Category Archives: Medical research

‘Real hope’ for cystic fibrosis patients as NHS rolls out life-changing drug

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Campaigners hail decision to give thousands of sufferers access to new set of drugs known as ‘modulators’

Alix Oxlade was 30 weeks into her pregnancy when scans showed fluid building up in the stomach and bowels of her unborn son, Rufus. The cause was unclear, though there was an early suspect: cystic fibrosis.

One of the most common inherited illnesses in the west, cystic fibrosis is caused by a defective protein that allows mucus to build up in the lungs, bowels and other organs and can lead to chronic infections that worsen through life. Tests subsequently showed Alix and her partner, Ben, who live in East Yorkshire, were both carriers of the disease.

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Mpox outbreak in Africa is public health emergency, declares WHO

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Outbreak resembles early days of HIV, say experts, urging accelerated access to vaccines and testing

An outbreak in Africa of mpox, the disease formerly known as monkeypox, resembles the early days of HIV, scientists have said, as the World Health Organization declared it a public health emergency.

The declaration must accelerate access to testing, vaccines and therapeutic drugs in the affected areas, medical experts urged, and kickstart campaigns to reduce stigma surrounding the virus.

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Cannabis could help people cut down or stop opioid use, research shows

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USC study finds cannabis can help manage withdrawal symptoms, as well as cravings and anxiety after withdrawal

New research from the University of Southern California shows that cannabis might help some people stop or cut down on their opioid use.

“We interviewed 30 people who were using opioids and cannabis and injecting drugs,” said Sid Ganesh, a PhD student at USC’s medical school and lead author of the study.

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Bereavement in early life may accelerate ageing, research shows

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Separate study shows poor diet and added sugar also linked to rise in biological age

The stress of bereavement may accelerate the ageing process, according to researchers who found evidence that losing a loved one early in life had an impact long before people reach middle age.

Scientists spotted biological markers of faster ageing in people who had lost a parent, partner, sibling or child, but the signs were absent in others who had not experienced the death of someone close to them.

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Doctor behind trial of HIV prevention drug recounts breakthrough moment

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Prof Linda-Gail Bekker receives ovation at Aids summit after presenting trial results of ‘miracle’ drug lenacapavir

When the doctor behind the trial of a new HIV prevention drug heard the results, she could not contain her emotions. “I literally burst into tears,” said Prof Linda-Gail Bekker.

“I’m 62, I’ve lived through this epidemic … I had family members who died of HIV, as did many, many Africans – many people around the world,” she said.

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Childhood air pollution directly linked to adult lung health, study says

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Connection found between early exposure and bronchitic symptoms in adults without previous lung problems

Air pollution breathed in during childhood is one of the factors in adult lung health, according to a new study.

The origins of the study date back to 1992 when researchers began investigating the effects of air pollution on groups of children in California. Some of these children are now in their 40s.

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NHS urged to prioritise cancer care basics over tech and AI ‘magic bullets’

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Health service is at tipping point, say experts, and ‘novel solutions’ have been wrongly hyped

The NHS must concentrate on the basics of cancer treatment rather than the “magic bullets” of novel technologies and artificial intelligence, or risk the health of thousands of patients, experts have warned.

In a paper published in the journal Lancet Oncology, nine leading cancer doctors and academics say the NHS is at a tipping point in cancer care with survival rates lagging behind many other developed countries.

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Work on synthetic human embryos to get code of practice in UK

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Code will remove grey area around stem cell-based technology and ensure responsible research, say scientists

Biological models of human embryos that can develop heartbeats, spinal cords and other distinctive features will be governed by a code of practice in Britain to ensure that researchers work on them responsibly.

Made from stem cells, they mimic, to a greater or less extent, the biological processes at work in real embryos. By growing them in the laboratory, scientists hope to learn more about how human embryos develop and respond to their environment, questions that would be impossible to answer with real embryos donated for research.

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Egyptian scribes suffered work-related injuries, study says

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Higher incidence of damage to hips, jaws and thumbs reveals their writing efforts may have taken a toll

From bad backs to eye strain, office work can take its toll on the body.

But it seems such perils are nothing new: researchers have found Egyptian scribes experienced damage to their hips, jaws and thumbs as a result of their efforts.

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Warnings over lethal and contagious strain of mpox as children in DRC die

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Alarm over high mortality and miscarriage rates as mutated virus spreads in eastern Democratic Republic of the Congo

A dangerous strain of mpox that is killing children and causing miscarriages in the Democratic Republic of the Congo is the most transmissible yet and could spread internationally, scientists have warned.

The virus appears to be spreading from person to person via both sexual and non-sexual contact, in places ranging from brothels to schools.

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Weightlifting at retirement age keeps legs strong years later, study finds

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Year of heavy weights resistance training around retirement age has long-lasting benefits, research suggests

Lifting heavy weights three times a week around the age of retirement could dramatically preserve your leg strength long into the later stages of life, research suggests.

People naturally lose muscle function as they get older, and experts say faltering leg strength is a strong predictor of death in elderly people.

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Akira Endo, ‘remarkable’ scientist who discovered statins, dies aged 90

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Biochemist found cholesterol-lowering compound in 1973 and the drugs have prolonged millions of lives

The scientist whose work led to the creation of statins, a chemical that prevents heart attacks and strokes, has died aged 90.

Akira Endo found the first cholesterol-lowering compound in 1973 in a lab in Tokyo. The Japanese biochemist was said to have been inspired by Alexander Fleming’s discovery of penicillin in 1928, which lead him to study mould or fungi in order to develop medicines.

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Scientists develop glowing dye that sticks to cancer cells in breakthrough study

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Experts say fluorescent dye, which spotlights tiny cancerous tissue invisible to naked eye, could reduce risk of cancer returning

Scientists have developed a glowing dye that sticks to cancer cells and gives surgeons a “second pair of eyes” to remove them in real time and permanently eradicate the disease. Experts say the breakthrough could reduce the risk of cancer coming back and prevent debilitating side-effects.

The fluorescent dye spotlights tiny cancerous tissue that cannot be seen by the naked eye, enabling surgeons to remove every last cancer cell while preserving healthy tissue. That could mean fewer life-changing side effects after surgery.

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Bowel disease breakthrough as researchers make ‘holy grail’ discovery

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Scientists pinpoint driver of IBD and other disorders with work under way to adapt existing drugs to treat patients

Researchers have discovered a major driver of inflammatory bowel disease (IBD) and several other immune disorders that affect the spine, liver and arteries, raising hopes for millions of people worldwide.

The breakthrough is particularly exciting because the newly found biological pathway can be targeted by drugs that are already used, with work under way to adapt them to patients with IBD and other conditions.

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Mounjaro is second obesity drug to be approved for use in England

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Those with BMI of 35 and a comorbidity can now be prescribed tirzepatide and Nice says it is more effective than Wegovy

The medical treatment regulator for England has approved a second drug to combat obesity, giving patients and doctors what it says is a more effective alternative to semaglutide.

The National Institute for Health and Care Excellence (Nice) issued draft guidance on Tuesday recommending that very obese people should be prescribed tirzepatide, which is marketed in the UK as Mounjaro.

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Women in England and Wales denied ‘exciting’ drug that can stop breast cancer spreading

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Latest study shows Enhertu, rejected by Nice, can stall growth of tumours by a year, longer than standard chemotherapy

Thousands of women with advanced breast cancer in England and Wales are being denied a drug that cuts the risk of the disease spreading by more than a third.

Enhertu has been rolled out to patients with HER2-low breast cancer in Scotland and Northern Ireland, but the National Institute for Health and Care Excellence (Nice) has rejected it for patients in England. Women in Wales are also being denied the drug.

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Trial results for new lung cancer drug are ‘off the charts’, say doctors

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More than half of patients with advanced forms of disease who took lorlatinib were still alive after five years with no progression

Doctors are hailing “off the chart” trial results that show a new drug stopped lung cancer advancing for longer than any other treatment in medical history.

Lung cancer is the world’s leading cause of cancer death, accounting for about 1.8m deaths every year. Survival rates in those with advanced forms of the disease, where tumours have spread, are particularly poor.

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Huge number of deaths linked to superbugs can be avoided, say experts

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Models suggest deaths in poorer countries could be cut by 18% – or about 750,000 a year – with preventive measures

Every year 750,000 deaths linked to drug-resistant superbugs could be prevented through better access to clean water and sanitation, infection control and childhood vaccinations, research suggests.

Antimicrobial resistance, or AMR, is a huge global challenge, with the evolution of drug-resistant superbugs, driven by factors including inappropriate and excessive antibiotic use, raising the prospect of a future where modern medicine fails.

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Scientists make potential breast cancer breakthrough after preserving tissue in gel

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Ability to preserve tissue in a special gel solution for at least a week will help doctors identify most effective drug treatments

Scientists say they have a made a potentially “gamechanging” breakthrough in breast cancer research after discovering how to preserve breast tissue outside the body for at least a week.

The study, which was funded by the Prevent Breast Cancer charity, found tissue could be preserved in a special gel solution, which will help scientists identify the most effective drug treatments for patients.

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Great Ormond Street hoping to license gene therapy for ‘bubble baby’ syndrome

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Hospital to take unprecedented step after drug firm pulled out despite successful trial of treatment

When Great Ormond Street hospital (Gosh) published the results of its gene therapy trial for “bubble baby” syndrome it was hailed as a medical breakthrough. The treatment had a more than 95% success rate for treating the life-threatening disorder in which children have no immune system. But less than a year later, the therapy had been dropped by the pharmaceutical company that planned to bring it to market.

Now, Gosh is taking the unprecedented step of attempting to license the therapy itself on a non-profit basis and without industry involvement, in order to make it more widely available to babies and children worldwide.

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