What price a child’s life? India’s quest to make rare disease drugs affordable

Parents whose only hope was finding foreign sponsorship or a clinical trial are now looking for homegrown breakthroughs

For three years, Vidya tried to find the cause of her son’s recurrent fevers and low cognitive development. When she found out, she was devastated.

Vineeth, 10, has an incurable illness – mucopolysaccharidosis type 2 – that affects his organs. Afflicting just one in a million, the enzyme-replacement medication that can help stop the illness getting any worse costs £100,000 a year, far beyond the reach of even a wealthier Indian parent.

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Ireland suspends AstraZeneca Covid vaccine over blood clot concerns

Deployment of Oxford vaccine temporarily deferred after latest reports from Norway

Ireland is suspending use of the Oxford/AstraZeneca coronavirus vaccine as a precautionary measure following further reports of blood clots in people who have received it, this time from Norway.

The deputy chief medical officer, Dr Ronan Glynn, said Ireland’s advisory body on vaccines had recommended that deployment of the AstraZeneca jab should be “temporarily deferred” with immediate effect. He stressed, though, that there was no proof that the vaccine had caused blood clots.

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Coronavirus live news: Scott Morrison and chief medical officer get second vaccine dose; US administers first vaccine dose to more than 100m

Germany warns cases could hit Christmas peak by April; Australia records first local Covid case in more than two weeks; Poland reports rise in daily cases

In Australia a person who works in two Sydney quarantine hotels has tested positive to Covid-19.New South Wales health said it was notified of the new infection late last night. Urgent genomic testing is underway to determine the source of the infection, and the person’s close contacts have also been tested. It is the first locally-acquired case in 55 days in NSW. It’s not counted in today’s numbers but will be included in tomorrow’s.

NSW Health was notified late last night of a new case of COVID-19 in a person who works at two Sydney hotels which provide hotel quarantine for returned travellers. This case will be included in tomorrow’s numbers. pic.twitter.com/seNuUfBHBD

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‘The ketamine blew my mind’: can psychedelics cure addiction and depression?

This week sees the opening of the first UK high-street clinic offering psychedelic-assisted therapy. Could popping psilocybin be the future of mental healthcare?

In the summer of 1981, when he was 13, Grant crashed a trail motorbike into a wall at his parents’ house in Cambridgeshire. He’d been hiding it in the shed, but “it was far too powerful for me, and on my very first time starting it in the garden, I smashed it into a wall”. His mother came outside to find the skinny teenager in a heap next to the crumpled motorbike. “I was in a lot of trouble.”

Grant hadn’t given this childhood memory much thought in the intervening years, but one hot August day in 2019, it came back to him with such clarity that, at 53, now a stocky father of two, he suddenly understood it as a clue to his dangerously unhealthy relationship with alcohol.

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Take things slowly as lockdown ends to avoid ‘re-entry’ syndrome

A psychiatrist advises us not to catastrophise post-Covid life and to be compassionate towards others


First of all, it’s normal to be anxious when there’s such a big change for us as a society. I think the last time there was something similar was post-9/11 when people had to adjust to using transport at a time when people were anxious about that.

The “re-entry” syndrome people might be experiencing as lockdown ends is part of a healthy readjustment and something that people have to deal with when they’ve been off sick or on maternity leave for long periods.

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‘Imperially nostalgic racists’ target Empireland author with hate mail

Sathnam Sanghera speaks out against ‘vicious’ abuse he is receiving over his bestselling book: ‘Empire has been weaponised by the right wing, ever since Black Lives Matter’

Sathnam Sanghera’s Empireland, a journey through Britain’s imperial past, has been a bestseller since it was pubished last month, acclaimed by critics as “unflinching … moving and stimulating” (the Guardian), and “excellent” and “balanced” (the Sunday Times). And yet, from the British public the author has received handwritten hate mail, and thousands of abusive tweets from “imperially nostalgic racists”, as he succinctly replied, some of them verging, he says, on death threats.

Related: Empireland by Sathnam Sanghera and Slave Empire by Padraic X Scanlan – review

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El Salvador abortion laws on trial in case of woman jailed after miscarriage

Demands for justice for Manuela, who died of cancer during 30-year sentence, taken to international court in country first

When Manuela, a 33-year-old mother of two from rural El Salvador, had a miscarriage in 2008, she did what most women would do: she went to hospital.

There she was handcuffed to her hospital bed, accused of having an abortion, and charged with aggravated homicide.

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Endemic violence against women is causing a wave of anger

Analysis: Sarah Everard’s disappearance sparks furious demands to address misogyny in UK

Women feared this was coming. They waited, messaging each other in WhatsApp groups and on social media. They talked about their own attempts to stay safe, discussed their near misses.

When the news came on Wednesday evening – that police investigating the disappearance of Sarah Everard had found the remains of a body – a wave of grief crashed over them, followed quickly by anger.

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Delaying second Pfizer dose leaves cancer patients at risk, say researchers

Covid vaccination policy review urged after study finds 12-week gap leaves patients vulnerable

Delaying the second dose of the Pfizer/BioNTech vaccine must be urgently reviewed for cancer patients after a single shot was found to offer inadequate protection, researchers have said.

A study from King’s College London and the Francis Crick Institute – which has not yet been peer reviewed – found that three weeks after the first jab antibody responses were found in 39% of people with solid cancers and 13% of people with blood cancer.

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EMA says AstraZeneca vaccine can continue to be used during investigation

Several countries suspend inoculations but regulator says vaccine benefits outweigh its risks

The European Medicines Agency has said the Oxford/AstraZeneca Covid vaccine can continue to be used during an investigation into cases of blood clots that have prompted several European countries to pause their use of the shot.

The EMA said 30 cases of “thromboembolic events” or blood clots had been reported among 5 million people who had received the jab in Europe so far. “The vaccine’s benefits continue to outweigh its risks,” the regulator said in a statement.

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Why we need to take bad sex more seriously

Consent has been portrayed as the cure for all the ills of our sexual culture. But what if the injunction to ‘know what you want’ is another form of coercion?

Sometime in the early 2010s, the porn actor James Deen made a film with a fan whom he called Girl X. He would do this now and then; fans would write to him, wanting to have sex with him, or he would put out a call to “Do a Scene with James Deen”, and the results would go up on his website.

In an interview in May 2017, only a few months before the media would be overwhelmed with discussions of assault and harassment by Harvey Weinstein and others – and only two years after Deen himself was accused of (but not charged with) multiple assaults (which he denied) – he said: “I have a ‘Do a scene with James Deen’ contest, where women can submit an application, and then, after a very long talk and months of me saying, you know, ‘Everyone’s going to find out, it’s going to affect your future’, and trying to talk them out of it kind of, then we shoot a scene.”

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Majority think Covid has increased UK social inequality, survey shows

Social Mobility Commission says results show need for urgent action to stop gap growing even wider

Over half of the public believes the coronavirus outbreak has driven greater social inequality in the UK over the past few months, according to a study by the government’s independent advisers.

The Social Mobility Commission said its annual survey of public attitudes revealed 56% of adults believed social inequality had increased during the pandemic. A quarter said Covid had made no difference to inequality and 16% were unsure.

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Cocaine Bear: the must-see and must-avoid movie of 2022

Elizabeth Banks’s new film, about the aftermath of a narcotics drop in a Georgia national park, may be less hilarious than it first sounds

There is a school of thought that Elizabeth Banks’s version of Charlie’s Angels flopped because it was too familiar; it was in effect a reboot of a reboot of an iconic television series that had long wrung itself dry. People knew exactly what to expect from it, so they stayed away. That’s unlikely to happen with her next film, though, because her next film is going to be called Cocaine Bear.

And, I mean, you’re in, right? You’d watch a film called Cocaine Bear. Regardless of quality or budget or genre, you’d watch Cocaine Bear. You wouldn’t even buy your tickets online, because that would rob you of the opportunity to say out loud to a cinema employee: “I would like to spend my own money to watch a film called Cocaine Bear.”

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Quarter of women and girls have been abused by a partner, says WHO

Largest such study finds domestic violence experienced by one-in-four teenage girls with worst levels faced by women in their 30s

One in four women and girls around the world have been physically or sexually assaulted by a husband or male partner, according to the largest study yet of the prevalence of violence against women.

The report, conducted by the World Health Organization (WHO) and UN partners, found that domestic violence started young, with a quarter of 15- to 19-year-old girls and young women estimated to have been abused at least once in their lives. The highest rates were found to be among 30- to 39-year-olds.

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Aid spending cuts may not get put to Commons vote, No 10 suggests

Denying MPs their say could head off Tory rebellion but potentially open government to legal action

A planned reduction in aid spending may not go to a vote in the Commons, Downing Street has indicated, which would head off a likely rebellion by Conservative MPs but could expose the government to legal action.

Pressed repeatedly on whether the cut in the aid budget from 0.7% of national income – which is set out in law under the 2015 International Development Act – would be subject to a Commons vote or a new act, Boris Johnson’s spokesperson declined to confirm this.

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Hopes, dreams and fears: the world of teenage girls through their diaries

To mark International Women’s Day, explore beyond the stereotypes with Masuma Ahuja’s book Girlhood, a collection of diary entries from girls around the world

Masuma Ahuja was tired of seeing the same stories told about teenage girls. They were either victimised or sexualised, even if an “exceptional girl” such as Greta Thunberg or Malala Yousafzai was occasionally held up as a role model for fighting back.

“We have very little understanding of the day-to-day life of girls and what life looks like for them,” says Ahuja. “I wanted to create a small portrait of what girlhood looks like in different places, and something that girls can pick up and feel seen by … and seen by girls elsewhere who share their own experiences.”

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The Guardian view on women and the pandemic: what happened to building back better? | Editorial

Around the world, coronavirus has both highlighted and worsened existing inequalities

One year into the pandemic, women have little cause to celebrate International Women’s Day tomorrow, and less energy to battle for change. Men are more likely to die from Covid-19. But women have suffered the greatest economic and social blows. They have taken the brunt of increased caregiving, have been more likely to lose their jobs and have seen a sharp rise in domestic abuse.

In the UK, women did two-thirds of the extra childcare in the first lockdown, and were more likely to be furloughed. In the US, every one of the 140,000 jobs lost in December belonged to a woman: they saw 156,000 jobs disappear, while men gained 16,000. But white women actually made gains, while black and Latina women – disproportionately in jobs that offer no sick pay and little flexibility – lost out. Race, wealth, disability and migration status have all determined who is hit hardest. Previous experience suggests that the effects of health crises can be long-lasting: in Sierra Leone, over a year after Ebola broke out, 63% of men had returned to work but only 17% of women.

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What do near-death experiences mean, and why do they fascinate us?

Psychiatrist Bruce Greyson has spent decades talking to people about near-death experiences. His work raises questions about what happens when we die, and how we ought to choose to live

When Gregg Nome was 24 years old, he slipped into the churn beneath a waterfall and began to drown, his body pummelled against the sandy riverbed. What he saw there surprised him. Suddenly, his vision filled with crystal-clear scenes from his childhood, events he had mostly forgotten, and then moments from early adulthood. The memories, if that’s what they were, were vivid and crisp. Was he reliving them? Not quite. They came at high speed, almost all at once, in a wave. And yet he could process each one individually. In fact, he was able to perceive everything around him: the rush of the water, the sandy bed, all of it brilliantly distinct. He could “hear and see as never before,” he recalled later. And, despite being trapped underwater, he felt calm and at ease. He remembered thinking that prior to this moment his senses must have been dulled somehow, because only now could he fully understand the world, perhaps even the true meaning of the universe. Eventually, the imagery faded. Next, “There was only darkness,” he said, “and a feeling of a short pause, like something was about to happen.”

Nome recounted this story at a support group in Connecticut, in 1985, four years after the experience. He had survived, but now he hoped to understand why, during a moment of extreme mortal crisis, his mind had behaved the way it did. The meeting had been organised by Bruce Greyson, now a professor emeritus in psychiatry at the University of Virginia. (Some of the group’s members had responded to an ad Greyson placed in a local newspaper.) As Nome spoke, Greyson sat in a circle of 30 or so others, as if at an AA meeting, listening intently, nodding along.

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Sir Alex Ferguson: ‘I feared I would never speak again’

Former Manchester United manager tells of brain surgery worries ahead of documentary about his life

Sir Alex Ferguson has said he feared he would never be able to speak again after suffering a brain haemorrhage in 2018. The former Manchester United manager told a Q&A at Glasgow film festival he was worried that he could lose his voice and memory after undergoing emergency surgery.

A new documentary about the two-time Champions League-winning manager premiered at the the film festival on Saturday.

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