases

Here are some striking images of Dr. Luigi Cavanna visiting his patients in their homes in small towns and rural areas in the Emilia-Romagna region of northern Italy.

He checks his patients’ oxygen levels, uses ultrasound to scan their lungs and tests them and their relatives for coronavirus.

Residents in Jersey care homes are receiving Covid vaccinations a day earlier than expected, the island’s government has announced.

Officials said the government made the call to start on Sunday rather than Monday “in view of the positive Covid cases in care homes”, which have seen a recent 400% surge, from four on Thursday to 19 by Saturday.

Continue reading...

Covid vaccines roll out of Pfizer plant in US but Trump says he is not taking it yet

President says he is not scheduled to take vaccine as the most complex distribution project ever in the US gets underway

Trucks hauling trailers loaded with suitcase–sized containers of Covid-19 vaccine rolled out of Pfizer’s manufacturing facility in Kalamazoo, Michigan, on Sunday – launching the largest and most complex vaccine distribution project in the US.

However, public confidence in the vaccine risked being eroded after President Donald Trump – who has had Covid – said he was “not scheduled to take the vaccine” but would do so “at the appropriate time”.

Continue reading...

Has a year of living with Covid-19 rewired our brains?

The pandemic is expected to precipitate a mental health crisis, but perhaps also a chance to approach life with new clarity

When the bubonic plague spread through England in the 17th century, Sir Isaac Newton fled Cambridge where he was studying for the safety of his family home in Lincolnshire. The Newtons did not live in a cramped apartment; they enjoyed a large garden with many fruit trees. In these uncertain times, out of step with ordinary life, his mind roamed free of routines and social distractions. And it was in this context that a single apple falling from a tree struck him as more intriguing than any of the apples he had previously seen fall. Gravity was a gift of the plague. So, how is this pandemic going for you?

In different ways, this is likely a question we are all asking ourselves. Whether you have experienced illness, relocated, lost a loved one or a job, got a kitten or got divorced, eaten more or exercised more, spent longer showering each morning or reached every day for the same clothes, it is an inescapable truth that the pandemic alters us all. But how? And when will we have answers to these questions – because surely there will be a time when we can scan our personal balance sheets and see in the credit column something more than grey hairs, a thicker waist and a kitten? (Actually, the kitten is pretty rewarding.) What might be the psychological impact of living through a pandemic? Will it change us for ever?

Continue reading...

Origin story: what do we know now about where coronavirus came from?

When Chinese scientists alerted colleagues to a new virus last December, suspicion fell on a Wuhan market. What have health officials learned since then?

Maria van Kerkhove was staying with her sister in the US for the Christmas holidays, but checking her emails. As always. Every day there are signals of potential trouble, said the World Health Organization virologist who was to become a household name and face within weeks.

“There’s always something that happens at Christmas time. There’s always some alert, or a signal of a suspected case. The last several years it’s been Mers [Middle East respiratory syndrome] – a suspect case travelling to Malaysia or Indonesia or Korea or somewhere in Asia from the Middle East. So there’s always some kind of signal. There’s always something that happens,” she said.

Continue reading...

‘Covid-19 has an odour, and the dogs are detecting it’: meet the canine super-squad sniffing out the virus

They’re loyal, diligent – and have unbeatable noses. Could dogs play a key part in the fight against the pandemic?

A single-storey building in a lonely rural business park, a few miles from Milton Keynes on a grey autumn day. It looks like a location for a bleak thriller: where a kidnap victim is held, perhaps, or the scene of a final shootout. Inside, though, something kind of cool is happening.

In a brightly lit room, four inverted metal cups have been placed on the red carpet, each containing a small glass jar. One of these contains a smell: a “training odour”. Into the room bursts Billy, followed by Jess. Billy is a labrador, and Jess his human trainer. Billy bounces about the place, clearly super excited. He sniffs at everything – furniture, people, the cups – wagging ferociously. When he sniffs at the cup that contains the smell, another trainer, Jayde, indicates success with a clicking noise. Billy is rewarded with his favourite toy, a well-chewed rubber ball, and a chorus of “good boy”.

Continue reading...

Coronavirus live news: US vaccinations to begin ‘in 24 hours’ after FDA approves Pfizer jab

Trump hails rollout of immunisation program; UK coronavirus hospitalisations increase; WHO warns number of deaths surging

Germany has recorded 28,438 new Covid-19 cases in the past 24 hours, taking the total in the country to 1,300,516, according to the Robert Koch Institute for infectious diseases.

An additional 496 people died from the virus, taking the total death toll to 21,466.

In Australia, parts of New South Wales and Queensland are on flood watch as heavy rains continue.

Overnight, Coffs Harbour received 180mm in less than 24 hours and Bowraville got 195mm.

Related: Australia storms: NSW flood warnings as torrential rain to hit south-east Queensland

Continue reading...

Coronavirus live news: Italy overtakes UK for European highest death toll; Germany to close shops as part of tougher restrictions

Trump hails start of immunisation programme; UK coronavirus hospitalisations increase; WHO warns number of deaths surging

Here the latest developments at a glance:

Continue reading...

Oxford Covid vaccine to be combined with Sputnik jab for trial

UK and Russian scientists to explore whether vaccines given together improves efficacy

UK and Russian scientists are to test whether combining shots of the Oxford/AstraZeneca and Sputnik V coronavirus vaccines could result in better protection than two doses of the same one.

Trials will start by the end of the year, the Russian Direct Investment Fund (RDIF), which funded the development of the Sputnik V vaccine by Russia’s Gamaleya Institute, said on Friday. AstraZeneca confirmed that it was considering how it could assess combinations of different vaccines, and would soon begin exploring with the Gamaleya Institute whether their two vaccines could be successfully combined.

Continue reading...

The magnifying glass: how Covid revealed the truth about our world

The pandemic has illuminated deprivation, inequalities and political unrest, while reminding us of the power and beauty of nature and humanity

What might be the enduring symbol of the coronavirus that turned our world upside down in 2020? Might it be those Thursday evenings of spring and summer when, at the stroke of 8pm, Britons overcame the national traits of embarrassment and reserve and ventured out on to the doorstep to applaud doctors, nurses and key workers, banging saucepans and nodding to neighbours in a synchronised “clap for carers”? Or might it be the first sign that trouble was coming this way, that footage of Italians singing to each other from their balconies in a ritual that seemed as exotic, distant and unlikely then as the very notion of a “lockdown”, back before that dramatically punitive word lost its sting?

A chequerboard computer screen of faces as Zoom became the prime means of face-to-face contact with those who didn’t live under one roof? The smaller, quieter sight of families visiting grandparents but getting no further than the garden path, toddlers waving through the glass at elderly relatives?

Continue reading...

Coronavirus live news: infections down in England – but not London; 7pm curfew introduced in Switzerland

London bucks trend of declining positive tests in England; Switzerland orders restaurants, bars and shops to close down from 7pm

Companies in America are considering various options to get employees back to work after the Covid vaccine has been rolled out, Reuters is reporting.

Options on the table include giving workers a choice between a free vaccine and a cash bonus if everyone gets inoculated, to being reassigned or even losing your job.

Australia has cancelled the production of a locally made vaccine against Covid-19 after trials showed it could interfere with HIV diagnosis, Reuters is reporting.

The government has instead securing additional doses of rival vaccines.

Continue reading...

UK Covid self-isolation period set to be reduced to 10 days

Chief medical officers of all four UK nations expected to formally announce change later on Friday

Governments across the UK are to announce a reduction in the coronavirus self-isolation period, from 14 to 10 days, it is understood.

It is expected the chief medical officers of all four UK nations will formally announce the change later on Friday.

Continue reading...

Coronavirus live news: Italy reports steep rise in daily deaths; Israel abandons Hanukkah curfew plan

Italy reports 887 coronavirus-related deaths, up from 499 on previous day; Israel abandons Covid-19 curfew plan ahead of Hanukkah

Bolivia’s cholita wrestlers are making a comeback to the ring after the iconic female fighters were forced to hang up their billowing skirts and bowler hats due to the Covid-19 pandemic, Reuters reports.

I’ve been wrestling for about 10 years. I am a single mother of two children, and I have a trade. Because of the trade I am in, I am able to dedicate enough time to my children, to take them to school and to study.

Before the pandemic, we were a part of the cultural heritage that wasn’t recognised, tourists came from all over the world to see just us, the fighting cholita luchadores of wrestling.

Continue reading...

Chinese Covid-19 vaccine has 86% efficacy, UAE says

First results released from trial of Sinopharm shot involving 31,000 people

The United Arab Emirates said a Chinese coronavirus vaccine tested in the federation of sheikhdoms has 86% efficacy, in a statement that provided few details but marked the first public release of information on the performance of the shot.

The announcement brought yet another contender into the worldwide race for a vaccine to end the pandemic, a scientific effort in which China and Russia are competing with western firms to develop an effective inoculation.

Continue reading...

Coronavirus live news: furious Merkel says German death rate ‘unacceptable’; Moldovan PM has Covid

German chancellor calls for new year shutdown; UK science chief warns Britons may need masks next winter; Ion Chicu tests positive, adviser says

Brazil will “quite likely” begin vaccinations to stem the coronavirus pandemic in January or February, the health minister, Eduardo Pazuello, said in a Wednesday interview with CNN Brasil, according to a report by Reuters.

Pazuello said on Tuesday that Brazil had signed a letter of intent to receive 70m Covid-19 vaccine doses from Pfizer starting in January

Oman will exempt nationals of 103 counties from needing an entry visa for a stay of up to 10 days, Reuters reports, in a move to support tourism and shore up its struggling economy.

Visitors must have a confirmed hotel reservation, health insurance and a return ticket, Royal Oman Police said on its Twitter account.

Continue reading...