Brazilian Covid variant: what do we know about P1?

What threat does variant that is causing devastation in Brazil pose, and how is it different?

The P1 variant is causing devastation in Brazil, where an uncontrolled Covid pandemic is raging. P1, behind the terrible scenes of hospital overload in Manaus with patients’ relatives pleading for oxygen cylinders, is now the dominant form of coronavirus in many of Brazil’s cities and partly responsible for the high death toll. Other Latin American countries have closed their borders and restricted travel to and from Brazil but P1 is now in at least 15 countries in the Americas, according to the Pan American Health Organization (PAHO).

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‘Think of others’: elderly people in Zimbabwe dispel scepticism on Covid vaccine

While younger generations remain suspicious, growing numbers of senior citizens are taking up the jab

They may be old, frail, and vulnerable but they are the foot soldiers at the front of Zimbabwe’s Covid vaccination drive. Amid widespread scepticism among the younger population, it is elderly people who are coming out to lead by example.

The queues at the vaccination centres in the capital, Harare, are dominated by older people. At Wilkins Hospital, Felda Mupemhi, 85, grasps her walking stick as she trudges toward a white tent, where nurses are administering the Sinopharm vaccine.

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UK’s ‘headlong rush into abandoning human rights’ rebuked by Amnesty

Covid failings, crackdown on protest, police discrimination and resumed arms trade with Saudi Arabia all listed in annual report

Amnesty International has published a stark rebuke of the UK government’s stance on human rights, saying that it is “speeding towards the cliff edge” in its policies on housing and immigration, and criticising its seeming determination to end the legal right for the public to challenge government decisions in court.

In its annual report on human rights around the world, Amnesty International says the UK’s increasingly hostile attitude towards upholding and preserving human rights legislation raises “serious concerns”.

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Patients in Wales to be first in UK to receive Moderna Covid vaccine

Nation’s mass rollout begins on Wednesday, while Scotland will administer first doses later this week

Patients in Wales will from Wednesday become the first in the UK to receive the Moderna vaccine as part of a mass vaccination programme, with the first doses in Scotland set to come later this week.

The initial jabs would be given at the West Wales general hospital in Carmarthen, the Welsh government said.

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AstraZeneca Covid vaccine: weighing up the risks and rewards

Despite scientific advice to continue getting the jab, answers about fatal blood clots are urgently needed

Vaccines have side-effects, as do all medicines. Most often, jabs cause sore arms, a headache or a bit of nausea – none of which would be very significant when weighed against the toll of a serious virus such as Covid-19.

But sometimes the risk-benefit calculation may look less simple, as in the case of Oxford/AstraZeneca’s Covid jab and cerebral venous sinus thrombosis (CVST), the blood clots in the brain that have led to fatalities in the UK and Europe.

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EU drug agency denies already finding causal link between AstraZeneca vaccine and blood clots

European Medicines Agency says review ongoing after head of vaccines spoke of ‘clear’ association

Europe’s drug regulator has denied it has already established a causal connection between the Oxford/AstraZeneca vaccine and a rare blood clotting syndrome, after a senior official from the agency said there was a link.

In a statement to Agence France-Presse, the European Medicines Agency (EMA) said on Tuesday it had “not yet reached a conclusion and the review is currently ongoing”, adding that it expected to announce its findings on Wednesday or Thursday.

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Letting go: my battle to help my parents die a good death

My parents were determined to avoid heroic medical interventions in their dying days, even before the pandemic. Why wasn’t anybody listening?

Almost as soon as the word Covid is coined, my parents update their “advance decision” documents. They’re constantly adjusting them, fine-tuning their wishes for future medical treatment. “Like a dowager with an elaborate will,” I tease them, blowing the ink dry on yet another signature.

When they first completed their advance decision document, 20 years ago, they were mostly concerned with not being resuscitated should they have a stroke, perhaps while shopping in the market or cycling home. Now, aged 84 and 82 and debilitated by multiple illnesses, they’ve had to give up their bikes and those hopes of a dramatic end. “We look like the old people road sign,” says my mum, bent over her walking aid, handing my dad his stick. And they do. Frail as leaves, they totter down the road to the vegetarian cafe: the wind could blow them away.

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Family of Captain Sir Tom Moore issue charity challenge to nation

People encouraged to set fundraising goal that echoes Moore’s 100 garden laps on his 101st birthday weekend

Captain Sir Tom Moore made it his mission to raise money for the NHS by doing 100 laps of his garden before his 100th birthday.

Now, one year and nearly £39m later, his family are asking people to follow in his footsteps and come up with their own challenge based around the number 100 that they can complete over what would have been his 101st birthday weekend.

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How will England’s Covid restrictions be changing from 12 April?

Next stage of easing of lockdown will mean non-essential retail can reopen, among other changes

England is gearing up for the next stage of coronavirus restrictions being eased from 12 April. So far, step 1 of the proposed roadmap has been completed: on 8 March, pupils and college students returned to the classroom, and care home residents were allowed to receive one regular, named visitor; then on 29 March, outdoor gatherings of up two six people, or two households, were allowed, outdoor sports continued, and the official “stay at home” advice came to an end.

There is a minimum of five weeks between each stage, with four weeks to collect and assess data and then a week for people and businesses to prepare for the next step.

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As a sense of normality returns, we must not forget what this last year has been like for the NHS

I’m an NHS consultant. We barely had the resources to keep people alive – let alone cope with longer effects of Covid

One year ago, lockdown had just come in. A creeping sense of dread was spreading across the hospital. We were focused on the first wave of admissions, the peak of which for us occurred in early April. We were desperately learning how to keep people from dying due to this new disease. The longer-term consequences were the last thing on our minds.

Now, a year on, there is a superficial sense of normality returning. Our respiratory support unit, for so long hidden behind closed doors with “STOP: CORONAVIRUS” signs and staffed by hooded figures in head-to-toe PPE, has turned back into the bright, airy ward it used to be. Nurses, doctors, porters are back in their usual clothes instead of uniform scrubs; conversation has replaced the incessant hiss of Cpap machines. Our ITU is shrinking back to its normal size. It is easy to forget how things were even a couple of months ago.

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‘I miss school’: 800m children still not fully back in classes

Rights groups warn that children across the world are being pushed into abusive situations, from early marriage to child labour

Across the world 800 million children are still not fully back in school, Unicef is warning, with many at risk of never returning to the classroom the longer closures go on. There are at least 90 countries where schools are either closed or offering a mix of remote and in-person learning.

The UN agency’s chief of education, Robert Jenkins, told the Guardian that the closures are part of “unimaginable” disruption to children’s education.

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Plea to ease Covid maternity rules as women continue to get bad news alone

But Not Maternity Alliance says postcode lottery remains despite guidance issued in December

The majority of women who have received bad news about their pregnancy since December were on their own at the time, despite the NHS ordering trusts to allow partners to be present throughout scans, labour and birth, the Guardian can reveal.

An alliance of pregnancy rights campaigners have written to the health secretary, Matt Hancock, urging him to draw up a roadmap for easing visiting restrictions in maternity services.

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The ‘elite controllers’ who can naturally suppress HIV

Research into how some HIV-positive people keep the virus at bay promises to yield new treatment possibilities, from vaccines to gene therapies

The year was 1998 when Joel Blankson encountered a patient he would never forget. Blankson was working in the HIV clinic at John Hopkins School of Medicine, Baltimore, when an HIV-positive woman in her mid-40s arrived for some routine tests.

Blankson gave her a PCR test, intending to prescribe a newly developed combination of medicines called antiretroviral therapies to suppress the infection, and prevent her developing Aids.

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Lockdown brings alarming rise in modern slavery

Sexual exploitation rose by a quarter and criminal exploitation by 42% in 2020, analysis of helpline data shows

Reports of sexual and criminal exploitation have risen alarmingly during the pandemic, according to new data measuring the scale of modern slavery and trafficking in the UK.

Cases of sexual exploitation, which includes people held captive in brothels and coerced into prostitution, rose by a quarter in 2020 compared with the previous year. Nearly a quarter of cases involved children.

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George Floyd’s girlfriend shared his opioids pain – Derek Chauvin refused to see it

Courteney Ross’s testimony showed how police departments fail in their duty to protect those who battle addiction

Of all the accounts of George Floyd’s life and death heard in a Minneapolis courtroom this week, perhaps the least expected was his girlfriend’s description of their shared struggle with opioid addiction.

Courteney Ross’s wrenching testimony gave a very human glimpse into the remorseless search for a fix and a mutual fight to shake off drug dependency.

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‘I was the only black kid in the pool’: why swimming is so white

Only 2% of regular swimmers in England are black. A new film examines the reasons behind the statistic

Filmmaker Ed Accura was 53 when he learned to swim, and only then through fear that his young daughter might get into trouble and he wouldn’t be able to save her.

“I live near the Thames and I said to myself, if anything happened to her and I couldn’t help, I would never forgive myself.”

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Seven UK recipients of Oxford jab reported dead after clotting

Experts say numbers of rare blood clots remain low and benefits of Covid vaccine far outweigh risks

Further cases of a rare blood clotting syndrome including seven deaths have been reported among recipients of the Oxford/AstraZeneca jab in the UK, although experts say the numbers remain low and the benefits of the vaccine far outweigh any risks.

The Medicines and Healthcare products Regulatory Agency (MHRA), runs a “yellow card” scheme to pick up suspected side-effects or other concerns for medicines and medical devices.

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Carrie Symonds, a network of family wealth and a charity investigation

Behind the Aspinall Foundation is a history of power, riches and links to the Tory party

When Carrie Symonds was welcomed to her job at the wildlife conservation charity the Aspinall Foundation in January, her new boss gushed that she had arrived at an “exciting time” for the organisation. Symonds, said Damian Aspinall, would be a “huge asset to us”.

Coverage of Boris Johnson’s fiancee’s appointment as head of communications focused on her well-publicised love of animals – useful, given the foundation’s charitable mission. It oversees Howletts and Port Lympne wildlife parks in Kent, home to exotic threatened species including rhinos, elephants, gorillas and cheetahs, which are prepared for a return to the wild in Africa.

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Pfizer vaccine has 91% efficacy for up to six months, trial shows

Findings based on two doses three weeks apart are first to show shot remains effective for many months

The coronavirus vaccine developed by Pfizer and its German partner BioNTech protects against symptomatic Covid for up to six months, an updated analysis of clinical trial data has found.

In a statement released on Thursday, the companies reported efficacy of 91.3% against any symptoms of the disease in participants assessed up to six months after their second shot. The level of protection is only marginally lower than the 95% achieved soon after vaccination.

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