Gene therapy could treat rare brain disorder in unborn babies

Doctors could use Crispr tool to inject benign virus into foetus’s brain to ‘switch on’ key genes

Scientists are developing a radical form of gene therapy that could cure a devastating medical disorder by mending mutations in the brains of foetuses in the womb.

The treatment, which has never been attempted before, would involve doctors injecting the feotus’s brain with a harmless virus that infects the neurons and delivers a suite of molecules that correct the genetic faults.

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Colombia’s homemade prosthetics – in pictures

Since 1992, more than 11,500 Colombians have been killed or injured by landmines, a legacy of more than 50 years of internal conflict. Many impoverished amputees without access to the healthcare system have resorted to making homemade prosthetics from wood, leather, metal and plastic bottles

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The Guardian view on vaccination: a duty of public health | Editorial

The anti-vaxx movement arises from mistrust but threatens the physical health of society

The latest World Health Organization report on measles epidemics shows that cases jumped by 50% last year. In one of the poorest and least connected countries in the world, Madagascar, nearly a thousand children are reported to have died after a measles outbreak in the countryside. The real figure is likely to be much higher, because of difficulties of reporting. An emergency programme of vaccination seems to have contained that epidemic for the moment but it is a reminder of how devastating the disease can be against unprepared populations. In the rich world, meanwhile, previously prepared populations are having their defences dismantled from the inside.

The discovery of ad campaigns against vaccination on Facebook that are carefully targeted at pregnant women is unusually worrying. It shows how the widespread availability of sophisticated advertising techniques is going to give considerable power to people who previously had no way of getting their message across to large numbers. In the most recent US campaigns against vaccination, 147 different advertisements have been used and some viewed more than 5m times. There is an arms race under way, whether we like it or not.

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German minister calls for ban on conversion therapy

‘Homosexuality is not an illness,’ says health minister Jens Spahn

The German health minister, Jens Spahn, has said that he will seek to ban “conversion therapies” that claim to change sexual orientation. “Homosexuality is not an illness, which is why it does not need to be treated,” Spahn, who is gay himself, told the left-leaning Berlin daily Die Tageszeitung.

Related: ‘I still have flashbacks’: the ‘global epidemic’ of LGBT conversion therapy

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Condom handouts in schools prevent disease without encouraging sex

UN study finds misgivings over impact of condom distribution in secondary schools are misplaced

Making condoms available to teenagers at school does not make them more promiscuous – but neither does it reduce teenage pregnancy rates.

According to a major review by the UN Population Fund (UNFPA), giving out condoms in secondary schools does not increase sexual activity, or encourage young people to have sex at an earlier age.

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Measles: WHO warns cases have jumped 50%

Falsehoods spread by ‘anti-vax’ movement in part to blame for ‘backsliding’ in progress against potentially deadly illness, experts warn

The World Health Organization has warned that efforts to halt the spread of measles are “backsliding”, with case numbers worldwide surging around 50% last year.

The UN health agency pointed to preliminary data showing that the disturbing trend of resurgent measles cases was happening at a global level, including in wealthy nations where vaccination coverage has historically been high.

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New drug raises hopes of reversing memory loss in old age

Toronto researchers believe the drug can also help those with depression, schizophrenia and Alzheimer’s

An experimental drug that bolsters ailing brain cells has raised hopes of a treatment for memory loss, poor decision making and other mental impairments that often strike in old age.

The drug could be taken as a daily pill by over-55s if clinical trials, which are expected to start within two years, show that the medicine is safe and effective at preventing memory lapses.

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Citizenship report puts national security reform on back burner – politics live

Joint committee calls for further review of bill stripping terrorists of citizenship, as PM hands down Closing the Gap report and Coalition keeps up medical transfers scare campaign. All the day’s events, live

The attorney-general’s office released the transcript of his interview with Kieran Gilbert on Sky News this morning.

It includes this exchange between Christian Porter, as the first law officer and Gilbert:

Chris Bowen and Mark Butler have held a press conference to blast the government for dumping the big stick.

Labor doesn’t support this policy but the Bowen/Butler argument is the government did, and this is yet another energy policy that has now bitten the dust. The government says it will take the policy to the coming election, and seek a mandate.

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Breast-ironing: UK government vows to tackle abusive practice

Home Office says ritual is child abuse and should be prosecuted under assault laws

The government has vowed to confront the practice of breast-ironing, calling it child abuse and saying the police should prosecute offenders under assault laws.

In a written parliamentary statement following Guardian revelations that the abusive practice was spreading in the UK, the Home Office said it was committed to challenging the cultural attitudes behind all “honour-based abuse”, but gave no indication it would legislate.

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Labor starts fightback on border security as medical evacuation bill passes Senate – as it happened

Labor, the Greens, Tim Storer, Derryn Hinch and the Centre Alliance vote in favour of the refugee transfer legislation. This blog has now closed.

That is where we will leave you today. It’s been a big week and after the last few days, I think we all need a bex and a lie down.

Obviously, for me, when I say bex, I mean vodka, but insert whatever self-care aid is necessary.

From the valedictories

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Austerity causing stress and trauma to officers, say police

Call for more government funding as survey finds 80% of officers felt stress in past year

Police officers have reported being driven to breaking point by the dual pressures of staffing cuts and rising demands, with a survey finding eight out of 10 had felt stressed in the past year.

The survey by the Police Federation is part of a campaign to pressure the government to fund more officers on the beat after years of cuts.

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Study links heavily processed foods to risk of earlier death

French research involved more than 44,000 people over a period of seven years

Eating a lot of heavily processed foods is linked to a risk of earlier death, according to a study.

A team in France worked with more than 44,000 people in a study running from 2009 called NutriNet-Santé. They looked at how much of their diet – and calories – was made up of “ultra-processed” foods – those made in factories with industrial ingredients and additives, such as dried ready meals, cakes and biscuits.

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Queensland girls subjected to female genital mutilation in Somalia, court told

Mother is on trial in Brisbane after girls were allegedly taken from grandmother’s house and subjected to procedure

Two Queensland girls were playing outside their grandmother’s house in Somalia when they were allegedly taken away to have their genitals mutilated, a court has heard.

Their mother, who cannot be named for legal reasons, is on trial in Brisbane district court.

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Opioid strong enough to sedate elephants on rise in Ohio, coroners warn

Carfentanil, described as ‘extremely potent’ and often undetectable, involved in multiple overdose deaths

Coroners in two of Ohio’s largest counties have issued drug abuse warnings following the reappearance of an opioid so powerful it’s sometimes used to sedate elephants.

Dr Anahi Ortiz is coroner in Franklin county in central Ohio. She said Friday that the county which calls Columbus home had at least three carfentanil-related overdose deaths in January.

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Our stories: the women mutilated by Emil Gayed

An independent inquiry has delivered its findings about the gynaecologist Emil Shawky Gayed after Guardian Australia revealed he was the subject of dozens of complaints from women about botched surgery and other practices at numerous hospitals in New South Wales and the ACT. Here are some of the cases uncovered so far – the list will be updated as more information is received or when more patients give permission

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‘You will have an emotional reboot’: the ultimate guide to stress at every age

Every life stage brings its own pressures, from worrying about exams to juggling the needs of family. Here are the best coping tactics for each generation

Triggers
“Children are really the canaries in the mineshaft of human society. They are the individuals within our cultures that are the most sensitive to the difficulties – and stresses – that societies experience,” Tom Boyce tells me. Professor of pediatrics and psychiatry at the University of California, he specialises in the treatment of three- to eight-year-olds. Major stressors in this age group include marital conflict, violence in the home, violence in the community, problems with parental mental health – a mum or dad who is depressed – maltreatment and disciplinary behaviours that become punitive.

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‘Getting out of bed is the first hurdle’: how I cope with my anxiety

Dread and despair have been a part of my life since childhood – and then I started writing about politics ...

The anxiety is ever-present. Sometimes only as a form of background noise; a voice that tells me I’ve failed at the day before it’s even begun. At other times it’s more insistent. An almost physical presence. A heart-pounding feeling of dread that makes it a struggle to get out of bed. A longed for desire to go back to sleep, to rewind the clock, in the desperate hope that I could start the day again.

I stare at the clock, calculating how long I can leave it before I have to get out of bed and engage with the day. Another 10 minutes maybe? Twenty if I choose to skip breakfast. Hoping that the anxiety will have passed by the time I do get up, while knowing that every delay merely makes it worse. I know it’s a kind of madness. But it’s one to which I invariably succumb.

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‘Trauma packs’ being stockpiled in UK over fears of no-deal Brexit

Exclusive: pharmaceutical giant Johnson & Johnson fears border delays could disrupt flow of vital medical supplies

Emergency “trauma packs” flown into the UK during terrorist attacks are being stockpiled in Britain by the pharmaceutical giant Johnson & Johnson over concerns of a risk to life from border delays in the event of a no-deal Brexit.

The company said the move was being made due to the danger posed to the “routine and rapid” provision of the vital emergency equipment it provides to the NHS in times of emergency from a distribution plant in Belgium.

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Nearly half of Australians don’t think private health insurance is ‘essential’

Growing number of people also find it difficult to understand what they are covered for

The number of people who believe private health insurance is essential has declined since five years ago, while more people agree that it is difficult to understand what is covered by their policies.

The findings are from in-depth, face-to-face interviews with more than 50,000 Australians in a year conducted by Roy Morgan researchers. The latest results are based on the 12 months to October 2018.

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Victorian doctors who object to abortion ‘attempting to delay or deny access’

Study reveals failure of legal protections to ensure women’s access to terminations

Victorian doctors who conscientiously object to abortion are breaking the law by failing to refer women on to practitioners who will perform the procedure, leading to some women having abortions later than necessary or having the baby despite wanting a termination.

This was the finding from a study led by associate professor Louise Keogh at the University of Melbourne, who examined whether mandatory referral, introduced in Victoria during abortion law reforms in 2008, was making healthcare more accessible to women.

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